Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.0273 | uM | 10261.121 | 0.9506 | 0.9556 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.136 | uM | 10261.121 | 1.0137 | 1.0121 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 0.682 | uM | 10261.121 | 0.9121 | 0.9200 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 3.41 | uM | 10261.121 | 0.5787 | 0.5691 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 17.1 | uM | 10261.121 | 0.1623 | -0.1074 | 2.2540 | |
| BT-549 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 85.2 | uM | 10261.121 | 0.0188 | -0.6572 | 2.2540 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.000218 | uM | 9210.121 | 1.0631 | 1.1411 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00109 | uM | 9210.121 | 1.0447 | 1.1000 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.00546 | uM | 9210.121 | 1.0734 | 1.1644 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.0273 | uM | 9210.121 | 1.1527 | 1.3432 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.136 | uM | 9210.121 | 1.1325 | 1.2977 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 0.682 | uM | 9210.121 | 1.1196 | 1.2684 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 3.41 | uM | 9210.121 | 0.8868 | 0.7493 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 17.1 | uM | 9210.121 | 0.7702 | 0.4948 | 0.8970 | |
| CAMA-1 | HR+ | Luminal | CPT-11 | TOP1 | TOP | 85.2 | uM | 9210.121 | 0.6244 | 0.1830 | 0.8970 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.000189 | uM | 7808.043 | 0.9033 | 0.9167 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.000945 | uM | 7808.043 | 1.0858 | 1.0701 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.00472 | uM | 7808.043 | 0.9152 | 0.9272 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.0236 | uM | 7808.043 | 1.0047 | 1.0039 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.118 | uM | 7808.043 | 0.9841 | 0.9866 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.59 | uM | 7808.043 | 0.8067 | 0.8281 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 2.95 | uM | 7808.043 | 0.7807 | 0.8032 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 14.8 | uM | 7808.043 | 0.1240 | -0.1647 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 73.8 | uM | 7808.043 | 0.3766 | 0.3293 | 2.3907 | |
| HBL-100 | Unknown | Unknown | CPT-11 | TOP1 | TOP | 0.000189 | uM | 9226.034 | 0.9739 | 0.9799 | 2.6175 |