Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7464.067 | 0.5125 | -0.1988 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7464.067 | 0.5775 | -0.0566 | 0.7308 | |
| HCC2185 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7464.067 | 0.0041 | -0.9989 | 0.7308 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7466.067 | 1.0461 | 1.0976 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7466.067 | 1.0060 | 1.0127 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7466.067 | 1.0132 | 1.0279 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7466.067 | 1.0061 | 1.0129 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7466.067 | 0.3453 | -0.3503 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7466.067 | 0.2666 | -0.5058 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7466.067 | 0.2744 | -0.4906 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7466.067 | 0.2360 | -0.5656 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7466.067 | 0.0072 | -0.9891 | 0.9457 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7467.067 | 0.9924 | 0.9886 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7467.067 | 0.9575 | 0.9355 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7467.067 | 1.0062 | 1.0094 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7467.067 | 0.8947 | 0.8389 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7467.067 | 0.3303 | -0.1331 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7467.067 | 0.2950 | -0.2041 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7467.067 | 0.2797 | -0.2353 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7467.067 | 0.2210 | -0.3599 | 1.3252 | |
| HCC3153 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7467.067 | 0.0032 | -0.9735 | 1.3252 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7468.067 | 0.9904 | 0.9861 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7468.067 | 0.9808 | 0.9722 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7468.067 | 1.0383 | 1.0550 | 1.3847 | |
| HCC38 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7468.067 | 1.0363 | 1.0522 | 1.3847 |