Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 14825.203 | 0.2015 | -0.8853 | 0.5604 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 5908.074 | 0.9686 | 0.8815 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 5908.074 | 0.9686 | 0.8815 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 5908.074 | 0.8906 | 0.6020 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 5908.074 | 0.8906 | 0.6020 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 5908.074 | 0.9537 | 0.8266 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 5908.074 | 0.9537 | 0.8266 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.0533 | uM | 5908.074 | 0.9337 | 0.7539 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.0533 | uM | 5908.074 | 0.9337 | 0.7539 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.267 | uM | 5908.074 | 0.8254 | 0.3853 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 0.267 | uM | 5908.074 | 0.8254 | 0.3853 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 5908.074 | 0.6587 | -0.1007 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 5908.074 | 0.6587 | -0.1007 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 5908.074 | 0.5137 | -0.4411 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 5908.074 | 0.5137 | -0.4411 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 5908.074 | 0.4581 | -0.5512 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 5908.074 | 0.4581 | -0.5512 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 167 | uM | 5908.074 | 0.4087 | -0.6393 | 0.5224 | |
| BT-483 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 167 | uM | 5908.074 | 0.4087 | -0.6393 | 0.5224 | |
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 5909.074 | 1.1047 | 1.0709 | 2.8598 | |
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 5909.074 | 1.1047 | 1.0709 | 2.8598 | |
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 5909.074 | 1.0980 | 1.0664 | 2.8598 | |
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 5909.074 | 1.0980 | 1.0664 | 2.8598 | |
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 5909.074 | 1.0412 | 1.0285 | 2.8598 | |
| BT-549 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 5909.074 | 1.0412 | 1.0285 | 2.8598 |