High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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Hs 578T | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1262 | 191 | 1146 | 5093 | 90.2 | 37.96 | 173.01 | 291.74 | 37 | 56 | 70 | 80 | 89 | 98 | 108 | 122 | 139 | 0.1056 | 538 | 0.246 | 326.81 | 58.25 | 3 | 1.2321 | 1412 | 0.0022 | 29.57 | 6.284 | 0.2125 | 9584.0 | 1150000 | 154000000 | 22500000000 | 0.3879 | 0.2271 | 0.0045 | 0.0000 | 0.0182 | 0.0000 | 0.0795 | 0.0040 | 0.0932 | 0.0173 | 0.1295 | 0.0840 | 0.1705 | 0.1280 | 0.1705 | 0.1333 | 0.1955 | 0.1453 | 0.1386 | 0.4880 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0025 | 0.0000 | 0.0064 | 0.0032 | 0.0446 | 0.0319 | 0.0841 | 0.0554 | 0.0828 | 0.0405 | 0.1338 | 0.0692 | 0.6459 | 0.7998 | 0.0000 | 0.0106 | 0.0087 | 0.0212 | 0.0203 | 0.0159 | 0.0580 | 0.0847 | 0.1130 | 0.2328 | 0.1652 | 0.2011 | 0.1275 | 0.1164 | 0.1739 | 0.1270 | 0.3333 | 0.1905 | 0.0035 | 0.0018 | 0.0089 | 0.0319 | 0.0904 | 0.1294 | 0.1188 | 0.1489 | 0.4663 | 14 | 16 | 18 | 21 | 25 | 39 | 104 | 323 | 583 | 0.0764 | 34.57 | 4.571 | 0.5346 | 115023.0 | 109000000 | 127000000000 | 170000000000000 | 0.7263 | 0.0444 | 0.0738 | 0.0122 | 0.3020 | 0.0550 | 0.3087 | 0.1498 | 0.1477 | 0.2385 | 0.1208 | 0.2599 | 0.0201 | 0.1346 | 0.0134 | 0.0642 | 0.0134 | 0.0367 | 0.0000 | 0.0489 | 0.0000 | 0.0007 | 0.0028 | 0.0013 | 0.0028 | 0.0033 | 0.0264 | 0.0209 | 0.0674 | 0.0712 | 0.1035 | 0.0935 | 0.0757 | 0.0745 | 0.1070 | 0.1085 | 0.6143 | 0.6261 | 0.0016 | 0.0000 | 0.0023 | 0.0025 | 0.0047 | 0.0183 | 0.0287 | 0.0241 | 0.0636 | 0.0665 | 0.1116 | 0.1155 | 0.0853 | 0.0840 | 0.1124 | 0.1139 | 0.5899 | 0.5752 | 0.0007 | 0.0029 | 0.0066 | 0.0269 | 0.0655 | 0.1077 | 0.0852 | 0.1033 | 0.6012 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 892 | 528 | 438 | 4290 | 99.4 | 30.58 | 45.69 | 79.25 | 57 | 73 | 84 | 93 | 98 | 106 | 113 | 122 | 143 | 0.0991 | 425 | 0.186 | 244.68 | 30.23 | 3 | 2.7374 | 1199 | 0.0033 | 47.98 | 5.825 | 0.1324 | 10807.1 | 1270000 | 158000000 | 20800000000 | 0.3355 | 0.2955 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0091 | 0.0000 | 0.0727 | 0.0060 | 0.1182 | 0.0925 | 0.1318 | 0.0896 | 0.1591 | 0.0985 | 0.2045 | 0.1254 | 0.3045 | 0.5881 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0031 | 0.0000 | 0.0123 | 0.0026 | 0.0679 | 0.0596 | 0.0494 | 0.0570 | 0.0710 | 0.0440 | 0.0802 | 0.0648 | 0.7160 | 0.7720 | 0.0096 | 0.0000 | 0.0192 | 0.0000 | 0.0096 | 0.0392 | 0.0288 | 0.0196 | 0.1154 | 0.1961 | 0.1250 | 0.1765 | 0.0962 | 0.1176 | 0.1731 | 0.2745 | 0.4231 | 0.1765 | 0.0046 | 0.0092 | 0.0184 | 0.0276 | 0.0783 | 0.1014 | 0.1060 | 0.1382 | 0.5161 | 14 | 17 | 19 | 23 | 26 | 30 | 36 | 48 | 74 | 0.2037 | 1.21 | 2.394 | 0.8309 | 8367.0 | 4140000 | 2720000000 | 1970000000000 | 0.5493 | 0.1523 | 0.0193 | 0.0111 | 0.0456 | 0.0222 | 0.1298 | 0.0341 | 0.1333 | 0.0632 | 0.1754 | 0.1091 | 0.2140 | 0.1543 | 0.1386 | 0.1508 | 0.0930 | 0.1737 | 0.0509 | 0.2814 | 0.0072 | 0.0081 | 0.0087 | 0.0163 | 0.0223 | 0.0229 | 0.0405 | 0.0366 | 0.0692 | 0.0630 | 0.0922 | 0.0885 | 0.0978 | 0.0976 | 0.1065 | 0.1205 | 0.5556 | 0.5465 | 0.0029 | 0.0000 | 0.0116 | 0.0303 | 0.0305 | 0.0227 | 0.0349 | 0.0360 | 0.0799 | 0.0833 | 0.1105 | 0.1174 | 0.1017 | 0.0947 | 0.1366 | 0.1193 | 0.4913 | 0.4962 | 0.0022 | 0.0076 | 0.0174 | 0.0239 | 0.0827 | 0.0914 | 0.1012 | 0.1164 | 0.5571 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 870 | 152 | 2506 | 5703 | 72.8 | 23.73 | 226.65 | 206.12 | 44 | 52 | 59 | 65 | 71 | 77 | 83 | 92 | 106 | 0.1012 | 577 | 0.226 | 301.04 | 33.94 | 3 | 0.4254 | 1066 | 0.0017 | 34.53 | 6.624 | 0.1875 | 5856.8 | 514772 | 48800000 | 4950000000 | 0.4100 | 0.2367 | 0.0000 | 0.0000 | 0.0094 | 0.0000 | 0.0309 | 0.0015 | 0.0738 | 0.0082 | 0.1639 | 0.0494 | 0.1966 | 0.0937 | 0.1949 | 0.1105 | 0.1768 | 0.1549 | 0.1536 | 0.5818 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0011 | 0.0009 | 0.0147 | 0.0035 | 0.0548 | 0.0288 | 0.0892 | 0.0399 | 0.0926 | 0.0465 | 0.1242 | 0.0798 | 0.6222 | 0.8005 | 0.0050 | 0.0068 | 0.0149 | 0.0068 | 0.0215 | 0.0375 | 0.0809 | 0.1024 | 0.1601 | 0.2321 | 0.1700 | 0.1945 | 0.1221 | 0.1229 | 0.1535 | 0.1468 | 0.2723 | 0.1502 | 0.0017 | 0.0025 | 0.0142 | 0.0418 | 0.0879 | 0.1431 | 0.1305 | 0.1423 | 0.4360 | 33 | 48 | 74 | 110 | 160 | 220 | 294 | 390 | 525 | 0.0110 | 30.01 | 5.917 | 0.3620 | 93846.7 | 52100000 | 34500000000 | 25800000000000 | 0.5031 | 0.1657 | 0.0592 | 0.0019 | 0.2513 | 0.0205 | 0.2592 | 0.1189 | 0.1526 | 0.1841 | 0.1079 | 0.1937 | 0.0921 | 0.1688 | 0.0434 | 0.1119 | 0.0224 | 0.0985 | 0.0118 | 0.1017 | 0.0000 | 0.0000 | 0.0023 | 0.0013 | 0.0080 | 0.0035 | 0.0221 | 0.0190 | 0.0865 | 0.0723 | 0.1319 | 0.1138 | 0.1021 | 0.0826 | 0.1444 | 0.1157 | 0.5027 | 0.5919 | 0.0011 | 0.0026 | 0.0038 | 0.0026 | 0.0145 | 0.0168 | 0.0376 | 0.0510 | 0.1175 | 0.1395 | 0.1760 | 0.1802 | 0.1180 | 0.1298 | 0.1352 | 0.1486 | 0.3965 | 0.3288 | 0.0009 | 0.0018 | 0.0086 | 0.0378 | 0.0991 | 0.1535 | 0.1153 | 0.1346 | 0.4484 | |
MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 441 | 854 | 1964 | 2153 | 94.0 | 19.07 | 5.89 | 2.19 | 65 | 75 | 84 | 91 | 97 | 103 | 107 | 111 | 116 | 0.2216 | 477 | 0.494 | 340.58 | 73.33 | 1 | 0.5046 | 991 | 0.0224 | 1.75 | 4.105 | 0.5669 | 9205.0 | 931383 | 96800000 | 10300000000 | 0.4309 | 0.2010 | 0.0000 | 0.0000 | 0.0073 | 0.0000 | 0.0147 | 0.0005 | 0.0359 | 0.0058 | 0.0661 | 0.0242 | 0.1184 | 0.0453 | 0.1380 | 0.0353 | 0.1959 | 0.0679 | 0.4237 | 0.8211 | 0.0000 | 0.0000 | 0.0019 | 0.0000 | 0.0013 | 0.0005 | 0.0109 | 0.0052 | 0.0300 | 0.0235 | 0.0504 | 0.0434 | 0.0549 | 0.0314 | 0.0709 | 0.0581 | 0.7797 | 0.8378 | 0.0235 | 0.0909 | 0.0293 | 0.0000 | 0.0704 | 0.1818 | 0.1056 | 0.0909 | 0.1144 | 0.3636 | 0.1525 | 0.2727 | 0.1290 | 0.0000 | 0.1290 | 0.0000 | 0.2463 | 0.0000 | 0.0000 | 0.0027 | 0.0045 | 0.0163 | 0.0506 | 0.0624 | 0.0678 | 0.0850 | 0.7107 | 3 | 4 | 5 | 5 | 6 | 7 | 7 | 8 | 9 | 0.5417 | 0.29 | 0.926 | 0.8524 | 39.5 | 290.243 | 2305.17 | 19573.6 | 0.5333 | 0.1268 | 0.0126 | 0.0006 | 0.0816 | 0.0054 | 0.1641 | 0.0320 | 0.2592 | 0.0633 | 0.2505 | 0.1333 | 0.1534 | 0.1960 | 0.0621 | 0.2340 | 0.0155 | 0.2117 | 0.0010 | 0.1236 | 0.0000 | 0.0000 | 0.0139 | 0.0011 | 0.0357 | 0.0096 | 0.1130 | 0.0340 | 0.1897 | 0.0919 | 0.2161 | 0.1338 | 0.2254 | 0.1875 | 0.1586 | 0.2953 | 0.0476 | 0.2469 | 0.1946 | 0.4222 | 0.2754 | 0.2667 | 0.2402 | 0.1378 | 0.1718 | 0.1244 | 0.0787 | 0.0400 | 0.0311 | 0.0089 | 0.0062 | 0.0000 | 0.0021 | 0.0000 | 0.0000 | 0.0000 | 0.0076 | 0.0552 | 0.1027 | 0.1986 | 0.2182 | 0.1910 | 0.1171 | 0.0849 | 0.0246 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1202 | 629 | 3328 | 8418 | 107.3 | 34.23 | 123.15 | 94.86 | 68 | 80 | 88 | 96 | 104 | 112 | 122 | 135 | 151 | 0.0986 | 830 | 0.231 | 169.10 | 42.20 | 3 | 0.2897 | 964 | 0.0010 | 62.39 | 7.144 | 0.1516 | 12681.7 | 1630000 | 227000000 | 34000000000 | 0.4848 | 0.1833 | 0.0006 | 0.0000 | 0.0062 | 0.0004 | 0.0296 | 0.0037 | 0.0889 | 0.0116 | 0.1705 | 0.0511 | 0.2341 | 0.1335 | 0.1692 | 0.1051 | 0.1316 | 0.1491 | 0.1692 | 0.5455 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0016 | 0.0003 | 0.0213 | 0.0046 | 0.0585 | 0.0354 | 0.1101 | 0.0827 | 0.0876 | 0.0423 | 0.1146 | 0.0813 | 0.6052 | 0.7534 | 0.0036 | 0.0109 | 0.0024 | 0.0163 | 0.0182 | 0.0245 | 0.0812 | 0.1226 | 0.1818 | 0.2670 | 0.1782 | 0.1853 | 0.1224 | 0.0981 | 0.1479 | 0.1390 | 0.2642 | 0.1362 | 0.0006 | 0.0006 | 0.0077 | 0.0379 | 0.1247 | 0.1433 | 0.1093 | 0.1549 | 0.4210 | 27 | 47 | 62 | 77 | 96 | 120 | 152 | 193 | 257 | 0.0090 | 14.86 | 5.556 | 0.4071 | 24163.0 | 6350000 | 2030000000 | 746000000000 | 0.5797 | 0.1151 | 0.0304 | 0.0016 | 0.1306 | 0.0066 | 0.2172 | 0.0487 | 0.1928 | 0.1050 | 0.1637 | 0.1644 | 0.1333 | 0.2011 | 0.0683 | 0.1502 | 0.0501 | 0.1416 | 0.0135 | 0.1808 | 0.0005 | 0.0008 | 0.0036 | 0.0010 | 0.0061 | 0.0053 | 0.0229 | 0.0187 | 0.0800 | 0.0542 | 0.1217 | 0.0941 | 0.1144 | 0.0875 | 0.1389 | 0.1205 | 0.5119 | 0.6179 | 0.0011 | 0.0034 | 0.0053 | 0.0116 | 0.0167 | 0.0198 | 0.0456 | 0.0545 | 0.1094 | 0.1369 | 0.1759 | 0.1803 | 0.1265 | 0.1345 | 0.1527 | 0.1572 | 0.3666 | 0.3018 | 0.0012 | 0.0055 | 0.0092 | 0.0348 | 0.0944 | 0.1521 | 0.1225 | 0.1512 | 0.4291 | |
MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 715 | 284 | 4349 | 24088 | 89.5 | 13.78 | 5.43 | 2.07 | 73 | 77 | 80 | 84 | 87 | 91 | 97 | 103 | 109 | 0.0418 | 1008 | 0.588 | 324.65 | 84.85 | 1 | 0.2175 | 946 | 0.0394 | 0.86 | 3.496 | 0.6959 | 8200.8 | 769285 | 73900000 | 7250000000 | 0.4494 | 0.2031 | 0.0008 | 0.0000 | 0.0051 | 0.0000 | 0.0102 | 0.0007 | 0.0254 | 0.0044 | 0.0392 | 0.0120 | 0.0621 | 0.0294 | 0.0708 | 0.0204 | 0.1033 | 0.0328 | 0.6830 | 0.9003 | 0.0005 | 0.0000 | 0.0027 | 0.0000 | 0.0056 | 0.0007 | 0.0144 | 0.0037 | 0.0237 | 0.0115 | 0.0345 | 0.0283 | 0.0362 | 0.0170 | 0.0511 | 0.0255 | 0.8312 | 0.9133 | 0.0183 | 0.0800 | 0.0220 | 0.0800 | 0.0661 | 0.0000 | 0.0771 | 0.2400 | 0.0789 | 0.1600 | 0.0881 | 0.0400 | 0.0844 | 0.2800 | 0.1101 | 0.0400 | 0.4550 | 0.0800 | 0.0079 | 0.0173 | 0.0283 | 0.0336 | 0.0378 | 0.0420 | 0.0535 | 0.0991 | 0.6807 | 3 | 4 | 4 | 5 | 5 | 6 | 7 | 7 | 8 | 0.5147 | 0.30 | 0.895 | 0.8351 | 33.8 | 231.792 | 1719.99 | 13657.8 | 0.5085 | 0.1610 | 0.0301 | 0.0016 | 0.0914 | 0.0107 | 0.1790 | 0.0368 | 0.2367 | 0.0927 | 0.2312 | 0.1792 | 0.1506 | 0.2518 | 0.0667 | 0.2459 | 0.0126 | 0.1425 | 0.0017 | 0.0387 | 0.0000 | 0.0000 | 0.0003 | 0.0001 | 0.0019 | 0.0004 | 0.0124 | 0.0041 | 0.0401 | 0.0133 | 0.1042 | 0.0327 | 0.2310 | 0.0785 | 0.3474 | 0.2650 | 0.2627 | 0.6059 | 0.0142 | 0.0719 | 0.0704 | 0.1807 | 0.1551 | 0.2535 | 0.2061 | 0.2209 | 0.2091 | 0.1486 | 0.1568 | 0.0748 | 0.1088 | 0.0355 | 0.0596 | 0.0115 | 0.0198 | 0.0026 | 0.0004 | 0.0054 | 0.0302 | 0.0848 | 0.1735 | 0.2508 | 0.2509 | 0.1550 | 0.0492 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 153 | 736 | 17577 | 32431 | 213.5 | 66.22 | 119.98 | 191.83 | 136 | 158 | 175 | 190 | 206 | 224 | 243 | 267 | 300 | 0.0595 | 1929 | 0.787 | 314.94 | 107.02 | 13 | 0.0531 | 934 | 0.0006 | 60.12 | 7.718 | 0.1576 | 49951.2 | 12700000 | 3480000000 | 1030000000000 | 0.4279 | 0.2038 | 