Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9997.024 | 1.0518 | 1.1069 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9997.024 | 1.0196 | 1.0405 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9997.024 | 1.0129 | 1.0266 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9997.024 | 0.8218 | 0.6339 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9997.024 | 0.6743 | 0.3325 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9997.024 | 0.5850 | 0.1509 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9997.024 | 0.5443 | 0.0687 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9997.024 | 0.4865 | -0.0481 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9997.024 | 0.4482 | -0.1253 | 0.9704 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.000256 | uM | 9997.049 | 0.9944 | 0.9901 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.00128 | uM | 9997.049 | 1.0444 | 1.0775 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.0064 | uM | 9997.049 | 1.0223 | 1.0390 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.032 | uM | 9997.049 | 0.8474 | 0.7301 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.16 | uM | 9997.049 | 0.6815 | 0.4297 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 0.8 | uM | 9997.049 | 0.6911 | 0.4474 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 4 | uM | 9997.049 | 0.7360 | 0.5292 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 20 | uM | 9997.049 | 0.5498 | 0.1847 | 1.1423 | |
| ZR75B | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 100 | uM | 9997.049 | 0.5477 | 0.1808 | 1.1423 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.00037 | uM | 9047.011 | 0.9508 | 0.8459 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.00185 | uM | 9047.011 | 0.8788 | 0.6287 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.00925 | uM | 9047.011 | 0.9655 | 0.8913 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.0462 | uM | 9047.011 | 0.9194 | 0.7501 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 0.231 | uM | 9047.011 | 0.8880 | 0.6559 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 1.16 | uM | 9047.011 | 0.7886 | 0.3712 | 0.6293 | |
| 184A1 | NM | Basal | Gemcitabine | DNA replication | DNA replication | 5.78 | uM | 9047.011 | 0.5902 | -0.1349 | 0.6293 |