Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 10579.142 | 1.0427 | 1.0818 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 10579.142 | 1.0277 | 1.0531 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 10579.142 | 1.0354 | 1.0679 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 1.33 | uM | 10579.142 | 0.9848 | 0.9709 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 10579.142 | 0.9801 | 0.9618 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 10579.142 | 0.8281 | 0.6694 | 1.0435 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 12098.154 | 0.9590 | 0.9157 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.000427 | uM | 12098.154 | 1.0297 | 1.0612 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.00213 | uM | 12098.154 | 1.0373 | 1.0767 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 12098.154 | 0.9268 | 0.8495 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 12098.154 | 0.9698 | 0.9378 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 12098.154 | 0.9788 | 0.9563 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 1.33 | uM | 12098.154 | 0.9573 | 0.9122 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 12098.154 | 0.9036 | 0.8020 | 0.9724 | |
| SUM225CWN | HER2amp | Basal A | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 12098.154 | 0.7443 | 0.4762 | 0.9724 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 11058.154 | 0.9042 | 0.9059 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 0.000427 | uM | 11058.154 | 0.9915 | 0.9919 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 0.00213 | uM | 11058.154 | 0.9145 | 0.9162 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 0.0107 | uM | 11058.154 | 0.9601 | 0.9614 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 0.0533 | uM | 11058.154 | 1.0070 | 1.0067 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 0.267 | uM | 11058.154 | 0.9017 | 0.9033 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 1.33 | uM | 11058.154 | 1.0148 | 1.0141 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 6.67 | uM | 11058.154 | 0.8746 | 0.8758 | 2.0897 | |
| SUM229PE | TNBC | - | FTase Inhibitor I | Ftase | MAPK | 33.3 | uM | 11058.154 | 0.7998 | 0.7973 | 2.0897 | |
| SUM52PE | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 0.0000853 | uM | 10695.154 | 0.9634 | 0.9501 | 1.4756 |