0.0008 | 0.0001 | 0.0017 | 0.0000 | 0.0105 | 0.0012 | 0.0391 | 0.0061 | 0.0988 | 0.0278 | 0.1631 | 0.0552 | 0.1671 | 0.0671 | 0.1808 | 0.0927 | 0.3382 | 0.7498 | 0.0004 | 0.0001 | 0.0009 | 0.0000 | 0.0031 | 0.0002 | 0.0119 | 0.0026 | 0.0325 | 0.0130 | 0.0602 | 0.0251 | 0.0610 | 0.0279 | 0.0802 | 0.0411 | 0.7497 | 0.8899 | 0.0021 | 0.0077 | 0.0056 | 0.0131 | 0.0162 | 0.0219 | 0.0440 | 0.0848 | 0.0899 | 0.1297 | 0.1362 | 0.1822 | 0.1144 | 0.1160 | 0.1320 | 0.1510 | 0.4596 | 0.2938 | 0.0007 | 0.0020 | 0.0072 | 0.0280 | 0.0589 | 0.0957 | 0.0855 | 0.1131 | 0.6090 | 12 | 15 | 17 | 19 | 25 | 43 | 91 | 197 | 387 | 0.1336 | 21.39 | 4.248 | 0.6174 | 51191.5 | 32500000 | 25000000000 | 21700000000000 | 0.5704 | 0.1134 | 0.0562 | 0.0029 | 0.1967 | 0.0294 | 0.2199 | 0.1289 | 0.1503 | 0.1471 | 0.1472 | 0.1759 | 0.1038 | 0.1638 | 0.0562 | 0.1096 | 0.0452 | 0.1055 | 0.0244 | 0.1370 | 0.0001 | 0.0003 | 0.0006 | 0.0007 | 0.0023 | 0.0022 | 0.0121 | 0.0103 | 0.0469 | 0.0439 | 0.0761 | 0.0620 | 0.0514 | 0.0494 | 0.0790 | 0.0736 | 0.7315 | 0.7577 | 0.0001 | 0.0003 | 0.0009 | 0.0010 | 0.0024 | 0.0040 | 0.0148 | 0.0174 | 0.0598 | 0.0709 | 0.0992 | 0.1012 | 0.0685 | 0.0794 | 0.1031 | 0.1055 | 0.6513 | 0.6204 | 0.0001 | 0.0002 | 0.0016 | 0.0130 | 0.0555 | 0.0840 | 0.0645 | 0.0934 | 0.6877 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 821 | 296 | 10441 | 19427 | 121.6 | 37.86 | 144.94 | 161.51 | 79 | 90 | 99 | 108 | 116 | 126 | 138 | 153 | 174 | 0.0627 | 1218 | 0.254 | 218.68 | 45.79 | 4 | 0.0876 | 915 | 0.0020 | 18.42 | 6.592 | 0.2752 | 16229.4 | 2350000 | 367000000 | 61000000000 | 0.4705 | 0.1773 | 0.0012 | 0.0001 | 0.0034 | 0.0006 | 0.0120 | 0.0011 | 0.0412 | 0.0074 | 0.1063 | 0.0358 | 0.1638 | 0.0724 | 0.1588 | 0.0758 | 0.1756 | 0.1072 | 0.3378 | 0.6997 | 0.0007 | 0.0001 | 0.0015 | 0.0001 | 0.0029 | 0.0005 | 0.0135 | 0.0023 | 0.0368 | 0.0171 | 0.0641 | 0.0363 | 0.0621 | 0.0302 | 0.0774 | 0.0464 | 0.7412 | 0.8670 | 0.0044 | 0.0067 | 0.0016 | 0.0117 | 0.0148 | 0.0341 | 0.0487 | 0.0908 | 0.0907 | 0.1341 | 0.1362 | 0.1882 | 0.1286 | 0.1440 | 0.1354 | 0.1440 | 0.4395 | 0.2465 | 0.0006 | 0.0041 | 0.0103 | 0.0299 | 0.0638 | 0.1050 | 0.0907 | 0.1158 | 0.5798 | 11 | 14 | 20 | 40 | 78 | 132 | 194 | 273 | 378 | 0.0407 | 25.51 | 5.518 | 0.4667 | 47091.3 | 20600000 | 10800000000 | 6430000000000 | 0.5620 | 0.1280 | 0.0686 | 0.0021 | 0.1796 | 0.0256 | 0.2678 | 0.1420 | 0.1409 | 0.1373 | 0.1146 | 0.1747 | 0.0965 | 0.1718 | 0.0578 | 0.1136 | 0.0428 | 0.1049 | 0.0315 | 0.1281 | 0.0001 | 0.0004 | 0.0010 | 0.0007 | 0.0020 | 0.0019 | 0.0094 | 0.0061 | 0.0535 | 0.0466 | 0.1056 | 0.0854 | 0.0759 | 0.0627 | 0.1166 | 0.0964 | 0.6358 | 0.6997 | 0.0008 | 0.0011 | 0.0017 | 0.0029 | 0.0042 | 0.0088 | 0.0152 | 0.0241 | 0.0795 | 0.0957 | 0.1485 | 0.1575 | 0.0994 | 0.1066 | 0.1429 | 0.1449 | 0.5079 | 0.4585 | 0.0003 | 0.0016 | 0.0031 | 0.0113 | 0.0700 | 0.1221 | 0.0927 | 0.1315 | 0.5675 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 207 | 478 | 13048 | 26519 | 97.0 | 27.99 | 161.98 | 234.77 | 64 | 74 | 81 | 88 | 95 | 102 | 109 | 119 | 134 | 0.0514 | 1363 | 0.414 | 318.40 | 44.82 | 2 | 0.0676 | 882 | 0.0022 | 19.38 | 6.429 | 0.2488 | 10191.1 | 1150000 | 139000000 | 17800000000 | 0.4486 | 0.1898 | 0.0006 | 0.0001 | 0.0026 | 0.0001 | 0.0142 | 0.0005 | 0.0573 | 0.0057 | 0.1294 | 0.0245 | 0.1873 | 0.0596 | 0.1931 | 0.0819 | 0.1988 | 0.1265 | 0.2168 | 0.7010 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0021 | 0.0002 | 0.0123 | 0.0021 | 0.0425 | 0.0125 | 0.0796 | 0.0275 | 0.0907 | 0.0335 | 0.1311 | 0.0529 | 0.6415 | 0.8713 | 0.0086 | 0.0180 | 0.0124 | 0.0237 | 0.0341 | 0.0606 | 0.0834 | 0.1219 | 0.1405 | 0.1457 | 0.1777 | 0.1833 | 0.1230 | 0.1129 | 0.1467 | 0.1211 | 0.2735 | 0.2128 | 0.0013 | 0.0034 | 0.0092 | 0.0433 | 0.0938 | 0.1445 | 0.1259 | 0.1491 | 0.4295 | 12 | 14 | 16 | 18 | 33 | 81 | 172 | 311 | 501 | 0.1539 | 30.24 | 4.603 | 0.5818 | 81353.0 | 57600000 | 49500000000 | 48800000000000 | 0.6313 | 0.0832 | 0.0968 | 0.0061 | 0.2891 | 0.0382 | 0.3119 | 0.2073 | 0.1514 | 0.1858 | 0.0786 | 0.1931 | 0.0396 | 0.1633 | 0.0221 | 0.0966 | 0.0084 | 0.0664 | 0.0019 | 0.0433 | 0.0002 | 0.0001 | 0.0014 | 0.0006 | 0.0029 | 0.0019 | 0.0159 | 0.0126 | 0.0664 | 0.0555 | 0.1013 | 0.0925 | 0.0752 | 0.0680 | 0.1062 | 0.0957 | 0.6305 | 0.6731 | 0.0001 | 0.0004 | 0.0027 | 0.0026 | 0.0041 | 0.0069 | 0.0213 | 0.0238 | 0.0829 | 0.0859 | 0.1261 | 0.1347 | 0.0905 | 0.1014 | 0.1246 | 0.1340 | 0.5478 | 0.5103 | 0.0002 | 0.0021 | 0.0035 | 0.0166 | 0.0752 | 0.1103 | 0.0892 | 0.1185 | 0.5844 | |
