Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 10696.148 | 0.9829 | 0.9124 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 10696.148 | 0.9469 | 0.7356 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 10696.148 | 0.9747 | 0.8710 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 10696.148 | 0.9526 | 0.7630 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 10696.148 | 0.9010 | 0.5256 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 10696.148 | 0.7879 | 0.0768 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 10696.148 | 0.7332 | -0.1069 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 10696.148 | 0.8348 | 0.2512 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 10696.148 | 0.8372 | 0.2605 | 0.3850 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 11855.135 | 0.9448 | 0.8301 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 11855.135 | 0.8838 | 0.6485 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 11855.135 | 0.9376 | 0.8083 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 11855.135 | 0.9410 | 0.8184 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 11855.135 | 0.9622 | 0.8832 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 11855.135 | 0.9099 | 0.7255 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 11855.135 | 0.9144 | 0.7387 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 13.3 | uM | 11855.135 | 0.9348 | 0.7998 | 0.6394 | |
| BT-483 | HR+ | Luminal | Pevonedistat | NAE1 | NAE1 | 66.7 | uM | 11855.135 | 0.9834 | 0.9484 | 0.6394 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000171 | uM | 12305.135 | 0.9428 | 0.9568 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.000853 | uM | 12305.135 | 1.0252 | 1.0185 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.00427 | uM | 12305.135 | 0.9842 | 0.9883 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.0213 | uM | 12305.135 | 1.0024 | 1.0018 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.107 | uM | 12305.135 | 0.8465 | 0.8803 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 0.533 | uM | 12305.135 | 0.3167 | 0.3064 | 2.6998 | |
| BT-549 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 2.67 | uM | 12305.135 | 0.1173 | -0.0957 | 2.6998 |