High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 791 | 738 | 2836 | 2758 | 119.5 | 28.32 | 225.10 | 172.38 | 89 | 99 | 105 | 111 | 115 | 121 | 128 | 137 | 155 | 0.1653 | 456 | 0.603 | 236.69 | 51.26 | 1 | 0.2341 | 664 | 0.0036 | 15.13 | 5.972 | 0.2993 | 15085.0 | 2020000 | 291000000 | 45400000000 | 0.4422 | 0.2144 | 0.0000 | 0.0000 | 0.0005 | 0.0004 | 0.0021 | 0.0000 | 0.0185 | 0.0042 | 0.0723 | 0.0261 | 0.1083 | 0.0465 | 0.1591 | 0.0519 | 0.1657 | 0.0711 | 0.4736 | 0.7998 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0008 | 0.0000 | 0.0067 | 0.0011 | 0.0387 | 0.0176 | 0.0627 | 0.0269 | 0.0753 | 0.0298 | 0.0867 | 0.0384 | 0.7285 | 0.8863 | 0.0070 | 0.0054 | 0.0234 | 0.0163 | 0.0422 | 0.0217 | 0.0749 | 0.0761 | 0.1218 | 0.1848 | 0.1124 | 0.1902 | 0.1101 | 0.1196 | 0.1077 | 0.1413 | 0.4005 | 0.2446 | 0.0041 | 0.0033 | 0.0231 | 0.0430 | 0.1017 | 0.1479 | 0.1083 | 0.1380 | 0.4306 | 20 | 53 | 93 | 143 | 203 | 256 | 310 | 368 | 462 | 0.0047 | 47.42 | 6.617 | 0.2813 | 80370.2 | 35100000 | 17400000000 | 9480000000000 | 0.5310 | 0.1251 | 0.0062 | 0.0011 | 0.1040 | 0.0067 | 0.1996 | 0.0540 | 0.2100 | 0.1012 | 0.1580 | 0.1609 | 0.1393 | 0.2014 | 0.1123 | 0.1620 | 0.0499 | 0.1215 | 0.0208 | 0.1912 | 0.0000 | 0.0000 | 0.0007 | 0.0012 | 0.0033 | 0.0024 | 0.0127 | 0.0135 | 0.0560 | 0.0483 | 0.1133 | 0.0889 | 0.0833 | 0.0700 | 0.1227 | 0.0948 | 0.6080 | 0.6810 | 0.0000 | 0.0025 | 0.0010 | 0.0074 | 0.0059 | 0.0086 | 0.0285 | 0.0395 | 0.1050 | 0.1210 | 0.1501 | 0.1444 | 0.0991 | 0.1222 | 0.1511 | 0.1543 | 0.4593 | 0.4000 | 0.0008 | 0.0008 | 0.0032 | 0.0244 | 0.0630 | 0.1198 | 0.1072 | 0.1308 | 0.5500 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 821 | 296 | 10441 | 19427 | 121.6 | 37.86 | 144.94 | 161.51 | 79 | 90 | 99 | 108 | 116 | 126 | 138 | 153 | 174 | 0.0627 | 1218 | 0.254 | 218.68 | 45.79 | 4 | 0.0876 | 915 | 0.0020 | 18.42 | 6.592 | 0.2752 | 16229.4 | 2350000 | 367000000 | 61000000000 | 0.4705 | 0.1773 | 0.0012 | 0.0001 | 0.0034 | 0.0006 | 0.0120 | 0.0011 | 0.0412 | 0.0074 | 0.1063 | 0.0358 | 0.1638 | 0.0724 | 0.1588 | 0.0758 | 0.1756 | 0.1072 | 0.3378 | 0.6997 | 0.0007 | 0.0001 | 0.0015 | 0.0001 | 0.0029 | 0.0005 | 0.0135 | 0.0023 | 0.0368 | 0.0171 | 0.0641 | 0.0363 | 0.0621 | 0.0302 | 0.0774 | 0.0464 | 0.7412 | 0.8670 | 0.0044 | 0.0067 | 0.0016 | 0.0117 | 0.0148 | 0.0341 | 0.0487 | 0.0908 | 0.0907 | 0.1341 | 0.1362 | 0.1882 | 0.1286 | 0.1440 | 0.1354 | 0.1440 | 0.4395 | 0.2465 | 0.0006 | 0.0041 | 0.0103 | 0.0299 | 0.0638 | 0.1050 | 0.0907 | 0.1158 | 0.5798 | 11 | 14 | 20 | 40 | 78 | 132 | 194 | 273 | 378 | 0.0407 | 25.51 | 5.518 | 0.4667 | 47091.3 | 20600000 | 10800000000 | 6430000000000 | 0.5620 | 0.1280 | 0.0686 | 0.0021 | 0.1796 | 0.0256 | 0.2678 | 0.1420 | 0.1409 | 0.1373 | 0.1146 | 0.1747 | 0.0965 | 0.1718 | 0.0578 | 0.1136 | 0.0428 | 0.1049 | 0.0315 | 0.1281 | 0.0001 | 0.0004 | 0.0010 | 0.0007 | 0.0020 | 0.0019 | 0.0094 | 0.0061 | 0.0535 | 0.0466 | 0.1056 | 0.0854 | 0.0759 | 0.0627 | 0.1166 | 0.0964 | 0.6358 | 0.6997 | 0.0008 | 0.0011 | 0.0017 | 0.0029 | 0.0042 | 0.0088 | 0.0152 | 0.0241 | 0.0795 | 0.0957 | 0.1485 | 0.1575 | 0.0994 | 0.1066 | 0.1429 | 0.1449 | 0.5079 | 0.4585 | 0.0003 | 0.0016 | 0.0031 | 0.0113 | 0.0700 | 0.1221 | 0.0927 | 0.1315 | 0.5675 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 935 | 650 | 4467 | 9610 | 94.8 | 24.92 | 207.00 | 159.98 | 69 | 75 | 80 | 84 | 89 | 95 | 102 | 111 | 128 | 0.0728 | 700 | 0.935 | 58.80 | 21.38 | 2 | 0.0374 | 167 | 0.0023 | 22.65 | 6.438 | 0.2515 | 9610.2 | 1050000 | 124000000 | 15700000000 | 0.4444 | 0.2134 | 0.0007 | 0.0000 | 0.0055 | 0.0010 | 0.0092 | 0.0005 | 0.0283 | 0.0039 | 0.0881 | 0.0217 | 0.1418 | 0.0440 | 0.1686 | 0.0426 | 0.1851 | 0.0733 | 0.3728 | 0.8130 | 0.0000 | 0.0000 | 0.0017 | 0.0000 | 0.0048 | 0.0000 | 0.0127 | 0.0016 | 0.0469 | 0.0122 | 0.0720 | 0.0228 | 0.0813 | 0.0176 | 0.1042 | 0.0375 | 0.6764 | 0.9083 | 0.0098 | 0.0137 | 0.0147 | 0.0000 | 0.0244 | 0.0192 | 0.0452 | 0.0658 | 0.1345 | 0.1699 | 0.1516 | 0.2000 | 0.1186 | 0.1151 | 0.1528 | 0.1699 | 0.3484 | 0.2466 | 0.0039 | 0.0055 | 0.0171 | 0.0473 | 0.0892 | 0.1244 | 0.1007 | 0.1172 | 0.4948 | 54 | 84 | 111 | 137 | 168 | 203 | 242 | 303 | 400 | 0.0032 | 28.25 | 6.373 | 0.3196 | 68440.7 | 32700000 | 20600000000 | 15800000000000 | 0.5401 | 0.1476 | 0.0155 | 0.0007 | 0.0447 | 0.0007 | 0.1182 | 0.0190 | 0.1771 | 0.0542 | 0.2087 | 0.1259 | 0.1908 | 0.1667 | 0.1258 | 0.1621 | 0.0810 | 0.1828 | 0.0382 | 0.2878 | 0.0008 | 0.0002 | 0.0010 | 0.0003 | 0.0045 | 0.0026 | 0.0207 | 0.0082 | 0.0649 | 0.0465 | 0.1107 | 0.0798 | 0.0944 | 0.0796 | 0.1265 | 0.1118 | 0.5765 | 0.6712 | 0.0018 | 0.0019 | 0.0080 | 0.0062 | 0.0123 | 0.0162 | 0.0355 | 0.0380 | 0.0952 | 0.1102 | 0.1509 | 0.1501 | 0.0955 | 0.1083 | 0.1404 | 0.1406 | 0.4604 | 0.4285 | 0.0005 | 0.0013 | 0.0099 | 0.0259 | 0.0863 | 0.1255 | 0.0978 | 0.1408 | 0.5120 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 780 | 643 | 4246 | 9503 | 153.2 | 43.23 | 163.95 | 111.35 | 107 | 118 | 127 | 135 | 144 | 155 | 167 | 184 | 213 | 0.0930 | 884 | 1.215 | 66.84 | 30.36 | 1 | 