Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.107 | uM | 7456.091 | 0.9028 | 0.8873 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.533 | uM | 7456.091 | 0.7157 | 0.6544 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 2.67 | uM | 7456.091 | 0.6451 | 0.5597 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 13.3 | uM | 7456.091 | 0.4366 | 0.2499 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 66.7 | uM | 7456.091 | 0.3915 | 0.1750 | 1.7629 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.000171 | uM | 7457.09 | 0.9794 | 0.9762 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.000853 | uM | 7457.09 | 0.9452 | 0.9363 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.00427 | uM | 7457.09 | 1.0030 | 1.0035 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.0213 | uM | 7457.09 | 0.9346 | 0.9238 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.107 | uM | 7457.09 | 0.8720 | 0.8486 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 0.533 | uM | 7457.09 | 0.7740 | 0.7261 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 2.67 | uM | 7457.09 | 0.7025 | 0.6325 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 13.3 | uM | 7457.09 | 0.5572 | 0.4289 | 1.7392 | |
| HCC1954 | HER2amp | Basal A | Erlotinib | EGFR | ErbB | 66.7 | uM | 7457.09 | 0.4272 | 0.2264 | 1.7392 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.000171 | uM | 7458.091 | 0.9886 | 0.9588 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.000853 | uM | 7458.091 | 0.9829 | 0.9382 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.00427 | uM | 7458.091 | 0.9646 | 0.8731 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.0213 | uM | 7458.091 | 0.9761 | 0.9140 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.107 | uM | 7458.091 | 0.9934 | 0.9761 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 0.533 | uM | 7458.091 | 0.9900 | 0.9638 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 2.67 | uM | 7458.091 | 0.9724 | 0.9009 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 13.3 | uM | 7458.091 | 0.9561 | 0.8432 | 0.5499 | |
| HCC202 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 66.7 | uM | 7458.091 | 0.6553 | -0.0727 | 0.5499 | |
| HCC2185 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 0.0000853 | uM | 7462.092 | 1.0236 | 1.1107 | 0.4336 | |
| HCC2185 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 0.000427 | uM | 7462.092 | 0.9855 | 0.9337 | 0.4336 |