Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 11936.161 | 0.9893 | 0.9711 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 11936.161 | 1.0053 | 1.0144 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 11936.161 | 1.0254 | 1.0688 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 4 | uM | 11936.161 | 1.0257 | 1.0698 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 20 | uM | 11936.161 | 0.9399 | 0.8395 | 0.7410 | |
| HCC1428 | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 100 | uM | 11936.161 | 0.7717 | 0.4098 | 0.7410 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0000853 | uM | 10872.149 | 0.9558 | 0.9438 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.000427 | uM | 10872.149 | 0.9716 | 0.9641 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.00213 | uM | 10872.149 | 0.9752 | 0.9686 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0107 | uM | 10872.149 | 0.9239 | 0.9027 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0533 | uM | 10872.149 | 0.9573 | 0.9457 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.267 | uM | 10872.149 | 0.9102 | 0.8848 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 1.33 | uM | 10872.149 | 0.9398 | 0.9232 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 6.67 | uM | 10872.149 | 0.8834 | 0.8496 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 33.3 | uM | 10872.149 | 0.8793 | 0.8442 | 1.5861 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12523.166 | 1.0042 | 1.0084 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.00128 | uM | 12523.166 | 0.9266 | 0.8524 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.0064 | uM | 12523.166 | 0.9821 | 0.9641 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.032 | uM | 12523.166 | 0.9957 | 0.9913 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.16 | uM | 12523.166 | 0.9562 | 0.9118 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 0.8 | uM | 12523.166 | 0.9858 | 0.9715 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 4 | uM | 12523.166 | 1.0366 | 1.0738 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 20 | uM | 12523.166 | 1.0323 | 1.0651 | 0.9938 | |
| HCC1569 | HER2amp | Basal A | FR180204 | ERK1/2 | MAPK | 100 | uM | 12523.166 | 0.9099 | 0.8187 | 0.9938 | |
| HCC1806 | TNBC | Basal A | FR180204 | ERK1/2 | MAPK | 0.000256 | uM | 12239.161 | 0.9831 | 0.9812 | 1.8129 |