0.0445 | 189 | 0.0016 | 33.38 | 6.721 | 0.2068 | 25324.3 | 4540000 | 884000000 | 186000000000 | 0.4222 | 0.2177 | 0.0004 | 0.0000 | 0.0009 | 0.0000 | 0.0065 | 0.0005 | 0.0285 | 0.0037 | 0.1085 | 0.0264 | 0.1876 | 0.0650 | 0.1746 | 0.0647 | 0.2040 | 0.0836 | 0.2891 | 0.7561 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0002 | 0.0110 | 0.0012 | 0.0397 | 0.0171 | 0.0784 | 0.0293 | 0.0800 | 0.0238 | 0.1178 | 0.0358 | 0.6711 | 0.8927 | 0.0023 | 0.0000 | 0.0047 | 0.0049 | 0.0140 | 0.0196 | 0.0756 | 0.1225 | 0.1465 | 0.1716 | 0.1686 | 0.2059 | 0.1128 | 0.1152 | 0.1419 | 0.1127 | 0.3337 | 0.2475 | 0.0011 | 0.0022 | 0.0056 | 0.0332 | 0.0917 | 0.1507 | 0.1074 | 0.1277 | 0.4803 | 49 | 74 | 95 | 116 | 139 | 164 | 198 | 245 | 310 | 0.0019 | 44.15 | 6.783 | 0.2632 | 39278.6 | 12800000 | 5480000000 | 3000000000000 | 0.5562 | 0.1215 | 0.0241 | 0.0012 | 0.0805 | 0.0056 | 0.1411 | 0.0391 | 0.1416 | 0.0770 | 0.1754 | 0.1299 | 0.1546 | 0.1697 | 0.1157 | 0.1456 | 0.0995 | 0.1528 | 0.0676 | 0.2792 | 0.0014 | 0.0002 | 0.0026 | 0.0009 | 0.0069 | 0.0057 | 0.0242 | 0.0137 | 0.0746 | 0.0545 | 0.1063 | 0.0876 | 0.0950 | 0.0778 | 0.1295 | 0.1115 | 0.5595 | 0.6480 | 0.0031 | 0.0018 | 0.0045 | 0.0054 | 0.0118 | 0.0145 | 0.0478 | 0.0559 | 0.1069 | 0.1335 | 0.1491 | 0.1807 | 0.1301 | 0.1326 | 0.1557 | 0.1685 | 0.3910 | 0.3070 | 0.0018 | 0.0050 | 0.0089 | 0.0404 | 0.0908 | 0.1409 | 0.1049 | 0.1375 | 0.4699 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1092 | 85 | 5449 | 11450 | 95.0 | 23.16 | 86.45 | 60.42 | 71 | 77 | 81 | 86 | 91 | 95 | 101 | 110 | 125 | 0.0779 | 892 | 0.747 | 88.84 | 18.03 | 1 | 0.0376 | 205 | 0.0045 | 11.97 | 5.782 | 0.3166 | 9560.2 | 1030000 | 119000000 | 14900000000 | 0.4517 | 0.1982 | 0.0017 | 0.0000 | 0.0031 | 0.0000 | 0.0068 | 0.0002 | 0.0214 | 0.0018 | 0.0749 | 0.0225 | 0.1219 | 0.0393 | 0.1611 | 0.0466 | 0.2022 | 0.0826 | 0.4069 | 0.8069 | 0.0013 | 0.0000 | 0.0016 | 0.0000 | 0.0029 | 0.0000 | 0.0120 | 0.0006 | 0.0334 | 0.0144 | 0.0484 | 0.0215 | 0.0776 | 0.0164 | 0.1074 | 0.0354 | 0.7154 | 0.9118 | 0.0096 | 0.0216 | 0.0160 | 0.0377 | 0.0310 | 0.0377 | 0.0652 | 0.0970 | 0.1485 | 0.1375 | 0.1485 | 0.1563 | 0.1239 | 0.1186 | 0.1528 | 0.1456 | 0.3045 | 0.2480 | 0.0022 | 0.0066 | 0.0254 | 0.0521 | 0.0902 | 0.1139 | 0.1248 | 0.1323 | 0.4525 | 21 | 33 | 45 | 59 | 73 | 90 | 110 | 133 | 169 | 0.0064 | 12.20 | 5.702 | 0.3894 | 11125.0 | 1840000 | 360000000 | 80100000000 | 0.5551 | 0.1175 | 0.0169 | 0.0024 | 0.0852 | 0.0089 | 0.1933 | 0.0316 | 0.2046 | 0.0842 | 0.1860 | 0.1444 | 0.1445 | 0.1944 | 0.0848 | 0.1671 | 0.0580 | 0.1675 | 0.0268 | 0.1994 | 0.0005 | 0.0011 | 0.0025 | 0.0020 | 0.0062 | 0.0051 | 0.0237 | 0.0164 | 0.0697 | 0.0496 | 0.1043 | 0.0775 | 0.0994 | 0.0776 | 0.1410 | 0.1147 | 0.5528 | 0.6561 | 0.0008 | 0.0052 | 0.0066 | 0.0098 | 0.0138 | 0.0265 | 0.0517 | 0.0622 | 0.1115 | 0.1306 | 0.1502 | 0.1614 | 0.1351 | 0.1383 | 0.1523 | 0.1453 | 0.3780 | 0.3206 | 0.0019 | 0.0031 | 0.0080 | 0.0331 | 0.0932 | 0.1245 | 0.1171 | 0.1566 | 0.4623 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 680 | 628 | 3358 | 11383 | 103.9 | 36.00 | 189.92 | 222.69 | 55 | 73 | 87 | 96 | 104 | 113 | 121 | 132 | 150 | 0.0693 | 789 | 0.744 | 53.00 | 13.15 | 2 | 0.0408 | 137 | 0.0010 | 53.73 | 7.119 | 0.1747 | 12086.9 | 1530000 | 208000000 | 30200000000 | 0.4241 | 0.1918 | 0.0000 | 0.0000 | 0.0045 | 0.0012 | 0.0166 | 0.0028 | 0.0487 | 0.0107 | 0.1236 | 0.0396 | 0.1818 | 0.0832 | 0.1639 | 0.0788 | 0.1748 | 0.1097 | 0.2862 | 0.6739 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0065 | 0.0034 | 0.0352 | 0.0250 | 0.0660 | 0.0370 | 0.0567 | 0.0301 | 0.0895 | 0.0510 | 0.7456 | 0.8534 | 0.0011 | 0.0025 | 0.0066 | 0.0127 | 0.0287 | 0.0253 | 0.0562 | 0.0911 | 0.1257 | 0.1671 | 0.1312 | 0.1873 | 0.1125 | 0.1013 | 0.1389 | 0.1646 | 0.3991 | 0.2481 | 0.0023 | 0.0006 | 0.0053 | 0.0299 | 0.0679 | 0.1066 | 0.0978 | 0.1101 | 0.5796 | 14 | 17 | 23 | 40 | 82 | 156 | 248 | 368 | 533 | 0.0760 | 19.94 | 5.078 | 0.5051 | 85655.4 | 51000000 | 35300000000 | 27300000000000 | 0.6172 | 0.0984 | 0.0318 | 0.0041 | 0.1500 | 0.0191 | 0.2403 | 0.0909 | 0.1748 | 0.1415 | 0.1639 | 0.1829 | 0.1281 | 0.1921 | 0.0616 | 0.1271 | 0.0318 | 0.1054 | 0.0179 | 0.1369 | 0.0002 | 0.0006 | 0.0011 | 0.0010 | 0.0067 | 0.0019 | 0.0132 | 0.0101 | 0.0529 | 0.0477 | 0.1008 | 0.0924 | 0.0697 | 0.0570 | 0.0934 | 0.0891 | 0.6621 | 0.7003 | 0.0014 | 0.0009 | 0.0047 | 0.0046 | 0.0143 | 0.0118 | 0.0201 | 0.0236 | 0.0593 | 0.0611 | 0.1023 | 0.1045 | 0.0662 | 0.0856 | 0.1017 | 0.1135 | 0.6300 | 0.5945 | 0.0005 | 0.0017 | 0.0083 | 0.0225 | 0.0605 | 0.1037 | 0.0722 | 0.0930 | 0.6376 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1039 | 381 | 3800 | 9893 | 128.9 | 35.24 | 177.58 | 105.97 | 91 | 99 | 107 | 113 | 121 | 131 | 142 | 156 | 177 | 0.0668 | 661 | 1.078 | 92.18 | 30.89 | 1 | 0.0611 | 232 | 0.0025 | 19.96 | 6.337 | 0.2693 | 17862.2 | 2670000 | 431000000 | 74800000000 | 0.4064 | 0.2310 | 0.0020 | 0.0000 | 0.0049 | 0.0000 | 0.0133 | 0.0003 | 0.0405 | 0.0023 | 0.0968 | 0.0290 | 0.1532 | 0.0582 | 0.1502 | 0.0603 | 0.1789 | 