Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9583.026 | 0.3001 | -0.2230 | 1.2731 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10073.034 | 1.0191 | 1.0695 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 10073.034 | 0.9843 | 0.9437 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 10073.034 | 0.9865 | 0.9515 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 10073.034 | 0.9847 | 0.9451 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 10073.034 | 0.9714 | 0.8979 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 10073.034 | 0.9541 | 0.8372 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 10073.034 | 0.9360 | 0.7747 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 10073.034 | 0.9924 | 0.9724 | 0.5531 | ||
| MCF7 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 10073.034 | 0.2197 | -0.8708 | 0.5531 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10077.026 | 1.3074 | 2.9095 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 10077.026 | 1.1397 | 1.7735 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 10077.026 | 1.1783 | 2.0141 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 10077.026 | 1.0448 | 1.2318 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 10077.026 | 1.1487 | 1.8288 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 10077.026 | 1.0613 | 1.3206 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 10077.026 | 1.1349 | 1.7444 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 10077.026 | 0.9483 | 0.7515 | 0.3999 | ||
| MDA-MB-134-VI | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 10077.026 | 0.3720 | -0.8312 | 0.3999 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7879.018 | 1.0037 | 1.0041 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 7879.018 | 1.0097 | 1.0109 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 7879.018 | 0.9191 | 0.9079 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 7879.018 | 0.7766 | 0.7367 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7879.018 | 0.8014 | 0.7674 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 7879.018 | 0.7445 | 0.6962 | 1.7910 |