Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9420.037 | 1.0040 | 1.0205 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9420.037 | 0.9837 | 0.9169 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9420.037 | 0.6484 | -0.3481 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9420.037 | 0.4460 | -0.7526 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9420.037 | 0.4002 | -0.8131 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9420.037 | 0.3540 | -0.8639 | 0.3864 | |
| HCC2185 | TNBC | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9420.037 | 0.1756 | -0.9778 | 0.3864 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7853.04 | 1.0246 | 1.0296 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7853.04 | 0.9547 | 0.9449 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7853.04 | 0.9972 | 0.9966 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7853.04 | 0.9800 | 0.9758 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7853.04 | 0.6344 | 0.5200 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7853.04 | 0.2979 | -0.0366 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7853.04 | 0.2701 | -0.0917 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7853.04 | 0.2848 | -0.0624 | 1.6581 | |
| HCC3153 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7853.04 | 0.1866 | -0.2733 | 1.6581 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7854.05 | 1.0239 | 1.0447 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7854.05 | 0.9520 | 0.9099 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7854.05 | 0.9130 | 0.8364 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7854.05 | 0.8232 | 0.6665 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7854.05 | 0.4646 | -0.0254 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7854.05 | 0.3087 | -0.3357 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7854.05 | 0.2790 | -0.3958 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7854.05 | 0.1909 | -0.5767 | 1.0664 | |
| HCC38 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7854.05 | 0.1673 | -0.6260 | 1.0664 |