Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 10264.131 | 0.9864 | 0.9812 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 10264.131 | 1.0038 | 1.0053 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 10264.131 | 1.0322 | 1.0441 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 10264.131 | 0.9699 | 0.9585 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 10264.131 | 0.8906 | 0.8469 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 10264.131 | 0.8394 | 0.7732 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 10264.131 | 0.6102 | 0.4243 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 10264.131 | 0.2152 | -0.3042 | 1.4548 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 10264.131 | 0.0893 | -0.6200 | 1.4548 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7867.017 | 1.0075 | 1.0060 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7867.017 | 1.0029 | 1.0023 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7867.017 | 1.0140 | 1.0110 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7867.017 | 0.9471 | 0.9574 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7867.017 | 0.9641 | 0.9712 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7867.017 | 0.7722 | 0.8054 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7867.017 | 0.5775 | 0.6092 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 50 | uM | 7867.017 | 0.0467 | -0.4057 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 250 | uM | 7867.017 | 0.0041 | -0.7724 | 2.5255 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.00064 | uM | 7870.017 | 1.0955 | 1.0912 | 2.0447 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.0032 | uM | 7870.017 | 0.9980 | 0.9980 | 2.0447 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.016 | uM | 7870.017 | 1.0709 | 1.0681 | 2.0447 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.08 | uM | 7870.017 | 1.0240 | 1.0233 | 2.0447 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 0.4 | uM | 7870.017 | 0.9946 | 0.9947 | 2.0447 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 2 | uM | 7870.017 | 0.7406 | 0.7268 | 2.0447 | |
| MCF 10A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10 | uM | 7870.017 | 0.6587 | 0.6306 | 2.0447 |