Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10520.135 | 0.4235 | 0.5845 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10520.135 | 0.1553 | 0.2073 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10520.135 | 0.0744 | -0.0110 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10520.135 | 0.0649 | -0.0471 | 3.6895 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11057.135 | 0.9466 | 0.9723 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11057.135 | 1.0228 | 1.0115 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11057.135 | 1.0419 | 1.0210 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11057.135 | 0.9367 | 0.9671 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11057.135 | 0.8665 | 0.9285 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11057.135 | 0.5321 | 0.7037 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11057.135 | 0.2178 | 0.3575 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11057.135 | 0.1157 | 0.1560 | 3.9340 | |
| SUM159PT | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11057.135 | 0.1183 | 0.1626 | 3.9340 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12269.135 | 0.9775 | 0.9573 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12269.135 | 0.6447 | 0.3183 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12269.135 | 0.9940 | 0.9886 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12269.135 | 0.8098 | 0.6368 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12269.135 | 0.6835 | 0.3934 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12269.135 | 0.5104 | 0.0559 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12269.135 | 0.4042 | -0.1540 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 12269.135 | 0.5054 | 0.0462 | 1.0530 | |
| SUM185PE | TNBC | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 12269.135 | 0.2539 | -0.4560 | 1.0530 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10579.135 | 0.9549 | 0.8858 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10579.135 | 1.0628 | 1.1613 | 0.7853 | |
| SUM225CWN | HER2amp | Basal A | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10579.135 | 0.8580 | 0.6457 | 0.7853 |