Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 10061.037 | 0.0477 | -0.6495 | 1.7478 | |
| MCF12A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 10061.037 | 0.9567 | 0.9500 | 1.7478 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7874.05 | 1.0180 | 1.0226 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7874.05 | 1.0644 | 1.0803 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7874.05 | 0.9892 | 0.9863 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7874.05 | 1.0465 | 1.0581 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7874.05 | 0.7081 | 0.6089 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7874.05 | 0.6101 | 0.4648 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7874.05 | 0.5541 | 0.3784 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7874.05 | 0.3503 | 0.0324 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7874.05 | 0.2707 | -0.1226 | 1.5863 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7875.037 | 1.0231 | 1.0286 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7875.037 | 1.0025 | 1.0032 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7875.037 | 1.0382 | 1.0473 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7875.037 | 0.9181 | 0.8964 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7875.037 | 0.5864 | 0.4344 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7875.037 | 0.4385 | 0.1969 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 7875.037 | 0.4846 | 0.2738 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7875.037 | 0.3058 | -0.0437 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7875.037 | 0.1836 | -0.3040 | 1.6059 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9583.037 | 0.9690 | 0.9487 | 1.2109 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9583.037 | 0.9876 | 0.9794 | 1.2109 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9583.037 | 0.9931 | 0.9885 | 1.2109 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9583.037 | 0.9656 | 0.9430 | 1.2109 | |
| MCF7 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9583.037 | 0.7121 | 0.5109 | 1.2109 |