High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 443 | 181 | 15600 | 34303 | 188.2 | 54.70 | 154.95 | 208.03 | 119 | 143 | 160 | 175 | 188 | 201 | 216 | 233 | 258 | 0.0475 | 1631 | 1.299 | 27.66 | 11.00 | 2 | 0.0046 | 72 | 0.0004 | 108.38 | 8.177 | 0.1198 | 38397.0 | 8360000 | 1930000000 | 466000000000 | 0.4679 | 0.1823 | 0.0004 | 0.0001 | 0.0026 | 0.0001 | 0.0097 | 0.0012 | 0.0358 | 0.0053 | 0.0933 | 0.0269 | 0.1554 | 0.0528 | 0.1646 | 0.0630 | 0.1873 | 0.0910 | 0.3510 | 0.7598 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0023 | 0.0002 | 0.0099 | 0.0029 | 0.0301 | 0.0153 | 0.0539 | 0.0244 | 0.0604 | 0.0263 | 0.0836 | 0.0395 | 0.7594 | 0.8915 | 0.0043 | 0.0083 | 0.0062 | 0.0113 | 0.0231 | 0.0354 | 0.0593 | 0.1032 | 0.1094 | 0.1620 | 0.1512 | 0.1809 | 0.1215 | 0.1281 | 0.1357 | 0.1326 | 0.3894 | 0.2381 | 0.0015 | 0.0030 | 0.0071 | 0.0246 | 0.0622 | 0.0965 | 0.0932 | 0.1282 | 0.5835 | 16 | 20 | 27 | 40 | 62 | 106 | 174 | 266 | 412 | 0.0628 | 20.08 | 4.869 | 0.5440 | 67285.9 | 49100000 | 50400000000 | 64700000000000 | 0.4173 | 0.2427 | 0.0913 | 0.0020 | 0.2477 | 0.0254 | 0.3084 | 0.1572 | 0.1589 | 0.1986 | 0.0885 | 0.2038 | 0.0561 | 0.1589 | 0.0310 | 0.1065 | 0.0129 | 0.0838 | 0.0052 | 0.0638 | 0.0002 | 0.0001 | 0.0005 | 0.0000 | 0.0017 | 0.0015 | 0.0143 | 0.0116 | 0.0709 | 0.0573 | 0.1133 | 0.0932 | 0.0852 | 0.0701 | 0.1288 | 0.1064 | 0.5851 | 0.6598 | 0.0006 | 0.0005 | 0.0015 | 0.0023 | 0.0063 | 0.0108 | 0.0215 | 0.0289 | 0.0926 | 0.1079 | 0.1548 | 0.1646 | 0.1067 | 0.1186 | 0.1497 | 0.1513 | 0.4664 | 0.4151 | 0.0004 | 0.0008 | 0.0032 | 0.0197 | 0.0800 | 0.1330 | 0.1011 | 0.1397 | 0.5221 | |
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 699 | 471 | 4304 | 9250 | 675.2 | 100.28 | 112.63 | 227.13 | 526 | 609 | 656 | 678 | 694 | 707 | 722 | 740 | 781 | 0.0782 | 723 | 1.058 | 105.04 | 31.11 | 1 | 0.0602 | 259 | 0.0017 | 29.52 | 6.816 | 0.2429 | 465980.0 | 327000000 | 234000000000 | 169000000000000 | 0.4313 | 0.2103 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0028 | 0.0000 | 0.0204 | 0.0139 | 0.0353 | 0.0238 | 0.0311 | 0.0120 | 0.0487 | 0.0205 | 0.8609 | 0.9297 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0149 | 0.0139 | 0.0259 | 0.0238 | 0.0191 | 0.0120 | 0.0254 | 0.0205 | 0.9130 | 0.9297 | 0.0082 | 0.0000 | 0.0163 | 0.0000 | 0.0245 | 0.0000 | 0.0367 | 0.0000 | 0.0816 | 0.0000 | 0.0857 | 0.0000 | 0.0816 | 0.0000 | 0.1143 | 0.0000 | 0.5510 | 0.0000 | 0.0004 | 0.0015 | 0.0038 | 0.0128 | 0.0342 | 0.0556 | 0.0680 | 0.0992 | 0.7244 | 8 | 10 | 12 | 14 | 17 | 26 | 59 | 148 | 341 | 0.1976 | 21.25 | 3.579 | 0.6813 | 64269.9 | 61100000 | 74500000000 | 106000000000000 | 0.4869 | 0.1485 | 0.0430 | 0.0000 | 0.1471 | 0.0171 | 0.1991 | 0.0910 | 0.1222 | 0.1229 | 0.1357 | 0.1456 | 0.1154 | 0.1581 | 0.1086 | 0.1229 | 0.0633 | 0.1024 | 0.0656 | 0.2400 | 0.0000 | 0.0000 | 0.0008 | 0.0004 | 0.0013 | 0.0011 | 0.0109 | 0.0094 | 0.0419 | 0.0410 | 0.0747 | 0.0556 | 0.0516 | 0.0402 | 0.0763 | 0.0676 | 0.7425 | 0.7847 | 0.0000 | 0.0006 | 0.0010 | 0.0022 | 0.0031 | 0.0028 | 0.0175 | 0.0185 | 0.0577 | 0.0612 | 0.0911 | 0.1021 | 0.0695 | 0.0606 | 0.0901 | 0.0948 | 0.6699 | 0.6571 | 0.0000 | 0.0009 | 0.0032 | 0.0125 | 0.0529 | 0.0779 | 0.0682 | 0.0904 | 0.6939 | |||
MCF7 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 318 | 872 | 12186 | 25790 | 350.1 | 84.35 | 180.74 | 231.33 | 250 | 278 | 300 | 319 | 340 | 362 | 386 | 419 | 463 | 0.0459 | 1185 | 1.241 | 90.52 | 37.58 | 1 | 0.0197 | 240 | 0.0006 | 79.84 | 7.705 | 0.1428 | 129698.0 | 50800000 | 21000000000 | 9160000000000 | 0.4637 | 0.1985 | 0.0008 | 0.0000 | 0.0050 | 0.0002 | 0.0093 | 0.0019 | 0.0269 | 0.0039 | 0.0810 | 0.0184 | 0.1487 | 0.0417 | 0.1625 | 0.0489 | 0.1712 | 0.0732 | 0.3947 | 0.8118 | 0.0001 | 0.0000 | 0.0006 | 0.0000 | 0.0020 | 0.0001 | 0.0091 | 0.0003 | 0.0330 | 0.0101 | 0.0662 | 0.0219 | 0.0745 | 0.0199 | 0.0941 | 0.0344 | 0.7203 | 0.9133 | 0.0050 | 0.0088 | 0.0083 | 0.0113 | 0.0190 | 0.0479 | 0.0690 | 0.1614 | 0.1467 | 0.1589 | 0.1789 | 0.2320 | 0.1149 | 0.1236 | 0.1471 | 0.1097 | 0.3112 | 0.1463 | 0.0009 | 0.0031 | 0.0086 | 0.0355 | 0.0810 | 0.1311 | 0.1118 | 0.1336 | 0.4943 | 10 | 15 | 25 | 45 | 80 | 130 | 204 | 324 | 514 | 0.0440 | 29.42 | 5.543 | 0.4890 | 86176.2 | 59000000 | 49700000000 | 48200000000000 | 0.4861 | 0.1546 | 0.0520 | 0.0023 | 0.1701 | 0.0129 | 0.2665 | 0.0966 | 0.1459 | 0.1378 | 0.1201 | 0.1935 | 0.1172 | 0.1886 | 0.0605 | 0.1155 | 0.0372 | 0.1007 | 0.0305 | 0.1521 | 0.0003 | 0.0004 | 0.0012 | 0.0006 | 0.0023 | 0.0023 | 0.0133 | 0.0093 | 0.0591 | 0.0486 | 0.0997 | 0.0816 | 0.0694 | 0.0558 | 0.1037 | 0.0915 | 0.6512 | 0.7099 | 0.0005 | 0.0003 | 0.0007 | 0.0026 | 0.0046 | 0.0032 | 0.0156 | 0.0218 | 0.0784 | 0.0855 | 0.1293 | 0.1333 | 0.0752 | 0.0852 | 0.1163 | 0.1277 | 0.5793 | 0.5404 | 0.0006 | 0.0014 | 0.0033 | 0.0161 | 0.0656 | 0.1205 | 0.0715 | 0.1126 | 0.6084 | |
