LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | PIK-93 | 10 | uM | LJP5 | 72 | hr | 2543 | 2171 | 5752 | 0.3776 | -0.1256 |
| SK-BR-3 | Dactolisib | 0.04 | uM | LJP5 | 72 | hr | 2543 | 2638 | 5752 | 0.4587 | 0.0315 |
| SK-BR-3 | Dactolisib | 0.12 | uM | LJP5 | 72 | hr | 2543 | 2331 | 5752 | 0.4053 | -0.0713 |
| SK-BR-3 | Dactolisib | 0.37 | uM | LJP5 | 72 | hr | 2543 | 2042 | 5752 | 0.3550 | -0.1704 |
| SK-BR-3 | Dactolisib | 1.11 | uM | LJP5 | 72 | hr | 2543 | 2073 | 5752 | 0.3604 | -0.1595 |
| SK-BR-3 | Dactolisib | 3.33 | uM | LJP5 | 72 | hr | 2543 | 2075 | 5752 | 0.3609 | -0.1585 |
| SK-BR-3 | Dactolisib | 10 | uM | LJP5 | 72 | hr | 2543 | 2257 | 5752 | 0.3924 | -0.0965 |
| SK-BR-3 | Alpelisib | 0.04 | uM | LJP5 | 72 | hr | 2543 | 5299 | 5752 | 0.9213 | 0.8652 |
| SK-BR-3 | Alpelisib | 0.12 | uM | LJP5 | 72 | hr | 2543 | 5068 | 5752 | 0.8810 | 0.7957 |
| SK-BR-3 | Alpelisib | 0.37 | uM | LJP5 | 72 | hr | 2543 | 4719 | 5752 | 0.8204 | 0.6901 |
| SK-BR-3 | Alpelisib | 1.11 | uM | LJP5 | 72 | hr | 2543 | 4334 | 5752 | 0.7535 | 0.5725 |
| SK-BR-3 | Alpelisib | 3.33 | uM | LJP5 | 72 | hr | 2543 | 3337 | 5752 | 0.5801 | 0.2591 |
| SK-BR-3 | Alpelisib | 10 | uM | LJP5 | 72 | hr | 2543 | 1938 | 5752 | 0.3370 | -0.2061 |
| SK-BR-3 | GDC-0980 | 0.04 | uM | LJP5 | 72 | hr | 2543 | 3273 | 5752 | 0.5690 | 0.2386 |
| SK-BR-3 | GDC-0980 | 0.12 | uM | LJP5 | 72 | hr | 2543 | 2423 | 5752 | 0.4214 | -0.0402 |
| SK-BR-3 | GDC-0980 | 0.37 | uM | LJP5 | 72 | hr | 2543 | 2123 | 5752 | 0.3691 | -0.1424 |
| SK-BR-3 | GDC-0980 | 1.11 | uM | LJP5 | 72 | hr | 2543 | 1909 | 5752 | 0.3320 | -0.2164 |
| SK-BR-3 | GDC-0980 | 3.33 | uM | LJP5 | 72 | hr | 2543 | 1998 | 5752 | 0.3474 | -0.1854 |
| SK-BR-3 | GDC-0980 | 10 | uM | LJP5 | 72 | hr | 2543 | 1803 | 5752 | 0.3135 | -0.2534 |
| SK-BR-3 | Mitoxantrone | 0.04 | uM | LJP5 | 72 | hr | 2543 | 2003 | 5752 | 0.3482 | -0.1839 |
| SK-BR-3 | Mitoxantrone | 0.04 | uM | LJP6 | 72 | hr | 2543 | 1620 | 5418 | 0.2994 | -0.3386 |
| SK-BR-3 | Mitoxantrone | 0.12 | uM | LJP5 | 72 | hr | 2543 | 1877 | 5752 | 0.3263 | -0.2275 |
| SK-BR-3 | Mitoxantrone | 0.12 | uM | LJP6 | 72 | hr | 2543 | 1527 | 5418 | 0.2821 | -0.3737 |
| SK-BR-3 | Mitoxantrone | 0.37 | uM | LJP5 | 72 | hr | 2543 | 1784 | 5752 | 0.3102 | -0.2601 |
| SK-BR-3 | Mitoxantrone | 0.37 | uM | LJP6 | 72 | hr | 2543 | 1404 | 5418 | 0.2593 | -0.4202 |