Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9664.049 | 0.3772 | -0.4845 | 0.7193 | |
| MDA-MB-415 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9664.049 | 0.3458 | -0.5430 | 0.7193 | |
| MDA-MB-415 | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9664.049 | 0.3232 | -0.5840 | 0.7193 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7898.04 | 0.9206 | 0.8549 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7898.04 | 1.1718 | 1.3104 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7898.04 | 0.9384 | 0.8875 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7898.04 | 0.9703 | 0.9458 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7898.04 | 0.7169 | 0.4773 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7898.04 | 0.6274 | 0.3084 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7898.04 | 0.6203 | 0.2950 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7898.04 | 0.6541 | 0.3590 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7898.04 | 0.4849 | 0.0350 | 1.0987 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 7900.012 | 0.8663 | 0.6747 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 7900.012 | 0.8914 | 0.7351 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 7900.012 | 0.4551 | -0.2442 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 7900.012 | 0.6837 | 0.2499 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 7900.012 | 0.6116 | 0.0892 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 7900.012 | 0.5812 | 0.0225 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 4 | uM | 7900.012 | 0.5610 | -0.0211 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 20 | uM | 7900.012 | 0.4415 | -0.2721 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 100 | uM | 7900.012 | 0.6997 | 0.2863 | 0.8090 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 10266.024 | 0.9390 | 0.8163 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 10266.024 | 1.2157 | 1.6970 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 10266.024 | 0.9232 | 0.7697 | 0.6533 | |
| MDA-MB-436 | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 10266.024 | 0.8608 | 0.5900 | 0.6533 |