LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. - Dataset (ID:20249)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Fedratinib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 4729 | 5905 | 0.8020 | 0.7991 |
| MCF7 | Fedratinib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 2122 | 5905 | 0.3587 | 0.2227 |
| MCF7 | Fedratinib | 10 | uM | LJP5 | 72 | hr | 1389 | 862 | 5905 | 0.1457 | -0.2057 |
| MCF7 | Trametinib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 2684 | 5905 | 0.4546 | 0.3708 |
| MCF7 | Trametinib | 0.12 | uM | LJP5 | 72 | hr | 1389 | 2715 | 5905 | 0.4586 | 0.3737 |
| MCF7 | Trametinib | 0.37 | uM | LJP5 | 72 | hr | 1389 | 2689 | 5905 | 0.4554 | 0.3720 |
| MCF7 | Trametinib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 2616 | 5905 | 0.4428 | 0.3535 |
| MCF7 | Trametinib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 2929 | 5905 | 0.4961 | 0.4295 |
| MCF7 | Trametinib | 10 | uM | LJP5 | 72 | hr | 1389 | 2877 | 5905 | 0.4862 | 0.4137 |
| MCF7 | Omipalisib | 0.04 | uM | LJP6 | 72 | hr | 1389 | 1402 | 5445 | 0.2574 | 0.0032 |
| MCF7 | Omipalisib | 0.12 | uM | LJP6 | 72 | hr | 1389 | 1383 | 5445 | 0.2538 | -0.0050 |
| MCF7 | Omipalisib | 0.37 | uM | LJP6 | 72 | hr | 1389 | 1294 | 5445 | 0.2370 | -0.0387 |
| MCF7 | Omipalisib | 1.11 | uM | LJP6 | 72 | hr | 1389 | 1179 | 5445 | 0.2164 | -0.0811 |
| MCF7 | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 1389 | 1081 | 5445 | 0.1986 | -0.1204 |
| MCF7 | Omipalisib | 10 | uM | LJP6 | 72 | hr | 1389 | 746 | 5445 | 0.1367 | -0.2743 |
| MCF7 | Buparlisib | 0.04 | uM | LJP5 | 72 | hr | 1389 | 5379 | 5905 | 0.9099 | 0.9103 |
| MCF7 | Buparlisib | 0.12 | uM | LJP5 | 72 | hr | 1389 | 3825 | 5905 | 0.6466 | 0.6209 |
| MCF7 | Buparlisib | 0.37 | uM | LJP5 | 72 | hr | 1389 | 2134 | 5905 | 0.3607 | 0.2256 |
| MCF7 | Buparlisib | 1.11 | uM | LJP5 | 72 | hr | 1389 | 1167 | 5905 | 0.1975 | -0.0810 |
| MCF7 | Buparlisib | 3.33 | uM | LJP5 | 72 | hr | 1389 | 890 | 5905 | 0.1508 | -0.1921 |
| MCF7 | Buparlisib | 10 | uM | LJP5 | 72 | hr | 1389 | 844 | 5905 | 0.1430 | -0.2124 |
| MCF7 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1389 | 6668 | 5905 | 1.1278 | 1.1172 |
| MCF7 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1389 | 6374 | 5905 | 1.0787 | 1.0732 |
| MCF7 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1389 | 6139 | 5905 | 1.0402 | 1.0384 |
| MCF7 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1389 | 6175 | 5905 | 1.0443 | 1.0402 |