LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Omipalisib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 1425 | 3643 | 0.3910 | -0.0292 |
| SK-BR-3 | Omipalisib | 0.37 | uM | LJP6 | 72 | hr | 1476 | 1296 | 3643 | 0.3562 | -0.0961 |
| SK-BR-3 | Omipalisib | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1277 | 3643 | 0.3492 | -0.1109 |
| SK-BR-3 | Omipalisib | 3.33 | uM | LJP6 | 72 | hr | 1476 | 1048 | 3643 | 0.2866 | -0.2359 |
| SK-BR-3 | Omipalisib | 10 | uM | LJP6 | 72 | hr | 1476 | 765 | 3643 | 0.2101 | -0.3979 |
| SK-BR-3 | Buparlisib | 0.04 | uM | LJP5 | 72 | hr | 1476 | 3742 | 3772 | 0.9918 | 0.9876 |
| SK-BR-3 | Buparlisib | 0.12 | uM | LJP5 | 72 | hr | 1476 | 3057 | 3772 | 0.8104 | 0.7121 |
| SK-BR-3 | Buparlisib | 0.37 | uM | LJP5 | 72 | hr | 1476 | 1678 | 3772 | 0.4447 | 0.0986 |
| SK-BR-3 | Buparlisib | 1.11 | uM | LJP5 | 72 | hr | 1476 | 1141 | 3772 | 0.3025 | -0.1736 |
| SK-BR-3 | Buparlisib | 3.33 | uM | LJP5 | 72 | hr | 1476 | 1031 | 3772 | 0.2733 | -0.2336 |
| SK-BR-3 | Buparlisib | 10 | uM | LJP5 | 72 | hr | 1476 | 856 | 3772 | 0.2271 | -0.3316 |
| SK-BR-3 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4230 | 3772 | 1.1217 | 1.1770 |
| SK-BR-3 | XL147 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 4313 | 3772 | 1.1433 | 1.2076 |
| SK-BR-3 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4284 | 3772 | 1.1358 | 1.1969 |
| SK-BR-3 | XL147 | 1.11 | uM | LJP5 | 72 | hr | 1476 | 4479 | 3772 | 1.1871 | 1.2687 |
| SK-BR-3 | XL147 | 3.33 | uM | LJP5 | 72 | hr | 1476 | 4341 | 3772 | 1.1507 | 1.2181 |
| SK-BR-3 | XL147 | 10 | uM | LJP5 | 72 | hr | 1476 | 2821 | 3772 | 0.7481 | 0.6136 |
| SK-BR-3 | Y39983 | 0.04 | uM | LJP6 | 72 | hr | 1476 | 3281 | 3643 | 0.9014 | 0.8474 |
| SK-BR-3 | Y39983 | 0.12 | uM | LJP6 | 72 | hr | 1476 | 3322 | 3643 | 0.9142 | 0.8702 |
| SK-BR-3 | Y39983 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 3113 | 3643 | 0.8577 | 0.7810 |
| SK-BR-3 | Y39983 | 1.11 | uM | LJP6 | 72 | hr | 1476 | 2751 | 3643 | 0.7563 | 0.6143 |
| SK-BR-3 | Y39983 | 3.33 | uM | LJP6 | 72 | hr | 1476 | 2365 | 3643 | 0.6507 | 0.4384 |
| SK-BR-3 | Y39983 | 10 | uM | LJP6 | 72 | hr | 1476 | 1243 | 3643 | 0.3424 | -0.1234 |
| SK-BR-3 | Nintedanib | 0.04 | uM | LJP6 | 72 | hr | 1476 | 3824 | 3643 | 1.0518 | 1.0833 |
| SK-BR-3 | Nintedanib | 0.12 | uM | LJP6 | 72 | hr | 1476 | 3786 | 3643 | 1.0416 | 1.0677 |