0.0892 | 0.3602 | 0.7607 | 0.0007 | 0.0000 | 0.0028 | 0.0000 | 0.0032 | 0.0000 | 0.0142 | 0.0011 | 0.0383 | 0.0165 | 0.0663 | 0.0315 | 0.0670 | 0.0221 | 0.1018 | 0.0464 | 0.7057 | 0.8824 | 0.0013 | 0.0000 | 0.0025 | 0.0150 | 0.0226 | 0.0240 | 0.0477 | 0.1201 | 0.1206 | 0.1592 | 0.1520 | 0.1742 | 0.1244 | 0.1171 | 0.1595 | 0.1411 | 0.3693 | 0.2492 | 0.0019 | 0.0038 | 0.0107 | 0.0239 | 0.0704 | 0.1157 | 0.0855 | 0.1157 | 0.5723 | 56 | 84 | 110 | 137 | 161 | 189 | 217 | 254 | 321 | 0.0018 | 32.40 | 6.743 | 0.2735 | 42762.9 | 12800000 | 4530000000 | 1830000000000 | 0.5224 | 0.1428 | 0.0069 | 0.0004 | 0.0360 | 0.0032 | 0.1033 | 0.0123 | 0.1645 | 0.0379 | 0.1920 | 0.0917 | 0.1882 | 0.1453 | 0.1446 | 0.1523 | 0.1037 | 0.1707 | 0.0608 | 0.3863 | 0.0007 | 0.0000 | 0.0011 | 0.0007 | 0.0051 | 0.0014 | 0.0161 | 0.0074 | 0.0562 | 0.0314 | 0.0904 | 0.0636 | 0.0907 | 0.0624 | 0.1212 | 0.0865 | 0.6186 | 0.7466 | 0.0019 | 0.0053 | 0.0061 | 0.0144 | 0.0200 | 0.0202 | 0.0517 | 0.0554 | 0.0950 | 0.1391 | 0.1363 | 0.1464 | 0.1266 | 0.1165 | 0.1315 | 0.1310 | 0.4309 | 0.3717 | 0.0011 | 0.0046 | 0.0090 | 0.0264 | 0.0790 | 0.1152 | 0.1061 | 0.1299 | 0.5287 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1049 | 270 | 3875 | 7952 | 133.1 | 35.91 | 157.83 | 125.74 | 94 | 104 | 113 | 121 | 128 | 136 | 145 | 157 | 179 | 0.0832 | 662 | 0.854 | 78.82 | 25.55 | 2 | 0.0565 | 219 | 0.0020 | 26.25 | 6.494 | 0.2455 | 18997.6 | 2930000 | 490000000 | 89600000000 | 0.4209 | 0.2213 | 0.0000 | 0.0003 | 0.0004 | 0.0000 | 0.0074 | 0.0003 | 0.0302 | 0.0020 | 0.0944 | 0.0294 | 0.1627 | 0.0582 | 0.1605 | 0.0616 | 0.1828 | 0.0913 | 0.3616 | 0.7570 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0030 | 0.0000 | 0.0097 | 0.0003 | 0.0462 | 0.0196 | 0.0716 | 0.0346 | 0.0726 | 0.0291 | 0.1044 | 0.0471 | 0.6921 | 0.8694 | 0.0086 | 0.0097 | 0.0143 | 0.0065 | 0.0399 | 0.0259 | 0.0799 | 0.1003 | 0.1241 | 0.1586 | 0.1526 | 0.1715 | 0.0984 | 0.1100 | 0.1184 | 0.1683 | 0.3638 | 0.2492 | 0.0024 | 0.0083 | 0.0166 | 0.0391 | 0.1073 | 0.1375 | 0.1203 | 0.1316 | 0.4369 | 26 | 44 | 68 | 98 | 128 | 163 | 203 | 251 | 336 | 0.0035 | 41.32 | 6.588 | 0.3220 | 40720.6 | 13800000 | 5550000000 | 2540000000000 | 0.4558 | 0.2138 | 0.0196 | 0.0022 | 0.0713 | 0.0072 | 0.1578 | 0.0421 | 0.1767 | 0.0623 | 0.2000 | 0.1326 | 0.1804 | 0.1870 | 0.1084 | 0.1581 | 0.0531 | 0.1675 | 0.0327 | 0.2410 | 0.0012 | 0.0000 | 0.0015 | 0.0021 | 0.0055 | 0.0037 | 0.0159 | 0.0118 | 0.0585 | 0.0468 | 0.0938 | 0.0773 | 0.0774 | 0.0664 | 0.1074 | 0.0880 | 0.6388 | 0.7040 | 0.0008 | 0.0034 | 0.0053 | 0.0087 | 0.0120 | 0.0135 | 0.0361 | 0.0429 | 0.0847 | 0.1118 | 0.1295 | 0.1301 | 0.1043 | 0.1186 | 0.1401 | 0.1533 | 0.4872 | 0.4178 | 0.0006 | 0.0033 | 0.0108 | 0.0222 | 0.0752 | 0.1049 | 0.0869 | 0.1254 | 0.5707 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 933 | 123 | 15895 | 25256 | 160.6 | 49.99 | 222.36 | 201.78 | 108 | 123 | 135 | 145 | 155 | 167 | 180 | 197 | 224 | 0.0522 | 1319 | 1.013 | 68.60 | 26.63 | 1 | 0.0118 | 188 | 0.0011 | 38.56 | 7.182 | 0.2007 | 28277.2 | 5410000 | 1120000000 | 250000000000 | 0.4469 | 0.2019 | 0.0004 | 0.0000 | 0.0020 | 0.0000 | 0.0077 | 0.0004 | 0.0316 | 0.0036 | 0.1026 | 0.0245 | 0.1744 | 0.0573 | 0.1683 | 0.0626 | 0.1924 | 0.0950 | 0.3207 | 0.7567 | 0.0002 | 0.0000 | 0.0008 | 0.0000 | 0.0020 | 0.0001 | 0.0095 | 0.0013 | 0.0356 | 0.0107 | 0.0680 | 0.0249 | 0.0660 | 0.0239 | 0.0986 | 0.0414 | 0.7192 | 0.8976 | 0.0038 | 0.0039 | 0.0105 | 0.0143 | 0.0212 | 0.0306 | 0.0646 | 0.0971 | 0.1280 | 0.1519 | 0.1664 | 0.1956 | 0.1271 | 0.1167 | 0.1414 | 0.1402 | 0.3371 | 0.2497 | 0.0010 | 0.0033 | 0.0088 | 0.0321 | 0.0763 | 0.1269 | 0.1097 | 0.1304 | 0.5115 | 26 | 46 | 75 | 111 | 161 | 221 | 294 | 379 | 507 | 0.0037 | 85.09 | 7.177 | 0.2606 | 90156.2 | 49000000 | 32300000000 | 24700000000000 | 0.5277 | 0.1518 | 0.0405 | 0.0017 | 0.1859 | 0.0114 | 0.2913 | 0.0812 | 0.1595 | 0.1431 | 0.1289 | 0.2051 | 0.0931 | 0.1986 | 0.0540 | 0.1320 | 0.0300 | 0.1078 | 0.0167 | 0.1190 | 0.0003 | 0.0003 | 0.0017 | 0.0005 | 0.0033 | 0.0024 | 0.0137 | 0.0100 | 0.0734 | 0.0561 | 0.1231 | 0.1010 | 0.0947 | 0.0796 | 0.1369 | 0.1199 | 0.5529 | 0.6302 | 0.0009 | 0.0011 | 0.0033 | 0.0060 | 0.0084 | 0.0108 | 0.0290 | 0.0412 | 0.1013 | 0.1114 | 0.1586 | 0.1680 | 0.1119 | 0.1173 | 0.1427 | 0.1435 | 0.4438 | 0.4007 | 0.0005 | 0.0008 | 0.0048 | 0.0220 | 0.0840 | 0.1483 | 0.1014 | 0.1428 | 0.4955 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 534 | 923 | 4850 | 8622 | 162.0 | 44.63 | 180.98 | 189.76 | 115 | 127 | 136 | 144 | 153 | 163 | 176 | 194 | 220 | 0.0923 | 796 | 1.107 | 100.01 | 36.69 | 1 | 0.0542 | 263 | 0.0016 | 35.56 | 6.803 | 0.2042 | 28220.0 | 5320000 | 1090000000 | 244000000000 | 0.4589 | 0.1995 | 0.0007 | 0.0000 | 0.0029 | 0.0005 | 0.0119 | 0.0016 | 0.0353 | 0.0018 | 0.0965 | 0.0224 | 0.1780 | 0.0576 | 0.1567 | 0.0576 | 0.1780 | 0.0908 | 0.3401 | 0.7676 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0024 | 0.0000 | 0.0113 | 0.0004 | 0.0464 | 0.0146 | 0.0848 | 0.0310 | 0.0754 | 0.0240 | 0.1095 | 0.0437 | 0.6690 | 0.8863 | 