Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 0.107 | uM | 11939.164 | 0.5595 | 0.4052 | 1.6455 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 0.533 | uM | 11939.164 | 0.4810 | 0.2819 | 1.6455 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 2.67 | uM | 11939.164 | 0.4633 | 0.2530 | 1.6455 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 13.3 | uM | 11939.164 | 0.4221 | 0.1841 | 1.6455 | |
| ZR75B | HR+ | Luminal | Everolimus | MTOR | MTOR | 66.7 | uM | 11939.164 | 0.0297 | -0.7640 | 1.6455 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5894.084 | 1.0756 | 1.0938 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5894.084 | 1.0236 | 1.0296 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5894.084 | 1.0233 | 1.0291 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5894.084 | 1.0157 | 1.0196 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5894.084 | 1.0020 | 1.0025 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5894.084 | 0.8615 | 0.8210 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5894.084 | 0.0753 | -0.6067 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5894.084 | 0.0034 | -0.9438 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5894.084 | 0.0052 | -0.9270 | 1.5903 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5895.085 | 1.0819 | 1.1124 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5895.085 | 1.0077 | 1.0106 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.00213 | uM | 5895.085 | 1.0130 | 1.0181 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0107 | uM | 5895.085 | 0.9583 | 0.9417 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0533 | uM | 5895.085 | 0.9310 | 0.9031 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.267 | uM | 5895.085 | 0.7780 | 0.6799 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 1.33 | uM | 5895.085 | 0.0893 | -0.6266 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 6.67 | uM | 5895.085 | 0.0055 | -0.9460 | 1.4396 | |
| 184A1 | NM | Basal | Fascaplysin | CDK4 | CDK | 33.3 | uM | 5895.085 | 0.0060 | -0.9429 | 1.4396 | |
| 184B5 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.0000853 | uM | 5896.084 | 0.9919 | 0.9894 | 1.5200 | |
| 184B5 | NM | Basal | Fascaplysin | CDK4 | CDK | 0.000427 | uM | 5896.084 | 0.9741 | 0.9658 | 1.5200 |