High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 564 | 834 | 5735 | 9264 | 386.5 | 90.39 | 113.25 | 134.91 | 287 | 312 | 332 | 351 | 371 | 393 | 423 | 457 | 512 | 0.0955 | 885 | 1.153 | 94.87 | 36.50 | 1 | 0.0424 | 243 | 0.0010 | 39.47 | 7.169 | 0.1888 | 157556.0 | 67800000 | 30700000000 | 14700000000000 | 0.4429 | 0.2115 | 0.0008 | 0.0000 | 0.0019 | 0.0006 | 0.0036 | 0.0017 | 0.0202 | 0.0044 | 0.0679 | 0.0189 | 0.1422 | 0.0466 | 0.1486 | 0.0405 | 0.1705 | 0.0615 | 0.4443 | 0.8259 | 0.0004 | 0.0000 | 0.0011 | 0.0002 | 0.0024 | 0.0009 | 0.0105 | 0.0021 | 0.0358 | 0.0126 | 0.0710 | 0.0308 | 0.0693 | 0.0219 | 0.0813 | 0.0324 | 0.7282 | 0.8991 | 0.0076 | 0.0105 | 0.0123 | 0.0026 | 0.0123 | 0.0211 | 0.0550 | 0.0632 | 0.0920 | 0.1395 | 0.1404 | 0.1447 | 0.0920 | 0.1289 | 0.1262 | 0.1421 | 0.4620 | 0.3474 | 0.0012 | 0.0032 | 0.0097 | 0.0385 | 0.0838 | 0.1187 | 0.0956 | 0.1126 | 0.5367 | 9 | 11 | 13 | 22 | 52 | 96 | 147 | 211 | 309 | 0.0380 | 20.61 | 5.347 | 0.4709 | 31025.6 | 11600000 | 5240000000 | 2690000000000 | 0.6389 | 0.0617 | 0.0305 | 0.0023 | 0.1469 | 0.0170 | 0.2362 | 0.0978 | 0.1627 | 0.1213 | 0.1345 | 0.1582 | 0.0949 | 0.1687 | 0.0983 | 0.1201 | 0.0588 | 0.1125 | 0.0373 | 0.2021 | 0.0005 | 0.0000 | 0.0003 | 0.0002 | 0.0016 | 0.0026 | 0.0128 | 0.0086 | 0.0534 | 0.0432 | 0.0826 | 0.0776 | 0.0631 | 0.0491 | 0.1081 | 0.0918 | 0.6777 | 0.7269 | 0.0000 | 0.0008 | 0.0010 | 0.0008 | 0.0054 | 0.0051 | 0.0217 | 0.0249 | 0.0633 | 0.0785 | 0.1178 | 0.1224 | 0.0796 | 0.0890 | 0.1260 | 0.1383 | 0.5852 | 0.5404 | 0.0000 | 0.0006 | 0.0027 | 0.0183 | 0.0601 | 0.0914 | 0.0787 | 0.1213 | 0.6269 | |||
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 854 | 856 | 7221 | 14570 | 49.4 | 17.53 | 78.00 | 136.28 | 28 | 34 | 38 | 43 | 47 | 52 | 58 | 64 | 73 | 0.0925 | 1347 | 0.564 | 226.82 | 39.32 | 13 | 0.0867 | 626 | 0.0060 | 6.82 | 5.419 | 0.3768 | 2746.4 | 169000 | 11300000 | 819000000 | 0.4385 | 0.1979 | 0.0021 | 0.0002 | 0.0092 | 0.0013 | 0.0509 | 0.0036 | 0.1206 | 0.0209 | 0.1835 | 0.0519 | 0.1998 | 0.1171 | 0.1729 | 0.1192 | 0.1266 | 0.1517 | 0.1344 | 0.5342 | 0.0004 | 0.0000 | 0.0012 | 0.0005 | 0.0037 | 0.0013 | 0.0217 | 0.0112 | 0.0562 | 0.0266 | 0.0864 | 0.0540 | 0.0848 | 0.0579 | 0.1085 | 0.0691 | 0.6371 | 0.7796 | 0.0039 | 0.0097 | 0.0073 | 0.0154 | 0.0194 | 0.0328 | 0.0682 | 0.0936 | 0.1094 | 0.1380 | 0.1510 | 0.1979 | 0.1292 | 0.1342 | 0.1549 | 0.1467 | 0.3567 | 0.2317 | 0.0017 | 0.0026 | 0.0125 | 0.0408 | 0.0755 | 0.1098 | 0.1078 | 0.1329 | 0.5163 | 11 | 13 | 15 | 17 | 20 | 26 | 46 | 104 | 234 | 0.1860 | 10.58 | 3.510 | 0.6862 | 24655.2 | 13200000 | 8940000000 | 7000000000000 | 0.6410 | 0.1101 | 0.1548 | 0.0039 | 0.3289 | 0.0394 | 0.2946 | 0.2229 | 0.1131 | 0.2327 | 0.0565 | 0.2189 | 0.0298 | 0.1433 | 0.0134 | 0.0671 | 0.0074 | 0.0493 | 0.0015 | 0.0224 | 0.0008 | 0.0002 | 0.0008 | 0.0005 | 0.0032 | 0.0053 | 0.0201 | 0.0138 | 0.0823 | 0.0766 | 0.1173 | 0.0994 | 0.0839 | 0.0713 | 0.1284 | 0.1266 | 0.5631 | 0.6063 | 0.0003 | 0.0007 | 0.0023 | 0.0021 | 0.0058 | 0.0053 | 0.0229 | 0.0248 | 0.1011 | 0.1076 | 0.1308 | 0.1522 | 0.0995 | 0.0995 | 0.1485 | 0.1501 | 0.4889 | 0.4577 | 0.0000 | 0.0023 | 0.0053 | 0.0197 | 0.0978 | 0.1169 | 0.0934 | 0.1436 | 0.5211 | |
MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1040 | 910 | 3585 | 10231 | 344.3 | 84.59 | 34.10 | 76.86 | 243 | 270 | 294 | 317 | 338 | 360 | 384 | 412 | 458 | 0.0777 | 795 | 0.975 | 80.16 | 26.08 | 1 | 0.0555 | 199 | 0.0010 | 48.18 | 7.091 | 0.1715 | 125705.0 | 48500000 | 19700000000 | 8380000000000 | 0.4417 | 0.2214 | 0.0005 | 0.0000 | 0.0029 | 0.0000 | 0.0058 | 0.0006 | 0.0346 | 0.0056 | 0.1029 | 0.0262 | 0.1587 | 0.0586 | 0.1640 | 0.0586 | 0.1722 | 0.0873 | 0.3583 | 0.7630 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0014 | 0.0006 | 0.0122 | 0.0029 | 0.0480 | 0.0161 | 0.0735 | 0.0365 | 0.0724 | 0.0276 | 0.0882 | 0.0419 | 0.7031 | 0.8745 | 0.0056 | 0.0041 | 0.0014 | 0.0331 | 0.0324 | 0.0455 | 0.0606 | 0.0909 | 0.1437 | 0.2066 | 0.1521 | 0.1901 | 0.1211 | 0.1116 | 0.1563 | 0.1570 | 0.3268 | 0.1612 | 0.0006 | 0.0041 | 0.0094 | 0.0241 | 0.0700 | 0.1329 | 0.0988 | 0.1424 | 0.5176 | 5 | 6 | 6 | 8 | 9 | 10 | 14 | 28 | 84 | 0.2835 | 3.77 | 2.562 | 0.7553 | 7069.4 | 2850000 | 1600000000 | 1100000000000 | 0.6411 | 0.0755 | 0.0751 | 0.0073 | 0.1503 | 0.0125 | 0.2306 | 0.0658 | 0.2098 | 0.1524 | 0.1710 | 0.1994 | 0.0984 | 0.1754 | 0.0492 | 0.1242 | 0.0130 | 0.1420 | 0.0026 | 0.1211 | 0.0063 | 0.0020 | 0.0073 | 0.0041 | 0.0078 | 0.0138 | 0.0195 | 0.0292 | 0.0640 | 0.0604 | 0.0762 | 0.0835 | 0.0703 | 0.0722 | 0.0996 | 0.1078 | 0.6489 | 0.6271 | 0.0012 | 0.0040 | 0.0030 | 0.0020 | 0.0084 | 0.0080 | 0.0247 | 0.0172 | 0.0596 | 0.0669 | 0.0915 | 0.0948 | 0.0686 | 0.0749 | 0.1113 | 0.1021 | 0.6318 | 0.6302 | 0.0027 | 0.0027 | 0.0092 | 0.0223 | 0.0566 | 0.0886 | 0.0691 | 0.1033 | 0.6455 | |