0.0021 | 0.0124 | 0.0095 | 0.0173 | 0.0148 | 0.0173 | 0.0674 | 0.0990 | 0.1349 | 0.1708 | 0.1802 | 0.1931 | 0.1117 | 0.0990 | 0.1454 | 0.1411 | 0.3340 | 0.2500 | 0.0025 | 0.0020 | 0.0129 | 0.0373 | 0.0821 | 0.1318 | 0.1035 | 0.1274 | 0.5005 | 14 | 24 | 41 | 71 | 110 | 159 | 230 | 325 | 469 | 0.0065 | 92.57 | 6.832 | 0.2972 | 68756.7 | 35000000 | 20900000000 | 13800000000000 | 0.4654 | 0.1787 | 0.0372 | 0.0015 | 0.1157 | 0.0126 | 0.2314 | 0.0576 | 0.2038 | 0.0919 | 0.1826 | 0.1859 | 0.1210 | 0.2273 | 0.0605 | 0.1485 | 0.0297 | 0.1348 | 0.0180 | 0.1399 | 0.0011 | 0.0005 | 0.0019 | 0.0018 | 0.0057 | 0.0016 | 0.0164 | 0.0127 | 0.0655 | 0.0540 | 0.0911 | 0.0881 | 0.0668 | 0.0623 | 0.0898 | 0.0865 | 0.6617 | 0.6924 | 0.0018 | 0.0000 | 0.0015 | 0.0081 | 0.0066 | 0.0098 | 0.0239 | 0.0242 | 0.0668 | 0.0752 | 0.1146 | 0.1134 | 0.0856 | 0.0935 | 0.1050 | 0.1143 | 0.5942 | 0.5616 | 0.0003 | 0.0028 | 0.0070 | 0.0215 | 0.0579 | 0.0958 | 0.0730 | 0.1078 | 0.6339 | |||
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 306 | 371 | 4494 | 4270 | 161.8 | 42.70 | 234.69 | 215.83 | 112 | 124 | 135 | 145 | 156 | 167 | 180 | 196 | 218 | 0.1239 | 529 | 1.009 | 96.75 | 25.96 | 1 | 0.0514 | 231 | 0.0014 | 36.68 | 6.820 | 0.2137 | 28010.0 | 5190000 | 1030000000 | 219000000000 | 0.4291 | 0.2251 | 0.0008 | 0.0000 | 0.0024 | 0.0000 | 0.0126 | 0.0000 | 0.0423 | 0.0007 | 0.1057 | 0.0278 | 0.1680 | 0.0566 | 0.1590 | 0.0556 | 0.1745 | 0.0831 | 0.3347 | 0.7761 | 0.0006 | 0.0000 | 0.0015 | 0.0000 | 0.0047 | 0.0000 | 0.0109 | 0.0005 | 0.0393 | 0.0157 | 0.0730 | 0.0314 | 0.0659 | 0.0243 | 0.0878 | 0.0444 | 0.7163 | 0.8838 | 0.0022 | 0.0030 | 0.0119 | 0.0211 | 0.0249 | 0.0544 | 0.0692 | 0.0967 | 0.1405 | 0.1601 | 0.1665 | 0.1994 | 0.1373 | 0.0967 | 0.1395 | 0.1178 | 0.3081 | 0.2508 | 0.0005 | 0.0040 | 0.0079 | 0.0287 | 0.0773 | 0.1229 | 0.1145 | 0.1378 | 0.5064 | 19 | 34 | 69 | 122 | 179 | 238 | 316 | 406 | 546 | 0.0057 | 104.66 | 6.818 | 0.2641 | 101650.0 | 57600000 | 38800000000 | 29800000000000 | 0.4229 | 0.2444 | 0.0242 | 0.0057 | 0.1288 | 0.0139 | 0.2254 | 0.0632 | 0.1771 | 0.1165 | 0.1659 | 0.1509 | 0.1385 | 0.1985 | 0.0821 | 0.1600 | 0.0403 | 0.1493 | 0.0177 | 0.1419 | 0.0005 | 0.0004 | 0.0005 | 0.0008 | 0.0063 | 0.0025 | 0.0169 | 0.0144 | 0.0743 | 0.0534 | 0.1139 | 0.0974 | 0.0816 | 0.0732 | 0.1071 | 0.1007 | 0.5989 | 0.6572 | 0.0014 | 0.0016 | 0.0034 | 0.0025 | 0.0096 | 0.0140 | 0.0310 | 0.0404 | 0.0855 | 0.0947 | 0.1365 | 0.1417 | 0.0848 | 0.1046 | 0.1192 | 0.1038 | 0.5286 | 0.4967 | 0.0012 | 0.0040 | 0.0058 | 0.0295 | 0.0728 | 0.1248 | 0.0872 | 0.1092 | 0.5656 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1162 | 503 | 2529 | 2344 | 126.3 | 43.34 | 188.90 | 122.03 | 73 | 88 | 100 | 110 | 122 | 133 | 145 | 162 | 185 | 0.1950 | 457 | 0.720 | 84.38 | 20.03 | 1 | 0.0834 | 211 | 0.0009 | 89.32 | 7.225 | 0.1409 | 17828.9 | 2770000 | 469000000 | 85100000000 | 0.4531 | 0.1879 | 0.0000 | 0.0000 | 0.0045 | 0.0021 | 0.0334 | 0.0032 | 0.0885 | 0.0117 | 0.1554 | 0.0573 | 0.2069 | 0.1183 | 0.1527 | 0.1210 | 0.1509 | 0.1666 | 0.2078 | 0.5199 | 0.0000 | 0.0000 | 0.0006 | 0.0013 | 0.0023 | 0.0018 | 0.0153 | 0.0081 | 0.0512 | 0.0346 | 0.0904 | 0.0606 | 0.0745 | 0.0454 | 0.0944 | 0.0718 | 0.6714 | 0.7764 | 0.0031 | 0.0088 | 0.0077 | 0.0263 | 0.0153 | 0.0351 | 0.0537 | 0.0906 | 0.1503 | 0.1579 | 0.1656 | 0.1813 | 0.1012 | 0.0906 | 0.1518 | 0.1579 | 0.3512 | 0.2515 | 0.0000 | 0.0009 | 0.0043 | 0.0282 | 0.1059 | 0.1443 | 0.1059 | 0.1460 | 0.4646 | 57 | 75 | 104 | 135 | 169 | 201 | 239 | 281 | 355 | 0.0049 | 19.35 | 5.900 | 0.3617 | 50569.7 | 17000000 | 6670000000 | 2960000000000 | 0.5121 | 0.1476 | 0.0119 | 0.0010 | 0.0889 | 0.0089 | 0.1976 | 0.0207 | 0.1621 | 0.0720 | 0.1581 | 0.1519 | 0.1561 | 0.2002 | 0.0870 | 0.1322 | 0.0870 | 0.1686 | 0.0514 | 0.2446 | 0.0000 | 0.0006 | 0.0008 | 0.0006 | 0.0093 | 0.0025 | 0.0202 | 0.0153 | 0.0644 | 0.0567 | 0.1149 | 0.0943 | 0.0901 | 0.0732 | 0.1335 | 0.1115 | 0.5668 | 0.6452 | 0.0013 | 0.0090 | 0.0064 | 0.0162 | 0.0153 | 0.0252 | 0.0435 | 0.0629 | 0.1228 | 0.1457 | 0.1662 | 0.1853 | 0.1368 | 0.1097 | 0.1675 | 0.1583 | 0.3402 | 0.2878 | 0.0000 | 0.0019 | 0.0135 | 0.0348 | 0.0890 | 0.1277 | 0.1180 | 0.1750 | 0.4400 | |
MCF 10A | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 121 | 590 | 6826 | 22797 | 692.3 | 141.16 | 184.25 | 147.65 | 524 | 569 | 603 | 636 | 672 | 711 | 754 | 812 | 894 | 0.0504 | 1149 | 1.195 | 96.01 | 36.50 | 1 | 0.0355 | 242 | 0.0006 | 74.81 | 7.679 | 0.1333 | 499160.0 | 375000000 | 293000000000 | 238000000000000 | 0.4097 | 0.2333 | 0.0000 | 0.0000 | 0.0007 | 0.0003 | 0.0033 | 0.0000 | 0.0134 | 0.0015 | 0.0541 | 0.0141 | 0.1179 | 0.0327 | 0.1221 | 0.0242 | 0.1447 | 0.0447 | 0.5439 | 0.8825 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0054 | 0.0001 | 0.0244 | 0.0100 | 0.0560 | 0.0208 | 0.0529 | 0.0091 | 0.0796 | 0.0171 | 0.7802 | 0.9428 | 0.0000 | 0.0210 | 0.0059 | 0.0385 | 0.0245 | 0.0559 | 0.0422 | 0.0594 | 0.1114 | 0.1713 | 0.1401 | 0.1608 | 0.1241 | 0.1014 | 0.1595 | 0.1399 | 0.3924 | 0.2517 | 0.0007 | 0.0033 | 0.0052 | 