Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 12112.155 | 0.9109 | 0.8988 | 1.7965 | |
| HCC1143 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 12112.155 | 0.8466 | 0.8229 | 1.7965 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 10753.146 | 0.9625 | 0.9479 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.000427 | uM | 10753.146 | 0.8913 | 0.8475 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.00213 | uM | 10753.146 | 0.9518 | 0.9330 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0107 | uM | 10753.146 | 0.9354 | 0.9100 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.0533 | uM | 10753.146 | 0.9258 | 0.8965 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 0.267 | uM | 10753.146 | 0.9439 | 0.9219 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 1.33 | uM | 10753.146 | 0.9301 | 0.9025 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 6.67 | uM | 10753.146 | 0.8968 | 0.8553 | 1.4503 | |
| HCC1187 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 33.3 | uM | 10753.146 | 0.8476 | 0.7845 | 1.4503 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12000.155 | 0.9265 | 0.8299 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12000.155 | 0.9402 | 0.8615 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12000.155 | 0.9381 | 0.8567 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12000.155 | 0.8939 | 0.7553 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12000.155 | 0.9200 | 0.8149 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.267 | uM | 12000.155 | 0.8138 | 0.5736 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 1.33 | uM | 12000.155 | 0.6506 | 0.2127 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 6.67 | uM | 12000.155 | 0.9315 | 0.8415 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 33.3 | uM | 12000.155 | 0.8554 | 0.6675 | 0.8592 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0000853 | uM | 12084.155 | 1.0474 | 1.0728 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.000427 | uM | 12084.155 | 1.0740 | 1.1133 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.00213 | uM | 12084.155 | 1.0214 | 1.0329 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0107 | uM | 12084.155 | 1.0116 | 1.0178 | 1.2955 | |
| HCC1395 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 0.0533 | uM | 12084.155 | 1.0058 | 1.0089 | 1.2955 |