Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9163.011 | 0.8771 | 0.6223 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9163.011 | 0.8575 | 0.5647 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9163.011 | 0.8649 | 0.5863 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9163.011 | 0.8051 | 0.4150 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 28.9 | uM | 9163.011 | 0.8082 | 0.4237 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 144 | uM | 9163.011 | 0.8690 | 0.5984 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.000325 | uM | 9163.03 | 0.9193 | 0.5765 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00162 | uM | 9163.03 | 0.8800 | 0.3931 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.00812 | uM | 9163.03 | 0.8958 | 0.4649 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0406 | uM | 9163.03 | 0.9027 | 0.4972 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 0.203 | uM | 9163.03 | 0.8024 | 0.0731 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 1.01 | uM | 9163.03 | 0.9547 | 0.7541 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 5.07 | uM | 9163.03 | 0.8248 | 0.1600 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 25.4 | uM | 9163.03 | 0.8078 | 0.0934 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 127 | uM | 9163.03 | 0.5820 | -0.5674 | 0.3535 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0185 | uM | 9186.119 | 0.6746 | -0.1278 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.0924 | uM | 9186.119 | 0.7168 | -0.0089 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 0.462 | uM | 9186.119 | 0.7012 | -0.0537 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 2.31 | uM | 9186.119 | 0.6724 | -0.1340 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 11.5 | uM | 9186.119 | 0.6257 | -0.2557 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 57.7 | uM | 9186.119 | 0.6616 | -0.1630 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 289 | uM | 9186.119 | 0.7410 | 0.0629 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 1440 | uM | 9186.119 | 0.5657 | -0.3982 | 0.4743 | |
| BT-483 | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 7220 | uM | 9186.119 | 0.5756 | -0.3759 | 0.4743 | |
| BT-549 | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 7803.011 | 0.9877 | 0.9918 | 3.0094 |