Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 22.6 | uM | 5897.091 | 0.7573 | 0.5954 | 1.2296 | |
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 5897.091 | 0.0244 | -0.9025 | 1.2296 | |
| 184B5 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 5897.091 | 0.0095 | -0.9547 | 1.2296 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00145 | uM | 5898.091 | 0.9515 | 0.8447 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00723 | uM | 5898.091 | 0.9543 | 0.8538 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.0362 | uM | 5898.091 | 0.9865 | 0.9565 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.181 | uM | 5898.091 | 1.0352 | 1.1156 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.904 | uM | 5898.091 | 1.0394 | 1.1297 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 4.52 | uM | 5898.091 | 1.0405 | 1.1332 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 22.6 | uM | 5898.091 | 0.8838 | 0.6366 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 5898.091 | 0.0115 | -0.9986 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 5898.091 | 0.0059 | -0.9995 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00145 | uM | 5899.09 | 0.9842 | 0.9696 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00723 | uM | 5899.09 | 0.9629 | 0.9286 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.0362 | uM | 5899.09 | 0.9718 | 0.9458 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.181 | uM | 5899.09 | 1.0203 | 1.0391 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.904 | uM | 5899.09 | 1.0299 | 1.0574 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 4.52 | uM | 5899.09 | 1.0156 | 1.0299 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 22.6 | uM | 5899.09 | 0.7913 | 0.5969 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 113 | uM | 5899.09 | 0.0093 | -0.9778 | 1.0401 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 565 | uM | 5899.09 | 0.0057 | -0.9860 | 1.0401 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00145 | uM | 5900.092 | 0.9843 | 0.9880 | 2.6334 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.00723 | uM | 5900.092 | 1.0170 | 1.0128 | 2.6334 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.0362 | uM | 5900.092 | 0.9896 | 0.9921 | 2.6334 | |
| AU565 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 0.181 | uM | 5900.092 | 1.0340 | 1.0256 | 2.6334 |