MCF 10A | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 525 | 784 | 306 | 3162 | 64.0 | 11.66 | 117.65 | 178.73 | 49 | 52 | 58 | 61 | 64 | 67 | 70 | 74 | 79 | 0.1395 | 441 | 1.153 | 68.73 | 23.77 | 1 | 0.5556 | 170 | 0.0077 | 10.17 | 5.047 | 0.3110 | 4226.0 | 287862 | 20200000 | 1450000000 | 0.4562 | 0.1761 | 0.0000 | 0.0000 | 0.0147 | 0.0033 | 0.0196 | 0.0000 | 0.0686 | 0.0133 | 0.1520 | 0.0365 | 0.1765 | 0.1794 | 0.1520 | 0.0332 | 0.1912 | 0.1296 | 0.2255 | 0.6047 | 0.0000 | 0.0000 | 0.0118 | 0.0033 | 0.0039 | 0.0000 | 0.0433 | 0.0131 | 0.0630 | 0.0359 | 0.1299 | 0.1634 | 0.0591 | 0.0327 | 0.1378 | 0.0882 | 0.5512 | 0.6634 | 0.0400 | 0.0000 | 0.0000 | 0.0000 | 0.0800 | 0.0000 | 0.0600 | 0.8000 | 0.2200 | 0.2000 | 0.2000 | 0.0000 | 0.1400 | 0.0000 | 0.1400 | 0.0000 | 0.1200 | 0.0000 | 0.0062 | 0.0124 | 0.0248 | 0.0559 | 0.1242 | 0.0994 | 0.1242 | 0.1180 | 0.4348 | 11 | 12 | 13 | 15 | 18 | 44 | 106 | 220 | 400 | 0.1851 | 37.34 | 4.002 | 0.6018 | 45776.0 | 25200000 | 16900000000 | 13200000000000 | 0.6720 | 0.0567 | 0.1282 | 0.0081 | 0.1949 | 0.0782 | 0.2513 | 0.1240 | 0.1179 | 0.1563 | 0.1128 | 0.1725 | 0.0667 | 0.1590 | 0.0359 | 0.0755 | 0.0359 | 0.0916 | 0.0564 | 0.1348 | 0.0010 | 0.0000 | 0.0010 | 0.0009 | 0.0040 | 0.0027 | 0.0210 | 0.0153 | 0.0791 | 0.0694 | 0.1351 | 0.1127 | 0.1011 | 0.0902 | 0.1592 | 0.1461 | 0.4985 | 0.5627 | 0.0000 | 0.0000 | 0.0012 | 0.0014 | 0.0012 | 0.0054 | 0.0348 | 0.0312 | 0.1057 | 0.1098 | 0.1480 | 0.1707 | 0.1294 | 0.1328 | 0.1654 | 0.1667 | 0.4142 | 0.3821 | 0.0011 | 0.0000 | 0.0033 | 0.0255 | 0.0909 | 0.1408 | 0.1098 | 0.1663 | 0.4623 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 420 | 407 | 25302 | 42176 | 171.8 | 49.38 | 147.43 | 237.23 | 112 | 132 | 146 | 157 | 168 | 180 | 193 | 209 | 237 | 0.0462 | 1948 | 0.760 | 83.49 | 25.63 | 2 | 0.0098 | 247 | 0.0005 | 62.65 | 7.913 | 0.1534 | 31965.7 | 6390000 | 1360000000 | 309000000000 | 0.4638 | 0.1892 | 0.0006 | 0.0001 | 0.0017 | 0.0002 | 0.0040 | 0.0010 | 0.0225 | 0.0052 | 0.0688 | 0.0183 | 0.1379 | 0.0386 | 0.1421 | 0.0455 | 0.1734 | 0.0654 | 0.4489 | 0.8256 | 0.0003 | 0.0000 | 0.0009 | 0.0001 | 0.0012 | 0.0003 | 0.0082 | 0.0023 | 0.0254 | 0.0102 | 0.0549 | 0.0202 | 0.0570 | 0.0218 | 0.0776 | 0.0313 | 0.7745 | 0.9136 | 0.0031 | 0.0052 | 0.0063 | 0.0083 | 0.0203 | 0.0270 | 0.0520 | 0.0513 | 0.0941 | 0.0896 | 0.1249 | 0.1265 | 0.0922 | 0.0926 | 0.1087 | 0.1087 | 0.4984 | 0.4909 | 0.0012 | 0.0029 | 0.0075 | 0.0285 | 0.0609 | 0.0972 | 0.0953 | 0.1135 | 0.5931 | 15 | 18 | 20 | 25 | 35 | 63 | 116 | 226 | 460 | 0.1298 | 9.91 | 4.162 | 0.6635 | 78010.9 | 64000000 | 64700000000 | 75200000000000 | 0.5804 | 0.1109 | 0.0461 | 0.0048 | 0.1404 | 0.0150 | 0.1993 | 0.0735 | 0.1444 | 0.1068 | 0.1579 | 0.1632 | 0.1301 | 0.1918 | 0.0879 | 0.1258 | 0.0525 | 0.1221 | 0.0414 | 0.1970 | 0.0003 | 0.0004 | 0.0022 | 0.0006 | 0.0037 | 0.0016 | 0.0126 | 0.0129 | 0.0488 | 0.0445 | 0.0771 | 0.0675 | 0.0547 | 0.0498 | 0.0753 | 0.0744 | 0.7252 | 0.7484 | 0.0003 | 0.0004 | 0.0020 | 0.0030 | 0.0029 | 0.0043 | 0.0165 | 0.0197 | 0.0624 | 0.0647 | 0.0891 | 0.0998 | 0.0647 | 0.0673 | 0.0892 | 0.0949 | 0.6728 | 0.6458 | 0.0008 | 0.0012 | 0.0033 | 0.0140 | 0.0563 | 0.0848 | 0.0591 | 0.0848 | 0.6958 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1140 | 503 | 4025 | 13483 | 436.8 | 85.79 | 132.10 | 242.48 | 338 | 368 | 391 | 415 | 440 | 463 | 488 | 513 | 540 | 0.0518 | 698 | 1.105 | 49.03 | 18.38 | 2 | 0.0330 | 133 | 0.0012 | 33.18 | 6.972 | 0.2087 | 198109.0 | 92600000 | 44400000000 | 21800000000000 | 0.4526 | 0.1884 | 0.0007 | 0.0000 | 0.0014 | 0.0000 | 0.0035 | 0.0000 | 0.0139 | 0.0010 | 0.0522 | 0.0198 | 0.1099 | 0.0311 | 0.0967 | 0.0257 | 0.1398 | 0.0363 | 0.5819 | 0.8861 | 0.0006 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0037 | 0.0005 | 0.0267 | 0.0189 | 0.0517 | 0.0288 | 0.0402 | 0.0186 | 0.0577 | 0.0283 | 0.8190 | 0.9049 | 0.0050 | 0.0000 | 0.0033 | 0.0606 | 0.0429 | 0.1515 | 0.0759 | 0.2121 | 0.1188 | 0.1212 | 0.1914 | 0.2424 | 0.1452 | 0.1515 | 0.1551 | 0.0303 | 0.2624 | 0.0303 | 0.0005 | 0.0024 | 0.0058 | 0.0169 | 0.0551 | 0.0851 | 0.0807 | 0.1054 | 0.6481 | 6 | 7 | 9 | 10 | 14 | 25 | 74 | 196 | 483 | 0.1545 | 27.57 | 4.157 | 0.6237 | 76242.5 | 60100000 | 54300000000 | 53300000000000 | 0.5764 | 0.1021 | 0.0301 | 0.0017 | 0.1284 | 0.0108 | 0.1997 | 0.0687 | 0.1458 | 0.1026 | 0.1838 | 0.1745 | 0.1331 | 0.1977 | 0.0666 | 0.1266 | 0.0602 | 0.1290 | 0.0523 | 0.1886 | 0.0003 | 0.0000 | 0.0005 | 0.0008 | 0.0025 | 0.0013 | 0.0066 | 0.0078 | 0.0442 | 0.0373 | 0.0700 | 0.0607 | 0.0437 | 0.0396 | 0.0626 | 0.0595 | 0.7696 | 0.7931 | 0.0000 | 0.0014 | 0.0013 | 0.0014 | 0.0027 | 0.0036 | 0.0166 | 0.0159 | 0.0525 | 0.0587 | 0.0807 | 0.0844 | 0.0558 | 0.0543 | 0.0751 | 0.0736 | 0.7153 | 0.7065 | 0.0003 | 0.0012 | 0.0033 | 0.0100 | 0.0504 | 0.0697 | 0.0573 | 0.0733 | 0.7346 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 571 | 922 | 4617 | 8322 | 491.0 | 95.75 | 198.40 | 274.48 | 372 | 405 | 431 | 459 | 485 | 511 | 541 | 573 | 621 | 0.0908 | 756 | 1.217 | 121.30 | 48.70 | 1 | 0.0682 | 315 | 0.0006 | 68.44 | 7.576 | 0.1426 | 250279.0 | 132000000 | 72100000000 | 40600000000000 | 0.4178 | 0.2313 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0019 | 0.0002 | 0.0112 | 0.0025 | 0.0586 | 0.0169 | 0.1189 | 0.0373 | 0.1287 | 0.0263 | 0.1587 | 0.0443 | 0.5217 | 0.8725 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0008 | 0.0000 | 0.0064 | 0.0011 | 0.0309 | 0.0133 | 0.0554 | 0.0279 | 0.0492 | 0.0168 | 0.0717 | 0.0251 | 0.7855 | 0.9157 | 0.0040 | 0.0000 | 0.0081 | 0.0000 | 0.0256 | 0.0000 | 0.0823 | 0.0000 | 0.1107 | 0.0000 | 0.1741 | 0.0000 | 0.1039 | 0.0000 | 0.1323 | 0.0000 | 0.3590 | 0.0000 | 0.0005 | 0.0023 | 0.0059 | 0.0244 | 0.0765 | 0.1199 | 0.0851 | 0.1231 | 0.5624 | 15 | 20 | 25 | 38 | 68 | 118 | 188 | 348 | 633 | 0.0340 | 31.16 | 5.359 | 0.5201 | 114691.0 | 92700000 | 87100000000 | 90400000000000 | 0.3987 | 0.2243 | 0.0214 | 0.0007 | 0.1193 | 0.0152 | 0.2370 | 0.0550 | 0.1330 | 0.0774 | 0.1361 | 0.1527 | 0.1055 | 0.2069 | 0.0826 | 0.1122 | 0.0841 | 0.1165 | 0.0810 | 0.2634 | 0.0004 | 0.0003 | 0.0029 | 0.0015 | 0.0022 | 0.0021 | 0.0122 | 0.0114 | 0.0561 | 0.0418 | 0.0820 | 0.0749 | 0.0557 | 0.0523 | 0.0805 | 0.0737 | 0.7080 | 0.7419 | 0.0005 | 0.0000 | 0.0014 | 0.0010 | 0.0056 | 0.0031 | 0.0118 | 0.0118 | 0.0592 | 0.0536 | 0.0870 | 0.1050 | 0.0602 | 0.0551 | 0.0827 | 0.0881 | 0.6916 | 0.6823 | 0.0008 | 0.0017 | 0.0033 | 0.0124 | 0.0541 | 0.0880 | 0.0570 | 0.0843 | 0.6985 | |
