Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 12239.154 | 0.8325 | 0.8402 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 12239.154 | 0.4084 | 0.3316 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 12239.154 | 0.0100 | -0.7525 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 12239.154 | 0.0088 | -0.7674 | 2.2015 | |
| HCC1806 | TNBC | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 12239.154 | 0.0101 | -0.7519 | 2.2015 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11849.154 | 0.9231 | 0.8702 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 11849.154 | 0.9978 | 0.9964 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 11849.154 | 1.0420 | 1.0702 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 11849.154 | 1.0798 | 1.1331 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 11849.154 | 0.8810 | 0.7985 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 11849.154 | 0.6289 | 0.3557 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 11849.154 | 0.1971 | -0.4876 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 11849.154 | 0.1565 | -0.5776 | 1.1927 | |
| HCC1937 | TNBC | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 11849.154 | 0.0967 | -0.7180 | 1.1927 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0000853 | uM | 11055.154 | 0.9712 | 0.9674 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.000427 | uM | 11055.154 | 0.9517 | 0.9450 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.00213 | uM | 11055.154 | 1.0484 | 1.0539 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0107 | uM | 11055.154 | 1.0146 | 1.0164 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.0533 | uM | 11055.154 | 0.9582 | 0.9525 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 0.267 | uM | 11055.154 | 0.7084 | 0.6473 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 1.33 | uM | 11055.154 | 0.2569 | -0.0692 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 6.67 | uM | 11055.154 | 0.0668 | -0.5639 | 1.7768 | |
| HCC1954 | HER2amp | Basal A | LBH589 | HDAC | HDAC | 33.3 | uM | 11055.154 | 0.0318 | -0.7128 | 1.7768 | |
| HCC2185 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.0000853 | uM | 10996.154 | 0.9852 | 0.9439 | 0.5230 | |
| HCC2185 | TNBC | Luminal | LBH589 | HDAC | HDAC | 0.000427 | uM | 10996.154 | 1.0048 | 1.0186 | 0.5230 |