Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9760.026 | 0.6405 | 0.3201 | 1.0724 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.000256 | uM | 10127.123 | 1.0076 | 1.0173 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.00128 | uM | 10127.123 | 0.7262 | 0.3886 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0064 | uM | 10127.123 | 0.8413 | 0.6421 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.032 | uM | 10127.123 | 0.9346 | 0.8516 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.16 | uM | 10127.123 | 0.9572 | 0.9026 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.8 | uM | 10127.123 | 0.7792 | 0.5047 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 4 | uM | 10127.123 | 0.9612 | 0.9117 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 20 | uM | 10127.123 | 0.6419 | 0.2063 | 0.8767 | ||
| SK-BR-3 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 100 | uM | 10127.123 | 0.0635 | -0.9138 | 0.8767 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.00128 | uM | 9777.124 | 1.0508 | 1.1643 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0064 | uM | 9777.124 | 1.1387 | 1.4598 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.032 | uM | 9777.124 | 1.0363 | 1.1169 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.16 | uM | 9777.124 | 0.8750 | 0.6168 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.8 | uM | 9777.124 | 0.8597 | 0.5719 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 4 | uM | 9777.124 | 0.8867 | 0.6513 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 20 | uM | 9777.124 | 0.3476 | -0.6285 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 100 | uM | 9777.124 | 0.0024 | -0.9999 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 500 | uM | 9777.124 | 0.0024 | -0.9999 | 0.6278 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9797.006 | 1.1026 | 1.5242 | 0.4196 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 9797.006 | 1.0449 | 1.2209 | 0.4196 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 9797.006 | 1.0073 | 1.0351 | 0.4196 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 9797.006 | 0.9145 | 0.6161 | 0.4196 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 9797.006 | 0.9059 | 0.5804 | 0.4196 | ||
| SUM1315MO2 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 9797.006 | 0.9297 | 0.6811 | 0.4196 |