Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 10127.037 | 0.7325 | 0.3027 | 0.7262 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7529.05 | 0.9694 | 0.8776 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7529.05 | 1.0180 | 1.0738 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7529.05 | 0.9346 | 0.7431 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7529.05 | 0.8675 | 0.4982 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7529.05 | 0.3957 | -0.6961 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7529.05 | 0.3956 | -0.6962 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7529.05 | 0.4176 | -0.6609 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7529.05 | 0.3556 | -0.7553 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7529.05 | 0.1644 | -0.9490 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9797.037 | 0.9993 | 0.9962 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9797.037 | 1.0718 | 1.3922 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9797.037 | 0.9398 | 0.7035 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9797.037 | 0.7953 | 0.1067 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9797.037 | 0.4820 | -0.6964 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9797.037 | 0.5973 | -0.4718 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 9797.037 | 0.5899 | -0.4884 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 9797.037 | 0.0510 | -0.9991 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 9797.037 | 0.0118 | -1.0000 | 0.3871 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7917.05 | 0.9737 | 0.9808 | 2.7707 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7917.05 | 1.0429 | 1.0306 | 2.7707 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7917.05 | 0.8917 | 0.9189 | 2.7707 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7917.05 | 0.9118 | 0.9344 | 2.7707 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7917.05 | 0.0954 | -0.1434 | 2.7707 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7917.05 | 0.0386 | -0.3822 | 2.7707 |