MDA-MB-231 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 680 | 102 | 4304 | 6744 | 541.8 | 144.02 | 32.62 | 45.34 | 329 | 395 | 450 | 516 | 566 | 606 | 638 | 670 | 705 | 0.0948 | 639 | 0.542 | 117.00 | 26.02 | 1 | 0.0853 | 367 | 0.0008 | 32.43 | 7.325 | 0.2185 | 314288.0 | 192000000 | 122000000000 | 80400000000000 | 0.3875 | 0.2444 | 0.0010 | 0.0000 | 0.0025 | 0.0003 | 0.0069 | 0.0003 | 0.0212 | 0.0022 | 0.0562 | 0.0210 | 0.0877 | 0.0339 | 0.0946 | 0.0234 | 0.1252 | 0.0358 | 0.6047 | 0.8831 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0006 | 0.0003 | 0.0044 | 0.0015 | 0.0197 | 0.0172 | 0.0292 | 0.0288 | 0.0251 | 0.0175 | 0.0368 | 0.0275 | 0.8842 | 0.9070 | 0.0000 | 0.0000 | 0.0080 | 0.0000 | 0.0187 | 0.0000 | 0.0276 | 0.0000 | 0.0480 | 0.0000 | 0.0730 | 0.0000 | 0.0747 | 0.0000 | 0.1103 | 0.0000 | 0.6397 | 1.0000 | 0.0000 | 0.0013 | 0.0017 | 0.0055 | 0.0233 | 0.0355 | 0.0364 | 0.0508 | 0.8455 | 8 | 9 | 11 | 12 | 15 | 18 | 26 | 44 | 83 | 0.2567 | 1.27 | 2.377 | 0.7837 | 3119.9 | 589671 | 172000000 | 67600000000 | 0.6419 | 0.0827 | 0.0252 | 0.0246 | 0.1124 | 0.0419 | 0.1550 | 0.0583 | 0.2190 | 0.0887 | 0.1725 | 0.1297 | 0.1570 | 0.1478 | 0.1066 | 0.1445 | 0.0504 | 0.1650 | 0.0019 | 0.1995 | 0.0035 | 0.0115 | 0.0080 | 0.0167 | 0.0141 | 0.0199 | 0.0251 | 0.0267 | 0.0693 | 0.0554 | 0.1065 | 0.0940 | 0.0749 | 0.0737 | 0.0965 | 0.0992 | 0.6020 | 0.6029 | 0.0034 | 0.0031 | 0.0054 | 0.0085 | 0.0075 | 0.0124 | 0.0360 | 0.0325 | 0.0658 | 0.0688 | 0.1126 | 0.1145 | 0.0855 | 0.0828 | 0.1119 | 0.1121 | 0.5719 | 0.5654 | 0.0012 | 0.0070 | 0.0153 | 0.0282 | 0.0728 | 0.1045 | 0.0752 | 0.1057 | 0.5901 | |
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 844 | 729 | 5195 | 6746 | 513.2 | 118.34 | 131.41 | 201.76 | 374 | 422 | 455 | 484 | 509 | 533 | 559 | 598 | 663 | 0.1269 | 856 | 1.179 | 136.50 | 52.00 | 4 | 0.0670 | 348 | 0.0006 | 81.67 | 7.590 | 0.1403 | 277409.0 | 157000000 | 93300000000 | 57800000000000 | 0.4641 | 0.1828 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0092 | 0.0002 | 0.0187 | 0.0015 | 0.0728 | 0.0317 | 0.1260 | 0.0589 | 0.1091 | 0.0502 | 0.1534 | 0.0757 | 0.5108 | 0.7819 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0037 | 0.0008 | 0.0387 | 0.0254 | 0.0701 | 0.0404 | 0.0576 | 0.0258 | 0.0831 | 0.0416 | 0.7456 | 0.8661 | 0.0059 | 0.0100 | 0.0118 | 0.0134 | 0.0178 | 0.0334 | 0.0675 | 0.1104 | 0.1349 | 0.1371 | 0.1527 | 0.1605 | 0.0982 | 0.1171 | 0.1396 | 0.1371 | 0.3716 | 0.2809 | 0.0012 | 0.0020 | 0.0083 | 0.0313 | 0.0944 | 0.1583 | 0.1035 | 0.1432 | 0.4578 | 7 | 9 | 11 | 15 | 30 | 63 | 128 | 229 | 416 | 0.1248 | 27.25 | 4.487 | 0.5729 | 57968.2 | 37400000 | 29800000000 | 27700000000000 | 0.6421 | 0.0717 | 0.0374 | 0.0045 | 0.1828 | 0.0269 | 0.3106 | 0.1256 | 0.1806 | 0.1469 | 0.1564 | 0.2096 | 0.0639 | 0.2096 | 0.0419 | 0.1188 | 0.0176 | 0.0953 | 0.0088 | 0.0628 | 0.0000 | 0.0004 | 0.0004 | 0.0024 | 0.0009 | 0.0028 | 0.0121 | 0.0108 | 0.0689 | 0.0667 | 0.1123 | 0.0895 | 0.0671 | 0.0667 | 0.0988 | 0.0927 | 0.6395 | 0.6681 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0028 | 0.0050 | 0.0213 | 0.0292 | 0.0786 | 0.0856 | 0.1296 | 0.1290 | 0.0836 | 0.0862 | 0.1072 | 0.1141 | 0.5758 | 0.5509 | 0.0000 | 0.0010 | 0.0035 | 0.0180 | 0.0721 | 0.1181 | 0.0756 | 0.1086 | 0.6031 | |
SK-BR-3 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 981 | 384 | 5976 | 15063 | 375.2 | 139.04 | 87.22 | 138.43 | 122 | 252 | 332 | 379 | 411 | 436 | 459 | 488 | 529 | 0.0690 | 1040 | 1.006 | 89.27 | 27.02 | 6 | 0.0370 | 221 | 0.0008 | 30.99 | 7.402 | 0.2347 | 160087.0 | 72700000 | 34300000000 | 16600000000000 | 0.3898 | 0.2387 | 0.0000 | 0.0007 | 0.0017 | 0.0002 | 0.0067 | 0.0009 | 0.0168 | 0.0037 | 0.0750 | 0.0273 | 0.1215 | 0.0375 | 0.1056 | 0.0371 | 0.1567 | 0.0526 | 0.5159 | 0.8400 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0010 | 0.0162 | 0.0143 | 0.0270 | 0.0202 | 0.0191 | 0.0149 | 0.0299 | 0.0212 | 0.9067 | 0.9283 | 0.0010 | 0.0079 | 0.0044 | 0.0111 | 0.0092 | 0.0142 | 0.0247 | 0.0190 | 0.0499 | 0.0774 | 0.0727 | 0.0900 | 0.0751 | 0.0979 | 0.0931 | 0.1327 | 0.6699 | 0.5498 | 0.0000 | 0.0000 | 0.0003 | 0.0047 | 0.0261 | 0.0387 | 0.0368 | 0.0506 | 0.8428 | 6 | 9 | 12 | 16 | 25 | 42 | 68 | 128 | 272 | 0.0676 | 12.92 | 4.513 | 0.5910 | 26768.0 | 12200000 | 6560000000 | 3860000000000 | 0.6432 | 0.1082 | 0.0291 | 0.0037 | 0.1315 | 0.0140 | 0.2008 | 0.0494 | 0.1526 | 0.1090 | 0.1345 | 0.1747 | 0.1305 | 0.1850 | 0.0723 | 0.1072 | 0.0773 | 0.1235 | 0.0713 | 0.2335 | 0.0004 | 0.0011 | 0.0020 | 0.0030 | 0.0027 | 0.0032 | 0.0162 | 0.0112 | 0.0605 | 0.0539 | 0.0900 | 0.0723 | 0.0693 | 0.0632 | 0.0924 | 0.0883 | 0.6664 | 0.7038 | 0.0017 | 0.0010 | 0.0017 | 0.0041 | 0.0049 | 0.0073 | 0.0171 | 0.0188 | 0.0713 | 0.0786 | 0.0991 | 0.0958 | 0.0739 | 0.0856 | 0.1026 | 0.1117 | 0.6275 | 0.5969 | 0.0016 | 0.0028 | 0.0041 | 0.0173 | 0.0693 | 0.0929 | 0.0745 | 0.0962 | 0.6412 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 170 | 550 | 8750 | 8424 | 502.4 | 87.96 | 41.36 | 73.23 | 382 | 421 | 449 | 477 | 504 | 533 | 561 | 587 | 616 | 0.0991 | 835 | 0.776 | 84.48 | 24.52 | 5 | 0.0277 | 242 | 0.0010 | 31.96 | 7.187 | 0.2170 | 260103.0 | 138000000 | 75400000000 | 41900000000000 | 0.4172 | 0.2234 | 0.0005 | 0.0000 | 0.0021 | 0.0000 | 0.0032 | 0.0000 | 0.0111 | 0.0005 | 0.0476 | 0.0114 | 0.0760 | 0.0187 | 0.0904 | 0.0131 | 0.1317 | 0.0244 | 0.6373 | 0.9319 | 0.0003 | 0.0000 | 0.0001 | 0.0000 | 0.0008 | 0.0000 | 0.0043 | 0.0005 | 0.0214 | 0.0113 | 0.0331 | 0.0183 | 0.0365 | 0.0119 | 0.0525 | 0.0214 | 0.8509 | 0.9367 | 0.0126 | 0.1000 | 0.0126 | 0.2000 | 0.0356 | 0.5000 | 0.0617 | 0.2000 | 0.1146 | 0.0000 | 0.1486 | 0.0000 | 0.1328 | 0.0000 | 0.1518 | 0.0000 | 0.3296 | 0.0000 | 0.0014 | 0.0023 | 0.0063 | 0.0160 | 0.0405 | 0.0657 | 0.0673 | 0.0822 | 0.7184 | 8 | 10 | 12 | 13 | 16 | 20 | 28 | 44 | 98 | 0.1584 | 2.61 | 3.052 | 0.7597 | 7073.0 | 2420000 | 1080000000 | 547000000000 | 0.6438 | 0.0750 | 0.0266 | 0.0119 | 0.0620 | 0.0252 | 0.1004 | 0.0365 | 0.1492 | 0.0697 | 0.1905 | 0.1048 | 0.1418 | 0.1287 | 0.1536 | 0.1301 | 0.0960 | 0.1858 | 0.0798 | 0.3072 | 0.0055 | 0.0063 | 0.0104 | 0.0116 | 0.0127 | 0.0137 | 0.0209 | 0.0256 | 0.0563 | 0.0460 | 0.0700 | 0.0674 | 0.0691 | 0.0593 | 0.1004 | 0.1092 | 0.6547 | 0.6608 | 0.0000 | 0.0045 | 0.0052 | 0.0037 | 0.0085 | 0.0082 | 0.0184 | 0.0231 | 0.0636 | 0.0723 | 0.0932 | 0.0835 | 0.0636 | 0.0776 | 0.1122 | 0.1148 | 0.6352 | 0.6122 | 0.0011 | 0.0038 | 0.0098 | 0.0235 | 0.0573 | 0.0742 | 0.0770 | 0.1070 | 0.6463 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 208 | 697 | 4527 | 6306 | 102.3 | 37.27 | 112.28 | 143.75 | 55 | 71 | 81 | 90 | 99 | 108 | 118 | 131 | 151 | 0.0815 | 514 | 0.356 | 141.55 | 33.02 | 1 | 0.1199 | 543 | 0.0021 | 18.08 | 6.438 | 0.2850 | 11862.3 | 1530000 | 217000000 | 33600000000 | 0.4631 | 0.1918 | 0.0025 | 0.0009 | 0.0066 | 0.0006 | 0.0244 | 0.0036 | 0.0533 | 0.0097 | 0.1102 | 0.0425 | 0.1554 | 0.0857 | 0.1640 | 0.0808 | 0.1971 | 0.1227 | 0.2864 | 0.6534 | 0.0000 | 0.0005 | 0.0003 | 0.0003 | 0.0054 | 0.0021 | 0.0123 | 0.0049 | 0.0377 | 0.0210 | 0.0595 | 0.0395 | 0.0687 | 0.0333 | 0.1013 | 0.0546 | 0.7149 | 0.8438 | 0.0025 | 0.0115 | 0.0025 | 0.0263 | 0.0193 | 0.0197 | 0.0495 | 0.0609 | 0.1050 | 0.1184 | 0.1310 | 0.1760 | 0.1125 | 0.1250 | 0.1453 | 0.1612 | 0.4324 | 0.3010 | 0.0009 | 0.0033 | 0.0127 | 0.0216 | 0.0701 | 0.1040 | 0.0861 | 0.1092 | 0.5920 | 15 | 19 | 25 | 33 | 49 | 75 | 115 | 180 | 306 | 0.0287 | 20.58 | 5.086 | 0.4862 | 33266.2 | 15000000 | 8150000000 | 4970000000000 | 0.6440 | 0.0881 | 0.0377 | 0.0048 | 0.1319 | 0.0168 | 0.1852 | 0.0743 | 0.1397 | 0.1086 | 0.1570 | 0.1829 | 0.1287 | 0.1589 | 0.0958 | 0.1238 | 0.0628 | 0.1286 | 0.0612 | 0.2013 | 0.0013 | 0.0007 | 0.0027 | 0.0015 | 0.0080 | 0.0067 | 0.0212 | 0.0176 | 0.0734 | 0.0639 | 0.1008 | 0.1002 | 0.0787 | 0.0740 | 0.1084 | 0.1073 | 0.6055 | 0.6279 | 0.0018 | 0.0028 | 0.0025 | 0.0035 | 0.0135 | 0.0063 | 0.0308 | 0.0232 | 0.0776 | 0.0752 | 0.1145 | 0.1308 | 0.0844 | 0.0893 | 0.1041 | 0.1069 | 0.5708 | 0.5619 | 0.0016 | 0.0057 | 0.0109 | 0.0274 | 0.0677 | 0.1117 | 0.0858 | 0.1101 | 0.5791 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 407 | 716 | 7114 | 12770 | 534.1 | 94.65 | 61.96 | 146.06 | 380 | 451 | 508 | 534 | 555 | 577 | 594 | 611 | 633 | 0.0662 | 846 | 0.850 | 97.59 | 26.25 | 2 | 0.0417 | 297 | 0.0011 | 32.30 | 7.208 | 0.2276 | 294243.0 | 166000000 | 95600000000 | 55900000000000 | 0.4540 | 0.2027 | 0.0002 | 0.0001 | 0.0009 | 0.0006 | 0.0015 | 0.0003 | 0.0052 | 0.0017 | 0.0232 | 0.0121 | 0.0462 | 0.0176 | 0.0420 | 0.0150 | 0.0641 | 0.0232 | 0.8167 | 0.9294 | 0.0002 | 0.0001 | 0.0003 | 0.0006 | 0.0002 | 0.0003 | 0.0007 | 0.0017 | 0.0128 | 0.0121 | 0.0245 | 0.0176 | 0.0130 | 0.0150 | 0.0239 | 0.0232 | 0.9245 | 0.9294 | 0.0121 | 0.0000 | 0.0208 | 0.0000 | 0.0363 | 0.0000 | 0.0813 | 0.0000 | 0.1142 | 0.0000 | 0.1280 | 0.0000 | 0.1090 | 0.0000 | 0.1228 | 0.0000 | 0.3754 | 0.0000 | 0.0005 | 0.0014 | 0.0054 | 0.0119 | 0.0261 | 0.0428 | 0.0447 | 0.0612 | 0.8061 | 9 | 10 | 11 | 12 | 13 | 15 | 17 | 33 | 165 | 0.1905 | 3.26 | 2.362 | 0.6175 | 25171.9 | 16600000 | 13100000000 | 11600000000000 | 0.6507 | 0.0699 | 0.0193 | 0.0057 | 0.1322 | 0.0086 | 0.2204 | 0.0743 | 0.1736 | 0.1329 | 0.1267 | 0.2157 | 0.0909 | 0.1571 | 0.0716 | 0.0929 | 0.0661 | 0.1114 | 0.0992 | 0.2014 | 0.0000 | 0.0008 | 0.0009 | 0.0008 | 0.0031 | 0.0028 | 0.0098 | 0.0102 | 0.0459 | 0.0468 | 0.0570 | 0.0533 | 0.0459 | 0.0403 | 0.0731 | 0.0744 | 0.7643 | 0.7706 | 0.0011 | 0.0006 | 0.0021 | 0.0017 | 0.0069 | 0.0040 | 0.0133 | 0.0108 | 0.0436 | 0.0483 | 0.0760 | 0.0802 | 0.0452 | 0.0495 | 0.0803 | 0.0870 | 0.7315 | 0.7180 | 0.0005 | 0.0019 | 0.0048 | 0.0150 | 0.0446 | 0.0650 | 0.0509 | 0.0805 | 0.7368 | |
