Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1187 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 5.33 | uM | 10753.147 | 0.7853 | 0.6482 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 26.7 | uM | 10753.147 | 0.0429 | -0.8392 | 1.2493 | |
| HCC1187 | TNBC | Basal A | Olomoucine II | CDK1 | CDK | 133 | uM | 10753.147 | 0.0092 | -0.9532 | 1.2493 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12000.147 | 0.9840 | 0.9630 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12000.147 | 0.9688 | 0.9281 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12000.147 | 0.9833 | 0.9614 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12000.147 | 0.9448 | 0.8731 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12000.147 | 0.8956 | 0.7608 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12000.147 | 0.8140 | 0.5769 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12000.147 | 0.5976 | 0.1036 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12000.147 | 0.2242 | -0.6444 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 133 | uM | 12000.147 | 0.1436 | -0.7875 | 0.8658 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12084.147 | 1.0527 | 1.0966 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12084.147 | 0.9587 | 0.9239 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12084.147 | 1.0920 | 1.1684 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12084.147 | 1.0467 | 1.0856 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 0.213 | uM | 12084.147 | 0.9620 | 0.9301 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 1.07 | uM | 12084.147 | 0.8313 | 0.6878 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 5.33 | uM | 12084.147 | 0.5539 | 0.1624 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 26.7 | uM | 12084.147 | 0.0817 | -0.7996 | 1.0888 | |
| HCC1395 | TNBC | Basal B | Olomoucine II | CDK1 | CDK | 133 | uM | 12084.147 | 0.0290 | -0.9226 | 1.0888 | |
| HCC1419 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 0.000341 | uM | 12001.147 | 0.9935 | 0.9785 | 0.5989 | |
| HCC1419 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 0.00171 | uM | 12001.147 | 0.9920 | 0.9734 | 0.5989 | |
| HCC1419 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 0.00853 | uM | 12001.147 | 0.9581 | 0.8621 | 0.5989 | |
| HCC1419 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 0.0427 | uM | 12001.147 | 0.9644 | 0.8824 | 0.5989 |