Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9860.037 | 0.9248 | 0.9088 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9860.037 | 1.0101 | 1.0120 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9860.037 | 0.8691 | 0.8394 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9860.037 | 0.4799 | 0.2908 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9860.037 | 0.3016 | -0.0214 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9860.037 | 0.2717 | -0.0806 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 4 | uM | 9860.037 | 0.2647 | -0.0949 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 20 | uM | 9860.037 | 0.1994 | -0.2354 | 1.6767 | |
| SUM229PE | TNBC | - | 17-AAG | HSP90 | HSP90 | 100 | uM | 9860.037 | 0.0180 | -0.8181 | 1.6767 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7538.05 | 0.9765 | 0.9167 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7538.05 | 0.8365 | 0.4530 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7538.05 | 0.7857 | 0.2988 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7538.05 | 0.5289 | -0.3605 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7538.05 | 0.3569 | -0.6837 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7538.05 | 0.3663 | -0.6686 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7538.05 | 0.3192 | -0.7410 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7538.05 | 0.1224 | -0.9534 | 0.5587 | |
| SUM44PE | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7538.05 | 0.1918 | -0.8959 | 0.5587 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7540.05 | 0.9955 | 0.9869 | 0.6835 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7540.05 | 0.9309 | 0.8011 | 0.6835 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7540.05 | 0.9365 | 0.8168 | 0.6835 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7540.05 | 0.6627 | 0.0955 | 0.6835 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7540.05 | 0.4236 | -0.4309 | 0.6835 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7540.05 | 0.4245 | -0.4291 | 0.6835 | |
| SUM52PE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7540.05 | 0.4337 | -0.4109 | 0.6835 |