LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. - Dataset (ID:20250)

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Cell Small Molecule Small Mol Concentration Small Mol Conc Unit LJP Library Plate Timepoint Timepoint Unit Mean Total Cell Count Before Treatment Mean Total Cell Count After Treatment Mean Total Control Cell Count Mean Relative Cell Count Mean Normalized Growth Rate Inhibition Value
MDA-MB-231 Momelotinib
3.33
uM
LJP5
 72
hr
 1235 1339 4660 0.2869 0.0406
MDA-MB-231 Momelotinib
10
uM
LJP5
 72
hr
 1235 574 4660 0.1228 -0.3326
MDA-MB-231 Fedratinib
0.04
uM
LJP5
 72
hr
 1235 4389 4660 0.9400 0.9344
MDA-MB-231 Fedratinib
0.12
uM
LJP5
 72
hr
 1235 4035 4660 0.8640 0.8507
MDA-MB-231 Fedratinib
0.37
uM
LJP5
 72
hr
 1235 3655 4660 0.7810 0.7527
MDA-MB-231 Fedratinib
1.11
uM
LJP5
 72
hr
 1235 2577 4660 0.5521 0.4649
MDA-MB-231 Fedratinib
3.33
uM
LJP5
 72
hr
 1235 1103 4660 0.2366 -0.0590
MDA-MB-231 Fedratinib
10
uM
LJP5
 72
hr
 1235 398 4660 0.0849 -0.4514
MDA-MB-231 Trametinib
0.04
uM
LJP5
 72
hr
 1235 1343 4660 0.2885 0.0441
MDA-MB-231 Trametinib
0.12
uM
LJP5
 72
hr
 1235 1273 4660 0.2733 0.0149
MDA-MB-231 Trametinib
0.37
uM
LJP5
 72
hr
 1235 1329 4660 0.2854 0.0383
MDA-MB-231 Trametinib
1.11
uM
LJP5
 72
hr
 1235 1305 4660 0.2798 0.0275
MDA-MB-231 Trametinib
3.33
uM
LJP5
 72
hr
 1235 1275 4660 0.2737 0.0157
MDA-MB-231 Trametinib
10
uM
LJP5
 72
hr
 1235 1285 4660 0.2751 0.0177
MDA-MB-231 Omipalisib
0.04
uM
LJP6
 72
hr
 1235 2003 4405 0.4543 0.2996
MDA-MB-231 Omipalisib
0.12
uM
LJP6
 72
hr
 1235 1518 4405 0.3449 0.1186
MDA-MB-231 Omipalisib
0.37
uM
LJP6
 72
hr
 1235 1155 4405 0.2623 -0.0365
MDA-MB-231 Omipalisib
1.11
uM
LJP6
 72
hr
 1235 966 4405 0.2192 -0.1265
MDA-MB-231 Omipalisib
3.33
uM
LJP6
 72
hr
 1235 824 4405 0.1872 -0.1985
MDA-MB-231 Omipalisib
10
uM
LJP6
 72
hr
 1235 723 4405 0.1640 -0.2544
MDA-MB-231 Buparlisib
0.04
uM
LJP5
 72
hr
 1235 4633 4660 0.9956 0.9963
MDA-MB-231 Buparlisib
0.12
uM
LJP5
 72
hr
 1235 4457 4660 0.9554 0.9519
MDA-MB-231 Buparlisib
0.37
uM
LJP5
 72
hr
 1235 3987 4660 0.8539 0.8397
MDA-MB-231 Buparlisib
1.11
uM
LJP5
 72
hr
 1235 2909 4660 0.6221 0.5576
MDA-MB-231 Buparlisib
3.33
uM
LJP5
 72
hr
 1235 1350 4660 0.2889 0.0435