0.0244 | 0.0711 | 0.1157 | 0.0949 | 0.1252 | 0.5596 | 31 | 53 | 80 | 111 | 147 | 188 | 236 | 298 | 396 | 0.0053 | 17.90 | 6.140 | 0.3553 | 55747.2 | 22400000 | 11300000000 | 7040000000000 | 0.4802 | 0.1654 | 0.0189 | 0.0009 | 0.1045 | 0.0065 | 0.1943 | 0.0481 | 0.1712 | 0.0929 | 0.1772 | 0.1570 | 0.1568 | 0.1982 | 0.0804 | 0.1530 | 0.0592 | 0.1463 | 0.0375 | 0.1971 | 0.0006 | 0.0003 | 0.0018 | 0.0010 | 0.0062 | 0.0037 | 0.0214 | 0.0144 | 0.0636 | 0.0533 | 0.1041 | 0.0946 | 0.0826 | 0.0723 | 0.1081 | 0.1001 | 0.6117 | 0.6604 | 0.0021 | 0.0022 | 0.0055 | 0.0077 | 0.0141 | 0.0176 | 0.0366 | 0.0471 | 0.0854 | 0.0843 | 0.1155 | 0.1211 | 0.0905 | 0.0961 | 0.1101 | 0.1108 | 0.5402 | 0.5131 | 0.0011 | 0.0033 | 0.0088 | 0.0271 | 0.0757 | 0.1130 | 0.0967 | 0.1074 | 0.5670 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1002 | 903 | 2590 | 6854 | 671.8 | 130.82 | 57.85 | 118.91 | 504 | 556 | 597 | 632 | 666 | 700 | 730 | 773 | 852 | 0.0926 | 635 | 0.749 | 181.18 | 45.31 | 2 | 0.1853 | 480 | 0.0008 | 66.05 | 7.317 | 0.1448 | 468423.0 | 339000000 | 253000000000 | 195000000000000 | 0.4212 | 0.2260 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0004 | 0.0062 | 0.0020 | 0.0506 | 0.0208 | 0.1069 | 0.0425 | 0.0771 | 0.0261 | 0.1187 | 0.0357 | 0.6398 | 0.8725 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0032 | 0.0008 | 0.0272 | 0.0159 | 0.0614 | 0.0348 | 0.0378 | 0.0147 | 0.0591 | 0.0224 | 0.8113 | 0.9111 | 0.0051 | 0.0000 | 0.0000 | 0.0000 | 0.0103 | 0.0220 | 0.0282 | 0.0879 | 0.0872 | 0.1209 | 0.1385 | 0.1758 | 0.0923 | 0.1868 | 0.1256 | 0.1538 | 0.5128 | 0.2527 | 0.0008 | 0.0000 | 0.0040 | 0.0217 | 0.0593 | 0.1051 | 0.0842 | 0.1043 | 0.6207 | 10 | 12 | 13 | 16 | 22 | 33 | 42 | 64 | 129 | 0.1077 | 12.25 | 3.455 | 0.7303 | 17483.7 | 14800000 | 20400000000 | 35900000000000 | 0.6243 | 0.0943 | 0.0239 | 0.0079 | 0.0613 | 0.0126 | 0.0733 | 0.0238 | 0.1346 | 0.0516 | 0.1891 | 0.0827 | 0.1704 | 0.1263 | 0.1891 | 0.1468 | 0.1193 | 0.1640 | 0.0392 | 0.3843 | 0.0054 | 0.0046 | 0.0113 | 0.0057 | 0.0097 | 0.0092 | 0.0199 | 0.0218 | 0.0485 | 0.0402 | 0.0889 | 0.0766 | 0.0711 | 0.0808 | 0.0867 | 0.0938 | 0.6584 | 0.6673 | 0.0039 | 0.0018 | 0.0024 | 0.0027 | 0.0087 | 0.0064 | 0.0221 | 0.0282 | 0.0559 | 0.0645 | 0.1087 | 0.1064 | 0.0693 | 0.0709 | 0.0969 | 0.0982 | 0.6320 | 0.6209 | 0.0026 | 0.0066 | 0.0066 | 0.0178 | 0.0540 | 0.0949 | 0.0639 | 0.0988 | 0.6548 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 917 | 765 | 4787 | 6025 | 134.0 | 29.36 | 199.47 | 144.31 | 101 | 111 | 117 | 124 | 130 | 137 | 145 | 154 | 168 | 0.1200 | 723 | 1.159 | 112.49 | 39.01 | 1 | 0.0570 | 273 | 0.0026 | 20.01 | 6.253 | 0.2547 | 18810.6 | 2780000 | 434000000 | 72000000000 | 0.4427 | 0.2093 | 0.0000 | 0.0000 | 0.0018 | 0.0000 | 0.0064 | 0.0013 | 0.0155 | 0.0016 | 0.0709 | 0.0202 | 0.1267 | 0.0377 | 0.1506 | 0.0388 | 0.1815 | 0.0566 | 0.4467 | 0.8438 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0020 | 0.0000 | 0.0073 | 0.0004 | 0.0405 | 0.0149 | 0.0653 | 0.0246 | 0.0710 | 0.0181 | 0.0965 | 0.0305 | 0.7169 | 0.9114 | 0.0043 | 0.0000 | 0.0157 | 0.0082 | 0.0443 | 0.0286 | 0.0944 | 0.1224 | 0.1688 | 0.1510 | 0.1574 | 0.2041 | 0.0987 | 0.1102 | 0.1273 | 0.1224 | 0.2890 | 0.2531 | 0.0018 | 0.0042 | 0.0125 | 0.0365 | 0.0983 | 0.1347 | 0.1117 | 0.1440 | 0.4564 | 44 | 68 | 100 | 134 | 171 | 211 | 256 | 309 | 392 | 0.0015 | 70.67 | 7.066 | 0.2195 | 60610.6 | 23900000 | 11300000000 | 6160000000000 | 0.5305 | 0.1272 | 0.0202 | 0.0004 | 0.0960 | 0.0047 | 0.2098 | 0.0436 | 0.2030 | 0.0781 | 0.1955 | 0.1872 | 0.1348 | 0.1919 | 0.0851 | 0.1725 | 0.0447 | 0.1552 | 0.0110 | 0.1665 | 0.0006 | 0.0003 | 0.0009 | 0.0005 | 0.0019 | 0.0026 | 0.0206 | 0.0127 | 0.0768 | 0.0560 | 0.1070 | 0.0915 | 0.0989 | 0.0710 | 0.1385 | 0.1099 | 0.5548 | 0.6556 | 0.0015 | 0.0032 | 0.0064 | 0.0097 | 0.0124 | 0.0175 | 0.0500 | 0.0662 | 0.1199 | 0.1364 | 0.1640 | 0.1857 | 0.1189 | 0.1422 | 0.1690 | 0.1513 | 0.3578 | 0.2877 | 0.0008 | 0.0008 | 0.0077 | 0.0291 | 0.0926 | 0.1403 | 0.1170 | 0.1592 | 0.4525 | |
MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 817 | 307 | 12027 | 28545 | 384.6 | 103.18 | 211.70 | 323.15 | 261 | 292 | 319 | 344 | 373 | 404 | 437 | 474 | 525 | 0.0436 | 1244 | 0.752 | 109.04 | 32.80 | 1 | 0.0267 | 321 | 0.0007 | 50.15 | 7.537 | 0.1757 | 158542.0 | 69700000 | 32500000000 | 16000000000000 | 0.4289 | 0.2207 | 0.0003 | 0.0000 | 0.0018 | 0.0000 | 0.0060 | 0.0004 | 0.0202 | 0.0027 | 0.1007 | 0.0201 | 0.1791 | 0.0552 | 0.1602 | 0.0555 | 0.1833 | 0.0782 | 0.3484 | 0.7879 | 0.0001 | 0.0000 | 0.0002 | 0.0000 | 0.0011 | 0.0001 | 0.0064 | 0.0007 | 0.0379 | 0.0115 | 0.0683 | 0.0279 | 0.0628 | 0.0240 | 0.0862 | 0.0362 | 0.7370 | 0.8996 | 0.0014 | 0.0052 | 0.0061 | 0.0146 | 0.0112 | 0.0293 | 0.0404 | 0.0784 | 0.1156 | 0.1787 | 0.1603 | 0.1985 | 0.0932 | 0.0920 | 0.1564 | 0.1494 | 0.4153 | 0.2539 | 0.0018 | 0.0027 | 0.0054 | 0.0164 | 0.0567 | 0.1053 | 0.0810 | 0.1079 | 0.6227 | 8 | 10 | 13 | 17 | 35 | 112 | 226 | 396 | 663 | 0.1315 | 50.59 | 4.941 | 0.5343 | 149236.0 | 151000000 | 190000000000 | 278000000000000 | 0.5049 | 0.1716 | 0.0798 | 0.0036 | 0.2247 | 0.0328 | 0.2958 | 0.1757 | 0.1673 | 0.1637 | 0.1055 | 0.1861 | 0.0667 | 0.1779 | 0.0284 | 0.1106 | 0.0169 | 0.0810 | 0.0148 | 0.0684 | 0.0000 | 0.0002 | 0.0004 | 0.0005 | 0.0019 | 0.0005 | 0.0068 | 0.0058 | 0.0560 | 0.0442 | 0.0957 | 0.0808 | 0.0664 | 0.0597 | 0.1062 | 0.0944 | 0.6666 | 0.7139 | 0.0001 | 0.0001 | 0.0011 | 0.0012 | 0.0032 | 0.0032 | 0.0131 | 0.0145 | 0.0686 | 0.0791 | 0.1208 | 0.1326 | 0.0780 | 0.0825 | 0.1183 | 0.1317 | 0.5968 | 0.5551 | 0.0000 | 0.0006 | 0.0020 | 0.0124 | 0.0646 | 0.1037 | 0.0738 | 0.1162 | 0.6269 | |