BT-20 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 937 | 413 | 5991 | 6903 | 259.1 | 63.26 | 108.57 | 152.78 | 186 | 207 | 223 | 238 | 250 | 265 | 282 | 304 | 342 | 0.1114 | 769 | 0.943 | 112.29 | 28.65 | 1 | 0.0444 | 266 | 0.0008 | 62.88 | 7.417 | 0.1517 | 71152.1 | 20700000 | 6420000000 | 2110000000000 | 0.4321 | 0.2113 | 0.0005 | 0.0000 | 0.0011 | 0.0002 | 0.0030 | 0.0004 | 0.0169 | 0.0024 | 0.0651 | 0.0200 | 0.1350 | 0.0503 | 0.1430 | 0.0444 | 0.1793 | 0.0657 | 0.4560 | 0.8167 | 0.0002 | 0.0000 | 0.0008 | 0.0000 | 0.0017 | 0.0002 | 0.0065 | 0.0010 | 0.0301 | 0.0128 | 0.0639 | 0.0298 | 0.0612 | 0.0204 | 0.0850 | 0.0356 | 0.7507 | 0.9002 | 0.0047 | 0.0024 | 0.0084 | 0.0095 | 0.0196 | 0.0261 | 0.0673 | 0.0760 | 0.1047 | 0.1283 | 0.1551 | 0.1995 | 0.1075 | 0.1045 | 0.1299 | 0.1330 | 0.4028 | 0.3207 | 0.0008 | 0.0015 | 0.0094 | 0.0297 | 0.0884 | 0.1290 | 0.1027 | 0.1354 | 0.5032 | 11 | 13 | 15 | 17 | 26 | 49 | 103 | 211 | 341 | 0.0743 | 21.34 | 4.592 | 0.5689 | 35125.6 | 15800000 | 8350000000 | 5000000000000 | 0.6509 | 0.0801 | 0.1317 | 0.0068 | 0.3103 | 0.0476 | 0.2351 | 0.1766 | 0.1505 | 0.1929 | 0.0909 | 0.1984 | 0.0313 | 0.1508 | 0.0313 | 0.0761 | 0.0094 | 0.0788 | 0.0094 | 0.0720 | 0.0023 | 0.0020 | 0.0014 | 0.0020 | 0.0045 | 0.0024 | 0.0136 | 0.0129 | 0.0573 | 0.0488 | 0.0741 | 0.0815 | 0.0605 | 0.0521 | 0.1137 | 0.1013 | 0.6726 | 0.6969 | 0.0005 | 0.0000 | 0.0000 | 0.0000 | 0.0027 | 0.0023 | 0.0138 | 0.0166 | 0.0585 | 0.0603 | 0.0973 | 0.1194 | 0.0713 | 0.0758 | 0.1176 | 0.1361 | 0.6383 | 0.5896 | 0.0005 | 0.0020 | 0.0030 | 0.0114 | 0.0530 | 0.0956 | 0.0624 | 0.1115 | 0.6606 | |
MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 632 | 107 | 5692 | 8449 | 461.3 | 114.59 | 81.65 | 147.06 | 324 | 362 | 391 | 418 | 445 | 473 | 513 | 563 | 630 | 0.0921 | 778 | 1.004 | 71.59 | 22.36 | 1 | 0.0293 | 167 | 0.0009 | 39.64 | 7.251 | 0.1882 | 225883.0 | 117000000 | 63800000000 | 36400000000000 | 0.4330 | 0.2108 | 0.0000 | 0.0000 | 0.0013 | 0.0000 | 0.0078 | 0.0014 | 0.0210 | 0.0041 | 0.0784 | 0.0255 | 0.1563 | 0.0518 | 0.1327 | 0.0450 | 0.1660 | 0.0713 | 0.4365 | 0.8009 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0023 | 0.0000 | 0.0074 | 0.0007 | 0.0379 | 0.0141 | 0.0737 | 0.0297 | 0.0602 | 0.0251 | 0.0848 | 0.0373 | 0.7332 | 0.8931 | 0.0048 | 0.0043 | 0.0072 | 0.0043 | 0.0096 | 0.0215 | 0.0377 | 0.0667 | 0.0786 | 0.1419 | 0.1195 | 0.1699 | 0.0898 | 0.1548 | 0.0922 | 0.1462 | 0.5605 | 0.2903 | 0.0020 | 0.0075 | 0.0110 | 0.0272 | 0.0745 | 0.0926 | 0.0764 | 0.1068 | 0.6020 | 6 | 8 | 9 | 11 | 14 | 23 | 53 | 116 | 264 | 0.1415 | 20.12 | 4.010 | 0.6235 | 28288.5 | 14800000 | 9450000000 | 6870000000000 | 0.6511 | 0.0624 | 0.0586 | 0.0033 | 0.1302 | 0.0308 | 0.2256 | 0.1156 | 0.1757 | 0.1344 | 0.1952 | 0.1817 | 0.1106 | 0.1762 | 0.0521 | 0.1443 | 0.0282 | 0.1112 | 0.0239 | 0.1024 | 0.0009 | 0.0004 | 0.0035 | 0.0031 | 0.0035 | 0.0046 | 0.0173 | 0.0134 | 0.0658 | 0.0598 | 0.0879 | 0.0854 | 0.0602 | 0.0590 | 0.0974 | 0.0935 | 0.6635 | 0.6808 | 0.0016 | 0.0006 | 0.0005 | 0.0024 | 0.0043 | 0.0024 | 0.0173 | 0.0182 | 0.0758 | 0.0740 | 0.0963 | 0.1099 | 0.0568 | 0.0558 | 0.1034 | 0.1128 | 0.6439 | 0.6240 | 0.0014 | 0.0029 | 0.0043 | 0.0193 | 0.0696 | 0.0904 | 0.0541 | 0.1087 | 0.6491 | |||
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 125 | 887 | 914 | 10249 | 57.4 | 40.69 | 232.85 | 304.99 | 28 | 31 | 33 | 35 | 38 | 42 | 56 | 82 | 127 | 0.0631 | 647 | 1.229 | 27.66 | 9.43 | 1 | 0.0722 | 66 | 0.0076 | 22.99 | 5.445 | 0.3165 | 4951.9 | 588247 | 83100000 | 12800000000 | 0.3258 | 0.3035 | 0.0088 | 0.0152 | 0.0000 | 0.0127 | 0.0531 | 0.0482 | 0.1239 | 0.0736 | 0.3451 | 0.1624 | 0.2832 | 0.1574 | 0.1416 | 0.1650 | 0.0354 | 0.1421 | 0.0088 | 0.2234 | 0.0000 | 0.0103 | 0.0000 | 0.0086 | 0.0091 | 0.0325 | 0.0151 | 0.0462 | 0.0393 | 0.0856 | 0.0665 | 0.0805 | 0.0665 | 0.0702 | 0.0634 | 0.0771 | 0.7402 | 0.5890 | 0.0000 | 0.0053 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0046 | 0.0211 | 0.0826 | 0.0842 | 0.0872 | 0.0579 | 0.0459 | 0.0737 | 0.1101 | 0.0895 | 0.6697 | 0.6684 | 0.0000 | 0.0000 | 0.0037 | 0.0297 | 0.0409 | 0.0632 | 0.0743 | 0.0706 | 0.7175 | 22 | 26 | 32 | 50 | 83 | 141 | 256 | 424 | 686 | 0.0356 | 29.95 | 5.321 | 0.4926 | 147227.0 | 131000000 | 137000000000 | 161000000000000 | 0.6516 | 0.0660 | 0.0697 | 0.0026 | 0.1780 | 0.0222 | 0.2107 | 0.0941 | 0.1395 | 0.1359 | 0.1543 | 0.1737 | 0.1157 | 0.1966 | 0.0772 | 0.1261 | 0.0356 | 0.1261 | 0.0193 | 0.1228 | 0.0008 | 0.0002 | 0.0011 | 0.0012 | 0.0025 | 0.0051 | 0.0195 | 0.0177 | 0.0641 | 0.0572 | 0.0786 | 0.0824 | 0.0675 | 0.0545 | 0.0853 | 0.0863 | 0.6804 | 0.6953 | 0.0010 | 0.0015 | 0.0031 | 0.0035 | 0.0062 | 0.0073 | 0.0244 | 0.0289 | 0.0714 | 0.0763 | 0.0975 | 0.0960 | 0.0752 | 0.0867 | 0.0962 | 0.1044 | 0.6250 | 0.5954 | 0.0006 | 0.0012 | 0.0046 | 0.0178 | 0.0705 | 0.0911 | 0.0644 | 0.0929 | 0.6569 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 919 | 900 | 2948 | 8244 | 666.3 | 129.72 | 46.17 | 98.68 | 485 | 545 | 590 | 628 | 667 | 705 | 744 | 787 | 840 | 0.0761 | 627 | 1.113 | 69.64 | 24.02 | 1 | 0.0580 | 171 | 0.0007 | 51.40 | 7.349 | 0.1601 | 460748.0 | 329000000 | 243000000000 | 184000000000000 | 0.3935 | 0.2423 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0016 | 0.0000 | 0.0110 | 0.0014 | 0.0460 | 0.0183 | 0.0826 | 0.0341 | 0.0727 | 0.0251 | 0.1130 | 0.0389 | 0.6715 | 0.8822 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0000 | 0.0000 | 0.0041 | 0.0007 | 0.0202 | 0.0156 | 0.0326 | 0.0302 | 0.0223 | 0.0156 | 0.0396 | 0.0282 | 0.8808 | 0.9097 | 0.0019 | 0.0000 | 0.0039 | 0.0476 | 0.0273 | 0.0476 | 0.0253 | 0.1905 | 0.0916 | 0.2857 | 0.1443 | 0.1190 | 0.1033 | 0.2381 | 0.1618 | 0.0714 | 0.4405 | 0.0000 | 0.0007 | 0.0007 | 0.0027 | 0.0115 | 0.0392 | 0.0635 | 0.0581 | 0.0878 | 0.7360 | 9 | 11 | 12 | 14 | 16 | 21 | 28 | 43 | 87 | 0.1378 | 4.69 | 3.060 | 0.7458 | 11867.4 | 6550000 | 4590000000 | 3630000000000 | 0.6519 | 0.0809 | 0.0058 | 0.0114 | 0.0378 | 0.0178 | 0.0683 | 0.0242 | 0.1541 | 0.0604 | 0.1788 | 0.0768 | 0.1788 | 0.1230 | 0.1541 | 0.1393 | 0.1424 | 0.1628 | 0.0799 | 0.3845 | 0.0010 | 0.0064 | 0.0066 | 0.0092 | 0.0082 | 0.0104 | 0.0255 | 0.0249 | 0.0541 | 0.0385 | 0.0745 | 0.0686 | 0.0760 | 0.0735 | 0.1102 | 0.0951 | 0.6439 | 0.6732 | 0.0008 | 0.0018 | 0.0063 | 0.0055 | 0.0181 | 0.0101 | 0.0291 | 0.0194 | 0.0708 | 0.0738 | 0.0904 | 0.1042 | 0.0818 | 0.0821 | 0.1344 | 0.1245 | 0.5684 | 0.5784 | 0.0032 | 0.0051 | 0.0154 | 0.0199 | 0.0656 | 0.0836 | 0.0855 | 0.1215 | 0.6000 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 701 | 856 | 7996 | 17307 | 193.6 | 58.72 | 164.59 | 174.51 | 125 | 142 | 158 | 171 | 186 | 201 | 219 | 242 | 276 | 0.0699 | 1209 | 0.390 | 189.19 | 52.01 | 6 | 0.0969 | 775 | 0.0004 | 115.49 | 7.998 | 0.1188 | 40941.8 | 9380000 | 2310000000 | 607000000000 | 0.4229 | 0.2241 | 0.0005 | 0.0000 | 0.0018 | 0.0002 | 0.0094 | 0.0009 | 0.0411 | 0.0074 | 0.1168 | 0.0344 | 0.1900 | 0.0791 | 0.1790 | 0.0803 | 0.1954 | 0.1104 | 0.2659 | 0.6873 | 0.0003 | 0.0000 | 0.0010 | 0.0001 | 0.0019 | 0.0003 | 0.0127 | 0.0035 | 0.0368 | 0.0179 | 0.0736 | 0.0397 | 0.0694 | 0.0336 | 0.0989 | 0.0501 | 0.7053 | 0.8549 | 0.0011 | 0.0022 | 0.0058 | 0.0101 | 0.0132 | 0.0348 | 0.0529 | 0.0886 | 0.1242 | 0.1502 | 0.1564 | 0.1973 | 0.1036 | 0.1424 | 0.1416 | 0.1323 | 0.4012 | 0.2422 | 0.0011 | 0.0014 | 0.0067 | 0.0338 | 0.0799 | 0.1053 | 0.1028 | 0.1274 | 0.5416 | 12 | 17 | 27 | 57 | 103 | 156 | 220 | 301 | 416 | 0.0341 | 36.46 | 5.746 | 0.4218 | 57539.3 | 27000000 | 15300000000 | 10100000000000 | 0.6571 | 0.0586 | 0.0542 | 0.0031 | 0.1783 | 0.0167 | 0.2744 | 0.0940 | 0.1826 | 0.1421 | 0.1310 | 0.1851 | 0.0908 | 0.1972 | 0.0521 | 0.1171 | 0.0258 | 0.1158 | 0.0107 | 0.1290 | 0.0001 | 0.0001 | 0.0009 | 0.0003 | 0.0035 | 0.0017 | 0.0141 | 0.0100 | 0.0637 | 0.0508 | 0.1127 | 0.0947 | 0.0879 | 0.0669 | 0.1267 | 0.1070 | 0.5903 | 0.6684 | 0.0002 | 0.0012 | 0.0024 | 0.0030 | 0.0050 | 0.0089 | 0.0260 | 0.0344 | 0.0869 | 0.1000 | 0.1472 | 0.1606 | 0.1046 | 0.1172 | 0.1475 | 0.1538 | 0.4802 | 0.4209 | 0.0006 | 0.0016 | 0.0037 | 0.0192 | 0.0754 | 0.1313 | 0.0961 | 0.1295 | 0.5426 | |
MCF7 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 735 | 406 | 428 | 1601 | 77.0 | 10.85 | 11.27 | 14.00 | 65 | 67 | 70 | 72 | 75 | 77 | 82 | 86 | 93 | 0.1643 | 263 | 0.708 | 113.88 | 25.02 | 1 | 0.6636 | 284 | 0.0441 | 1.02 | 3.411 | 0.6516 | 6040.7 | 483894 | 39600000 | 3310000000 | 0.3996 | 0.2382 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0024 | 0.0053 | 0.0024 | 0.0718 | 0.0447 | 0.1011 | 0.0753 | 0.0638 | 0.0400 | 0.1277 | 0.0918 | 0.6303 | 0.7435 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0023 | 0.0047 | 0.0023 | 0.0498 | 0.0444 | 0.0687 | 0.0724 | 0.0332 | 0.0304 | 0.0782 | 0.0748 | 0.7654 | 0.7734 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0435 | 1.0000 | 0.0217 | 0.0000 | 0.1739 | 0.0000 | 0.1304 | 0.0000 | 0.1304 | 0.0000 | 0.1522 | 0.0000 | 0.3478 | 0.0000 | 0.0053 | 0.0000 | 0.0105 | 0.0474 | 0.0579 | 0.1000 | 0.0947 | 0.1263 | 0.5579 | 5 | 6 | 7 | 7 | 8 | 9 | 10 | 12 | 15 | 0.6009 | 2.10 | 1.178 | 0.8849 | 322.9 | 27681.3 | 3820000 | 619000000 | 0.6572 | 0.0788 | 0.0682 | 0.0020 | 0.1326 | 0.0188 | 0.1111 | 0.0683 | 0.1189 | 0.0960 | 0.1598 | 0.1317 | 0.1774 | 0.1545 | 0.1365 | 0.1535 | 0.0741 | 0.1723 | 0.0214 | 0.2030 | 0.0477 | 0.0017 | 0.0846 | 0.0145 | 0.0682 | 0.0513 | 0.0628 | 0.0803 | 0.1010 | 0.1103 | 0.1173 | 0.1350 | 0.1119 | 0.1325 | 0.1364 | 0.1556 | 0.2701 | 0.3188 | 0.0591 | 0.0313 | 0.0727 | 0.0313 | 0.0364 | 0.0313 | 0.0591 | 0.0625 | 0.0773 | 0.1188 | 0.1545 | 0.1688 | 0.1364 | 0.1813 | 0.1909 | 0.2125 | 0.2136 | 0.1625 | 0.0592 | 0.0547 | 0.0661 | 0.0957 | 0.1207 | 0.1276 | 0.1116 | 0.1344 | 0.2301 | |
MDA-MB-231 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1197 | 683 | 3842 | 9565 | 478.9 | 116.21 | 90.11 | 172.80 | 337 | 392 | 429 | 457 | 482 | 506 | 537 | 577 | 631 | 0.0859 | 822 | 0.710 | 156.82 | 38.91 | 4 | 0.1221 | 469 | 0.0007 | 53.66 | 7.428 | 0.1677 | 242853.0 | 129000000 | 70500000000 | 39900000000000 | 0.4854 | 0.1685 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0025 | 0.0003 | 0.0110 | 0.0026 | 0.0591 | 0.0372 | 0.0922 | 0.0507 | 0.0761 | 0.0389 | 0.1016 | 0.0595 | 0.6575 | 0.8108 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0048 | 0.0008 | 0.0315 | 0.0304 | 0.0481 | 0.0395 | 0.0344 | 0.0268 | 0.0452 | 0.0392 | 0.8356 | 0.8633 | 0.0025 | 0.0000 | 0.0076 | 0.0000 | 0.0051 | 0.0000 | 0.0242 | 0.0000 | 0.0509 | 0.0000 | 0.0738 | 0.0000 | 0.0725 | 0.0000 | 0.0725 | 0.0000 | 0.6908 | 0.0000 | 0.0010 | 0.0020 | 0.0061 | 0.0137 | 0.0461 | 0.0587 | 0.0613 | 0.0886 | 0.7225 | 9 | 11 | 13 | 14 | 