Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 9421.034 | 1.0056 | 1.0182 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 9421.034 | 1.0216 | 1.0698 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 9421.034 | 1.0110 | 1.0354 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 9421.034 | 1.0151 | 1.0488 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 9421.034 | 0.9965 | 0.9887 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 9421.034 | 0.8553 | 0.5557 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 9421.034 | 0.7266 | 0.1968 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 9421.034 | 0.6394 | -0.0256 | 0.6220 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.000189 | uM | 10263.034 | 1.0203 | 1.1102 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.000945 | uM | 10263.034 | 0.9622 | 0.8045 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.00472 | uM | 10263.034 | 1.0390 | 1.2146 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.0236 | uM | 10263.034 | 0.9751 | 0.8702 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.118 | uM | 10263.034 | 1.0213 | 1.1157 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 0.59 | uM | 10263.034 | 0.9749 | 0.8687 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 2.95 | uM | 10263.034 | 0.8217 | 0.1849 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 14.8 | uM | 10263.034 | 0.5965 | -0.4957 | 0.3750 | |
| HCC2185 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 73.8 | uM | 10263.034 | 0.5740 | -0.5448 | 0.3750 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7853.007 | 0.9982 | 0.9973 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7853.007 | 1.0225 | 1.0336 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7853.007 | 1.0117 | 1.0176 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7853.007 | 1.0134 | 1.0200 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.118 | uM | 7853.007 | 1.0363 | 1.0542 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 0.59 | uM | 7853.007 | 0.9929 | 0.9894 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 2.95 | uM | 7853.007 | 0.9455 | 0.9178 | 1.3351 | |
| HCC3153 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 14.8 | uM | 7853.007 | 0.7740 | 0.6509 | 1.3351 |