Hs 578T | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 688 | 724 | 382 | 3170 | 111.2 | 49.61 | 43.27 | 125.08 | 45 | 55 | 71 | 91 | 111 | 133 | 151 | 163 | 177 | 0.1344 | 426 | 0.422 | 253.34 | 46.17 | 1 | 2.3037 | 880 | 0.0037 | 31.49 | 5.680 | 0.1888 | 14813.4 | 2190000 | 345000000 | 56300000000 | 0.2747 | 0.3491 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0057 | 0.2262 | 0.0345 | 0.3929 | 0.1379 | 0.2857 | 0.2184 | 0.0357 | 0.1494 | 0.0595 | 0.2184 | 0.0000 | 0.2356 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0085 | 0.0072 | 0.0681 | 0.0578 | 0.0851 | 0.0866 | 0.0511 | 0.0433 | 0.0681 | 0.0650 | 0.7191 | 0.7401 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0097 | 0.0000 | 0.0194 | 0.0927 | 0.1553 | 0.1192 | 0.1165 | 0.0397 | 0.0971 | 0.1060 | 0.1165 | 0.6424 | 0.4854 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0733 | 0.1257 | 0.0314 | 0.0733 | 0.6963 | 7 | 8 | 9 | 10 | 10 | 11 | 12 | 15 | 33 | 0.6117 | 5.34 | 1.436 | 0.8850 | 17511.8 | 11000000 | 7740000000 | 5940000000000 | 0.6927 | 0.0495 | 0.0357 | 0.0000 | 0.1429 | 0.0385 | 0.2857 | 0.0641 | 0.2143 | 0.1538 | 0.1786 | 0.2436 | 0.1429 | 0.1923 | 0.0000 | 0.1154 | 0.0000 | 0.1538 | 0.0000 | 0.0385 | 0.0032 | 0.0000 | 0.0064 | 0.0085 | 0.0064 | 0.0141 | 0.0129 | 0.0226 | 0.0386 | 0.0621 | 0.0611 | 0.0424 | 0.0675 | 0.0621 | 0.0868 | 0.1017 | 0.7170 | 0.6864 | 0.0000 | 0.0000 | 0.0000 | 0.0036 | 0.0035 | 0.0000 | 0.0106 | 0.0181 | 0.0565 | 0.0471 | 0.0636 | 0.0870 | 0.0777 | 0.0725 | 0.0777 | 0.0725 | 0.7102 | 0.6993 | 0.0000 | 0.0000 | 0.0068 | 0.0102 | 0.0476 | 0.0612 | 0.0714 | 0.0884 | 0.7143 | |||
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 95 | 131 | 989 | 1640 | 89.4 | 13.84 | 29.47 | 62.84 | 71 | 77 | 82 | 85 | 89 | 93 | 96 | 101 | 107 | 0.2116 | 347 | 0.177 | 169.76 | 32.53 | 2 | 0.8817 | 872 | 0.0651 | 1.08 | 3.063 | 0.6829 | 8181.5 | 766522 | 73500000 | 7210000000 | 0.3997 | 0.2450 | 0.0013 | 0.0000 | 0.0025 | 0.0000 | 0.0063 | 0.0000 | 0.0304 | 0.0061 | 0.0608 | 0.0348 | 0.0989 | 0.0583 | 0.1343 | 0.0409 | 0.1926 | 0.0502 | 0.4728 | 0.8096 | 0.0011 | 0.0000 | 0.0011 | 0.0000 | 0.0022 | 0.0000 | 0.0169 | 0.0051 | 0.0371 | 0.0293 | 0.0573 | 0.0526 | 0.0629 | 0.0303 | 0.0843 | 0.0415 | 0.7371 | 0.8413 | 0.0594 | 0.0000 | 0.1089 | 0.3333 | 0.1188 | 0.2500 | 0.1485 | 0.2500 | 0.1485 | 0.0833 | 0.1782 | 0.0833 | 0.0594 | 0.0000 | 0.0792 | 0.0000 | 0.0990 | 0.0000 | 0.0019 | 0.0077 | 0.0232 | 0.0522 | 0.0754 | 0.1006 | 0.1528 | 0.2147 | 0.3714 | 8 | 10 | 12 | 13 | 15 | 17 | 20 | 26 | 43 | 0.3370 | 1.57 | 1.900 | 0.7940 | 4815.1 | 2160000 | 1340000000 | 961000000000 | 0.6590 | 0.0663 | 0.0476 | 0.0571 | 0.1429 | 0.0571 | 0.1905 | 0.0813 | 0.2434 | 0.1099 | 0.2487 | 0.1429 | 0.0794 | 0.1868 | 0.0476 | 0.1890 | 0.0000 | 0.1341 | 0.0000 | 0.0418 | 0.0128 | 0.0413 | 0.0434 | 0.0366 | 0.0561 | 0.0461 | 0.0918 | 0.0636 | 0.1429 | 0.0986 | 0.1709 | 0.1574 | 0.1301 | 0.1558 | 0.1071 | 0.1558 | 0.2449 | 0.2448 | 0.0246 | 0.0057 | 0.0148 | 0.0230 | 0.0296 | 0.0345 | 0.0788 | 0.0575 | 0.1478 | 0.1609 | 0.1773 | 0.2126 | 0.1281 | 0.1149 | 0.1232 | 0.1437 | 0.2759 | 0.2471 | 0.0223 | 0.0335 | 0.0520 | 0.0632 | 0.1561 | 0.1710 | 0.1227 | 0.1190 | 0.2602 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1056 | 445 | 5104 | 5780 | 74.9 | 19.31 | 218.45 | 175.33 | 50 | 58 | 64 | 69 | 74 | 79 | 84 | 91 | 100 | 0.1151 | 665 | 0.283 | 207.13 | 44.00 | 2 | 0.1532 | 782 | 0.0025 | 15.54 | 6.261 | 0.2795 | 5985.4 | 506947 | 45300000 | 4250000000 | 0.4661 | 0.1911 | 0.0004 | 0.0002 | 0.0039 | 0.0011 | 0.0191 | 0.0004 | 0.0399 | 0.0051 | 0.1042 | 0.0308 | 0.1402 | 0.0523 | 0.1568 | 0.0660 | 0.1812 | 0.0959 | 0.3543 | 0.7482 | 0.0000 | 0.0002 | 0.0010 | 0.0006 | 0.0066 | 0.0004 | 0.0081 | 0.0019 | 0.0403 | 0.0196 | 0.0608 | 0.0315 | 0.0613 | 0.0313 | 0.0861 | 0.0500 | 0.7359 | 0.8646 | 0.0063 | 0.0116 | 0.0188 | 0.0203 | 0.0385 | 0.0698 | 0.0626 | 0.1221 | 0.1181 | 0.1977 | 0.1503 | 0.1599 | 0.1351 | 0.1279 | 0.1485 | 0.1541 | 0.3220 | 0.1366 | 0.0024 | 0.0020 | 0.0083 | 0.0317 | 0.0797 | 0.1094 | 0.1023 | 0.1380 | 0.5262 | 37 | 65 | 100 | 137 | 174 | 217 | 278 | 349 | 460 | 0.0040 | 34.98 | 6.397 | 0.3275 | 78453.6 | 37400000 | 21600000000 | 14300000000000 | 0.5030 | 0.1632 | 0.0118 | 0.0034 | 0.0686 | 0.0049 | 0.1902 | 0.0303 | 0.1873 | 0.0654 | 0.2000 | 0.1563 | 0.1490 | 0.1904 | 0.0961 | 0.1553 | 0.0696 | 0.1484 | 0.0275 | 0.2456 | 0.0003 | 0.0003 | 0.0010 | 0.0006 | 0.0045 | 0.0020 | 0.0170 | 0.0107 | 0.0701 | 0.0457 | 0.1114 | 0.0835 | 0.0947 | 0.0760 | 0.1218 | 0.0998 | 0.5791 | 0.6816 | 0.0000 | 0.0000 | 0.0048 | 0.0039 | 0.0064 | 0.0086 | 0.0301 | 0.0368 | 0.0924 | 0.1092 | 0.1557 | 0.1908 | 0.1090 | 0.1132 | 0.1557 | 0.1586 | 0.4458 | 0.3789 | 0.0009 | 0.0009 | 0.0035 | 0.0242 | 0.0797 | 0.1277 | 0.1035 | 0.1364 | 0.5234 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 701 | 856 | 7996 | 17307 | 193.6 | 58.72 | 164.59 | 174.51 | 125 | 142 | 158 | 171 | 186 | 201 | 219 | 242 | 276 | 0.0699 | 1209 | 0.390 | 189.19 | 52.01 | 6 | 0.0969 | 775 | 0.0004 | 115.49 | 7.998 | 0.1188 | 40941.8 | 9380000 | 2310000000 | 607000000000 | 0.4229 | 0.2241 | 0.0005 | 0.0000 | 0.0018 | 0.0002 | 0.0094 | 0.0009 | 0.0411 | 0.0074 | 0.1168 | 0.0344 | 0.1900 | 0.0791 | 0.1790 | 0.0803 | 0.1954 | 0.1104 | 0.2659 | 0.6873 | 0.0003 | 0.0000 | 0.0010 | 0.0001 | 0.0019 | 0.0003 | 0.0127 | 0.0035 | 0.0368 | 0.0179 | 0.0736 | 0.0397 | 0.0694 | 0.0336 | 0.0989 | 0.0501 | 0.7053 | 0.8549 | 0.0011 | 0.0022 | 0.0058 | 0.0101 | 0.0132 | 0.0348 | 0.0529 | 0.0886 | 0.1242 | 0.1502 | 0.1564 | 0.1973 | 0.1036 | 0.1424 | 0.1416 | 0.1323 | 0.4012 | 0.2422 | 0.0011 | 0.0014 | 0.0067 | 0.0338 | 0.0799 | 0.1053 | 0.1028 | 0.1274 | 0.5416 | 12 | 17 | 27 | 57 | 103 | 156 | 220 | 301 | 416 | 0.0341 | 36.46 | 5.746 | 0.4218 | 57539.3 | 27000000 | 15300000000 | 10100000000000 | 0.6571 | 0.0586 | 0.0542 | 0.0031 | 0.1783 | 0.0167 | 0.2744 | 0.0940 | 0.1826 | 0.1421 | 0.1310 | 0.1851 | 0.0908 | 0.1972 | 0.0521 | 0.1171 | 0.0258 | 0.1158 | 0.0107 | 0.1290 | 0.0001 | 0.0001 | 0.0009 | 0.0003 | 0.0035 | 0.0017 | 0.0141 | 0.0100 | 0.0637 | 0.0508 | 0.1127 | 0.0947 | 0.0879 | 0.0669 | 0.1267 | 0.1070 | 0.5903 | 0.6684 | 0.0002 | 0.0012 | 0.0024 | 0.0030 | 0.0050 | 0.0089 | 0.0260 | 0.0344 | 0.0869 | 0.1000 | 0.1472 | 0.1606 | 0.1046 | 0.1172 | 0.1475 | 0.1538 | 0.4802 | 0.4209 | 0.0006 | 0.0016 | 0.0037 | 0.0192 | 0.0754 | 0.1313 | 0.0961 | 0.1295 | 0.5426 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 674 | 423 | 2494 | 12270 | 100.8 | 25.07 | 240.02 | 220.97 | 70 | 79 | 87 | 94 | 100 | 105 | 112 | 120 | 134 | 0.0824 | 1011 | 0.313 | 186.85 | 42.64 | 3 | 0.3091 | 771 | 0.0033 | 14.33 | 5.992 | 0.3037 | 10783.5 | 1220000 | 145000000 | 18200000000 | 0.4342 | 0.2159 | 0.0007 | 0.0000 | 0.0034 | 0.0000 | 0.0189 | 0.0009 | 0.0444 | 0.0076 | 0.1098 | 0.0438 | 0.1825 | 0.0795 | 0.1589 | 0.0831 | 0.1845 | 0.1273 | 0.2970 | 0.6577 | 0.0005 | 0.0000 | 0.0015 | 0.0000 | 0.0056 | 0.0004 | 0.0153 | 0.0054 | 0.0490 | 0.0321 | 0.0842 | 0.0534 | 0.0745 | 0.0434 | 0.0990 | 0.0671 | 0.6704 | 0.7982 | 0.0042 | 0.0062 | 0.0253 | 0.0186 | 0.0547 | 0.1056 | 0.0674 | 0.1801 | 0.1558 | 0.1988 | 0.1853 | 0.1801 | 0.1137 | 0.1242 | 0.1726 | 0.1056 | 0.2211 | 0.0807 | 0.0025 | 0.0050 | 0.0091 | 0.0380 | 0.0809 | 0.1353 | 0.1089 | 0.1601 | 0.4604 | 20 | 40 | 82 | 132 | 185 | 240 | 304 | 392 | 551 | 0.0090 | 45.80 | 6.615 | 0.3329 | 106431.0 | 63700000 | 46200000000 | 38100000000000 | 0.5619 | 0.1212 | 0.0208 | 0.0008 | 0.1223 | 0.0067 | 0.2152 | 0.0569 | 0.1437 | 0.0937 | 0.1675 | 0.1632 | 0.1477 | 0.2010 | 0.0898 | 0.1402 | 0.0589 | 0.1320 | 0.0340 | 0.2056 | 0.0003 | 0.0000 | 0.0013 | 0.0004 | 0.0035 | 0.0018 | 0.0145 | 0.0100 | 0.0650 | 0.0520 | 0.1181 | 0.0946 | 0.0828 | 0.0744 | 0.1196 | 0.1048 | 0.5949 | 0.6619 | 0.0007 | 0.0025 | 0.0030 | 0.0053 | 0.0117 | 0.0171 | 0.0319 | 0.0421 | 0.0986 | 0.1075 | 0.1463 | 0.1430 | 0.1003 | 0.0888 | 0.1232 | 0.1174 | 0.4843 | 0.4763 | 0.0010 | 0.0010 | 0.0057 | 0.0267 | 0.0786 | 0.1316 | 0.0970 | 0.1210 | 0.5374 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 976 | 627 | 9507 | 15770 | 172.7 | 40.39 | 150.51 | 142.96 | 124 | 138 | 148 | 159 | 169 | 180 | 192 | 205 | 226 | 0.0652 | 1028 | 0.252 | 178.21 | 38.29 | 2 | 0.0807 | 767 | 0.0013 | 30.28 | 6.953 | 0.2069 | 31455.3 | 6030000 | 1210000000 | 255000000000 | 0.4791 | 0.1735 | 0.0005 | 0.0001 | 0.0012 | 0.0000 | 0.0054 | 0.0005 | 0.0209 | 0.0019 | 0.0790 | 0.0197 | 0.1482 | 0.0402 | 0.1609 | 0.0520 | 0.1854 | 0.0737 | 0.3985 | 0.8119 | 0.0003 | 0.0000 | 0.0007 | 0.0000 | 0.0027 | 0.0001 | 0.0082 | 0.0004 | 0.0356 | 0.0131 | 0.0592 | 0.0224 | 0.0625 | 0.0227 | 0.0860 | 0.0360 | 0.7450 | 0.9053 | 0.0072 | 0.0075 | 0.0078 | 0.0226 | 0.0245 | 0.0395 | 0.0686 | 0.1598 | 0.1421 | 0.1692 | 0.1633 | 0.1805 | 0.1165 | 0.1297 | 0.1427 | 0.1147 | 0.3272 | 0.1767 | 0.0011 | 0.0022 | 0.0101 | 0.0314 | 0.0686 | 0.1188 | 0.1000 | 0.1331 | 0.5347 | 15 | 26 | 47 | 75 | 109 | 150 | 195 | 249 | 346 | 0.0111 | 36.23 | 6.317 | 0.3622 | 43089.9 | 16900000 | 8150000000 | 4520000000000 | 0.5500 | 0.1433 | 0.0300 | 0.0027 | 0.1203 | 0.0089 | 0.2106 | 0.0533 | 0.1413 | 0.1064 | 0.1498 | 0.1689 | 0.1341 | 0.1813 | 0.0903 | 0.1371 | 0.0662 | 0.1320 | 0.0577 | 0.2093 | 0.0005 | 0.0010 | 0.0013 | 0.0013 | 0.0051 | 0.0033 | 0.0142 | 0.0094 | 0.0556 | 0.0503 | 0.0990 | 0.0768 | 0.0770 | 0.0661 | 0.1045 | 0.0926 | 0.6428 | 0.6991 | 0.0008 | 0.0021 | 0.0025 | 0.0062 | 0.0081 | 0.0129 | 0.0272 | 0.0348 | 0.0805 | 0.0881 | 0.1303 | 0.1407 | 0.0956 | 0.1050 | 0.1222 | 0.1264 | 0.5327 | 0.4839 | 0.0003 | 0.0032 | 0.0054 | 0.0167 | 0.0715 | 0.1122 | 0.0858 | 0.1157 | 0.5891 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 702 | 223 | 941 | 12390 | 79.6 | 29.54 | 182.48 | 238.48 | 36 | 53 | 62 | 72 | 81 | 87 | 96 | 106 | 120 | 0.0553 | 685 | 0.420 | 238.65 | 45.22 | 1 | 0.8013 | 754 | 0.0030 | 21.04 | 6.013 | 0.2638 | 7208.4 | 713221 | 75200000 | 8310000000 | 0.4207 | 0.1971 | 0.0028 | 0.0000 | 0.0140 | 0.0000 | 0.0955 | 0.0016 | 0.1124 | 0.0078 | 0.1376 | 0.0889 | 0.1713 | 0.1404 | 0.1292 | 0.1420 | 0.1573 | 0.1451 | 0.1798 | 0.4743 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0077 | 0.0025 | 0.0526 | 0.0406 | 0.0896 | 0.0570 | 0.0526 | 0.0456 | 0.0881 | 0.0646 | 0.7079 | 0.7896 | 0.0000 | 0.0068 | 0.0069 | 0.0000 | 0.0309 | 0.0270 | 0.0378 | 0.1216 | 0.1478 | 0.2027 | 0.1890 | 0.2027 | 0.1168 | 0.1757 | 0.1787 | 0.1622 | 0.2921 | 0.1014 | 0.0000 | 0.0020 | 0.0041 | 0.0244 | 0.0815 | 0.1120 | 0.1303 | 0.1589 | 0.4868 | 13 | 16 | 20 | 30 | 62 | 129 | 225 | 349 | 522 | 0.0743 | 