LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | Linifanib | 0.12 | uM | LJP6 | 72 | hr | 1235 | 4619 | 4056 | 1.1392 | 1.1579 |
| MCF7 | Linifanib | 0.37 | uM | LJP6 | 72 | hr | 1235 | 4546 | 4056 | 1.1217 | 1.1380 |
| MCF7 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4163 | 4056 | 1.0263 | 1.0299 |
| MCF7 | Linifanib | 3.33 | uM | LJP6 | 72 | hr | 1235 | 3842 | 4056 | 0.9477 | 0.9381 |
| MCF7 | Linifanib | 10 | uM | LJP6 | 72 | hr | 1235 | 1365 | 4056 | 0.3368 | 0.0600 |
| MCF7 | PIK-93 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4925 | 4267 | 1.1553 | 1.1686 |
| MCF7 | PIK-93 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4937 | 4267 | 1.1567 | 1.1690 |
| MCF7 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 5022 | 4267 | 1.1763 | 1.1893 |
| MCF7 | PIK-93 | 1.11 | uM | LJP5 | 72 | hr | 1235 | 4643 | 4267 | 1.0866 | 1.0926 |
| MCF7 | PIK-93 | 3.33 | uM | LJP5 | 72 | hr | 1235 | 2438 | 4267 | 0.5713 | 0.4620 |
| MCF7 | PIK-93 | 10 | uM | LJP5 | 72 | hr | 1235 | 1417 | 4267 | 0.3326 | 0.0801 |
| MCF7 | Dactolisib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 1924 | 4267 | 0.4505 | 0.2798 |
| MCF7 | Dactolisib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 1777 | 4267 | 0.4165 | 0.2251 |
| MCF7 | Dactolisib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 1679 | 4267 | 0.3931 | 0.1858 |
| MCF7 | Dactolisib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 1371 | 4267 | 0.3216 | 0.0602 |
| MCF7 | Dactolisib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1206 | 4267 | 0.2822 | -0.0155 |
| MCF7 | Dactolisib | 10 | uM | LJP5 | 72 | hr | 1235 | 1328 | 4267 | 0.3114 | 0.0413 |
| MCF7 | Alpelisib | 0.04 | uM | LJP5 | 72 | hr | 1235 | 3948 | 4267 | 0.9273 | 0.9165 |
| MCF7 | Alpelisib | 0.12 | uM | LJP5 | 72 | hr | 1235 | 3450 | 4267 | 0.8083 | 0.7750 |
| MCF7 | Alpelisib | 0.37 | uM | LJP5 | 72 | hr | 1235 | 2680 | 4267 | 0.6288 | 0.5430 |
| MCF7 | Alpelisib | 1.11 | uM | LJP5 | 72 | hr | 1235 | 2254 | 4267 | 0.5283 | 0.3993 |
| MCF7 | Alpelisib | 3.33 | uM | LJP5 | 72 | hr | 1235 | 1698 | 4267 | 0.3982 | 0.1946 |
| MCF7 | Alpelisib | 10 | uM | LJP5 | 72 | hr | 1235 | 1043 | 4267 | 0.2448 | -0.0901 |
| MCF7 | GDC-0980 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 1394 | 4267 | 0.3265 | 0.0685 |
| MCF7 | GDC-0980 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 1163 | 4267 | 0.2727 | -0.0333 |