Hs 578T | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 987 | 380 | 12791 | 25828 | 244.0 | 56.67 | 95.18 | 198.31 | 177 | 201 | 217 | 230 | 243 | 256 | 271 | 289 | 316 | 0.0428 | 1106 | 0.611 | 50.00 | 6.08 | 2 | 0.0081 | 104 | 0.0009 | 41.29 | 7.385 | 0.1837 | 62748.8 | 16900000 | 4720000000 | 1370000000000 | 0.4150 | 0.2225 | 0.0007 | 0.0000 | 0.0010 | 0.0000 | 0.0040 | 0.0001 | 0.0139 | 0.0020 | 0.0437 | 0.0128 | 0.0935 | 0.0267 | 0.1037 | 0.0271 | 0.1485 | 0.0436 | 0.5911 | 0.8877 | 0.0004 | 0.0000 | 0.0005 | 0.0000 | 0.0012 | 0.0000 | 0.0051 | 0.0007 | 0.0167 | 0.0075 | 0.0370 | 0.0142 | 0.0370 | 0.0105 | 0.0578 | 0.0186 | 0.8443 | 0.9484 | 0.0051 | 0.0074 | 0.0136 | 0.0297 | 0.0230 | 0.0408 | 0.0519 | 0.1169 | 0.0928 | 0.1447 | 0.1328 | 0.1855 | 0.0992 | 0.1039 | 0.1507 | 0.1169 | 0.4308 | 0.2542 | 0.0013 | 0.0041 | 0.0084 | 0.0209 | 0.0523 | 0.0900 | 0.0917 | 0.1156 | 0.6157 | 10 | 11 | 13 | 16 | 19 | 30 | 61 | 128 | 252 | 0.1445 | 34.06 | 4.024 | 0.6355 | 48384.8 | 50100000 | 70500000000 | 115000000000000 | 0.4211 | 0.2561 | 0.0753 | 0.0013 | 0.2507 | 0.0276 | 0.3011 | 0.1619 | 0.1172 | 0.1639 | 0.1051 | 0.2101 | 0.0717 | 0.1905 | 0.0362 | 0.0921 | 0.0291 | 0.0768 | 0.0135 | 0.0758 | 0.0001 | 0.0002 | 0.0003 | 0.0001 | 0.0021 | 0.0012 | 0.0147 | 0.0116 | 0.0679 | 0.0616 | 0.1162 | 0.1005 | 0.0657 | 0.0596 | 0.1024 | 0.0930 | 0.6306 | 0.6721 | 0.0002 | 0.0012 | 0.0012 | 0.0028 | 0.0041 | 0.0058 | 0.0225 | 0.0271 | 0.0797 | 0.0776 | 0.1234 | 0.1387 | 0.0808 | 0.0856 | 0.1154 | 0.1264 | 0.5727 | 0.5349 | 0.0002 | 0.0013 | 0.0034 | 0.0168 | 0.0750 | 0.1186 | 0.0738 | 0.1066 | 0.6045 | |||
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1249 | 769 | 4803 | 11247 | 502.2 | 83.00 | 67.05 | 122.38 | 382 | 431 | 463 | 488 | 508 | 528 | 552 | 579 | 608 | 0.0648 | 729 | 1.156 | 88.46 | 33.06 | 1 | 0.0477 | 229 | 0.0014 | 23.98 | 6.830 | 0.2358 | 259094.0 | 137000000 | 73800000000 | 40500000000000 | 0.4284 | 0.2133 | 0.0011 | 0.0000 | 0.0019 | 0.0000 | 0.0044 | 0.0000 | 0.0091 | 0.0002 | 0.0299 | 0.0136 | 0.0517 | 0.0206 | 0.0575 | 0.0124 | 0.0811 | 0.0183 | 0.7632 | 0.9350 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0000 | 0.0014 | 0.0002 | 0.0170 | 0.0136 | 0.0276 | 0.0206 | 0.0218 | 0.0124 | 0.0377 | 0.0183 | 0.8937 | 0.9350 | 0.0072 | 0.0000 | 0.0181 | 0.0000 | 0.0325 | 0.0000 | 0.0597 | 0.0000 | 0.0868 | 0.0000 | 0.1374 | 0.0000 | 0.1230 | 0.0000 | 0.1754 | 0.0000 | 0.3599 | 0.0000 | 0.0019 | 0.0016 | 0.0054 | 0.0140 | 0.0384 | 0.0594 | 0.0602 | 0.0889 | 0.7301 | 6 | 8 | 10 | 12 | 15 | 20 | 38 | 86 | 207 | 0.1665 | 6.51 | 3.350 | 0.6502 | 19470.7 | 8860000 | 4860000000 | 2970000000000 | 0.5816 | 0.0962 | 0.0324 | 0.0043 | 0.1477 | 0.0208 | 0.2216 | 0.0720 | 0.2090 | 0.1276 | 0.1658 | 0.1753 | 0.1189 | 0.1840 | 0.0613 | 0.1372 | 0.0216 | 0.1345 | 0.0216 | 0.1441 | 0.0007 | 0.0003 | 0.0010 | 0.0009 | 0.0034 | 0.0039 | 0.0172 | 0.0128 | 0.0540 | 0.0538 | 0.0890 | 0.0805 | 0.0639 | 0.0589 | 0.0907 | 0.0838 | 0.6801 | 0.7050 | 0.0000 | 0.0005 | 0.0013 | 0.0019 | 0.0030 | 0.0033 | 0.0166 | 0.0196 | 0.0675 | 0.0650 | 0.0968 | 0.1182 | 0.0739 | 0.0715 | 0.0994 | 0.1005 | 0.6416 | 0.6196 | 0.0004 | 0.0015 | 0.0034 | 0.0145 | 0.0574 | 0.1015 | 0.0624 | 0.0915 | 0.6673 | |||
MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 537 | 652 | 760 | 4733 | 183.3 | 48.14 | 141.14 | 250.71 | 130 | 142 | 153 | 163 | 173 | 188 | 202 | 222 | 250 | 0.1054 | 499 | 0.979 | 146.17 | 42.01 | 2 | 0.4618 | 351 | 0.0030 | 36.55 | 6.002 | 0.2222 | 35909.5 | 7530000 | 1680000000 | 400000000000 | 0.4861 | 0.1592 | 0.0000 | 0.0000 | 0.0097 | 0.0000 | 0.0652 | 0.0044 | 0.0966 | 0.0175 | 0.1473 | 0.0773 | 0.1546 | 0.0962 | 0.1812 | 0.0845 | 0.1594 | 0.0962 | 0.1860 | 0.6239 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0070 | 0.0000 | 0.0297 | 0.0054 | 0.0822 | 0.0549 | 0.1154 | 0.0776 | 0.1136 | 0.0415 | 0.1416 | 0.0776 | 0.5105 | 0.7430 | 0.0000 | 0.0000 | 0.0063 | 0.0000 | 0.0253 | 0.0328 | 0.0823 | 0.2131 | 0.2595 | 0.2295 | 0.1329 | 0.2131 | 0.1139 | 0.0984 | 0.1835 | 0.1311 | 0.1962 | 0.0820 | 0.0000 | 0.0000 | 0.0150 | 0.0300 | 0.1502 | 0.1922 | 0.0991 | 0.1381 | 0.3754 | 7 | 8 | 10 | 12 | 18 | 39 | 88 | 210 | 496 | 0.1437 | 25.58 | 4.029 | 0.5929 | 82762.0 | 66600000 | 60800000000 | 59600000000000 | 0.6762 | 0.0517 | 0.0645 | 0.0022 | 0.2719 | 0.0410 | 0.3548 | 0.1339 | 0.1475 | 0.2009 | 0.0876 | 0.2203 | 0.0553 | 0.1749 | 0.0138 | 0.1058 | 0.0046 | 0.0756 | 0.0000 | 0.0454 | 0.0008 | 0.0000 | 0.0000 | 0.0007 | 