High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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| Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 125 | 887 | | 914 | 10249 | 57.4 | 40.69 | 232.85 | 304.99 | 28 | 31 | 33 | 35 | 38 | 42 | 56 | 82 | 127 | 0.0631 | 647 | 1.229 | 27.66 | 9.43 | 1 | 0.0722 | 66 | 0.0076 | 22.99 | 5.445 | 0.3165 | 4951.9 | 588247 | 83100000 | 12800000000 | 0.3258 | 0.3035 | 0.0088 | 0.0152 | 0.0000 | 0.0127 | 0.0531 | 0.0482 | 0.1239 | 0.0736 | 0.3451 | 0.1624 | 0.2832 | 0.1574 | 0.1416 | 0.1650 | 0.0354 | 0.1421 | 0.0088 | 0.2234 | 0.0000 | 0.0103 | 0.0000 | 0.0086 | 0.0091 | 0.0325 | 0.0151 | 0.0462 | 0.0393 | 0.0856 | 0.0665 | 0.0805 | 0.0665 | 0.0702 | 0.0634 | 0.0771 | 0.7402 | 0.5890 | 0.0000 | 0.0053 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0046 | 0.0211 | 0.0826 | 0.0842 | 0.0872 | 0.0579 | 0.0459 | 0.0737 | 0.1101 | 0.0895 | 0.6697 | 0.6684 | 0.0000 | 0.0000 | 0.0037 | 0.0297 | 0.0409 | 0.0632 | 0.0743 | 0.0706 | 0.7175 | 22 | 26 | 32 | 50 | 83 | 141 | 256 | 424 | 686 | 0.0356 | 29.95 | 5.321 | 0.4926 | 147227.0 | 131000000 | 137000000000 | 161000000000000 | 0.6516 | 0.0660 | 0.0697 | 0.0026 | 0.1780 | 0.0222 | 0.2107 | 0.0941 | 0.1395 | 0.1359 | 0.1543 | 0.1737 | 0.1157 | 0.1966 | 0.0772 | 0.1261 | 0.0356 | 0.1261 | 0.0193 | 0.1228 | 0.0008 | 0.0002 | 0.0011 | 0.0012 | 0.0025 | 0.0051 | 0.0195 | 0.0177 | 0.0641 | 0.0572 | 0.0786 | 0.0824 | 0.0675 | 0.0545 | 0.0853 | 0.0863 | 0.6804 | 0.6953 | 0.0010 | 0.0015 | 0.0031 | 0.0035 | 0.0062 | 0.0073 | 0.0244 | 0.0289 | 0.0714 | 0.0763 | 0.0975 | 0.0960 | 0.0752 | 0.0867 | 0.0962 | 0.1044 | 0.6250 | 0.5954 | 0.0006 | 0.0012 | 0.0046 | 0.0178 | 0.0705 | 0.0911 | 0.0644 | 0.0929 | 0.6569 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 968 | 97 | | 4897 | 1372 | 105.7 | 28.33 | 79.73 | 69.69 | 76 | 82 | 88 | 94 | 100 | 107 | 114 | 125 | 145 | 0.3797 | 521 | 0.626 | 127.78 | 26.91 | 1 | 0.0764 | 374 | 0.0037 | 15.12 | 6.016 | 0.3192 | 11982.1 | 1460000 | 194000000 | 27700000000 | 0.4561 | 0.1953 | 0.0004 | 0.0000 | 0.0056 | 0.0005 | 0.0215 | 0.0032 | 0.0318 | 0.0068 | 0.0787 | 0.0290 | 0.1126 | 0.0432 | 0.1242 | 0.0375 | 0.1958 | 0.0681 | 0.4294 | 0.8118 | 0.0000 | 0.0000 | 0.0016 | 0.0004 | 0.0081 | 0.0004 | 0.0118 | 0.0016 | 0.0430 | 0.0150 | 0.0568 | 0.0214 | 0.0627 | 0.0183 | 0.1052 | 0.0342 | 0.7108 | 0.9086 | 0.0068 | 0.0046 | 0.0136 | 0.0068 | 0.0340 | 0.0114 | 0.0498 | 0.0683 | 0.1053 | 0.1663 | 0.1268 | 0.2005 | 0.1031 | 0.1435 | 0.1291 | 0.1344 | 0.4315 | 0.2642 | 0.0049 | 0.0049 | 0.0147 | 0.0339 | 0.0776 | 0.1036 | 0.1046 | 0.1297 | 0.5260 | 14 | 20 | 34 | 45 | 59 | 78 | 97 | 125 | 177 | 0.0145 | 15.01 | 5.234 | 0.4127 | 11210.5 | 2240000 | 575000000 | 180000000000 | 0.5721 | 0.0938 | 0.0633 | 0.0085 | 0.1629 | 0.0277 | 0.2081 | 0.1043 | 0.1448 | 0.1447 | 0.1357 | 0.1936 | 0.1222 | 0.1723 | 0.0950 | 0.1191 | 0.0317 | 0.1064 | 0.0362 | 0.1234 | 0.0061 | 0.0013 | 0.0076 | 0.0088 | 0.0244 | 0.0175 | 0.0809 | 0.0489 | 0.1481 | 0.1529 | 0.1664 | 0.1867 | 0.1405 | 0.1291 | 0.1145 | 0.1291 | 0.3115 | 0.3258 | 0.0069 | 0.0061 | 0.0253 | 0.0457 | 0.0346 | 0.0640 | 0.1152 | 0.0854 | 0.1843 | 0.1829 | 0.1797 | 0.1707 | 0.1267 | 0.1646 | 0.1221 | 0.1311 | 0.2051 | 0.1494 | 0.0019 | 0.0168 | 0.0243 | 0.0935 | 0.1832 | 0.1664 | 0.1383 | 0.1421 | 0.2336 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 630 | 725 | | 3602 | 12705 | 123.5 | 28.89 | 207.97 | 184.41 | 91 | 99 | 107 | 113 | 120 | 127 | 135 | 145 | 162 | 0.0653 | 830 | 0.652 | 114.81 | 32.25 | 2 | 0.0999 | 360 | 0.0026 | 19.30 | 6.264 | 0.2653 | 16090.9 | 2210000 | 321000000 | 49000000000 | 0.4640 | 0.1807 | 0.0004 | 0.0000 | 0.0022 | 0.0000 | 0.0089 | 0.0003 | 0.0289 | 0.0036 | 0.1061 | 0.0245 | 0.1488 | 0.0660 | 0.1710 | 0.0554 | 0.1856 | 0.0845 | 0.3481 | 0.7657 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0035 | 0.0000 | 0.0104 | 0.0020 | 0.0494 | 0.0165 | 0.0841 | 0.0414 | 0.0838 | 0.0255 | 0.1088 | 0.0448 | 0.6587 | 0.8698 | 0.0048 | 0.0136 | 0.0144 | 0.0317 | 0.0256 | 0.0226 | 0.0832 | 0.1448 | 0.1344 | 0.1584 | 0.1648 | 0.2579 | 0.1328 | 0.1041 | 0.1360 | 0.1176 | 0.3040 | 0.1493 | 0.0019 | 0.0080 | 0.0161 | 0.0427 | 0.0860 | 0.1373 | 0.1132 | 0.1429 | 0.4521 | 17 | 41 | 80 | 122 | 166 | 214 | 273 | 344 | 450 | 0.0066 | 49.93 | 6.596 | 0.3005 | 77256.1 | 39900000 | 27300000000 | 24000000000000 | 0.5228 | 0.1478 | 0.0366 | 0.0017 | 0.1741 | 0.0093 | 0.2322 | 0.0745 | 0.1644 | 0.1242 | 0.1732 | 0.1875 | 0.1185 | 0.1933 | 0.0585 | 0.1480 | 0.0307 | 0.1381 | 0.0117 | 0.1234 | 0.0005 | 0.0001 | 0.0017 | 0.0009 | 0.0038 | 0.0032 | 0.0202 | 0.0107 | 0.0760 | 0.0570 | 0.1225 | 0.1019 | 0.0993 | 0.0819 | 0.1496 | 0.1250 | 0.5266 | 0.6193 | 0.0012 | 0.0014 | 0.0023 | 0.0064 | 0.0098 | 0.0188 | 0.0393 | 0.0507 | 0.1129 | 0.1298 | 0.1665 | 0.1799 | 0.1234 | 0.1272 | 0.1737 | 0.1599 | 0.3709 | 0.3259 | 0.0010 | 0.0040 | 0.0082 | 0.0276 | 0.0888 | 0.1485 | 0.1189 | 0.1654 | 0.4377 |
