Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5901.098 | 0.9861 | 0.9845 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5901.098 | 0.9413 | 0.9339 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5901.098 | 1.0471 | 1.0518 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5901.098 | 0.9631 | 0.9587 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5901.098 | 0.9052 | 0.8924 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5901.098 | 0.5371 | 0.4163 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5901.098 | 0.4293 | 0.2506 | 1.8013 | |
| AU565 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5901.098 | 0.3238 | 0.0695 | 1.8013 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5902.098 | 1.0105 | 1.0188 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5902.098 | 0.9873 | 0.9771 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5902.098 | 0.9813 | 0.9664 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5902.098 | 1.0381 | 1.0682 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5902.098 | 1.0144 | 1.0258 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5902.098 | 0.9858 | 0.9745 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5902.098 | 1.0226 | 1.0405 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5902.098 | 0.9922 | 0.9860 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 16.7 | uM | 5902.098 | 1.0074 | 1.0133 | 1.1137 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0000427 | uM | 5904.098 | 1.0647 | 1.0969 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.000213 | uM | 5904.098 | 0.9026 | 0.8514 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00107 | uM | 5904.098 | 1.0105 | 1.0158 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.00533 | uM | 5904.098 | 1.0029 | 1.0044 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.0267 | uM | 5904.098 | 1.0537 | 1.0804 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.133 | uM | 5904.098 | 0.9851 | 0.9776 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 0.667 | uM | 5904.098 | 0.9550 | 0.9318 | 1.3264 | |
| BT-20 | TNBC | Basal A | Lapatinib | EGFR/HER2 | ErbB | 3.33 | uM | 5904.098 | 0.9403 | 0.9092 | 1.3264 |