17 | 22 | 47 | 128 | 270 | 0.1570 | 5.23 | 3.104 | 0.6201 | 37975.0 | 27200000 | 25100000000 | 27100000000000 | 0.6578 | 0.0700 | 0.0976 | 0.0024 | 0.2415 | 0.0468 | 0.2512 | 0.1909 | 0.0976 | 0.1741 | 0.1146 | 0.1801 | 0.0951 | 0.1381 | 0.0439 | 0.1092 | 0.0390 | 0.0708 | 0.0195 | 0.0876 | 0.0004 | 0.0000 | 0.0004 | 0.0011 | 0.0039 | 0.0036 | 0.0162 | 0.0184 | 0.0774 | 0.0640 | 0.1086 | 0.1081 | 0.0632 | 0.0669 | 0.0968 | 0.0872 | 0.6331 | 0.6506 | 0.0000 | 0.0005 | 0.0024 | 0.0041 | 0.0042 | 0.0057 | 0.0264 | 0.0316 | 0.0792 | 0.0756 | 0.1216 | 0.1366 | 0.0726 | 0.0694 | 0.0975 | 0.1009 | 0.5961 | 0.5756 | 0.0000 | 0.0022 | 0.0047 | 0.0186 | 0.0768 | 0.1195 | 0.0673 | 0.0928 | 0.6182 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 95 | 131 | 989 | 1640 | 89.4 | 13.84 | 29.47 | 62.84 | 71 | 77 | 82 | 85 | 89 | 93 | 96 | 101 | 107 | 0.2116 | 347 | 0.177 | 169.76 | 32.53 | 2 | 0.8817 | 872 | 0.0651 | 1.08 | 3.063 | 0.6829 | 8181.5 | 766522 | 73500000 | 7210000000 | 0.3997 | 0.2450 | 0.0013 | 0.0000 | 0.0025 | 0.0000 | 0.0063 | 0.0000 | 0.0304 | 0.0061 | 0.0608 | 0.0348 | 0.0989 | 0.0583 | 0.1343 | 0.0409 | 0.1926 | 0.0502 | 0.4728 | 0.8096 | 0.0011 | 0.0000 | 0.0011 | 0.0000 | 0.0022 | 0.0000 | 0.0169 | 0.0051 | 0.0371 | 0.0293 | 0.0573 | 0.0526 | 0.0629 | 0.0303 | 0.0843 | 0.0415 | 0.7371 | 0.8413 | 0.0594 | 0.0000 | 0.1089 | 0.3333 | 0.1188 | 0.2500 | 0.1485 | 0.2500 | 0.1485 | 0.0833 | 0.1782 | 0.0833 | 0.0594 | 0.0000 | 0.0792 | 0.0000 | 0.0990 | 0.0000 | 0.0019 | 0.0077 | 0.0232 | 0.0522 | 0.0754 | 0.1006 | 0.1528 | 0.2147 | 0.3714 | 8 | 10 | 12 | 13 | 15 | 17 | 20 | 26 | 43 | 0.3370 | 1.57 | 1.900 | 0.7940 | 4815.1 | 2160000 | 1340000000 | 961000000000 | 0.6590 | 0.0663 | 0.0476 | 0.0571 | 0.1429 | 0.0571 | 0.1905 | 0.0813 | 0.2434 | 0.1099 | 0.2487 | 0.1429 | 0.0794 | 0.1868 | 0.0476 | 0.1890 | 0.0000 | 0.1341 | 0.0000 | 0.0418 | 0.0128 | 0.0413 | 0.0434 | 0.0366 | 0.0561 | 0.0461 | 0.0918 | 0.0636 | 0.1429 | 0.0986 | 0.1709 | 0.1574 | 0.1301 | 0.1558 | 0.1071 | 0.1558 | 0.2449 | 0.2448 | 0.0246 | 0.0057 | 0.0148 | 0.0230 | 0.0296 | 0.0345 | 0.0788 | 0.0575 | 0.1478 | 0.1609 | 0.1773 | 0.2126 | 0.1281 | 0.1149 | 0.1232 | 0.1437 | 0.2759 | 0.2471 | 0.0223 | 0.0335 | 0.0520 | 0.0632 | 0.1561 | 0.1710 | 0.1227 | 0.1190 | 0.2602 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 751 | 267 | 3996 | 13985 | 152.2 | 33.85 | 141.01 | 145.07 | 113 | 124 | 133 | 140 | 148 | 155 | 165 | 178 | 196 | 0.0633 | 885 | 1.001 | 83.55 | 24.08 | 2 | 0.0488 | 195 | 0.0021 | 21.13 | 6.445 | 0.2487 | 24325.1 | 4090000 | 723000000 | 135000000000 | 0.4071 | 0.2421 | 0.0004 | 0.0000 | 0.0008 | 0.0000 | 0.0046 | 0.0000 | 0.0217 | 0.0008 | 0.0685 | 0.0210 | 0.1371 | 0.0445 | 0.1470 | 0.0450 | 0.1702 | 0.0623 | 0.4497 | 0.8264 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0072 | 0.0003 | 0.0302 | 0.0141 | 0.0688 | 0.0303 | 0.0676 | 0.0197 | 0.0894 | 0.0351 | 0.7352 | 0.9005 | 0.0015 | 0.0049 | 0.0160 | 0.0099 | 0.0248 | 0.0049 | 0.0758 | 0.1626 | 0.1487 | 0.1576 | 0.1662 | 0.1921 | 0.1122 | 0.1379 | 0.1327 | 0.1281 | 0.3222 | 0.2020 | 0.0033 | 0.0044 | 0.0116 | 0.0311 | 0.0843 | 0.1337 | 0.0943 | 0.1281 | 0.5092 | 19 | 33 | 50 | 68 | 90 | 118 | 157 | 223 | 339 | 0.0069 | 33.28 | 6.213 | 0.3970 | 40926.9 | 17700000 | 9520000000 | 5890000000000 | 0.6594 | 0.0769 | 0.0120 | 0.0022 | 0.0718 | 0.0095 | 0.1486 | 0.0217 | 0.1626 | 0.0638 | 0.1950 | 0.1371 | 0.1406 | 0.1875 | 0.1077 | 0.1501 | 0.0803 | 0.1521 | 0.0813 | 0.2760 | 0.0019 | 0.0005 | 0.0029 | 0.0029 | 0.0075 | 0.0052 | 0.0196 | 0.0142 | 0.0618 | 0.0479 | 0.0945 | 0.0817 | 0.0723 | 0.0641 | 0.1133 | 0.0906 | 0.6263 | 0.6929 | 0.0008 | 0.0003 | 0.0044 | 0.0049 | 0.0072 | 0.0097 | 0.0294 | 0.0346 | 0.0744 | 0.0822 | 0.1224 | 0.1275 | 0.0945 | 0.1005 | 0.1237 | 0.1287 | 0.5430 | 0.5117 | 0.0017 | 0.0042 | 0.0089 | 0.0256 | 0.0701 | 0.1033 | 0.0830 | 0.1114 | 0.5917 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1055 | 344 | 487 | 5051 | 49.0 | 12.36 | 116.43 | 167.87 | 32 | 38 | 43 | 46 | 49 | 52 | 55 | 59 | 65 | 0.0810 | 409 | 1.242 | 45.35 | 19.21 | 2 | 0.2485 | 121 | 0.0057 | 11.72 | 5.356 | 0.3095 | 2555.8 | 140162 | 8020000 | 475000000 | 0.4385 | 0.1798 | 0.0000 | 0.0000 | 0.0075 | 0.0000 | 0.0522 | 0.0000 | 0.1045 | 0.0189 | 0.1604 | 0.0731 | 0.1604 | 0.0967 | 0.1642 | 0.1250 | 0.1604 | 0.1627 | 0.1903 | 0.5236 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0027 | 0.0000 | 0.0293 | 0.0177 | 0.0745 | 0.0576 | 0.0931 | 0.0665 | 0.1356 | 0.0687 | 0.1330 | 0.1020 | 0.5319 | 0.6874 | 0.0093 | 0.0370 | 0.0278 | 0.1111 | 0.0185 | 0.1481 | 0.1574 | 0.1852 | 0.1296 | 0.2222 | 0.2130 | 0.1481 | 0.1481 | 0.1111 | 0.1389 | 0.0000 | 0.1574 | 0.0370 | 0.0000 | 0.0000 | 0.0038 | 0.0651 | 0.1149 | 0.1609 | 0.1686 | 0.1801 | 0.3065 | 21 | 24 | 27 | 33 | 48 | 74 | 108 | 161 | 274 | 0.0561 | 13.35 | 4.308 | 0.5688 | 41728.7 | 26200000 | 21000000000 | 19200000000000 | 0.6628 | 0.0772 | 0.0483 | 0.0009 | 0.1324 | 0.0250 | 0.1843 | 0.1026 | 0.1395 | 0.1100 | 0.1467 | 0.1590 | 0.1521 | 0.1654 | 0.0912 | 