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 343 | 118 | | 16901 | 26398 | 141.3 | 44.30 | 218.23 | 252.21 | 94 | 105 | 114 | 123 | 132 | 143 | 157 | 175 | 204 | 0.0815 | 2151 | 0.681 | 101.95 | 26.17 | 6 | 0.0180 | 304 | 0.0015 | 29.37 | 6.914 | 0.2233 | 21941.5 | 3740000 | 696000000 | 140000000000 | 0.5305 | 0.1501 | 0.0011 | 0.0003 | 0.0048 | 0.0008 | 0.0158 | 0.0020 | 0.0410 | 0.0075 | 0.1072 | 0.0328 | 0.1650 | 0.0728 | 0.1666 | 0.0720 | 0.1890 | 0.1025 | 0.3095 | 0.7093 | 0.0006 | 0.0002 | 0.0026 | 0.0004 | 0.0058 | 0.0011 | 0.0146 | 0.0036 | 0.0408 | 0.0175 | 0.0693 | 0.0366 | 0.0679 | 0.0300 | 0.0954 | 0.0486 | 0.7030 | 0.8620 | 0.0021 | 0.0030 | 0.0070 | 0.0090 | 0.0120 | 0.0200 | 0.0527 | 0.0656 | 0.1020 | 0.1512 | 0.1411 | 0.1773 | 0.1049 | 0.1097 | 0.1331 | 0.1607 | 0.4451 | 0.3035 | 0.0015 | 0.0049 | 0.0131 | 0.0289 | 0.0754 | 0.1125 | 0.0940 | 0.1202 | 0.5495 | 20 | 29 | 48 | 79 | 120 | 175 | 259 | 375 | 570 | 0.0118 | 66.19 | 6.470 | 0.3644 | 111232.0 | 85900000 | 88000000000 | 113000000000000 | 0.5942 | 0.0903 | 0.0589 | 0.0022 | 0.1898 | 0.0187 | 0.2385 | 0.1095 | 0.1625 | 0.1457 | 0.1298 | 0.1893 | 0.1051 | 0.1818 | 0.0549 | 0.1192 | 0.0407 | 0.1100 | 0.0196 | 0.1236 | 0.0006 | 0.0005 | 0.0022 | 0.0016 | 0.0043 | 0.0051 | 0.0185 | 0.0152 | 0.0708 | 0.0630 | 0.1147 | 0.0979 | 0.0818 | 0.0754 | 0.1208 | 0.1064 | 0.5863 | 0.6349 | 0.0003 | 0.0018 | 0.0031 | 0.0043 | 0.0077 | 0.0110 | 0.0323 | 0.0372 | 0.0907 | 0.0969 | 0.1399 | 0.1479 | 0.1021 | 0.1013 | 0.1285 | 0.1341 | 0.4956 | 0.4656 | 0.0010 | 0.0025 | 0.0059 | 0.0245 | 0.0763 | 0.1324 | 0.0895 | 0.1228 | 0.5449 |
| MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 441 | 854 | | 1964 | 2153 | 94.0 | 19.07 | 5.89 | 2.19 | 65 | 75 | 84 | 91 | 97 | 103 | 107 | 111 | 116 | 0.2216 | 477 | 0.494 | 340.58 | 73.33 | 1 | 0.5046 | 991 | 0.0224 | 1.75 | 4.105 | 0.5669 | 9205.0 | 931383 | 96800000 | 10300000000 | 0.4309 | 0.2010 | 0.0000 | 0.0000 | 0.0073 | 0.0000 | 0.0147 | 0.0005 | 0.0359 | 0.0058 | 0.0661 | 0.0242 | 0.1184 | 0.0453 | 0.1380 | 0.0353 | 0.1959 | 0.0679 | 0.4237 | 0.8211 | 0.0000 | 0.0000 | 0.0019 | 0.0000 | 0.0013 | 0.0005 | 0.0109 | 0.0052 | 0.0300 | 0.0235 | 0.0504 | 0.0434 | 0.0549 | 0.0314 | 0.0709 | 0.0581 | 0.7797 | 0.8378 | 0.0235 | 0.0909 | 0.0293 | 0.0000 | 0.0704 | 0.1818 | 0.1056 | 0.0909 | 0.1144 | 0.3636 | 0.1525 | 0.2727 | 0.1290 | 0.0000 | 0.1290 | 0.0000 | 0.2463 | 0.0000 | 0.0000 | 0.0027 | 0.0045 | 0.0163 | 0.0506 | 0.0624 | 0.0678 | 0.0850 | 0.7107 | 3 | 4 | 5 | 5 | 6 | 7 | 7 | 8 | 9 | 0.5417 | 0.29 | 0.926 | 0.8524 | 39.5 | 290.243 | 2305.17 | 19573.6 | 0.5333 | 0.1268 | 0.0126 | 0.0006 | 0.0816 | 0.0054 | 0.1641 | 0.0320 | 0.2592 | 0.0633 | 0.2505 | 0.1333 | 0.1534 | 0.1960 | 0.0621 | 0.2340 | 0.0155 | 0.2117 | 0.0010 | 0.1236 | 0.0000 | 0.0000 | 0.0139 | 0.0011 | 0.0357 | 0.0096 | 0.1130 | 0.0340 | 0.1897 | 0.0919 | 0.2161 | 0.1338 | 0.2254 | 0.1875 | 0.1586 | 0.2953 | 0.0476 | 0.2469 | 0.1946 | 0.4222 | 0.2754 | 0.2667 | 0.2402 | 0.1378 | 0.1718 | 0.1244 | 0.0787 | 0.0400 | 0.0311 | 0.0089 | 0.0062 | 0.0000 | 0.0021 | 0.0000 | 0.0000 | 0.0000 | 0.0076 | 0.0552 | 0.1027 | 0.1986 | 0.2182 | 0.1910 | 0.1171 | 0.0849 | 0.0246 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 349 | 807 | | 6538 | 12626 | 588.0 | 86.69 | 128.31 | 222.66 | 469 | 530 | 562 | 584 | 602 | 620 | 637 | 657 | 683 | 0.0673 | 850 | 0.775 | 146.56 | 30.15 | 1 | 0.0509 | 333 | 0.0010 | 44.42 | 7.238 | 0.1938 | 353259.0 | 216000000 | 134000000000 | 83900000000000 | 0.4229 | 0.2180 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0007 | 0.0000 | 0.0030 | 0.0002 | 0.0197 | 0.0106 | 0.0355 | 0.0173 | 0.0365 | 0.0112 | 0.0673 | 0.0176 | 0.8370 | 0.9433 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0015 | 0.0002 | 0.0129 | 0.0106 | 0.0221 | 0.0173 | 0.0201 | 0.0112 | 0.0312 | 0.0176 | 0.9121 | 0.9433 | 0.0276 | 0.0000 | 0.0379 | 0.0000 | 0.0379 | 0.0000 | 0.1241 | 0.0000 | 0.1310 | 0.0000 | 0.1586 | 0.0000 | 0.1241 | 0.0000 | 0.0931 | 0.0000 | 0.2655 | 0.0000 | 0.0011 | 0.0034 | 0.0053 | 0.0169 | 0.0344 | 0.0573 | 0.0655 | 0.0922 | 0.7238 | 11 | 13 | 16 | 21 | 29 | 46 | 87 | 188 | 404 | 0.1397 | 11.93 | 3.675 | 0.6149 | 66036.9 | 54600000 | 58200000000 | 74400000000000 | 0.4876 | 0.1751 | 0.0820 | 0.0077 | 0.2182 | 0.0463 | 0.2753 | 0.1683 | 0.1406 | 0.1143 | 0.1083 | 0.1550 | 0.0849 | 0.1907 | 0.0395 | 0.1066 | 0.0249 | 0.0863 | 0.0264 | 0.1248 | 0.0000 | 0.0005 | 0.0009 | 0.0010 | 0.0026 | 0.0022 | 0.0131 | 0.0124 | 0.0707 | 0.0604 | 0.0993 | 0.0897 | 0.0678 | 0.0592 | 0.1013 | 0.0905 | 0.6443 | 0.6841 | 0.0000 | 0.0004 | 0.0004 | 0.0004 | 0.0039 | 0.0019 | 0.0218 | 0.0250 | 0.0761 | 0.0832 | 0.1208 | 0.1271 | 0.0778 | 0.0847 | 0.1127 | 0.1144 | 0.5866 | 0.5630 | 0.0003 | 0.0003 | 0.0029 | 0.0147 | 0.0809 | 0.1055 | 0.0723 | 0.1125 | 0.6106 |
| MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 977 | 301 | | 13922 | 26863 | 211.1 | 59.41 | 243.85 | 302.54 | 140 | 161 | 177 | 191 | 205 | 221 | 237 | 258 | 290 | 0.0529 | 1421 | 0.517 | 152.46 | 33.12 | 3 | 0.0332 | 462 | 0.0010 | 40.05 | 7.158 | 0.1901 | 48082.9 | 11800000 | 3080000000 | 860000000000 | 0.4554 | 0.1927 | 0.0003 | 0.0000 | 0.0020 | 0.0002 | 0.0126 | 0.0010 | 0.0382 | 0.0033 | 0.1052 | 0.0256 | 0.1779 | 0.0652 | 0.1708 | 0.0702 | 0.1853 | 0.1080 | 0.3078 | 0.7265 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0019 | 0.0001 | 0.0091 | 0.0017 | 0.0405 | 0.0146 | 0.0746 | 0.0338 | 0.0714 | 0.0312 | 0.0998 | 0.0497 | 0.7024 | 0.8688 | 0.0033 | 0.0099 | 0.0092 | 0.0108 | 0.0191 | 0.0381 | 0.0654 | 0.1094 | 0.1325 | 0.1930 | 0.1822 | 0.1872 | 0.1190 | 0.0969 | 0.1457 | 0.1367 | 0.3236 | 0.2179 | 0.0009 | 0.0022 | 0.0066 | 0.0320 | 0.0904 | 0.1306 | 0.1036 | 0.1336 | 0.5001 | 8 | 10 | 14 | 35 | 97 | 203 | 327 | 486 | 702 | 0.0530 | 47.80 | 5.717 | 0.4211 | 150993.0 | 122000000 | 114000000000 | 121000000000000 | 0.4350 | 0.2316 | 0.0406 | 0.0021 | 0.1879 | 0.0150 | 0.2563 | 0.1084 | 0.1660 | 0.1540 | 0.1487 | 0.1826 | 0.0976 | 0.1847 | 0.0579 | 0.1280 | 0.0269 | 0.1004 | 0.0182 | 0.1248 | 0.0001 | 0.0000 | 0.0006 | 0.0003 | 0.0014 | 0.0012 | 0.0074 | 0.0074 | 0.0475 | 0.0377 | 0.0763 | 0.0659 | 0.0613 | 0.0479 | 0.0889 | 0.0735 | 0.7164 | 0.7660 | 0.0003 | 0.0001 | 0.0006 | 0.0004 | 0.0025 | 0.0033 | 0.0148 | 0.0202 | 0.0626 | 0.0746 | 0.1137 | 0.1211 | 0.0770 | 0.0770 | 0.1055 | 0.1172 | 0.6229 | 0.5861 | 0.0001 | 0.0008 | 0.0026 | 0.0105 | 0.0553 | 0.0925 | 0.0698 | 0.1031 | 0.6653 |
| MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 779 | 488 | | 1658 | 7515 | 661.2 | 127.45 | 21.12 | 72.35 | 472 | 534 | 588 | 636 | 672 | 708 | 749 | 791 | 831 | 0.0896 | 673 | 1.056 | 79.26 | 20.40 | 1 | 0.1128 | 187 | 0.0037 | 8.63 | 5.897 | 0.3770 | 453371.0 | 321000000 | 233000000000 | 172000000000000 | 0.3992 | 0.2328 | 0.0000 | 0.0000 | 0.0020 | 0.0000 | 0.0029 | 0.0000 | 0.0098 | 0.0018 | 0.0479 | 0.0231 | 0.0685 | 0.0358 | 0.0607 | 0.0219 | 0.0881 | 0.0328 | 0.7202 | 0.8846 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0022 | 0.0018 | 0.0283 | 0.0231 | 0.0358 | 0.0358 | 0.0253 | 0.0219 | 0.0365 | 0.0328 | 0.8718 | 0.8846 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0125 | 0.0000 | 0.0344 | 0.0000 | 0.0531 | 0.0000 | 0.0531 | 0.0000 | 0.0688 | 0.0000 | 0.1000 | 0.0000 | 0.6781 | 0.0000 | 0.0011 | 0.0011 | 0.0034 | 0.0135 | 0.0270 | 0.0529 | 0.0450 | 0.0541 | 0.8018 | 4 | 5 | 6 | 7 | 7 | 8 | 9 | 12 | 17 | 0.1063 | 2.38 | 1.499 | 0.4250 | 5680.0 | 3330000 | 2380000000 | 1890000000000 | 0.4909 | 0.1207 | 0.0780 | 0.0610 | 0.2110 | 0.0749 | 0.2844 | 0.0999 | 0.2661 | 0.1207 | 0.0826 | 0.1914 | 0.0505 | 0.1692 | 0.0092 | 0.0874 | 0.0138 | 0.0707 | 0.0046 | 0.1248 | 0.0181 | 0.0352 | 0.0233 | 0.0424 | 0.0194 | 0.0488 | 0.0440 | 0.0456 | 0.0660 | 0.0697 | 0.0699 | 0.0689 | 0.0621 | 0.0817 | 0.0776 | 0.0961 | 0.6197 | 0.5116 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0054 | 0.0000 | 0.0090 | 0.0189 | 0.0667 | 0.0682 | 0.1189 | 0.0928 | 0.0360 | 0.0625 | 0.0811 | 0.0795 | 0.6829 | 0.6761 | 0.0016 | 0.0064 | 0.0096 | 0.0305 | 0.0595 | 0.0691 | 0.0740 | 0.0804 | 0.6688 |
| BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1189 | 718 | | 4088 | 19318 | 453.0 | 106.58 | 96.23 | 99.59 | 325 | 357 | 386 | 412 | 441 | 469 | 504 | 546 | 607 | 0.0500 | 965 | 1.115 | 111.23 | 32.65 | 1 | 0.0624 | 255 | 0.0007 | 67.51 | 7.409 | 0.1424 | 216555.0 | 109000000 | 57400000000 | 31500000000000 | 0.4176 | 0.2368 | 0.0004 | 0.0000 | 0.0008 | 0.0000 | 0.0042 | 0.0003 | 0.0275 | 0.0040 | 0.0803 | 0.0242 | 0.1695 | 0.0594 | 0.1357 | 0.0548 | 0.1682 | 0.0698 | 0.4134 | 0.7875 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0022 | 0.0000 | 0.0100 | 0.0017 | 0.0344 | 0.0160 | 0.0821 | 0.0397 | 0.0581 | 0.0242 | 0.0865 | 0.0410 | 0.7264 | 0.8774 | 0.0012 | 0.0071 | 0.0084 | 0.0000 | 0.0096 | 0.0249 | 0.0646 | 0.1068 | 0.0969 | 0.1459 | 0.1352 | 0.1851 | 0.1172 | 0.1281 | 0.1148 | 0.1637 | 0.4522 | 0.2384 | 0.0016 | 0.0043 | 0.0070 | 0.0290 | 0.0774 | 0.1198 | 0.0956 | 0.1263 | 0.5390 | 8 | 11 | 16 | 33 | 63 | 99 | 134 | 174 | 230 | 0.0320 | 16.16 | 5.428 | 0.4394 | 19177.9 | 5220000 | 1780000000 | 719000000000 | 0.4849 | 0.1488 | 0.0329 | 0.0012 | 0.1667 | 0.0102 | 0.2528 | 0.0730 | 0.1924 | 0.1400 | 0.1450 | 0.1900 | 0.1015 | 0.2083 | 0.0551 | 0.1299 | 0.0343 | 0.1220 | 0.0193 | 0.1254 | 0.0000 | 0.0000 | 0.0008 | 0.0002 | 0.0020 | 0.0012 | 0.0104 | 0.0077 | 0.0520 | 0.0427 | 0.0878 | 0.0780 | 0.0668 | 0.0541 | 0.0945 | 0.0813 | 0.6857 | 0.7349 | 0.0007 | 0.0007 | 0.0022 | 0.0028 | 0.0048 | 0.0102 | 0.0188 | 0.0254 | 0.0667 | 0.0816 | 0.1172 | 0.1331 | 0.0893 | 0.0932 | 0.1224 | 0.1264 | 0.5778 | 0.5265 | 0.0004 | 0.0004 | 0.0035 | 0.0151 | 0.0545 | 0.1053 | 0.0729 | 0.1062 | 0.6416 | ||
