Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 10262.001 | 0.9261 | 0.7636 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 10262.001 | 0.8510 | 0.5356 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 10262.001 | 0.8502 | 0.5331 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 10262.001 | 0.8078 | 0.4097 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 10262.001 | 0.7795 | 0.3299 | 0.6105 | |
| HCC1937 | TNBC | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 10262.001 | 0.4396 | -0.4796 | 0.6105 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7837.001 | 1.1091 | 1.1394 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7837.001 | 1.1029 | 1.1317 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7837.001 | 1.1176 | 1.1502 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7837.001 | 0.9997 | 0.9996 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7837.001 | 1.1746 | 1.2210 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7837.001 | 0.9942 | 0.9924 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7837.001 | 0.8074 | 0.7399 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7837.001 | 0.4136 | 0.1256 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7837.001 | 0.0154 | -0.8678 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 7839.001 | 1.1652 | 1.1683 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.000427 | uM | 7839.001 | 1.0282 | 1.0297 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.00213 | uM | 7839.001 | 1.1063 | 1.1097 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0107 | uM | 7839.001 | 0.9180 | 0.9115 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0533 | uM | 7839.001 | 1.0348 | 1.0365 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.267 | uM | 7839.001 | 1.0158 | 1.0167 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 1.33 | uM | 7839.001 | 0.7434 | 0.7099 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 6.67 | uM | 7839.001 | 0.4143 | 0.2553 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 33.3 | uM | 7839.001 | 0.0115 | -0.8109 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 0.0000853 | uM | 9386.001 | 1.0288 | 1.0434 | 1.3243 |