Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 7475.066 | 1.1848 | 1.1263 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 7475.066 | 1.2239 | 1.1514 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 7475.066 | 1.0826 | 1.0582 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 7475.066 | 1.0867 | 1.0610 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 7475.066 | 0.9912 | 0.9937 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 7475.066 | 1.3031 | 1.2006 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 7475.066 | 0.8245 | 0.8654 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0000853 | uM | 10379.066 | 1.0513 | 1.0423 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.000427 | uM | 10379.066 | 1.0018 | 1.0015 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.00213 | uM | 10379.066 | 0.9631 | 0.9688 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0107 | uM | 10379.066 | 0.9607 | 0.9668 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.0533 | uM | 10379.066 | 1.0324 | 1.0268 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 0.267 | uM | 10379.066 | 0.9799 | 0.9831 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 1.33 | uM | 10379.066 | 1.0222 | 1.0184 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 6.67 | uM | 10379.066 | 0.9777 | 0.9813 | 2.3931 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 33.3 | uM | 10379.066 | 0.8941 | 0.9086 | 2.3931 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0000853 | uM | 7477.066 | 1.3227 | 3.5429 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.000427 | uM | 7477.066 | 1.0360 | 1.2187 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.00213 | uM | 7477.066 | 0.9241 | 0.5865 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0107 | uM | 7477.066 | 0.8435 | 0.2142 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.0533 | uM | 7477.066 | 0.8311 | 0.1624 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 0.267 | uM | 7477.066 | 1.0989 | 1.6370 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 1.33 | uM | 7477.066 | 1.0707 | 1.4437 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 6.67 | uM | 7477.066 | 0.8599 | 0.2846 | 0.3409 | |
| LY2 | HR+ | Luminal | AG1024 | IGF1R | RTK | 33.3 | uM | 7477.066 | 0.8841 | 0.3936 | 0.3409 |