Hs 578T | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 987 | 380 | 12791 | 25828 | 244.0 | 56.67 | 95.18 | 198.31 | 177 | 201 | 217 | 230 | 243 | 256 | 271 | 289 | 316 | 0.0428 | 1106 | 0.611 | 50.00 | 6.08 | 2 | 0.0081 | 104 | 0.0009 | 41.29 | 7.385 | 0.1837 | 62748.8 | 16900000 | 4720000000 | 1370000000000 | 0.4150 | 0.2225 | 0.0007 | 0.0000 | 0.0010 | 0.0000 | 0.0040 | 0.0001 | 0.0139 | 0.0020 | 0.0437 | 0.0128 | 0.0935 | 0.0267 | 0.1037 | 0.0271 | 0.1485 | 0.0436 | 0.5911 | 0.8877 | 0.0004 | 0.0000 | 0.0005 | 0.0000 | 0.0012 | 0.0000 | 0.0051 | 0.0007 | 0.0167 | 0.0075 | 0.0370 | 0.0142 | 0.0370 | 0.0105 | 0.0578 | 0.0186 | 0.8443 | 0.9484 | 0.0051 | 0.0074 | 0.0136 | 0.0297 | 0.0230 | 0.0408 | 0.0519 | 0.1169 | 0.0928 | 0.1447 | 0.1328 | 0.1855 | 0.0992 | 0.1039 | 0.1507 | 0.1169 | 0.4308 | 0.2542 | 0.0013 | 0.0041 | 0.0084 | 0.0209 | 0.0523 | 0.0900 | 0.0917 | 0.1156 | 0.6157 | 10 | 11 | 13 | 16 | 19 | 30 | 61 | 128 | 252 | 0.1445 | 34.06 | 4.024 | 0.6355 | 48384.8 | 50100000 | 70500000000 | 115000000000000 | 0.4211 | 0.2561 | 0.0753 | 0.0013 | 0.2507 | 0.0276 | 0.3011 | 0.1619 | 0.1172 | 0.1639 | 0.1051 | 0.2101 | 0.0717 | 0.1905 | 0.0362 | 0.0921 | 0.0291 | 0.0768 | 0.0135 | 0.0758 | 0.0001 | 0.0002 | 0.0003 | 0.0001 | 0.0021 | 0.0012 | 0.0147 | 0.0116 | 0.0679 | 0.0616 | 0.1162 | 0.1005 | 0.0657 | 0.0596 | 0.1024 | 0.0930 | 0.6306 | 0.6721 | 0.0002 | 0.0012 | 0.0012 | 0.0028 | 0.0041 | 0.0058 | 0.0225 | 0.0271 | 0.0797 | 0.0776 | 0.1234 | 0.1387 | 0.0808 | 0.0856 | 0.1154 | 0.1264 | 0.5727 | 0.5349 | 0.0002 | 0.0013 | 0.0034 | 0.0168 | 0.0750 | 0.1186 | 0.0738 | 0.1066 | 0.6045 | |||
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1116 | 643 | 4192 | 3538 | 101.2 | 30.48 | 158.91 | 113.21 | 66 | 76 | 84 | 91 | 97 | 104 | 112 | 125 | 141 | 0.1888 | 668 | 0.252 | 105.39 | 16.55 | 4 | 0.1069 | 448 | 0.0013 | 39.51 | 6.913 | 0.1929 | 11171.4 | 1340000 | 175000000 | 24600000000 | 0.4594 | 0.2026 | 0.0014 | 0.0000 | 0.0041 | 0.0009 | 0.0124 | 0.0023 | 0.0464 | 0.0096 | 0.1319 | 0.0422 | 0.1994 | 0.0776 | 0.1641 | 0.0774 | 0.1567 | 0.1235 | 0.2835 | 0.6665 | 0.0006 | 0.0000 | 0.0010 | 0.0005 | 0.0022 | 0.0010 | 0.0128 | 0.0053 | 0.0491 | 0.0264 | 0.0952 | 0.0467 | 0.0789 | 0.0345 | 0.1084 | 0.0632 | 0.6518 | 0.8224 | 0.0000 | 0.0073 | 0.0032 | 0.0218 | 0.0170 | 0.0291 | 0.0668 | 0.1065 | 0.1188 | 0.1574 | 0.1739 | 0.1695 | 0.1294 | 0.1283 | 0.1379 | 0.1259 | 0.3531 | 0.2542 | 0.0016 | 0.0037 | 0.0132 | 0.0390 | 0.0895 | 0.1311 | 0.1101 | 0.1411 | 0.4708 | 37 | 66 | 88 | 111 | 133 | 160 | 195 | 241 | 311 | 0.0052 | 18.73 | 5.833 | 0.3641 | 38065.2 | 12000000 | 4640000000 | 2080000000000 | 0.5210 | 0.1303 | 0.0169 | 0.0013 | 0.0663 | 0.0074 | 0.1808 | 0.0207 | 0.1873 | 0.0702 | 0.1625 | 0.1318 | 0.1443 | 0.1839 | 0.0845 | 0.1498 | 0.0754 | 0.1639 | 0.0819 | 0.2709 | 0.0000 | 0.0000 | 0.0027 | 0.0009 | 0.0038 | 0.0021 | 0.0279 | 0.0141 | 0.0681 | 0.0513 | 0.1217 | 0.0881 | 0.1045 | 0.0783 | 0.1436 | 0.1245 | 0.5279 | 0.6407 | 0.0009 | 0.0047 | 0.0000 | 0.0107 | 0.0119 | 0.0225 | 0.0574 | 0.0664 | 0.1240 | 0.1163 | 0.1559 | 0.1720 | 0.1276 | 0.1139 | 0.1586 | 0.1649 | 0.3637 | 0.3286 | 0.0014 | 0.0028 | 0.0104 | 0.0369 | 0.0828 | 0.1711 | 0.1113 | 0.1474 | 0.4360 | |
BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 429 | 152 | 5147 | 13190 | 300.5 | 77.17 | 108.66 | 110.80 | 212 | 234 | 254 | 271 | 289 | 308 | 329 | 359 | 403 | 0.0728 | 960 | 0.674 | 104.17 | 19.70 | 1 | 0.0492 | 253 | 0.0006 | 94.37 | 7.666 | 0.1240 | 96226.5 | 32900000 | 12000000000 | 4710000000000 | 0.3982 | 0.2452 | 0.0017 | 0.0000 | 0.0014 | 0.0000 | 0.0024 | 0.0000 | 0.0279 | 0.0028 | 0.0927 | 0.0245 | 0.1714 | 0.0507 | 0.1714 | 0.0507 | 0.1830 | 0.0752 | 0.3480 | 0.7962 | 0.0013 | 0.0000 | 0.0005 | 0.0000 | 0.0018 | 0.0000 | 0.0109 | 0.0012 | 0.0344 | 0.0148 | 0.0725 | 0.0281 | 0.0803 | 0.0224 | 0.0990 | 0.0368 | 0.6993 | 0.8967 | 0.0020 | 0.0026 | 0.0107 | 0.0104 | 0.0176 | 0.0260 | 0.0547 | 0.0935 | 0.1270 | 0.1636 | 0.1680 | 0.1896 | 0.1240 | 0.1221 | 0.1416 | 0.1377 | 0.3545 | 0.2545 | 0.0004 | 0.0031 | 0.0118 | 0.0298 | 0.0815 | 0.1333 | 0.1109 | 0.1337 | 0.4954 | 12 | 16 | 22 | 38 | 65 | 103 | 146 | 200 | 271 | 0.0288 | 11.68 | 5.216 | 0.4837 | 24083.1 | 7070000 | 2440000000 | 950000000000 | 0.4467 | 0.1953 | 0.0280 | 0.0011 | 0.1405 | 0.0047 | 0.2943 | 0.0614 | 0.1729 | 0.1210 | 0.1545 | 0.2201 | 0.0890 | 0.2000 | 0.0655 | 0.1325 | 0.0361 | 0.1174 | 0.0191 | 0.1418 | 0.0002 