Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7541.084 | 0.6427 | 0.3876 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7541.084 | 0.0477 | -0.8385 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7541.084 | 0.0070 | -0.9669 | 1.2092 | |
| SUM52PE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7541.084 | 0.0061 | -0.9703 | 1.2092 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7543.084 | 1.0311 | 1.0461 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7543.084 | 1.0434 | 1.0642 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7543.084 | 1.0356 | 1.0527 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7543.084 | 1.0058 | 1.0086 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7543.084 | 0.9542 | 0.9314 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7543.084 | 0.8679 | 0.7998 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7543.084 | 0.1591 | -0.4912 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7543.084 | 0.0063 | -0.9541 | 1.3431 | |
| T47D | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7543.084 | 0.0014 | -0.9846 | 1.3431 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7546.084 | 0.9654 | 0.9263 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7546.084 | 0.9603 | 0.9154 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7546.084 | 0.9626 | 0.9203 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 7546.084 | 0.9822 | 0.9621 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 7546.084 | 0.6354 | 0.2329 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 0.267 | uM | 7546.084 | 0.0285 | -0.9550 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 1.33 | uM | 7546.084 | 0.0036 | -0.9951 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 6.67 | uM | 7546.084 | 0.0086 | -0.9875 | 0.9375 | |
| T47DKBLUC | Unknown | Unknown | Fascaplysin | CDK4 | CDK | 33.3 | uM | 7546.084 | 0.0053 | -0.9926 | 0.9375 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 7552.084 | 1.0166 | 1.0293 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 7552.084 | 1.0230 | 1.0406 | 1.1307 | |
| ZR-75-1 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 7552.084 | 0.9361 | 0.8865 | 1.1307 |