27.27 | 5.116 | 0.5188 | 90166.0 | 64100000 | 58300000000 | 64100000000000 | 0.4933 | 0.1833 | 0.0624 | 0.0027 | 0.1895 | 0.0226 | 0.2793 | 0.1183 | 0.1763 | 0.1656 | 0.1490 | 0.2005 | 0.0876 | 0.1919 | 0.0394 | 0.1156 | 0.0153 | 0.1102 | 0.0011 | 0.0726 | 0.0004 | 0.0002 | 0.0023 | 0.0013 | 0.0047 | 0.0036 | 0.0157 | 0.0126 | 0.0591 | 0.0491 | 0.0882 | 0.0803 | 0.0608 | 0.0573 | 0.0914 | 0.0794 | 0.6774 | 0.7162 | 0.0005 | 0.0015 | 0.0024 | 0.0015 | 0.0061 | 0.0041 | 0.0198 | 0.0215 | 0.0614 | 0.0684 | 0.1002 | 0.1256 | 0.0833 | 0.0902 | 0.1091 | 0.1368 | 0.6172 | 0.5505 | 0.0019 | 0.0029 | 0.0038 | 0.0150 | 0.0588 | 0.0954 | 0.0711 | 0.1004 | 0.6507 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 559 | 386 | 734 | 10113 | 39.1 | 16.71 | 545.35 | 386.84 | 28 | 29 | 30 | 31 | 32 | 34 | 37 | 45 | 64 | 0.0518 | 524 | 0.593 | 209.07 | 60.01 | 2 | 0.9973 | 732 | 0.0308 | 4.90 | 4.259 | 0.5054 | 1809.2 | 103002 | 7120000 | 567000000 | 0.4029 | 0.2328 | 0.0252 | 0.0000 | 0.0540 | 0.0000 | 0.0755 | 0.0000 | 0.1295 | 0.0174 | 0.1403 | 0.0616 | 0.1799 | 0.0585 | 0.1403 | 0.0932 | 0.1475 | 0.0853 | 0.1079 | 0.6840 | 0.0170 | 0.0000 | 0.0365 | 0.0000 | 0.0462 | 0.0000 | 0.0754 | 0.0136 | 0.0730 | 0.0409 | 0.0900 | 0.0368 | 0.0681 | 0.0587 | 0.1095 | 0.0559 | 0.4842 | 0.7940 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0376 | 0.0200 | 0.0752 | 0.1500 | 0.0827 | 0.0400 | 0.0977 | 0.1100 | 0.0752 | 0.1200 | 0.6316 | 0.5600 | 0.0000 | 0.0052 | 0.0103 | 0.0155 | 0.0619 | 0.0825 | 0.0825 | 0.0928 | 0.6495 | 110 | 186 | 267 | 361 | 473 | 591 | 720 | 874 | 1078 | 0.0014 | 42.72 | 7.230 | 0.2482 | 447031.0 | 456000000 | 536000000000 | 698000000000000 | 0.4409 | 0.2151 | 0.0049 | 0.0008 | 0.0213 | 0.0030 | 0.1079 | 0.0134 | 0.1706 | 0.0422 | 0.2262 | 0.1218 | 0.2011 | 0.1874 | 0.1226 | 0.1487 | 0.0823 | 0.1769 | 0.0632 | 0.3059 | 0.0004 | 0.0003 | 0.0013 | 0.0006 | 0.0037 | 0.0034 | 0.0144 | 0.0101 | 0.0397 | 0.0346 | 0.0744 | 0.0570 | 0.0498 | 0.0461 | 0.0699 | 0.0684 | 0.7464 | 0.7795 | 0.0017 | 0.0015 | 0.0017 | 0.0015 | 0.0043 | 0.0070 | 0.0218 | 0.0278 | 0.0519 | 0.0725 | 0.0930 | 0.1147 | 0.0904 | 0.1118 | 0.1106 | 0.1336 | 0.6246 | 0.5296 | 0.0007 | 0.0052 | 0.0059 | 0.0197 | 0.0437 | 0.0749 | 0.0656 | 0.0837 | 0.7007 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 118 | 70 | 1754 | 4174 | 82.7 | 19.21 | 183.51 | 192.01 | 60 | 66 | 71 | 76 | 81 | 86 | 92 | 98 | 108 | 0.1445 | 603 | 0.362 | 172.26 | 45.00 | 1 | 0.4025 | 706 | 0.0023 | 27.82 | 6.291 | 0.2092 | 7207.4 | 660678 | 63600000 | 6400000000 | 0.4497 | 0.1988 | 0.0009 | 0.0000 | 0.0066 | 0.0000 | 0.0161 | 0.0031 | 0.0530 | 0.0093 | 0.1258 | 0.0322 | 0.1542 | 0.0811 | 0.1987 | 0.0619 | 0.2271 | 0.1002 | 0.2176 | 0.7123 | 0.0000 | 0.0000 | 0.0036 | 0.0000 | 0.0065 | 0.0017 | 0.0210 | 0.0035 | 0.0564 | 0.0239 | 0.0694 | 0.0554 | 0.0845 | 0.0309 | 0.1185 | 0.0612 | 0.6402 | 0.8233 | 0.0183 | 0.0101 | 0.0367 | 0.0202 | 0.0765 | 0.0808 | 0.1009 | 0.2121 | 0.1407 | 0.2323 | 0.1529 | 0.2222 | 0.1315 | 0.0909 | 0.1070 | 0.0909 | 0.2355 | 0.0404 | 0.0024 | 0.0120 | 0.0240 | 0.0456 | 0.0948 | 0.1116 | 0.1273 | 0.1645 | 0.4178 | 24 | 30 | 42 | 62 | 105 | 161 | 244 | 333 | 444 | 0.0173 | 43.47 | 5.837 | 0.3746 | 70533.6 | 37800000 | 24900000000 | 19100000000000 | 0.4742 | 0.1698 | 0.1259 | 0.0058 | 0.2370 | 0.0559 | 0.2840 | 0.2328 | 0.1457 | 0.1420 | 0.0889 | 0.1700 | 0.0617 | 0.1455 | 0.0420 | 0.0873 | 0.0099 | 0.0733 | 0.0049 | 0.0873 | 0.0011 | 0.0010 | 0.0028 | 0.0020 | 0.0091 | 0.0024 | 0.0300 | 0.0215 | 0.0935 | 0.0842 | 0.1230 | 0.1214 | 0.0941 | 0.0773 | 0.1423 | 0.1214 | 0.5040 | 0.5688 | 0.0007 | 0.0000 | 0.0059 | 0.0051 | 0.0074 | 0.0144 | 0.0368 | 0.0405 | 0.1177 | 0.1267 | 0.1575 | 0.1976 | 0.1302 | 0.1351 | 0.1707 | 0.1520 | 0.3731 | 0.3285 | 0.0013 | 0.0026 | 0.0059 | 0.0300 | 0.1019 | 0.1457 | 0.1130 | 0.1470 | 0.4526 | |
Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1142 | 857 | 7401 | 14616 | 171.0 | 66.26 | 71.29 | 133.72 | 97 | 113 | 126 | 141 | 159 | 177 | 198 | 227 | 267 | 0.0757 | 1106 | 0.455 | 200.25 | 41.00 | 7 | 0.0947 | 701 | 0.0014 | 22.02 | 6.984 | 0.2885 | 33621.9 | 7480000 | 1840000000 | 492000000000 | 0.3427 | 0.2805 | 0.0023 | 0.0008 | 0.0023 | 0.0025 | 0.0164 | 0.0059 | 0.0279 | 0.0086 | 0.0707 | 0.0301 | 0.1250 | 0.0604 | 0.1170 | 0.0539 | 0.1514 | 0.0722 | 0.4868 | 0.7658 | 0.0004 | 0.0005 | 0.0013 | 0.0012 | 0.0054 | 0.0022 | 0.0073 | 0.0043 | 0.0207 | 0.0130 | 0.0326 | 0.0254 | 0.0318 | 0.0221 | 0.0443 | 0.0300 | 0.8561 | 0.9014 | 0.0010 | 0.0000 | 0.0030 | 0.0041 | 0.0094 | 0.0058 | 0.0189 | 0.0386 | 0.0506 | 0.0641 | 0.0839 | 0.1191 | 0.0645 | 0.0994 | 0.0948 | 0.1224 | 0.6738 | 0.5464 | 0.0012 | 0.0025 | 0.0065 | 0.0109 | 0.0349 | 0.0477 | 0.0514 | 0.0767 | 0.7681 | 10 | 12 | 14 | 16 | 20 | 33 | 59 | 100 | 185 | 0.1556 | 7.37 | 3.609 | 0.6941 | 22963.2 | 18300000 | 21700000000 | 29800000000000 | 0.5623 | 0.1121 | 0.0192 | 0.0013 | 0.1028 | 0.0217 | 0.1742 | 0.0579 | 0.2030 | 0.0744 | 0.1838 | 0.1431 | 0.1324 | 0.1783 | 0.0941 | 0.1601 | 