0.1451 | 0.0644 | 0.1146 | 0.0411 | 0.1774 | 0.0000 | 0.0000 | 0.0012 | 0.0014 | 0.0035 | 0.0029 | 0.0260 | 0.0211 | 0.0860 | 0.0694 | 0.1166 | 0.0991 | 0.0912 | 0.0804 | 0.1396 | 0.1197 | 0.5361 | 0.6060 | 0.0009 | 0.0000 | 0.0043 | 0.0050 | 0.0068 | 0.0099 | 0.0324 | 0.0417 | 0.1107 | 0.1202 | 0.1388 | 0.1400 | 0.0894 | 0.1043 | 0.1516 | 0.1589 | 0.4651 | 0.4201 | 0.0014 | 0.0007 | 0.0085 | 0.0318 | 0.1108 | 0.1200 | 0.0924 | 0.1623 | 0.4721 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 386 | 707 | 13530 | 19255 | 474.1 | 126.99 | 20.39 | 53.21 | 304 | 394 | 439 | 470 | 494 | 519 | 545 | 573 | 609 | 0.0718 | 1383 | 0.981 | 73.41 | 26.31 | 10 | 0.0152 | 205 | 0.0008 | 44.28 | 7.548 | 0.2080 | 240855.0 | 127000000 | 69400000000 | 38700000000000 | 0.5339 | 0.1308 | 0.0006 | 0.0000 | 0.0010 | 0.0001 | 0.0043 | 0.0006 | 0.0142 | 0.0018 | 0.0585 | 0.0189 | 0.1017 | 0.0371 | 0.0863 | 0.0264 | 0.1091 | 0.0426 | 0.6244 | 0.8725 | 0.0001 | 0.0000 | 0.0002 | 0.0001 | 0.0001 | 0.0000 | 0.0015 | 0.0008 | 0.0170 | 0.0145 | 0.0361 | 0.0292 | 0.0214 | 0.0147 | 0.0347 | 0.0225 | 0.8889 | 0.9183 | 0.0031 | 0.0204 | 0.0058 | 0.0051 | 0.0170 | 0.0636 | 0.0458 | 0.1018 | 0.1021 | 0.1552 | 0.1378 | 0.1578 | 0.1116 | 0.1603 | 0.1412 | 0.1425 | 0.4357 | 0.1934 | 0.0001 | 0.0006 | 0.0021 | 0.0108 | 0.0390 | 0.0782 | 0.0620 | 0.0866 | 0.7204 | 6 | 7 | 8 | 9 | 10 | 11 | 13 | 16 | 31 | 0.4315 | 1.39 | 1.784 | 0.8626 | 3247.0 | 1790000 | 1370000000 | 1200000000000 | 0.6652 | 0.0672 | 0.0808 | 0.0848 | 0.0820 | 0.0869 | 0.1165 | 0.0731 | 0.1440 | 0.0714 | 0.1647 | 0.0831 | 0.1540 | 0.1070 | 0.1277 | 0.1051 | 0.0977 | 0.1288 | 0.0326 | 0.2598 | 0.0277 | 0.0558 | 0.0224 | 0.0571 | 0.0301 | 0.0465 | 0.0388 | 0.0399 | 0.0653 | 0.0505 | 0.0774 | 0.0737 | 0.0629 | 0.0667 | 0.0863 | 0.0911 | 0.5891 | 0.5187 | 0.0078 | 0.0032 | 0.0078 | 0.0050 | 0.0078 | 0.0140 | 0.0168 | 0.0235 | 0.0588 | 0.0587 | 0.0748 | 0.0898 | 0.0643 | 0.0700 | 0.1019 | 0.1020 | 0.6599 | 0.6339 | 0.0183 | 0.0157 | 0.0223 | 0.0265 | 0.0465 | 0.0750 | 0.0550 | 0.0917 | 0.6490 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 193 | 840 | 364 | 9991 | 79.4 | 12.33 | 120.69 | 125.11 | 64 | 69 | 71 | 74 | 78 | 82 | 86 | 91 | 97 | 0.0656 | 655 | 0.892 | 100.23 | 30.02 | 0 | 0.7033 | 256 | 0.0097 | 8.20 | 4.818 | 0.3329 | 6458.0 | 537560 | 45800000 | 3980000000 | 0.4026 | 0.2222 | 0.0000 | 0.0000 | 0.0248 | 0.0028 | 0.0106 | 0.0055 | 0.0496 | 0.0138 | 0.1028 | 0.0608 | 0.1950 | 0.1326 | 0.1915 | 0.0856 | 0.2340 | 0.1105 | 0.1915 | 0.5884 | 0.0000 | 0.0000 | 0.0210 | 0.0027 | 0.0060 | 0.0055 | 0.0330 | 0.0137 | 0.0571 | 0.0604 | 0.1171 | 0.1319 | 0.0781 | 0.0742 | 0.1171 | 0.0934 | 0.5706 | 0.6181 | 0.0196 | 0.0000 | 0.0980 | 1.0000 | 0.0392 | 0.0000 | 0.2549 | 0.0000 | 0.1765 | 0.0000 | 0.2157 | 0.0000 | 0.0980 | 0.0000 | 0.0980 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0229 | 0.0571 | 0.0400 | 0.0971 | 0.1371 | 0.1371 | 0.1771 | 0.3314 | 24 | 37 | 47 | 57 | 70 | 90 | 126 | 190 | 293 | 0.0082 | 25.67 | 5.863 | 0.4219 | 30214.6 | 11500000 | 5470000000 | 2990000000000 | 0.6670 | 0.0790 | 0.0168 | 0.0063 | 0.0841 | 0.0145 | 0.1639 | 0.0396 | 0.1869 | 0.0903 | 0.1913 | 0.1538 | 0.1665 | 0.1778 | 0.0939 | 0.1436 | 0.0709 | 0.1429 | 0.0257 | 0.2312 | 0.0013 | 0.0029 | 0.0042 | 0.0050 | 0.0088 | 0.0091 | 0.0255 | 0.0213 | 0.0682 | 0.0615 | 0.1043 | 0.0886 | 0.0823 | 0.0797 | 0.1139 | 0.1042 | 0.5915 | 0.6276 | 0.0008 | 0.0009 | 0.0049 | 0.0070 | 0.0167 | 0.0127 | 0.0318 | 0.0417 | 0.0864 | 0.0961 | 0.1262 | 0.1298 | 0.0936 | 0.1039 | 0.1259 | 0.1373 | 0.5136 | 0.4706 | 0.0016 | 0.0055 | 0.0109 | 0.0257 | 0.0792 | 0.1136 | 0.0911 | 0.1171 | 0.5553 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 525 | 784 | 306 | 3162 | 64.0 | 11.66 | 117.65 | 178.73 | 49 | 52 | 58 | 61 | 64 | 67 | 70 | 74 | 79 | 0.1395 | 441 | 1.153 | 68.73 | 23.77 | 1 | 0.5556 | 170 | 0.0077 | 10.17 | 5.047 | 0.3110 | 4226.0 | 287862 | 20200000 | 1450000000 | 0.4562 | 0.1761 | 0.0000 | 0.0000 | 0.0147 | 0.0033 | 0.0196 | 0.0000 | 0.0686 | 0.0133 | 0.1520 | 0.0365 | 0.1765 | 0.1794 | 0.1520 | 0.0332 | 0.1912 | 0.1296 | 0.2255 | 0.6047 | 0.0000 | 0.0000 | 0.0118 | 0.0033 | 0.0039 | 0.0000 | 0.0433 | 0.0131 | 0.0630 | 0.0359 | 0.1299 | 0.1634 | 0.0591 | 0.0327 | 0.1378 | 0.0882 | 0.5512 | 0.6634 | 0.0400 | 0.0000 | 0.0000 | 0.0000 | 0.0800 | 0.0000 | 0.0600 | 0.8000 | 0.2200 | 0.2000 | 0.2000 | 0.0000 | 0.1400 | 0.0000 | 0.1400 | 0.0000 | 0.1200 | 0.0000 | 0.0062 | 0.0124 | 0.0248 | 0.0559 | 0.1242 | 0.0994 | 0.1242 | 0.1180 | 0.4348 | 11 | 12 | 13 | 15 | 18 | 44 | 106 | 220 | 400 | 0.1851 | 37.34 | 4.002 | 0.6018 | 45776.0 | 25200000 | 16900000000 | 13200000000000 | 0.6720 | 0.0567 | 0.1282 | 0.0081 | 0.1949 | 0.0782 | 0.2513 | 0.1240 | 0.1179 | 0.1563 | 0.1128 | 0.1725 | 0.0667 | 0.1590 | 0.0359 | 0.0755 | 0.0359 | 0.0916 | 0.0564 | 0.1348 | 0.0010 | 0.0000 | 0.0010 | 0.0009 | 0.0040 | 0.0027 | 0.0210 | 0.0153 | 0.0791 | 0.0694 | 0.1351 | 0.1127 | 0.1011 | 0.0902 | 0.1592 | 0.1461 | 0.4985 | 0.5627 | 0.0000 | 0.0000 | 0.0012 | 