Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0107 | uM | 10578.137 | 0.8811 | 0.8661 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0533 | uM | 10578.137 | 0.9605 | 0.9564 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.267 | uM | 10578.137 | 0.8934 | 0.8803 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 1.33 | uM | 10578.137 | 0.9836 | 0.9819 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 6.67 | uM | 10578.137 | 0.8875 | 0.8736 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 33.3 | uM | 10578.137 | 0.7327 | 0.6868 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000128 | uM | 11850.161 | 0.9215 | 0.9227 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00064 | uM | 11850.161 | 0.9192 | 0.9205 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0032 | uM | 11850.161 | 1.0075 | 1.0072 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.016 | uM | 11850.161 | 0.9708 | 0.9717 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.08 | uM | 11850.161 | 0.9748 | 0.9755 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.4 | uM | 11850.161 | 0.9494 | 0.9506 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 2 | uM | 11850.161 | 0.8898 | 0.8906 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 10 | uM | 11850.161 | 0.8223 | 0.8201 | 2.0754 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 50 | uM | 11850.161 | 0.0309 | -0.6253 | 2.0754 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10873.149 | 1.0036 | 1.0057 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10873.149 | 1.0232 | 1.0369 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10873.149 | 0.9830 | 0.9729 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10873.149 | 0.9524 | 0.9238 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10873.149 | 0.9796 | 0.9675 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10873.149 | 1.0785 | 1.1240 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10873.149 | 1.0966 | 1.1523 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10873.149 | 1.1042 | 1.1642 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10873.149 | 0.6091 | 0.3478 | 1.2562 | |
| HCC70 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 12400.166 | 0.9963 | 0.9946 | 1.3827 |