0.0662 | 0.1353 | 0.0244 | 0.2279 | 0.0000 | 0.0002 | 0.0020 | 0.0025 | 0.0051 | 0.0046 | 0.0151 | 0.0122 | 0.0523 | 0.0408 | 0.0785 | 0.0615 | 0.0621 | 0.0522 | 0.0923 | 0.0762 | 0.6926 | 0.7500 | 0.0006 | 0.0003 | 0.0012 | 0.0037 | 0.0062 | 0.0075 | 0.0211 | 0.0251 | 0.0699 | 0.0728 | 0.1077 | 0.1162 | 0.0759 | 0.0799 | 0.1107 | 0.1118 | 0.6067 | 0.5827 | 0.0003 | 0.0008 | 0.0031 | 0.0230 | 0.0637 | 0.0872 | 0.0730 | 0.0993 | 0.6497 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 297 | 552 | 14385 | 28437 | 82.4 | 25.65 | 78.88 | 67.92 | 54 | 61 | 67 | 72 | 78 | 84 | 92 | 102 | 118 | 0.0619 | 1760 | 0.262 | 166.21 | 32.56 | 3 | 0.0482 | 693 | 0.0019 | 19.35 | 6.626 | 0.2629 | 7444.0 | 736986 | 79600000 | 9310000000 | 0.4815 | 0.1870 | 0.0021 | 0.0003 | 0.0065 | 0.0003 | 0.0131 | 0.0021 | 0.0495 | 0.0068 | 0.1160 | 0.0333 | 0.1694 | 0.0768 | 0.1624 | 0.0699 | 0.1801 | 0.1101 | 0.3009 | 0.7002 | 0.0009 | 0.0001 | 0.0024 | 0.0002 | 0.0052 | 0.0010 | 0.0160 | 0.0027 | 0.0436 | 0.0170 | 0.0742 | 0.0391 | 0.0712 | 0.0313 | 0.0969 | 0.0550 | 0.6896 | 0.8537 | 0.0030 | 0.0071 | 0.0075 | 0.0071 | 0.0157 | 0.0308 | 0.0392 | 0.0711 | 0.1000 | 0.1257 | 0.1440 | 0.1814 | 0.1217 | 0.1209 | 0.1491 | 0.1375 | 0.4199 | 0.3183 | 0.0030 | 0.0033 | 0.0113 | 0.0296 | 0.0612 | 0.1057 | 0.0936 | 0.1170 | 0.5753 | 13 | 21 | 32 | 44 | 58 | 75 | 98 | 130 | 177 | 0.0288 | 3.28 | 4.562 | 0.5810 | 10835.9 | 2010000 | 449000000 | 114000000000 | 0.4815 | 0.2042 | 0.0179 | 0.0044 | 0.0831 | 0.0084 | 0.1602 | 0.0296 | 0.1876 | 0.0792 | 0.1946 | 0.1523 | 0.1540 | 0.1942 | 0.1033 | 0.1555 | 0.0667 | 0.1609 | 0.0325 | 0.2154 | 0.0015 | 0.0018 | 0.0051 | 0.0029 | 0.0095 | 0.0074 | 0.0231 | 0.0180 | 0.0558 | 0.0481 | 0.0860 | 0.0817 | 0.0704 | 0.0668 | 0.0931 | 0.0878 | 0.6555 | 0.6854 | 0.0035 | 0.0026 | 0.0057 | 0.0037 | 0.0118 | 0.0131 | 0.0292 | 0.0330 | 0.0623 | 0.0748 | 0.1026 | 0.1123 | 0.0901 | 0.1017 | 0.1112 | 0.1253 | 0.5837 | 0.5335 | 0.0017 | 0.0054 | 0.0113 | 0.0279 | 0.0579 | 0.0968 | 0.0744 | 0.1004 | 0.6242 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 465 | 733 | 7026 | 3656 | 100.6 | 30.90 | 148.26 | 167.04 | 65 | 73 | 81 | 89 | 97 | 104 | 113 | 123 | 140 | 0.1726 | 631 | 0.377 | 167.26 | 48.09 | 2 | 0.0985 | 692 | 0.0015 | 26.60 | 6.822 | 0.2400 | 11071.8 | 1330000 | 176000000 | 25200000000 | 0.4612 | 0.1922 | 0.0011 | 0.0000 | 0.0014 | 0.0002 | 0.0100 | 0.0020 | 0.0292 | 0.0062 | 0.0812 | 0.0251 | 0.1558 | 0.0583 | 0.1552 | 0.0650 | 0.1918 | 0.0938 | 0.3742 | 0.7495 | 0.0008 | 0.0000 | 0.0002 | 0.0002 | 0.0038 | 0.0018 | 0.0100 | 0.0042 | 0.0318 | 0.0143 | 0.0552 | 0.0292 | 0.0538 | 0.0280 | 0.0766 | 0.0453 | 0.7678 | 0.8770 | 0.0020 | 0.0030 | 0.0087 | 0.0210 | 0.0113 | 0.0299 | 0.0533 | 0.0629 | 0.1119 | 0.1647 | 0.1519 | 0.1467 | 0.1119 | 0.0943 | 0.1446 | 0.1287 | 0.4044 | 0.3488 | 0.0003 | 0.0038 | 0.0060 | 0.0287 | 0.0581 | 0.0975 | 0.0988 | 0.1287 | 0.5781 | 12 | 15 | 21 | 45 | 85 | 132 | 183 | 263 | 396 | 0.0560 | 25.88 | 5.095 | 0.4821 | 49874.3 | 22900000 | 12600000000 | 7790000000000 | 0.5707 | 0.1133 | 0.0493 | 0.0024 | 0.1525 | 0.0214 | 0.1771 | 0.0688 | 0.1435 | 0.1234 | 0.1525 | 0.1637 | 0.1211 | 0.1827 | 0.0785 | 0.1210 | 0.0807 | 0.1257 | 0.0448 | 0.1910 | 0.0006 | 0.0000 | 0.0019 | 0.0028 | 0.0032 | 0.0022 | 0.0158 | 0.0139 | 0.0676 | 0.0565 | 0.1098 | 0.0925 | 0.0909 | 0.0637 | 0.1199 | 0.1163 | 0.5903 | 0.6521 | 0.0026 | 0.0010 | 0.0009 | 0.0073 | 0.0097 | 0.0114 | 0.0325 | 0.0291 | 0.0958 | 0.1112 | 0.1318 | 0.1424 | 0.1019 | 0.1019 | 0.1371 | 0.1486 | 0.4877 | 0.4470 | 0.0000 | 0.0007 | 0.0037 | 0.0214 | 0.0953 | 0.1071 | 0.0960 | 0.1344 | 0.5414 | |
MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 214 | 329 | 2935 | 11303 | 279.9 | 61.40 | 6.40 | 2.56 | 193 | 217 | 240 | 262 | 283 | 300 | 320 | 339 | 363 | 0.0572 | 646 | 0.707 | 220.60 | 68.41 | 1 | 0.2290 | 672 | 0.0038 | 5.82 | 5.792 | 0.3874 | 82100.6 | 25100000 | 7920000000 | 2580000000000 | 0.3742 | 0.2640 | 0.0012 | 0.0000 | 0.0055 | 0.0000 | 0.0068 | 0.0003 | 0.0197 | 0.0035 | 0.0419 | 0.0219 | 0.0653 | 0.0299 | 0.0635 | 0.0285 | 0.1054 | 0.0597 | 0.6907 | 0.8563 | 0.0009 | 0.0000 | 0.0018 | 0.0000 | 0.0013 | 0.0003 | 0.0075 | 0.0027 | 0.0168 | 0.0196 | 0.0266 | 0.0240 | 0.0239 | 0.0192 | 0.0350 | 0.0343 | 0.8862 | 0.8998 | 0.0031 | 0.1875 | 0.0126 | 0.2813 | 0.0173 | 0.3750 | 0.0346 | 0.0938 | 0.0456 | 0.0625 | 0.0566 | 0.0000 | 0.0629 | 0.0000 | 0.0849 | 0.0000 | 0.6824 | 0.0000 | 0.0013 | 0.0020 | 0.0059 | 0.0092 | 0.0277 | 0.0323 | 0.0323 | 0.0554 | 0.8339 | 3 | 4 | 5 | 6 | 6 | 7 | 8 | 9 | 10 | 0.4396 | 0.38 | 1.169 | 0.8081 | 47.5 | 391.249 | 3512.14 | 33881.8 | 0.4867 | 0.1660 | 0.0087 | 0.0004 | 0.0533 | 0.0075 | 0.1339 | 0.0348 | 0.2382 | 0.1039 | 0.2579 | 0.1830 | 0.1883 | 0.2424 | 0.0921 | 0.2426 | 0.0230 | 0.1419 | 0.0046 | 0.0434 | 0.0002 | 0.0000 | 0.0018 | 0.0009 | 0.0097 | 0.0035 | 0.0393 | 0.0162 | 0.0799 | 0.0427 | 0.1426 | 0.0876 | 0.2155 | 0.1902 | 0.2757 | 0.3292 | 0.2352 | 0.3297 | 0.0810 | 0.1861 | 0.1648 | 0.2753 | 0.2049 | 0.2537 | 