Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7932.017 | 0.7470 | 0.5232 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7932.017 | 0.1404 | -0.6800 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7932.017 | 0.0404 | -0.8999 | 1.0712 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9958.021 | 1.0089 | 1.0349 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9958.021 | 0.9556 | 0.8303 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9958.021 | 1.0088 | 1.0343 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9958.021 | 0.9789 | 0.9184 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9958.021 | 0.9560 | 0.8319 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9958.021 | 0.9609 | 0.8502 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9958.021 | 0.7922 | 0.2699 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9958.021 | 0.5597 | -0.3549 | 0.5129 | |
| ZR-75-1 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9958.021 | 0.0959 | -0.9793 | 0.5129 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 9972.017 | 1.1006 | 1.1713 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 9972.017 | 1.0189 | 1.0324 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 9972.017 | 1.0589 | 1.1005 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 9972.017 | 0.9966 | 0.9942 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 9972.017 | 1.0397 | 1.0679 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 9972.017 | 0.9396 | 0.8960 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 9972.017 | 0.8137 | 0.6760 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 9972.017 | 0.4014 | -0.0855 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 9972.017 | 0.0830 | -0.7631 | 1.1666 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00128 | uM | 9997.049 | 1.0060 | 1.0106 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0064 | uM | 9997.049 | 0.9700 | 0.9474 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.032 | uM | 9997.049 | 1.0231 | 1.0404 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.16 | uM | 9997.049 | 0.9476 | 0.9080 | 1.1423 |