0.0014 | 0.0012 | 0.0054 | 0.0348 | 0.0312 | 0.1057 | 0.1098 | 0.1480 | 0.1707 | 0.1294 | 0.1328 | 0.1654 | 0.1667 | 0.4142 | 0.3821 | 0.0011 | 0.0000 | 0.0033 | 0.0255 | 0.0909 | 0.1408 | 0.1098 | 0.1663 | 0.4623 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1160 | 141 | 3233 | 11358 | 59.9 | 15.14 | 124.51 | 201.52 | 40 | 47 | 52 | 56 | 59 | 63 | 68 | 73 | 80 | 0.0812 | 922 | 1.116 | 66.27 | 24.02 | 8 | 0.0520 | 168 | 0.0039 | 9.71 | 5.841 | 0.3283 | 3816.7 | 256199 | 18000000 | 1310000000 | 0.4210 | 0.2075 | 0.0016 | 0.0007 | 0.0121 | 0.0007 | 0.0236 | 0.0021 | 0.0356 | 0.0084 | 0.0773 | 0.0453 | 0.1135 | 0.0541 | 0.1321 | 0.0699 | 0.1908 | 0.1173 | 0.4134 | 0.7015 | 0.0000 | 0.0000 | 0.0043 | 0.0000 | 0.0058 | 0.0007 | 0.0136 | 0.0046 | 0.0342 | 0.0320 | 0.0427 | 0.0346 | 0.0497 | 0.0369 | 0.0730 | 0.0515 | 0.7767 | 0.8398 | 0.0133 | 0.0415 | 0.0146 | 0.0553 | 0.0320 | 0.0968 | 0.0626 | 0.0829 | 0.0786 | 0.1613 | 0.1012 | 0.1705 | 0.1318 | 0.1475 | 0.1491 | 0.1521 | 0.4168 | 0.0922 | 0.0063 | 0.0101 | 0.0184 | 0.0380 | 0.0582 | 0.0671 | 0.0880 | 0.1063 | 0.6076 | 16 | 20 | 23 | 28 | 42 | 71 | 118 | 184 | 325 | 0.0815 | 10.02 | 4.228 | 0.6192 | 56109.0 | 50800000 | 64300000000 | 94700000000000 | 0.6731 | 0.0824 | 0.0382 | 0.0025 | 0.1393 | 0.0177 | 0.1670 | 0.0809 | 0.1460 | 0.1089 | 0.1651 | 0.1648 | 0.1431 | 0.1712 | 0.1002 | 0.1344 | 0.0716 | 0.1363 | 0.0296 | 0.1834 | 0.0000 | 0.0004 | 0.0018 | 0.0020 | 0.0063 | 0.0029 | 0.0266 | 0.0186 | 0.0673 | 0.0669 | 0.0986 | 0.0822 | 0.0819 | 0.0716 | 0.1122 | 0.1042 | 0.6054 | 0.6512 | 0.0004 | 0.0029 | 0.0043 | 0.0062 | 0.0093 | 0.0083 | 0.0377 | 0.0360 | 0.0890 | 0.0989 | 0.1328 | 0.1320 | 0.0800 | 0.0757 | 0.1120 | 0.1105 | 0.5345 | 0.5294 | 0.0012 | 0.0027 | 0.0067 | 0.0307 | 0.0828 | 0.1186 | 0.0791 | 0.1205 | 0.5577 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1223 | 452 | 6155 | 9803 | 128.7 | 28.06 | 148.51 | 137.13 | 95 | 105 | 112 | 119 | 126 | 133 | 141 | 152 | 166 | 0.0870 | 853 | 0.535 | 195.17 | 41.62 | 2 | 0.0980 | 603 | 0.0012 | 37.11 | 6.972 | 0.1989 | 17339.8 | 2450000 | 361000000 | 55800000000 | 0.4378 | 0.2119 | 0.0003 | 0.0000 | 0.0015 | 0.0000 | 0.0054 | 0.0000 | 0.0219 | 0.0026 | 0.0706 | 0.0184 | 0.1443 | 0.0426 | 0.1512 | 0.0447 | 0.1856 | 0.0693 | 0.4192 | 0.8224 | 0.0002 | 0.0000 | 0.0008 | 0.0000 | 0.0022 | 0.0000 | 0.0078 | 0.0007 | 0.0301 | 0.0139 | 0.0603 | 0.0269 | 0.0630 | 0.0203 | 0.0920 | 0.0328 | 0.7436 | 0.9054 | 0.0055 | 0.0231 | 0.0156 | 0.0423 | 0.0294 | 0.1000 | 0.0725 | 0.1577 | 0.1330 | 0.1577 | 0.1982 | 0.1731 | 0.1330 | 0.1269 | 0.1450 | 0.0885 | 0.2679 | 0.1308 | 0.0021 | 0.0067 | 0.0102 | 0.0376 | 0.0709 | 0.1254 | 0.1180 | 0.1394 | 0.4898 | 14 | 24 | 55 | 81 | 109 | 144 | 187 | 247 | 346 | 0.0183 | 16.97 | 5.620 | 0.4458 | 40857.3 | 15200000 | 6830000000 | 3500000000000 | 0.6750 | 0.0565 | 0.0233 | 0.0013 | 0.1047 | 0.0122 | 0.2115 | 0.0411 | 0.1937 | 0.0746 | 0.1814 | 0.1677 | 0.1513 | 0.1982 | 0.0767 | 0.1700 | 0.0431 | 0.1519 | 0.0144 | 0.1831 | 0.0004 | 0.0005 | 0.0002 | 0.0013 | 0.0026 | 0.0023 | 0.0199 | 0.0116 | 0.0656 | 0.0497 | 0.1179 | 0.0886 | 0.0905 | 0.0744 | 0.1297 | 0.1150 | 0.5731 | 0.6565 | 0.0000 | 0.0012 | 0.0016 | 0.0051 | 0.0090 | 0.0086 | 0.0347 | 0.0451 | 0.1006 | 0.1221 | 0.1546 | 0.1495 | 0.1060 | 0.1197 | 0.1375 | 0.1436 | 0.4560 | 0.4050 | 0.0003 | 0.0016 | 0.0047 | 0.0229 | 0.0938 | 0.1286 | 0.0967 | 0.1442 | 0.5071 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 566 | 807 | 4751 | 7725 | 404.9 | 192.17 | 127.70 | 196.98 | 142 | 186 | 268 | 341 | 396 | 464 | 540 | 611 | 670 | 0.1111 | 858 | 1.078 | 54.04 | 18.87 | 1 | 0.0280 | 133 | 0.0027 | 8.16 | 6.352 | 0.3795 | 200834.0 | 112000000 | 66500000000 | 41200000000000 | 0.3420 | 0.2744 | 0.0000 | 0.0005 | 0.0008 | 0.0005 | 0.0016 | 0.0005 | 0.0219 | 0.0064 | 0.0926 | 0.0401 | 0.1300 | 0.0724 | 0.1024 | 0.0519 | 0.1446 | 0.0738 | 0.5061 | 0.7540 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0033 | 0.0003 | 0.0189 | 0.0153 | 0.0314 | 0.0269 | 0.0245 | 0.0136 | 0.0453 | 0.0266 | 0.8762 | 0.9173 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0011 | 0.0008 | 0.0050 | 0.0111 | 0.0296 | 0.0325 | 0.0369 | 0.0507 | 0.0335 | 0.0428 | 0.0464 | 0.0642 | 0.8475 | 0.7971 | 0.0000 | 0.0004 | 0.0000 | 0.0104 | 0.0265 | 0.0370 | 0.0313 | 0.0487 | 0.8456 | 7 | 9 | 11 | 16 | 28 | 63 | 121 | 222 | 412 | 0.0706 | 13.58 | 4.145 | 0.5200 | 55103.2 | 34600000 | 26500000000 | 23100000000000 | 0.6752 | 0.0630 | 0.0314 | 0.0009 | 0.1458 | 0.0204 | 0.2288 | 0.0814 | 0.1513 | 0.1230 | 0.1439 | 0.1748 | 0.1328 | 0.1832 | 0.0627 | 0.1221 | 0.0424 | 0.1240 | 0.0609 | 0.1702 | 0.0008 | 0.0000 | 0.0008 | 0.0003 | 0.0020 | 0.0007 | 0.0106 | 0.0115 | 0.0701 | 0.0687 | 0.1133 | 0.0965 | 0.0830 | 0.0767 | 0.1251 | 0.1154 | 0.5943 | 0.6302 | 0.0015 | 0.0000 | 0.0035 | 0.0028 | 0.0095 | 0.0084 | 0.0160 | 0.0302 | 0.0845 | 0.0878 | 0.1191 | 0.1270 | 0.1046 | 0.1079 | 0.1251 | 0.1208 | 0.5363 | 0.5151 | 0.0000 | 0.0013 | 0.0013 | 0.0191 | 0.0756 | 0.1250 | 0.0894 | 0.1299 | 0.5583 |