0.1900 | 0.1433 | 0.1511 | 0.0792 | 0.1073 | 0.0385 | 0.0628 | 0.0186 | 0.0300 | 0.0043 | 0.0081 | 0.0009 | 0.0035 | 0.0243 | 0.0659 | 0.1244 | 0.1728 | 0.2058 | 0.2030 | 0.1370 | 0.0633 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 445 | 885 | 6720 | 10576 | 145.0 | 36.97 | 295.37 | 234.47 | 104 | 115 | 123 | 131 | 139 | 148 | 158 | 172 | 194 | 0.1029 | 1088 | 0.626 | 198.72 | 50.01 | 1 | 0.0999 | 671 | 0.0017 | 31.55 | 6.712 | 0.2250 | 22380.3 | 3690000 | 653000000 | 124000000000 | 0.4622 | 0.1938 | 0.0005 | 0.0000 | 0.0030 | 0.0002 | 0.0103 | 0.0013 | 0.0323 | 0.0038 | 0.0867 | 0.0230 | 0.1608 | 0.0551 | 0.1817 | 0.0633 | 0.1822 | 0.0935 | 0.3425 | 0.7598 | 0.0004 | 0.0000 | 0.0019 | 0.0002 | 0.0023 | 0.0009 | 0.0120 | 0.0021 | 0.0362 | 0.0137 | 0.0734 | 0.0334 | 0.0766 | 0.0241 | 0.1038 | 0.0442 | 0.6935 | 0.8815 | 0.0071 | 0.0081 | 0.0063 | 0.0444 | 0.0205 | 0.0282 | 0.0947 | 0.1290 | 0.1539 | 0.1673 | 0.1902 | 0.1714 | 0.1200 | 0.0968 | 0.1350 | 0.1310 | 0.2723 | 0.2238 | 0.0007 | 0.0044 | 0.0119 | 0.0408 | 0.0983 | 0.1353 | 0.1272 | 0.1452 | 0.4362 | 37 | 76 | 126 | 181 | 247 | 316 | 392 | 484 | 624 | 0.0023 | 85.50 | 7.315 | 0.2151 | 142212.0 | 87400000 | 63000000000 | 51000000000000 | 0.5432 | 0.1364 | 0.0279 | 0.0023 | 0.1381 | 0.0113 | 0.2587 | 0.0476 | 0.1904 | 0.1232 | 0.1774 | 0.1886 | 0.1211 | 0.2083 | 0.0551 | 0.1398 | 0.0244 | 0.1359 | 0.0068 | 0.1429 | 0.0004 | 0.0002 | 0.0022 | 0.0026 | 0.0044 | 0.0034 | 0.0196 | 0.0138 | 0.0714 | 0.0585 | 0.1250 | 0.1079 | 0.1052 | 0.0792 | 0.1248 | 0.1135 | 0.5471 | 0.6207 | 0.0022 | 0.0031 | 0.0054 | 0.0083 | 0.0165 | 0.0211 | 0.0326 | 0.0418 | 0.0979 | 0.1017 | 0.1600 | 0.1663 | 0.1128 | 0.1228 | 0.1279 | 0.1459 | 0.4447 | 0.3890 | 0.0009 | 0.0046 | 0.0110 | 0.0265 | 0.0867 | 0.1423 | 0.1125 | 0.1244 | 0.4912 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 791 | 738 | 2836 | 2758 | 119.5 | 28.32 | 225.10 | 172.38 | 89 | 99 | 105 | 111 | 115 | 121 | 128 | 137 | 155 | 0.1653 | 456 | 0.603 | 236.69 | 51.26 | 1 | 0.2341 | 664 | 0.0036 | 15.13 | 5.972 | 0.2993 | 15085.0 | 2020000 | 291000000 | 45400000000 | 0.4422 | 0.2144 | 0.0000 | 0.0000 | 0.0005 | 0.0004 | 0.0021 | 0.0000 | 0.0185 | 0.0042 | 0.0723 | 0.0261 | 0.1083 | 0.0465 | 0.1591 | 0.0519 | 0.1657 | 0.0711 | 0.4736 | 0.7998 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0008 | 0.0000 | 0.0067 | 0.0011 | 0.0387 | 0.0176 | 0.0627 | 0.0269 | 0.0753 | 0.0298 | 0.0867 | 0.0384 | 0.7285 | 0.8863 | 0.0070 | 0.0054 | 0.0234 | 0.0163 | 0.0422 | 0.0217 | 0.0749 | 0.0761 | 0.1218 | 0.1848 | 0.1124 | 0.1902 | 0.1101 | 0.1196 | 0.1077 | 0.1413 | 0.4005 | 0.2446 | 0.0041 | 0.0033 | 0.0231 | 0.0430 | 0.1017 | 0.1479 | 0.1083 | 0.1380 | 0.4306 | 20 | 53 | 93 | 143 | 203 | 256 | 310 | 368 | 462 | 0.0047 | 47.42 | 6.617 | 0.2813 | 80370.2 | 35100000 | 17400000000 | 9480000000000 | 0.5310 | 0.1251 | 0.0062 | 0.0011 | 0.1040 | 0.0067 | 0.1996 | 0.0540 | 0.2100 | 0.1012 | 0.1580 | 0.1609 | 0.1393 | 0.2014 | 0.1123 | 0.1620 | 0.0499 | 0.1215 | 0.0208 | 0.1912 | 0.0000 | 0.0000 | 0.0007 | 0.0012 | 0.0033 | 0.0024 | 0.0127 | 0.0135 | 0.0560 | 0.0483 | 0.1133 | 0.0889 | 0.0833 | 0.0700 | 0.1227 | 0.0948 | 0.6080 | 0.6810 | 0.0000 | 0.0025 | 0.0010 | 0.0074 | 0.0059 | 0.0086 | 0.0285 | 0.0395 | 0.1050 | 0.1210 | 0.1501 | 0.1444 | 0.0991 | 0.1222 | 0.1511 | 0.1543 | 0.4593 | 0.4000 | 0.0008 | 0.0008 | 0.0032 | 0.0244 | 0.0630 | 0.1198 | 0.1072 | 0.1308 | 0.5500 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 903 | 431 | 54613 | 82874 | 84.8 | 46.65 | 114.00 | 205.41 | 23 | 28 | 54 | 73 | 87 | 99 | 112 | 126 | 146 | 0.0303 | 2514 | 0.607 | 231.82 | 52.47 | 24 | 0.0118 | 645 | 0.0046 | 13.65 | 6.351 | 0.3627 | 9367.0 | 1190000 | 165000000 | 24700000000 | 0.5125 | 0.1476 | 0.0017 | 0.0007 | 0.0076 | 0.0010 | 0.0380 | 0.0040 | 0.0801 | 0.0150 | 0.1435 | 0.0575 | 0.1828 | 0.1084 | 0.1675 | 0.1062 | 0.1626 | 0.1362 | 0.2163 | 0.5709 | 0.0002 | 0.0000 | 0.0004 | 0.0000 | 0.0014 | 0.0002 | 0.0055 | 0.0015 | 0.0213 | 0.0119 | 0.0388 | 0.0234 | 0.0374 | 0.0198 | 0.0551 | 0.0316 | 0.8399 | 0.9117 | 0.0006 | 0.0018 | 0.0028 | 0.0048 | 0.0065 | 0.0130 | 0.0229 | 0.0391 | 0.0576 | 0.0808 | 0.0882 | 0.1189 | 0.0857 | 0.0985 | 0.1117 | 0.1228 | 0.6241 | 0.5203 | 0.0004 | 0.0014 | 0.0040 | 0.0124 | 0.0339 | 0.0605 | 0.0589 | 0.0824 | 0.7461 | 10 | 12 | 13 | 15 | 18 | 26 | 61 | 174 | 383 | 0.2390 | 19.16 | 3.787 | 0.6638 | 55186.4 | 40400000 | 36400000000 | 37700000000000 | 0.4605 | 0.1949 | 0.1576 | 0.0035 | 0.3814 | 0.0611 | 0.3071 | 0.3277 | 0.0839 | 0.2234 | 0.0408 | 0.1726 | 0.0158 | 0.1086 | 0.0071 | 0.0487 | 0.0039 | 0.0298 | 0.0026 | 0.0245 | 0.0001 | 0.0001 | 0.0006 | 0.0003 | 0.0013 | 0.0008 | 0.0117 | 0.0106 | 0.0652 | 0.0602 | 0.1027 | 0.0939 | 0.0640 | 0.0575 | 0.0983 | 0.0881 | 0.6561 | 0.6885 | 0.0000 | 0.0004 | 0.0009 | 0.0009 | 0.0020 | 0.0025 | 0.0164 | 0.0184 | 0.0742 | 0.0778 | 0.1173 | 0.1225 | 0.0764 | 0.0817 | 0.1085 | 0.1098 | 0.6044 | 0.5860 | 0.0001 | 0.0002 | 0.0017 | 0.0132 | 0.0722 | 0.1105 | 0.0693 | 0.1056 | 0.6272 |