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0011 | 0.0117 | 0.0076 | 0.0534 | 0.0462 | 0.0876 | 0.0766 | 0.0602 | 0.0517 | 0.0834 | 0.0797 | 0.7018 | 0.7371 | 0.0014 | 0.0008 | 0.0016 | 0.0011 | 0.0036 | 0.0074 | 0.0216 | 0.0198 | 0.0664 | 0.0805 | 0.1074 | 0.1116 | 0.0767 | 0.0818 | 0.1035 | 0.1076 | 0.6178 | 0.5896 | 0.0002 | 0.0006 | 0.0020 | 0.0129 | 0.0649 | 0.0943 | 0.0672 | 0.0976 | 0.6603 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 948 | 93 | 6191 | 5411 | 97.2 | 28.78 | 176.56 | 250.57 | 65 | 74 | 81 | 88 | 94 | 101 | 108 | 118 | 134 | 0.1785 | 966 | 0.915 | 160.59 | 50.92 | 3 | 0.0728 | 451 | 0.0012 | 44.43 | 7.019 | 0.1810 | 10281.0 | 1180000 | 147000000 | 20000000000 | 0.4296 | 0.2140 | 0.0006 | 0.0000 | 0.0021 | 0.0000 | 0.0200 | 0.0011 | 0.0445 | 0.0080 | 0.1179 | 0.0337 | 0.1765 | 0.0649 | 0.1815 | 0.0792 | 0.1824 | 0.1193 | 0.2744 | 0.6938 | 0.0004 | 0.0000 | 0.0004 | 0.0000 | 0.0019 | 0.0003 | 0.0120 | 0.0043 | 0.0482 | 0.0193 | 0.0816 | 0.0358 | 0.0819 | 0.0379 | 0.1103 | 0.0573 | 0.6632 | 0.8451 | 0.0046 | 0.0144 | 0.0144 | 0.0341 | 0.0311 | 0.0485 | 0.0971 | 0.0987 | 0.1115 | 0.1813 | 0.1624 | 0.1418 | 0.1252 | 0.0987 | 0.1373 | 0.1275 | 0.3164 | 0.2549 | 0.0028 | 0.0059 | 0.0121 | 0.0385 | 0.0905 | 0.1273 | 0.1099 | 0.1328 | 0.4802 | 19 | 24 | 31 | 44 | 66 | 104 | 177 | 282 | 478 | 0.0405 | 26.68 | 4.951 | 0.5100 | 93949.7 | 80000000 | 85800000000 | 105000000000000 | 0.6057 | 0.0948 | 0.1074 | 0.0033 | 0.2729 | 0.0546 | 0.2550 | 0.2116 | 0.1208 | 0.1860 | 0.1230 | 0.1815 | 0.0582 | 0.1503 | 0.0425 | 0.0846 | 0.0201 | 0.0579 | 0.0000 | 0.0702 | 0.0005 | 0.0005 | 0.0043 | 0.0019 | 0.0086 | 0.0075 | 0.0311 | 0.0230 | 0.1063 | 0.0962 | 0.1283 | 0.1304 | 0.1063 | 0.0863 | 0.1546 | 0.1487 | 0.4600 | 0.5056 | 0.0007 | 0.0016 | 0.0071 | 0.0049 | 0.0127 | 0.0138 | 0.0438 | 0.0454 | 0.1243 | 0.1410 | 0.1653 | 0.1896 | 0.1165 | 0.1135 | 0.1645 | 0.1564 | 0.3651 | 0.3339 | 0.0018 | 0.0037 | 0.0098 | 0.0331 | 0.1227 | 0.1466 | 0.1110 | 0.1724 | 0.3988 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 381 | 145 | 5192 | 12222 | 121.8 | 35.24 | 138.67 | 114.15 | 83 | 94 | 102 | 110 | 116 | 124 | 133 | 144 | 164 | 0.0965 | 1179 | 1.132 | 100.81 | 39.70 | 1 | 0.0516 | 268 | 0.0022 | 24.43 | 6.447 | 0.2469 | 16073.7 | 2320000 | 371000000 | 66000000000 | 0.4315 | 0.2137 | 0.0010 | 0.0000 | 0.0030 | 0.0007 | 0.0090 | 0.0011 | 0.0373 | 0.0037 | 0.0959 | 0.0307 | 0.1588 | 0.0609 | 0.1652 | 0.0620 | 0.1851 | 0.0955 | 0.3447 | 0.7455 | 0.0003 | 0.0000 | 0.0008 | 0.0002 | 0.0035 | 0.0008 | 0.0124 | 0.0022 | 0.0427 | 0.0179 | 0.0773 | 0.0373 | 0.0780 | 0.0291 | 0.1065 | 0.0474 | 0.6786 | 0.8651 | 0.0084 | 0.0169 | 0.0115 | 0.0217 | 0.0282 | 0.0241 | 0.0720 | 0.0964 | 0.1493 | 0.1831 | 0.1879 | 0.1735 | 0.1075 | 0.1108 | 0.1253 | 0.1181 | 0.3100 | 0.2554 | 0.0018 | 0.0071 | 0.0143 | 0.0442 | 0.1000 | 0.1420 | 0.1210 | 0.1353 | 0.4341 | 27 | 44 | 62 | 82 | 105 | 136 | 174 | 220 | 294 | 0.0026 | 46.29 | 6.781 | 0.2926 | 32257.1 | 10200000 | 3940000000 | 1760000000000 | 0.5055 | 0.1484 | 0.0285 | 0.0012 | 0.1160 | 0.0094 | 0.1792 | 0.0374 | 0.1845 | 0.0951 | 0.1492 | 0.1547 | 0.1481 | 0.1868 | 0.0912 | 0.1503 | 0.0580 | 0.1503 | 0.0453 | 0.2148 | 0.0007 | 0.0001 | 0.0028 | 0.0026 | 0.0047 | 0.0039 | 0.0200 | 0.0169 | 0.0617 | 0.0500 | 0.1072 | 0.0842 | 0.0897 | 0.0737 | 0.1141 | 0.1065 | 0.5992 | 0.6620 | 0.0010 | 0.0023 | 0.0033 | 0.0101 | 0.0123 | 0.0192 | 0.0327 | 0.0504 | 0.0939 | 0.1018 | 0.1401 | 0.1499 | 0.1034 | 0.1093 | 0.1273 | 0.1340 | 0.4860 | 0.4231 | 0.0013 | 0.0019 | 0.0073 | 0.0240 | 0.0788 | 0.1222 | 0.0988 | 0.1259 | 0.5398 | |||
MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1052 | 425 | 3025 | 6544 | 395.4 | 125.68 | 137.78 | 188.28 | 223 | 262 | 321 | 379 | 427 | 461 | 488 | 513 | 538 | 0.0767 | 502 | 0.961 | 105.32 | 29.00 | 2 | 0.0826 | 250 | 0.0010 | 36.99 | 7.117 | 0.2145 | 172122.0 | 79400000 | 38000000000 | 18700000000000 | 0.3829 | 0.2510 | 0.0000 | 0.0004 | 0.0066 | 0.0000 | 0.0094 | 0.0020 | 0.0169 | 0.0065 | 0.0778 | 0.0296 | 0.1321 | 0.0455 | 0.0965 | 0.0386 | 0.1781 | 0.0771 | 0.4827 | 0.8002 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0008 | 0.0014 | 0.0034 | 0.0182 | 0.0191 | 0.0383 | 0.0309 | 0.0163 | 0.0202 | 0.0299 | 0.0313 | 0.8954 | 0.8944 | 0.0019 | 0.0438 | 0.0028 | 0.0500 | 0.0112 | 0.0813 | 0.0168 | 0.0625 | 0.0493 | 0.1125 | 0.0503 | 0.1250 | 0.0615 | 0.1438 | 0.0829 | 0.1250 | 0.7235 | 0.2563 | 0.0000 | 0.0000 | 0.0012 | 0.0058 | 0.0226 | 0.0423 | 0.0359 | 0.0469 | 0.8454 | 11 | 15 | 21 | 35 | 61 | 94 | 140 | 217 | 376 | 0.0253 | 45.28 | 5.475 | 0.4795 | 54428.7 | 33000000 | 24600000000 | 20600000000000 | 0.5487 | 0.1238 | 0.0167 | 0.0007 | 0.0866 | 0.0051 | 0.1596 | 0.0425 | 0.1368 | 0.0717 | 0.1733 | 0.1281 | 0.1459 | 0.1801 | 0.1277 | 0.1274 | 0.0745 | 0.1384 | 0.0790 | 0.3060 | 0.0004 | 0.0000 | 0.0013 | 0.0000 | 0.0017 | 0.0014 | 0.0118 | 0.0099 | 0.0557 | 0.0437 | 0.0861 | 0.0757 | 0.0621 | 0.0493 | 0.0807 | 0.0746 | 0.7002 | 0.7454 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0082 | 0.0068 | 0.0211 | 0.0271 | 0.0637 | 0.0780 | 0.1129 | 0.1248 | 0.0825 | 0.0753 | 0.0953 | 0.1031 | 0.6152 | 0.5848 | 0.0000 | 0.0010 | 0.0035 | 0.0129 | 0.0662 | 0.1005 | 0.0672 | 0.0985 | 0.6502 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1139 | 881 | 6326 | 14317 | 189.9 | 47.31 | 165.02 | 129.26 | 138 | 151 | 161 | 171 | 182 | 193 | 206 | 224 | 252 | 0.0773 | 1106 | 1.024 | 100.80 | 38.29 | 1 | 0.0438 | 277 | 0.0012 | 42.09 | 7.012 | 0.1876 | 38280.7 | 8230000 | 1890000000 | 462000000000 | 0.4259 | 0.2291 | 0.0005 | 0.0000 | 0.0013 | 0.0000 | 0.0057 | 0.0000 | 0.0234 | 0.0019 | 0.0776 | 0.0210 | 0.1558 | 0.0447 | 0.1631 | 0.0445 | 0.1831 | 0.0635 | 0.3895 | 0.8244 | 0.0004 | 0.0000 | 0.0006 | 0.0000 | 0.0026 | 0.0000 | 0.0098 | 0.0003 | 0.0319 | 0.0121 | 0.0718 | 0.0241 | 0.0706 | 0.0168 | 0.0970 | 0.0254 | 0.7152 | 0.9213 | 0.0052 | 0.0064 | 0.0103 | 0.0107 | 0.0207 | 0.0258 | 0.0767 | 0.0794 | 0.1259 | 0.1803 | 0.1759 | 0.1674 | 0.1190 | 0.1180 | 0.1250 | 0.1545 | 0.3414 | 0.2575 | 0.0007 | 0.0055 | 0.0117 | 0.0371 | 0.0950 | 0.1273 | 0.1185 | 0.1383 | 0.4659 | 34 | 48 | 69 | 97 | 132 | 170 | 214 | 268 | 354 | 0.0028 | 59.79 | 6.896 | 0.2662 | 43937.1 | 15200000 | 6170000000 | 2820000000000 | 0.5199 | 0.1445 | 0.0243 | 0.0025 | 0.1004 | 0.0068 | 0.2160 | 0.0533 | 0.1831 | 0.1121 | 0.1711 | 0.1528 | 0.1263 | 0.1873 | 0.0814 | 0.1483 | 0.0675 | 0.1416 | 0.0300 | 0.1953 | 0.0008 | 0.0007 | 0.0008 | 0.0002 | 0.0040 | 0.0028 | 0.0205 | 0.0158 | 0.0656 | 0.0457 | 0.0960 | 0.0802 | 0.0795 | 0.0679 | 0.1224 | 0.0924 | 0.6103 | 0.6942 | 0.0013 | 0.0018 | 0.0055 | 0.0060 | 0.0103 | 0.0189 | 0.0352 | 0.0463 | 0.0967 | 0.1178 | 0.1415 | 0.1568 | 0.1118 | 0.1307 | 0.1417 | 0.1494 | 0.4561 | 0.3722 | 0.0007 | 0.0012 | 0.0066 | 0.0298 | 0.0752 | 0.1185 | 0.1015 | 0.1342 | 0.5323 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 804 | 192 | 9922 | 14775 | 134.6 | 40.27 | 276.51 | 259.87 | 90 | 102 | 111 | 120 | 129 | 139 | 151 | 165 | 185 | 0.0923 | 1363 | 0.678 | 210.00 | 48.17 | 5 | 0.0555 | 551 | 0.0016 | 25.40 | 6.776 | 0.2333 | 19732.5 | 3150000 | 551000000 | 105000000000 | 0.4834 | 0.1711 | 0.0002 | 0.0002 | 0.0017 | 0.0006 | 0.0103 | 0.0011 | 0.0422 | 0.0040 | 0.1105 | 0.0312 | 0.1807 | 0.0675 | 0.1790 | 0.0732 | 0.1797 | 0.1114 | 0.2958 | 0.7108 | 0.0000 | 0.0001 | 0.0008 | 0.0005 | 0.0029 | 0.0007 | 0.0109 | 0.0020 | 0.0409 | 0.0198 | 0.0753 | 0.0371 | 0.0711 | 0.0313 | 0.0968 | 0.0504 | 0.7013 | 0.8580 | 0.0027 | 0.0123 | 0.0096 | 0.0212 | 0.0183 | 0.0368 | 0.0636 | 0.0982 | 0.1208 | 0.1618 | 0.1707 | 0.1696 | 0.1304 | 0.1027 | 0.1405 | 0.1395 | 0.3432 | 0.2578 | 0.0009 | 0.0023 | 0.0100 | 0.0275 | 0.0776 | 0.1327 | 0.1116 | 0.1316 | 0.5059 | 27 | 54 | 105 | 157 | 206 | 265 | 334 | 441 | 628 | 0.0057 | 57.11 | 6.881 | 0.3026 | 143987.0 | 105000000 | 93700000000 | 95000000000000 | 0.6013 | 0.0968 | 0.0216 | 0.0014 | 0.0960 | 0.0083 | 0.1877 | 0.0540 | 0.1629 | 0.0789 | 0.1693 | 0.1505 | 0.1733 | 0.1848 | 0.0968 | 0.1576 | 0.0464 | 0.1582 | 0.0460 | 0.2061 | 0.0006 | 0.0002 | 0.0016 | 0.0005 | 0.0059 | 0.0036 | 0.0231 | 0.0129 | 0.0764 | 0.0640 | 0.1265 | 0.1009 | 0.0993 | 0.0832 | 0.1089 | 0.1172 | 0.5577 | 0.6175 | 0.0025 | 0.0011 | 0.0056 | 0.0083 | 0.0181 | 0.0174 | 0.0350 | 0.0365 | 0.0934 | 0.0970 | 0.1313 | 0.1352 | 0.0834 | 0.0918 | 0.1084 | 0.1086 | 0.5223 | 0.5041 | 0.0012 | 0.0041 | 0.0118 | 0.0325 | 0.0905 | 0.1330 | 0.0907 | 0.1109 | 0.5253 | |
BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 1011 | 503 | 8099 | 27715 | 207.4 | 49.29 | 90.32 | 133.45 | 151 | 164 | 175 | 187 | 199 | 212 | 228 | 248 | 276 | 0.0437 | 1212 | 1.109 | 152.01 | 45.19 | 2 | 0.0436 | 353 | 0.0011 | 36.08 | 7.089 | 0.1990 | 45423.4 | 10500000 | 2560000000 | 657000000000 | 0.4089 | 0.2364 | 0.0004 | 0.0000 | 0.0023 | 0.0001 | 0.0071 | 0.0004 | 0.0235 | 0.0021 | 0.0760 | 0.0188 | 0.1336 | 0.0422 | 0.1525 | 0.0391 | 0.1806 | 0.0611 | 0.4239 | 0.8362 | 0.0002 | 0.0000 | 0.0014 | 0.0000 | 0.0033 | 0.0001 | 0.0108 | 0.0006 | 0.0290 | 0.0107 | 0.0546 | 0.0216 | 0.0625 | 0.0137 | 0.0784 | 0.0235 | 0.7599 | 0.9297 | 0.0031 | 0.0101 | 0.0081 | 0.0067 | 0.0219 | 0.0236 | 0.0663 | 0.0809 | 0.1006 | 0.1720 | 0.1644 | 0.1585 | 0.1294 | 0.1282 | 0.1413 | 0.1619 | 0.3650 | 0.2580 | 0.0019 | 0.0022 | 0.0111 | 0.0259 | 0.0674 | 0.1078 | 0.1033 | 0.1236 | 0.5567 | 7 | 8 | 10 | 11 | 15 | 35 | 93 | 181 | 284 | 0.1964 | 12.37 | 4.050 | 0.6366 | 25966.7 | 10500000 | 5130000000 | 2920000000000 | 0.4760 | 0.1582 | 0.0839 | 0.0025 | 0.2737 | 0.0194 | 0.3606 | 0.1699 | 0.1380 | 0.2452 | 0.0745 | 0.2308 | 0.0467 | 0.1602 | 0.0182 | 0.0849 | 0.0044 | 0.0541 | 0.0000 | 0.0330 | 0.0001 | 0.0000 | 0.0004 | 0.0000 | 0.0003 | 0.0003 | 0.0065 | 0.0072 | 0.0442 | 0.0379 | 0.0776 | 0.0649 | 0.0515 | 0.0468 | 0.0806 | 0.0673 | 0.7388 | 0.7756 | 0.0000 | 0.0001 | 0.0003 | 0.0006 | 0.0004 | 0.0007 | 0.0094 | 0.0113 | 0.0554 | 0.0601 | 0.1006 | 0.1144 | 0.0720 | 0.0756 | 0.1022 | 0.1029 | 0.6597 | 0.6343 | 0.0001 | 0.0000 | 0.0006 | 0.0064 | 0.0501 | 0.0888 | 0.0621 | 0.0936 | 0.6982 |