Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 10937.155 | 0.4857 | 0.1545 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 10937.155 | 0.7912 | 0.6736 | 1.3142 | |
| HCC3153 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 10937.155 | 0.7151 | 0.5496 | 1.3142 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 11850.155 | 0.9298 | 0.9343 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 11850.155 | 0.9099 | 0.9153 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 11850.155 | 0.9154 | 0.9205 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 11850.155 | 0.9277 | 0.9324 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 11850.155 | 0.8643 | 0.8706 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 11850.155 | 0.8042 | 0.8098 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 11850.155 | 0.1041 | -0.2913 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 11850.155 | 0.5393 | 0.5069 | 2.1810 | |
| HCC38 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 11850.155 | 0.7218 | 0.7223 | 2.1810 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10873.155 | 0.8979 | 0.8385 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10873.155 | 0.9545 | 0.9285 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10873.155 | 0.8666 | 0.7881 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10873.155 | 0.8831 | 0.8147 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10873.155 | 0.8331 | 0.7338 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 10873.155 | 0.6503 | 0.4284 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 10873.155 | 0.3595 | -0.1015 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 10873.155 | 0.4689 | 0.1060 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 10873.155 | 0.6277 | 0.3895 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12400.155 | 1.0094 | 1.0149 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12400.155 | 0.9684 | 0.9496 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12400.155 | 0.9664 | 0.9463 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12400.155 | 0.9721 | 0.9554 | 1.2558 |