Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7863.018 | 1.0309 | 1.0293 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 7863.018 | 1.0314 | 1.0297 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 7863.018 | 0.8207 | 0.8199 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 7863.018 | 0.5214 | 0.4656 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 7863.018 | 0.6219 | 0.5942 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 7863.018 | 0.6207 | 0.5927 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 7863.018 | 0.6807 | 0.6644 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 7863.018 | 0.5691 | 0.5281 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 7863.018 | 0.0117 | -0.7605 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9511.034 | 1.0032 | 1.0058 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.064 | uM | 9511.034 | 1.0242 | 1.0433 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 0.32 | uM | 9511.034 | 0.8782 | 0.7806 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1.6 | uM | 9511.034 | 0.6678 | 0.3937 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 8 | uM | 9511.034 | 0.6538 | 0.3673 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 40 | uM | 9511.034 | 0.6716 | 0.4007 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 200 | uM | 9511.034 | 0.6746 | 0.4063 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 1000 | uM | 9511.034 | 0.6009 | 0.2680 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 5000 | uM | 9511.034 | 0.0121 | -0.9614 | 1.1177 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7865.018 | 0.3098 | -0.2517 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7865.018 | 1.1631 | 1.2704 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7865.018 | 0.3528 | -0.1654 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7865.018 | 0.6927 | 0.4698 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7865.018 | 0.3858 | -0.1005 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7865.018 | 0.2405 | -0.3950 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7865.018 | 0.2374 | -0.4016 | 1.1920 |