Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10264.001 | 0.8364 | 0.7803 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10264.001 | 0.6200 | 0.4650 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10264.001 | 0.7779 | 0.6983 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10264.001 | 0.8057 | 0.7375 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10264.001 | 0.5634 | 0.3765 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10264.001 | 0.1171 | -0.5051 | 1.5356 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7870.001 | 0.9503 | 0.9514 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7870.001 | 1.0555 | 1.0529 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7870.001 | 0.9598 | 0.9608 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7870.001 | 1.0189 | 1.0181 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7870.001 | 0.3707 | 0.2382 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7870.001 | 0.2318 | -0.0130 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7870.001 | 0.2909 | 0.1014 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7870.001 | 0.3793 | 0.2521 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7870.001 | 0.0462 | -0.5473 | 2.0700 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9551.001 | 1.0288 | 1.0212 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9551.001 | 1.0321 | 1.0236 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9551.001 | 0.9631 | 0.9722 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9551.001 | 0.9663 | 0.9747 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9551.001 | 0.3734 | 0.3870 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 9551.001 | 0.0923 | -0.1747 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 9551.001 | 0.0762 | -0.2317 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 9551.001 | 0.0972 | -0.1588 | 2.6913 | |
| MCF 10A | NM | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 9551.001 | 0.1866 | 0.0719 | 2.6913 | |
| MCF 10F | NM | - | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7871.001 | 1.0122 | 1.0236 | 1.0311 |