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 662 | 697 | | 5913 | 18261 | 491.0 | 67.94 | 138.35 | 220.58 | 396 | 436 | 462 | 484 | 500 | 513 | 528 | 544 | 572 | 0.0451 | 824 | 1.176 | 94.54 | 34.99 | 1 | 0.0404 | 239 | 0.0021 | 16.68 | 6.549 | 0.2788 | 245703.0 | 125000000 | 64600000000 | 33900000000000 | 0.4193 | 0.2254 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0010 | 0.0000 | 0.0052 | 0.0002 | 0.0206 | 0.0107 | 0.0401 | 0.0231 | 0.0409 | 0.0105 | 0.0497 | 0.0178 | 0.8421 | 0.9378 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0011 | 0.0002 | 0.0140 | 0.0105 | 0.0257 | 0.0222 | 0.0200 | 0.0095 | 0.0276 | 0.0162 | 0.9112 | 0.9414 | 0.0028 | 0.0000 | 0.0142 | 0.1111 | 0.0426 | 0.1111 | 0.0767 | 0.1111 | 0.1392 | 0.4444 | 0.1193 | 0.2222 | 0.1193 | 0.0000 | 0.1591 | 0.0000 | 0.3267 | 0.0000 | 0.0003 | 0.0033 | 0.0069 | 0.0169 | 0.0350 | 0.0555 | 0.0628 | 0.0872 | 0.7320 | 8 | 10 | 12 | 16 | 27 | 52 | 112 | 246 | 464 | 0.1339 | 21.44 | 4.364 | 0.6125 | 67793.0 | 46900000 | 38600000000 | 36000000000000 | 0.3682 | 0.2671 | 0.0646 | 0.0035 | 0.1579 | 0.0234 | 0.2759 | 0.1034 | 0.1692 | 0.1313 | 0.1344 | 0.1895 | 0.0985 | 0.2004 | 0.0595 | 0.1034 | 0.0236 | 0.1193 | 0.0164 | 0.1258 | 0.0004 | 0.0006 | 0.0011 | 0.0015 | 0.0025 | 0.0023 | 0.0114 | 0.0085 | 0.0461 | 0.0447 | 0.0764 | 0.0614 | 0.0517 | 0.0432 | 0.0719 | 0.0705 | 0.7384 | 0.7673 | 0.0011 | 0.0005 | 0.0009 | 0.0007 | 0.0026 | 0.0033 | 0.0168 | 0.0158 | 0.0521 | 0.0575 | 0.0907 | 0.0945 | 0.0618 | 0.0628 | 0.0783 | 0.0833 | 0.6958 | 0.6816 | 0.0006 | 0.0014 | 0.0028 | 0.0152 | 0.0474 | 0.0861 | 0.0548 | 0.0734 | 0.7183 | ||
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1125 | 294 | | 3689 | 5640 | 111.6 | 32.45 | 209.00 | 240.70 | 71 | 82 | 92 | 101 | 109 | 118 | 128 | 138 | 154 | 0.1225 | 691 | 1.145 | 36.89 | 14.32 | 4 | 0.0268 | 99 | 0.0011 | 36.53 | 6.994 | 0.1873 | 13497.5 | 1760000 | 244000000 | 36000000000 | 0.4226 | 0.2234 | 0.0011 | 0.0003 | 0.0055 | 0.0006 | 0.0082 | 0.0023 | 0.0448 | 0.0074 | 0.1055 | 0.0366 | 0.1393 | 0.0563 | 0.1650 | 0.0738 | 0.1984 | 0.1039 | 0.3322 | 0.7187 | 0.0007 | 0.0003 | 0.0026 | 0.0006 | 0.0022 | 0.0012 | 0.0137 | 0.0056 | 0.0290 | 0.0222 | 0.0475 | 0.0275 | 0.0561 | 0.0333 | 0.0750 | 0.0447 | 0.7732 | 0.8647 | 0.0046 | 0.0120 | 0.0174 | 0.0090 | 0.0231 | 0.0270 | 0.0556 | 0.1261 | 0.1088 | 0.1411 | 0.1574 | 0.1952 | 0.1088 | 0.1111 | 0.1586 | 0.1441 | 0.3657 | 0.2342 | 0.0029 | 0.0029 | 0.0080 | 0.0264 | 0.0568 | 0.0998 | 0.1096 | 0.1234 | 0.5703 | 25 | 37 | 55 | 75 | 103 | 150 | 232 | 361 | 559 | 0.0196 | 21.82 | 5.398 | 0.4816 | 101607.0 | 71300000 | 60000000000 | 56400000000000 | 0.6220 | 0.0932 | 0.0428 | 0.0027 | 0.1732 | 0.0150 | 0.3230 | 0.0707 | 0.2043 | 0.1405 | 0.1012 | 0.2102 | 0.0700 | 0.2191 | 0.0389 | 0.1104 | 0.0253 | 0.1051 | 0.0214 | 0.1263 | 0.0000 | 0.0008 | 0.0014 | 0.0008 | 0.0028 | 0.0040 | 0.0247 | 0.0127 | 0.0669 | 0.0618 | 0.1125 | 0.0907 | 0.0807 | 0.0713 | 0.1210 | 0.1125 | 0.5899 | 0.6455 | 0.0006 | 0.0014 | 0.0013 | 0.0022 | 0.0050 | 0.0086 | 0.0264 | 0.0402 | 0.0866 | 0.0782 | 0.1281 | 0.1407 | 0.1017 | 0.1070 | 0.1318 | 0.1386 | 0.5185 | 0.4831 | 0.0006 | 0.0011 | 0.0044 | 0.0237 | 0.0860 | 0.1113 | 0.0970 | 0.1333 | 0.5427 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 219 | 287 | | 7728 | 17407 | 156.2 | 33.25 | 151.14 | 137.62 | 117 | 127 | 135 | 144 | 153 | 161 | 171 | 184 | 201 | 0.0567 | 987 | 1.201 | 93.64 | 34.53 | 3 | 0.0299 | 231 | 0.0018 | 24.55 | 6.611 | 0.2248 | 25514.2 | 4360000 | 778000000 | 145000000000 | 0.3633 | 0.2904 | 0.0006 | 0.0000 | 0.0024 | 0.0001 | 0.0054 | 0.0000 | 0.0261 | 0.0015 | 0.0755 | 0.0144 | 0.1309 | 0.0416 | 0.1551 | 0.0359 | 0.1992 | 0.0585 | 0.4049 | 0.8479 | 0.0002 | 0.0000 | 0.0014 | 0.0000 | 0.0028 | 0.0000 | 0.0126 | 0.0000 | 0.0327 | 0.0093 | 0.0547 | 0.0253 | 0.0662 | 0.0117 | 0.0973 | 0.0232 | 0.7321 | 0.9304 | 0.0082 | 0.0229 | 0.0202 | 0.0229 | 0.0306 | 0.0430 | 0.0866 | 0.1891 | 0.1262 | 0.1834 | 0.1688 | 0.2092 | 0.1494 | 0.1117 | 0.1501 | 0.1060 | 0.2599 | 0.1117 | 0.0017 | 0.0053 | 0.0122 | 0.0344 | 0.0780 | 0.1005 | 0.1089 | 0.1414 | 0.5176 | 25 | 37 | 53 | 75 | 105 | 143 | 192 | 255 | 344 | 0.0048 | 46.59 | 6.610 | 0.3171 | 41782.2 | 15900000 | 7490000000 | 4110000000000 | 0.4349 | 0.1994 | 0.0438 | 0.0012 | 0.1710 | 0.0129 | 0.2590 | 0.0915 | 0.1689 | 0.1419 | 0.1480 | 0.1792 | 0.0966 | 0.1929 | 0.0651 | 0.1402 | 0.0336 | 0.1134 | 0.0140 | 0.1269 | 0.0006 | 0.0000 | 0.0016 | 0.0011 | 0.0035 | 0.0031 | 0.0209 | 0.0133 | 0.0660 | 0.0570 | 0.1224 | 0.0997 | 0.0905 | 0.0754 | 0.1165 | 0.0996 | 0.5779 | 0.6509 | 0.0004 | 0.0013 | 0.0043 | 0.0044 | 0.0077 | 0.0109 | 0.0342 | 0.0455 | 0.0992 | 0.1166 | 0.1564 | 0.1705 | 0.1123 | 0.1236 | 0.1422 | 0.1484 | 0.4433 | 0.3789 | 0.0009 | 0.0019 | 0.0058 | 0.0251 | 0.0859 | 0.1396 | 0.1007 | 0.1336 | 0.5064 |
| MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 512 | 618 | | 11255 | 20255 | 428.2 | 87.05 | 105.63 | 203.30 | 309 | 354 | 384 | 408 | 429 | 449 | 474 | 501 | 549 | 0.0544 | 1102 | 0.683 | 111.73 | 25.46 | 6 | 0.0275 | 310 | 0.0009 | 22.99 | 7.263 | 0.2438 | 190902.0 | 88200000 | 42000000000 | 20600000000000 | 0.4424 | 0.2031 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0026 | 0.0004 | 0.0084 | 0.0012 | 0.0280 | 0.0134 | 0.0584 | 0.0238 | 0.0474 | 0.0178 | 0.0713 | 0.0278 | 0.7829 | 0.9155 | 0.0001 | 0.0000 | 0.0003 | 0.0000 | 0.0008 | 0.0000 | 0.0033 | 0.0008 | 0.0135 | 0.0104 | 0.0281 | 0.0209 | 0.0204 | 0.0124 | 0.0313 | 0.0184 | 0.9022 | 0.9370 | 0.0011 | 0.0000 | 0.0063 | 0.0000 | 0.0110 | 0.0000 | 0.0226 | 0.0000 | 0.0479 | 0.0000 | 0.0805 | 0.0000 | 0.0642 | 0.0000 | 0.0789 | 0.0000 | 0.6875 | 0.0000 | 0.0009 | 0.0019 | 0.0058 | 0.0140 | 0.0333 | 0.0539 | 0.0552 | 0.0744 | 0.7606 | 8 | 9 | 10 | 11 | 13 | 16 | 42 | 145 | 378 | 0.0720 | 5.26 | 3.153 | 0.4465 | 52486.1 | 36900000 | 30400000000 | 27900000000000 | 0.5667 | 0.1091 | 0.0648 | 0.0042 | 0.2221 | 0.0305 | 0.2455 | 0.1491 | 0.1821 | 0.1574 | 0.1255 | 0.1533 | 0.0690 | 0.1678 | 0.0331 | 0.1262 | 0.0317 | 0.0846 | 0.0262 | 0.1269 | 0.0004 | 0.0000 | 0.0006 | 0.0006 | 0.0010 | 0.0017 | 0.0112 | 0.0092 | 0.0467 | 0.0430 | 0.0696 | 0.0628 | 0.0485 | 0.0415 | 0.0752 | 0.0685 | 0.7467 | 0.7729 | 0.0005 | 0.0005 | 0.0007 | 0.0007 | 0.0016 | 0.0025 | 0.0113 | 0.0152 | 0.0565 | 0.0539 | 0.0774 | 0.0786 | 0.0493 | 0.0607 | 0.0870 | 0.0851 | 0.7156 | 0.7027 | 0.0007 | 0.0000 | 0.0020 | 0.0119 | 0.0543 | 0.0701 | 0.0508 | 0.0795 | 0.7308 |
| MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 652 | 166 | | 1359 | 6119 | 428.9 | 60.31 | 32.37 | 70.62 | 351 | 373 | 390 | 405 | 426 | 446 | 465 | 483 | 508 | 0.0709 | 434 | 0.794 | 97.08 | 19.70 | 1 | 0.1670 | 227 | 0.0023 | 22.07 | 6.272 | 0.2405 | 187585.0 | 83600000 | 38000000000 | 17500000000000 | 0.4204 | 0.2216 | 0.0009 | 0.0000 | 0.0000 | 0.0000 | 0.0026 | 0.0000 | 0.0061 | 0.0000 | 0.0462 | 0.0221 | 0.0688 | 0.0324 | 0.0592 | 0.0191 | 0.0897 | 0.0316 | 0.7265 | 0.8948 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0024 | 0.0000 | 0.0016 | 0.0000 | 0.0293 | 0.0221 | 0.0443 | 0.0324 | 0.0332 | 0.0191 | 0.0546 | 0.0316 | 0.8347 | 0.8948 | 0.0259 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0776 | 0.0000 | 0.1638 | 0.0000 | 0.1983 | 0.0000 | 0.1207 | 0.0000 | 0.1379 | 0.0000 | 0.2759 | 0.0000 | 0.0000 | 0.0046 | 0.0077 | 0.0107 | 0.0475 | 0.0644 | 0.0706 | 0.0982 | 0.6963 | 6 | 8 | 9 | 10 | 11 | 13 | 15 | 23 | 79 | 0.3514 | 3.58 | 2.313 | 0.8106 | 6034.5 | 2460000 | 1350000000 | 863000000000 | 0.6003 | 0.1052 | 0.0807 | 0.0227 | 0.0807 | 0.0644 | 0.1211 | 0.0814 | 0.2870 | 0.1458 | 0.1435 | 0.1496 | 0.1480 | 0.1458 | 0.0762 | 0.1326 | 0.0583 | 0.1307 | 0.0045 | 0.1269 | 0.0088 | 0.0079 | 0.0044 | 0.0186 | 0.0071 | 0.0193 | 0.0274 | 0.0336 | 0.0398 | 0.0480 | 0.0548 | 0.0523 | 0.0610 | 0.0651 | 0.0839 | 0.0938 | 0.7129 | 0.6614 | 0.0000 | 0.0000 | 0.0044 | 0.0023 | 0.0055 | 0.0046 | 0.0143 | 0.0161 | 0.0539 | 0.0506 | 0.0462 | 0.0598 | 0.0616 | 0.0529 | 0.0935 | 0.0978 | 0.7206 | 0.7158 | 0.0020 | 0.0050 | 0.0090 | 0.0160 | 0.0548 | 0.0439 | 0.0499 | 0.1017 | 0.7178 |
| Hs 578T | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 171 | 227 | | 13156 | 26560 | 216.3 | 55.08 | 143.33 | 196.83 | 147 | 172 | 189 | 203 | 217 | 231 | 246 | 263 | 286 | 0.0570 | 1514 | 0.695 | 170.21 | 47.54 | 3 | 0.0364 | 479 | 0.0008 | 42.66 | 7.414 | 0.1765 | 49810.3 | 12100000 | 3040000000 | 797000000000 | 0.4175 | 0.2260 | 0.0007 | 0.0001 | 0.0014 | 0.0001 | 0.0076 | 0.0009 | 0.0228 | 0.0052 | 0.0655 | 0.0153 | 0.1188 | 0.0349 | 0.1344 | 0.0418 | 0.1753 | 0.0659 | 0.4735 | 0.8359 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0012 | 0.0004 | 0.0075 | 0.0020 | 0.0220 | 0.0098 | 0.0398 | 0.0182 | 0.0480 | 0.0148 | 0.0644 | 0.0241 | 0.8168 | 0.9308 | 0.0028 | 0.0282 | 0.0118 | 0.0267 | 0.0277 | 0.0847 | 0.0602 | 0.1278 | 0.0906 | 0.1798 | 0.1387 | 0.1575 | 0.1280 | 0.1189 | 0.1505 | 0.1218 | 0.3898 | 0.1545 | 0.0012 | 0.0034 | 0.0079 | 0.0230 | 0.0477 | 0.0880 | 0.0938 | 0.1052 | 0.6296 | 16 | 19 | 22 | 26 | 40 | 80 | 154 | 256 | 424 | 0.0499 | 24.57 | 5.020 | 0.5076 | 59283.3 | 35800000 | 26400000000 | 22500000000000 | 0.6077 | 0.0916 | 0.0465 | 0.0024 | 0.1573 | 0.0221 | 0.2370 | 0.0945 | 0.1899 | 0.1299 | 0.1567 | 0.1853 | 0.1107 | 0.1877 | 0.0559 | 0.1296 | 0.0288 | 0.1216 | 0.0172 | 0.1270 | 0.0004 | 0.0003 | 0.0007 | 0.0014 | 0.0025 | 0.0019 | 0.0149 | 0.0139 | 0.0556 | 0.0499 | 0.0753 | 0.0693 | 0.0592 | 0.0511 | 0.0899 | 0.0801 | 0.7015 | 0.7321 | 0.0005 | 0.0015 | 0.0016 | 0.0014 | 0.0046 | 0.0059 | 0.0219 | 0.0234 | 0.0658 | 0.0751 | 0.1028 | 0.1190 | 0.0811 | 0.0870 | 0.1118 | 0.1202 | 0.6099 | 0.5665 | 0.0007 | 0.0013 | 0.0027 | 0.0190 | 0.0556 | 0.0905 | 0.0669 | 0.0992 | 0.6642 |
| MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 828 | 486 | | 14994 | 31048 | 470.7 | 84.93 | 145.23 | 202.56 | 364 | 398 | 424 | 447 | 469 | 490 | 513 | 542 | 583 | 0.0407 | 1265 | 1.143 | 89.20 | 33.84 | 2 | 0.0156 | 234 | 0.0008 | 39.09 | 7.354 | 0.1815 | 228773.0 | 115000000 | 59000000000 | 31200000000000 | 0.4389 | 0.2085 | 0.0001 | 0.0000 | 0.0001 | 0.0000 | 0.0020 | 0.0001 | 0.0111 | 0.0005 | 0.0411 | 0.0092 | 0.0890 | 0.0204 | 0.0990 | 0.0211 | 0.1268 | 0.0342 | 0.6308 | 0.9146 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0001 | 0.0049 | 0.0001 | 0.0183 | 0.0077 | 0.0417 | 0.0152 | 0.0417 | 0.0114 | 0.0544 | 0.0195 | 0.8381 | 0.9459 | 0.0048 | 0.0278 | 0.0077 | 0.0556 | 0.0191 | 0.1065 | 0.0689 | 0.1991 | 0.1411 | 0.2083 | 0.1689 | 0.1435 | 0.1325 | 0.0694 | 0.1536 | 0.1019 | 0.3033 | 0.0880 | 0.0004 | 0.0009 | 0.0068 | 0.0261 | 0.0682 | 0.1054 | 0.0961 | 0.1216 | 0.5745 | 6 | 8 | 10 | 13 | 30 | 83 | 171 | 296 | 457 | 0.1239 | 27.73 | 4.902 | 0.5414 | 62118.6 | 35000000 | 22900000000 | 16700000000000 | 0.4409 | 0.1994 | 0.0472 | 0.0018 | 0.1760 | 0.0086 | 0.2720 | 0.1069 | 0.1840 | 0.1494 | 0.1220 | 0.1901 | 0.0838 | 0.2070 | 0.0520 | 0.1123 | 0.0355 | 0.0968 | 0.0276 | 0.1271 | 0.0004 | 0.0000 | 0.0002 | 0.0003 | 0.0004 | 0.0005 | 0.0104 | 0.0070 | 0.0419 | 0.0383 | 0.0677 | 0.0587 | 0.0504 | 0.0418 | 0.0695 | 0.0619 | 0.7590 | 0.7915 | 0.0002 | 0.0002 | 0.0013 | 0.0006 | 0.0008 | 0.0007 | 0.0105 | 0.0168 | 0.0580 | 0.0609 | 0.0871 | 0.0932 | 0.0560 | 0.0646 | 0.0902 | 0.0922 | 0.6960 | 0.6707 | 0.0000 | 0.0003 | 0.0015 | 0.0114 | 0.0475 | 0.0781 | 0.0516 | 0.0805 | 0.7292 |
| BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 958 | 125 | | 2932 | 10604 | 196.6 | 65.96 | 9.01 | 4.41 | 127 | 138 | 150 | 164 | 179 | 198 | 223 | 249 | 301 | 0.0658 | 698 | 0.614 | 76.01 | 21.95 | 1 | 0.0836 | 245 | 0.0079 | 2.74 | 5.180 | 0.5006 | 42980.6 | 10400000 | 2760000000 | 788000000000 | 0.4076 | 0.2304 | 0.0043 | 0.0013 | 0.0035 | 0.0013 | 0.0112 | 0.0042 | 0.0371 | 0.0097 | 0.0569 | 0.0295 | 0.1320 | 0.0687 | 0.1217 | 0.0442 | 0.1639 | 0.0720 | 0.4694 | 0.7692 | 0.0021 | 0.0011 | 0.0021 | 0.0007 | 0.0053 | 0.0032 | 0.0137 | 0.0064 | 0.0217 | 0.0207 | 0.0455 | 0.0454 | 0.0418 | 0.0264 | 0.0561 | 0.0482 | 0.8117 | 0.8477 | 0.0014 | 0.0000 | 0.0014 | 0.0000 | 0.0109 | 0.0047 | 0.0301 | 0.0165 | 0.0342 | 0.0425 | 0.0861 | 0.0778 | 0.0697 | 0.0472 | 0.0765 | 0.0802 | 0.6899 | 0.7311 | 0.0017 | 0.0025 | 0.0042 | 0.0151 | 0.0260 | 0.0519 | 0.0511 | 0.0611 | 0.7864 | 5 | 6 | 7 | 7 | 8 | 9 | 10 | 11 | 14 | 0.0111 | 13.72 | 5.076 | 0.3038 | 100.7 | 1416.1 | 25055.2 | 539238 | 0.4587 | 0.1802 | 0.0400 | 0.0040 | 0.1247 | 0.0070 | 0.2092 | 0.0206 | 0.2582 | 0.0465 | 0.1991 | 0.1010 | 0.1141 | 0.1792 | 0.0447 | 0.2550 | 0.0098 | 0.2595 | 0.0003 | 0.1273 | 0.0087 | 0.0002 | 0.0392 | 0.0012 | 0.0841 | 0.0078 | 0.1282 | 0.0233 | 0.1444 | 0.0654 | 0.1470 | 0.1201 | 0.1169 | 0.1781 | 0.1209 | 0.2377 | 0.2107 | 0.3662 | 0.1147 | 0.1071 | 0.0900 | 0.0750 | 0.0862 | 0.0679 | 0.0718 | 0.0968 | 0.0938 | 0.0859 | 0.1045 | 0.1000 | 0.0836 | 0.1019 | 0.0957 | 0.1167 | 0.2595 | 0.2487 | 0.0483 | 0.0956 | 0.1102 | 0.1089 | 0.1085 | 0.0986 | 0.0902 | 0.1128 | 0.2269 |
| MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 701 | 317 | | 1010 | 1709 | 117.2 | 14.08 | 14.40 | 13.12 | 99 | 104 | 109 | 112 | 117 | 120 | 125 | 130 | 137 | 0.2264 | 387 | 0.804 | 89.94 | 22.63 | 3 | 0.2515 | 254 | 0.0285 | 1.46 | 3.784 | 0.5971 | 13944.3 | 1680000 | 206000000 | 25500000000 | 0.4094 | 0.2171 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0032 | 0.0010 | 0.0173 | 0.0079 | 0.0539 | 0.0366 | 0.0949 | 0.0772 | 0.0949 | 0.0475 | 0.1284 | 0.0554 | 0.6063 | 0.7743 | 0.0000 | 0.0000 | 0.0010 | 0.0000 | 0.0031 | 0.0010 | 0.0153 | 0.0079 | 0.0408 | 0.0366 | 0.0704 | 0.0772 | 0.0551 | 0.0475 | 0.0643 | 0.0554 | 0.7500 | 0.7743 | 0.0755 | 0.0000 | 0.0566 | 0.0000 | 0.0755 | 0.0000 | 0.3019 | 0.0000 | 0.1509 | 0.0000 | 0.1698 | 0.0000 | 0.0566 | 0.0000 | 0.0755 | 0.0000 | 0.0377 | 0.0000 | 0.0000 | 0.0119 | 0.0119 | 0.0356 | 0.0652 | 0.1047 | 0.1126 | 0.1285 | 0.5296 | 6 | 7 | 8 | 9 | 10 | 12 | 14 | 18 | 27 | 0.2146 | 0.58 | 2.293 | 0.8004 | 379.5 | 17210.3 | 1060000 | 75400000 | 0.6023 | 0.1002 | 0.1389 | 0.0185 | 0.1528 | 0.0420 | 0.1910 | 0.0791 | 0.2014 | 0.1471 | 0.1632 | 0.1483 | 0.0868 | 0.1508 | 0.0417 | 0.1434 | 0.0243 | 0.1434 | 0.0000 | 0.1273 | 0.0532 | 0.0116 | 0.0388 | 0.0268 | 0.0403 | 0.0528 | 0.0446 | 0.0966 | 0.0935 | 0.1109 | 0.1410 | 0.1270 | 0.0777 | 0.1064 | 0.1410 | 0.1145 | 0.3698 | 0.3533 | 0.0197 | 0.0032 | 0.0221 | 0.0194 | 0.0246 | 0.0227 | 0.0491 | 0.0680 | 0.1302 | 0.1262 | 0.1474 | 0.1780 | 0.1179 | 0.1197 | 0.1843 | 0.1586 | 0.3047 | 0.3042 | 0.0209 | 0.0209 | 0.0342 | 0.0512 | 0.0892 | 0.1518 | 0.0854 | 0.1613 | 0.3852 |
| Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1205 | 176 | | 372 | 2800 | 40.2 | 10.05 | 84.88 | 173.91 | 28 | 30 | 34 | 37 | 39 | 41 | 45 | 49 | 53 | 0.1139 | 319 | 0.581 | 191.64 | 52.00 | 2 | 1.5618 | 581 | 0.0086 | 8.20 | 4.933 | 0.3440 | 1713.9 | 77670.5 | 3730000 | 189000000 | 0.3953 | 0.2248 | 0.0051 | 0.0000 | 0.0154 | 0.0000 | 0.0359 | 0.0000 | 0.1333 | 0.0088 | 0.1744 | 0.0821 | 0.1897 | 0.0645 | 0.2154 | 0.1026 | 0.1333 | 0.1378 | 0.0974 | 0.6041 | 0.0036 | 0.0000 | 0.0108 | 0.0000 | 0.0108 | 0.0000 | 0.0502 | 0.0054 | 0.0681 | 0.0622 | 0.0681 | 0.0514 | 0.0968 | 0.0514 | 0.1147 | 0.0784 | 0.5771 | 0.7514 | 0.0000 | 0.0000 | 0.0357 | 0.0345 | 0.1190 | 0.0690 | 0.0238 | 0.2069 | 0.1786 | 0.1379 | 0.1667 | 0.0345 | 0.0952 | 0.2069 | 0.1548 | 0.1379 | 0.2262 | 0.1724 | 0.0056 | 0.0056 | 0.0222 | 0.0444 | 0.0778 | 0.0944 | 0.0889 | 0.1778 | 0.4833 | 15 | 17 | 19 | 21 | 23 | 27 | 32 | 79 | 241 | 0.2089 | 3.35 | 2.782 | 0.7521 | 37440.5 | 29600000 | 28700000000 | 30700000000000 | 0.7152 | 0.0493 | 0.0130 | 0.0061 | 0.1299 | 0.0242 | 0.2987 | 0.0242 | 0.1948 | 0.0848 | 0.1429 | 0.2061 | 0.0779 | 0.2485 | 0.0649 | 0.1333 | 0.0260 | 0.1455 | 0.0519 | 0.1273 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0047 | 0.0120 | 0.0126 | 0.0342 | 0.0346 | 0.0496 | 0.0362 | 0.0479 | 0.0472 | 0.0803 | 0.0849 | 0.7761 | 0.7799 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0039 | 0.0021 | 0.0138 | 0.0085 | 0.0472 | 0.0446 | 0.0591 | 0.0807 | 0.0571 | 0.0573 | 0.1004 | 0.1083 | 0.7185 | 0.6985 | 0.0000 | 0.0000 | 0.0018 | 0.0091 | 0.0453 | 0.0507 | 0.0562 | 0.0888 | 0.7482 |
| MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 320 | 667 | | 5012 | 4003 | 144.6 | 31.00 | 256.96 | 210.61 | 110 | 119 | 126 | 133 | 139 | 146 | 155 | 168 | 187 | 0.1699 | 680 | 1.061 | 130.67 | 36.72 | 1 | 0.0599 | 300 | 0.0023 | 22.41 | 6.404 | 0.2450 | 21873.6 | 3470000 | 577000000 | 101000000000 | 0.4357 | 0.2084 | 0.0000 | 0.0000 | 0.0015 | 0.0000 | 0.0059 | 0.0000 | 0.0223 | 0.0013 | 0.0711 | 0.0189 | 0.1355 | 0.0456 | 0.1443 | 0.0439 | 0.1875 | 0.0634 | 0.4320 | 0.8269 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0028 | 0.0000 | 0.0083 | 0.0004 | 0.0355 | 0.0130 | 0.0649 | 0.0252 | 0.0675 | 0.0144 | 0.0966 | 0.0244 | 0.7237 | 0.9225 | 0.0073 | 0.0036 | 0.0158 | 0.0144 | 0.0280 | 0.0758 | 0.0767 | 0.1516 | 0.1571 | 0.1913 | 0.1705 | 0.1733 | 0.1255 | 0.1264 | 0.1437 | 0.1155 | 0.2753 | 0.1480 | 0.0038 | 0.0080 | 0.0127 | 0.0363 | 0.0930 | 0.1303 | 0.1085 | 0.1567 | 0.4507 | 33 | 63 | 100 | 155 | 208 | 265 | 333 | 424 | 568 | 0.0020 | 118.54 | 7.148 | 0.2176 | 110371.0 | 60900000 | 39200000000 | 28100000000000 | 0.4840 | 0.1833 | 0.0323 | 0.0038 | 0.1232 | 0.0212 | 0.2097 | 0.0613 | 0.2097 | 0.1272 | 0.1730 | 0.1779 | 0.1510 | 0.2059 | 0.0587 | 0.1476 | 0.0293 | 0.1272 | 0.0132 | 0.1279 | 0.0005 | 0.0000 | 0.0055 | 0.0033 | 0.0099 | 0.0087 | 0.0307 | 0.0229 | 0.0823 | 0.0715 | 0.1368 | 0.1227 | 0.1011 | 0.0932 | 0.1293 | 0.1165 | 0.5040 | 0.5611 | 0.0007 | 0.0055 | 0.0045 | 0.0028 | 0.0112 | 0.0148 | 0.0389 | 0.0572 | 0.1243 | 0.1210 | 0.1534 | 0.1681 | 0.1213 | 0.1385 | 0.1445 | 0.1376 | 0.4012 | 0.3546 | 0.0030 | 0.0066 | 0.0156 | 0.0361 | 0.0968 | 0.1437 | 0.1203 | 0.1371 | 0.4408 |
| MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 395 | 643 | | 5110 | 12647 | 411.8 | 82.88 | 98.24 | 223.44 | 296 | 332 | 362 | 387 | 413 | 442 | 469 | 492 | 516 | 0.0659 | 833 | 1.130 | 86.12 | 29.43 | 1 | 0.0421 | 215 | 0.0017 | 11.85 | 6.634 | 0.3156 | 176415.0 | 78200000 | 35700000000 | 16700000000000 | 0.4107 | 0.2254 | 0.0009 | 0.0000 | 0.0028 | 0.0000 | 0.0066 | 0.0000 | 0.0133 | 0.0006 | 0.0344 | 0.0142 | 0.0667 | 0.0259 | 0.0689 | 0.0150 | 0.0910 | 0.0273 | 0.7153 | 0.9170 | 0.0005 | 0.0000 | 0.0010 | 0.0000 | 0.0027 | 0.0000 | 0.0046 | 0.0006 | 0.0126 | 0.0131 | 0.0239 | 0.0224 | 0.0220 | 0.0115 | 0.0305 | 0.0206 | 0.9023 | 0.9318 | 0.0041 | 0.0000 | 0.0072 | 0.1290 | 0.0103 | 0.1935 | 0.0351 | 0.1290 | 0.0784 | 0.2258 | 0.0991 | 0.2258 | 0.0877 | 0.0645 | 0.1290 | 0.0323 | 0.5490 | 0.0000 | 0.0004 | 0.0043 | 0.0031 | 0.0105 | 0.0233 | 0.0361 | 0.0415 | 0.0562 | 0.8247 | 7 | 8 | 10 | 11 | 13 | 16 | 30 | 87 | 318 | 0.2398 | 18.28 | 3.252 | 0.6811 | 59570.0 | 56500000 | 65600000000 | 86800000000000 | 0.3448 | 0.2408 | 0.0274 | 0.0023 | 0.1471 | 0.0150 | 0.2893 | 0.0495 | 0.1845 | 0.1164 | 0.1621 | 0.2085 | 0.0998 | 0.2385 | 0.0299 | 0.1336 | 0.0324 | 0.1083 | 0.0274 | 0.1279 | 0.0000 | 0.0007 | 0.0004 | 0.0007 | 0.0015 | 0.0020 | 0.0091 | 0.0078 | 0.0380 | 0.0346 | 0.0673 | 0.0620 | 0.0395 | 0.0400 | 0.0589 | 0.0491 | 0.7852 | 0.8032 | 0.0009 | 0.0005 | 0.0040 | 0.0010 | 0.0040 | 0.0024 | 0.0094 | 0.0086 | 0.0395 | 0.0427 | 0.0686 | 0.0734 | 0.0413 | 0.0504 | 0.0659 | 0.0705 | 0.7663 | 0.7505 | 0.0004 | 0.0013 | 0.0042 | 0.0129 | 0.0400 | 0.0642 | 0.0396 | 0.0554 | 0.7821 | ||
| MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 821 | 296 | | 10441 | 19427 | 121.6 | 37.86 | 144.94 | 161.51 | 79 | 90 | 99 | 108 | 116 | 126 | 138 | 153 | 174 | 0.0627 | 1218 | 0.254 | 218.68 | 45.79 | 4 | 0.0876 | 915 | 0.0020 | 18.42 | 6.592 | 0.2752 | 16229.4 | 2350000 | 367000000 | 61000000000 | 0.4705 | 0.1773 | 0.0012 | 0.0001 | 0.0034 | 0.0006 | 0.0120 | 0.0011 | 0.0412 | 0.0074 | 0.1063 | 0.0358 | 0.1638 | 0.0724 | 0.1588 | 0.0758 | 0.1756 | 0.1072 | 0.3378 | 0.6997 | 0.0007 | 0.0001 | 0.0015 | 0.0001 | 0.0029 | 0.0005 | 0.0135 | 0.0023 | 0.0368 | 0.0171 | 0.0641 | 0.0363 | 0.0621 | 0.0302 | 0.0774 | 0.0464 | 0.7412 | 0.8670 | 0.0044 | 0.0067 | 0.0016 | 0.0117 | 0.0148 | 0.0341 | 0.0487 | 0.0908 | 0.0907 | 0.1341 | 0.1362 | 0.1882 | 0.1286 | 0.1440 | 0.1354 | 0.1440 | 0.4395 | 0.2465 | 0.0006 | 0.0041 | 0.0103 | 0.0299 | 0.0638 | 0.1050 | 0.0907 | 0.1158 | 0.5798 | 11 | 14 | 20 | 40 | 78 | 132 | 194 | 273 | 378 | 0.0407 | 25.51 | 5.518 | 0.4667 | 47091.3 | 20600000 | 10800000000 | 6430000000000 | 0.5620 | 0.1280 | 0.0686 | 0.0021 | 0.1796 | 0.0256 | 0.2678 | 0.1420 | 0.1409 | 0.1373 | 0.1146 | 0.1747 | 0.0965 | 0.1718 | 0.0578 | 0.1136 | 0.0428 | 0.1049 | 0.0315 | 0.1281 | 0.0001 | 0.0004 | 0.0010 | 0.0007 | 0.0020 | 0.0019 | 0.0094 | 0.0061 | 0.0535 | 0.0466 | 0.1056 | 0.0854 | 0.0759 | 0.0627 | 0.1166 | 0.0964 | 0.6358 | 0.6997 | 0.0008 | 0.0011 | 0.0017 | 0.0029 | 0.0042 | 0.0088 | 0.0152 | 0.0241 | 0.0795 | 0.0957 | 0.1485 | 0.1575 | 0.0994 | 0.1066 | 0.1429 | 0.1449 | 0.5079 | 0.4585 | 0.0003 | 0.0016 | 0.0031 | 0.0113 | 0.0700 | 0.1221 | 0.0927 | 0.1315 | 0.5675 |
| MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 608 | 285 | | 12711 | 40214 | 295.5 | 67.78 | 143.73 | 163.15 | 209 | 239 | 260 | 277 | 293 | 309 | 328 | 350 | 384 | 0.0353 | 1418 | 1.016 | 119.62 | 46.69 | 2 | 0.0271 | 344 | 0.0013 | 26.32 | 6.921 | 0.2277 | 91894.8 | 30000000 | 10200000000 | 3620000000000 | 0.4370 | 0.2187 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0043 | 0.0006 | 0.0194 | 0.0020 | 0.0643 | 0.0160 | 0.1388 | 0.0422 | 0.1306 | 0.0429 | 0.1606 | 0.0610 | 0.4809 | 0.8354 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0008 | 0.0001 | 0.0053 | 0.0011 | 0.0274 | 0.0105 | 0.0590 | 0.0245 | 0.0510 | 0.0194 | 0.0701 | 0.0291 | 0.7861 | 0.9154 | 0.0071 | 0.0128 | 0.0075 | 0.0192 | 0.0179 | 0.0417 | 0.0613 | 0.1330 | 0.1289 | 0.1875 | 0.1811 | 0.2051 | 0.1097 | 0.0865 | 0.1506 | 0.1330 | 0.3358 | 0.1811 | 0.0008 | 0.0024 | 0.0064 | 0.0265 | 0.0750 | 0.1260 | 0.1010 | 0.1299 | 0.5321 | 11 | 17 | 28 | 49 | 80 | 122 | 178 | 254 | 371 | 0.0435 | 17.85 | 5.232 | 0.4864 | 47276.4 | 22300000 | 13100000000 | 8910000000000 | 0.4347 | 0.1843 | 0.0559 | 0.0013 | 0.1725 | 0.0173 | 0.2681 | 0.1183 | 0.1475 | 0.1465 | 0.1431 | 0.1771 | 0.0944 | 0.1809 | 0.0533 | 0.1241 | 0.0376 | 0.1058 | 0.0276 | 0.1288 | 0.0001 | 0.0001 | 0.0004 | 0.0006 | 0.0019 | 0.0015 | 0.0116 | 0.0097 | 0.0649 | 0.0509 | 0.1109 | 0.0898 | 0.0752 | 0.0672 | 0.1098 | 0.0956 | 0.6253 | 0.6846 | 0.0006 | 0.0007 | 0.0011 | 0.0013 | 0.0036 | 0.0075 | 0.0213 | 0.0276 | 0.0840 | 0.0988 | 0.1417 | 0.1531 | 0.0910 | 0.0952 | 0.1254 | 0.1330 | 0.5313 | 0.4828 | 0.0003 | 0.0013 | 0.0032 | 0.0164 | 0.0787 | 0.1225 | 0.0861 | 0.1208 | 0.5707 |
| MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 701 | 856 | | 7996 | 17307 | 193.6 | 58.72 | 164.59 | 174.51 | 125 | 142 | 158 | 171 | 186 | 201 | 219 | 242 | 276 | 0.0699 | 1209 | 0.390 | 189.19 | 52.01 | 6 | 0.0969 | 775 | 0.0004 | 115.49 | 7.998 | 0.1188 | 40941.8 | 9380000 | 2310000000 | 607000000000 | 0.4229 | 0.2241 | 0.0005 | 0.0000 | 0.0018 | 0.0002 | 0.0094 | 0.0009 | 0.0411 | 0.0074 | 0.1168 | 0.0344 | 0.1900 | 0.0791 | 0.1790 | 0.0803 | 0.1954 | 0.1104 | 0.2659 | 0.6873 | 0.0003 | 0.0000 | 0.0010 | 0.0001 | 0.0019 | 0.0003 | 0.0127 | 0.0035 | 0.0368 | 0.0179 | 0.0736 | 0.0397 | 0.0694 | 0.0336 | 0.0989 | 0.0501 | 0.7053 | 0.8549 | 0.0011 | 0.0022 | 0.0058 | 0.0101 | 0.0132 | 0.0348 | 0.0529 | 0.0886 | 0.1242 | 0.1502 | 0.1564 | 0.1973 | 0.1036 | 0.1424 | 0.1416 | 0.1323 | 0.4012 | 0.2422 | 0.0011 | 0.0014 | 0.0067 | 0.0338 | 0.0799 | 0.1053 | 0.1028 | 0.1274 | 0.5416 | 12 | 17 | 27 | 57 | 103 | 156 | 220 | 301 | 416 | 0.0341 | 36.46 | 5.746 | 0.4218 | 57539.3 | 27000000 | 15300000000 | 10100000000000 | 0.6571 | 0.0586 | 0.0542 | 0.0031 | 0.1783 | 0.0167 | 0.2744 | 0.0940 | 0.1826 | 0.1421 | 0.1310 | 0.1851 | 0.0908 | 0.1972 | 0.0521 | 0.1171 | 0.0258 | 0.1158 | 0.0107 | 0.1290 | 0.0001 | 0.0001 | 0.0009 | 0.0003 | 0.0035 | 0.0017 | 0.0141 | 0.0100 | 0.0637 | 0.0508 | 0.1127 | 0.0947 | 0.0879 | 0.0669 | 0.1267 | 0.1070 | 0.5903 | 0.6684 | 0.0002 | 0.0012 | 0.0024 | 0.0030 | 0.0050 | 0.0089 | 0.0260 | 0.0344 | 0.0869 | 0.1000 | 0.1472 | 0.1606 | 0.1046 | 0.1172 | 0.1475 | 0.1538 | 0.4802 | 0.4209 | 0.0006 | 0.0016 | 0.0037 | 0.0192 | 0.0754 | 0.1313 | 0.0961 | 0.1295 | 0.5426 |
| MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1271 | 351 | | 4157 | 9898 | 475.9 | 89.44 | 163.26 | 251.77 | 360 | 394 | 423 | 449 | 475 | 498 | 524 | 554 | 594 | 0.0813 | 805 | 1.028 | 152.20 | 40.79 | 2 | 0.0871 | 362 | 0.0008 | 73.60 | 7.318 | 0.1483 | 234454.0 | 119000000 | 62600000000 | 33700000000000 | 0.4174 | 0.2233 | 0.0003 | 0.0000 | 0.0010 | 0.0000 | 0.0017 | 0.0000 | 0.0196 | 0.0010 | 0.0716 | 0.0187 | 0.1191 | 0.0382 | 0.1160 | 0.0296 | 0.1725 | 0.0500 | 0.4981 | 0.8625 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0009 | 0.0000 | 0.0069 | 0.0007 | 0.0343 | 0.0162 | 0.0480 | 0.0300 | 0.0474 | 0.0157 | 0.0809 | 0.0288 | 0.7811 | 0.9086 | 0.0000 | 0.0390 | 0.0204 | 0.0260 | 0.0471 | 0.1429 | 0.0973 | 0.2597 | 0.1476 | 0.2338 | 0.2057 | 0.1558 | 0.1350 | 0.0779 | 0.1162 | 0.0519 | 0.2308 | 0.0130 | 0.0010 | 0.0010 | 0.0048 | 0.0299 | 0.0676 | 0.1356 | 0.1236 | 0.1472 | 0.4894 | 7 | 10 | 13 | 22 | 39 | 75 | 136 | 293 | 547 | 0.0676 | 32.18 | 4.895 | 0.5343 | 90034.8 | 69000000 | 62100000000 | 62700000000000 | 0.5861 | 0.0893 | 0.0409 | 0.0025 | 0.1595 | 0.0187 | 0.2704 | 0.0934 | 0.2179 | 0.1214 | 0.1595 | 0.1766 | 0.0914 | 0.2054 | 0.0311 | 0.1350 | 0.0214 | 0.1180 | 0.0078 | 0.1290 | 0.0003 | 0.0003 | 0.0013 | 0.0017 | 0.0043 | 0.0049 | 0.0140 | 0.0129 | 0.0478 | 0.0466 | 0.0870 | 0.0765 | 0.0558 | 0.0552 | 0.0797 | 0.0797 | 0.7096 | 0.7222 | 0.0004 | 0.0000 | 0.0016 | 0.0017 | 0.0028 | 0.0043 | 0.0172 | 0.0170 | 0.0537 | 0.0679 | 0.1034 | 0.0909 | 0.0577 | 0.0635 | 0.0885 | 0.0905 | 0.6747 | 0.6642 | 0.0000 | 0.0026 | 0.0026 | 0.0125 | 0.0521 | 0.0922 | 0.0558 | 0.0845 | 0.6978 |