0.0008 | 0.0007 | 0.0094 | 0.0131 | 0.0602 | 0.0518 | 0.1063 | 0.0801 | 0.0493 | 0.0608 | 0.1009 | 0.0849 | 0.6724 | 0.7079 | 0.0000 | 0.0000 | 0.0019 | 0.0020 | 0.0028 | 0.0020 | 0.0104 | 0.0132 | 0.0669 | 0.0731 | 0.1121 | 0.1015 | 0.0574 | 0.0701 | 0.0989 | 0.1036 | 0.6497 | 0.6345 | 0.0000 | 0.0000 | 0.0034 | 0.0086 | 0.0738 | 0.0935 | 0.0626 | 0.0995 | 0.6587 | |
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 445 | 860 | 2608 | 8307 | 566.5 | 225.38 | 39.43 | 65.37 | 258 | 310 | 392 | 503 | 596 | 677 | 750 | 806 | 842 | 0.0768 | 638 | 0.880 | 77.20 | 20.00 | 3 | 0.0740 | 193 | 0.0009 | 51.94 | 7.257 | 0.1702 | 371659.0 | 266000000 | 199000000000 | 154000000000000 | 0.3620 | 0.2536 | 0.0000 | 0.0000 | 0.0000 | 0.0007 | 0.0062 | 0.0029 | 0.0123 | 0.0065 | 0.1200 | 0.0632 | 0.2369 | 0.1142 | 0.1323 | 0.0639 | 0.1477 | 0.1128 | 0.3446 | 0.6358 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0010 | 0.0012 | 0.0010 | 0.0244 | 0.0282 | 0.0463 | 0.0423 | 0.0220 | 0.0216 | 0.0404 | 0.0423 | 0.8657 | 0.8636 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0010 | 0.0034 | 0.0077 | 0.0151 | 0.0349 | 0.0689 | 0.0668 | 0.1109 | 0.0445 | 0.0723 | 0.0649 | 0.1008 | 0.7803 | 0.6269 | 0.0000 | 0.0000 | 0.0000 | 0.0021 | 0.0351 | 0.0537 | 0.0387 | 0.0530 | 0.8173 | 7 | 8 | 10 | 12 | 14 | 19 | 25 | 43 | 117 | 0.0947 | 6.43 | 3.634 | 0.6797 | 5827.2 | 1490000 | 484000000 | 182000000000 | 0.3887 | 0.2572 | 0.0457 | 0.0156 | 0.1087 | 0.0288 | 0.1130 | 0.0600 | 0.1478 | 0.1019 | 0.1870 | 0.1397 | 0.1565 | 0.1265 | 0.1326 | 0.1167 | 0.0913 | 0.1553 | 0.0174 | 0.2555 | 0.0059 | 0.0065 | 0.0054 | 0.0126 | 0.0049 | 0.0153 | 0.0178 | 0.0252 | 0.0425 | 0.0520 | 0.0623 | 0.0566 | 0.0440 | 0.0539 | 0.0667 | 0.0768 | 0.7505 | 0.7012 | 0.0019 | 0.0007 | 0.0051 | 0.0021 | 0.0064 | 0.0064 | 0.0230 | 0.0207 | 0.0499 | 0.0486 | 0.0671 | 0.0671 | 0.0486 | 0.0471 | 0.0633 | 0.0643 | 0.7347 | 0.7429 | 0.0011 | 0.0011 | 0.0034 | 0.0190 | 0.0514 | 0.0587 | 0.0509 | 0.0799 | 0.7345 | |
BT-20 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 465 | 620 | 9047 | 14449 | 390.5 | 71.92 | 168.72 | 172.88 | 299 | 329 | 350 | 370 | 388 | 407 | 428 | 452 | 486 | 0.0895 | 1293 | 1.076 | 123.98 | 51.35 | 1 | 0.0385 | 348 | 0.0005 | 92.93 | 7.898 | 0.1210 | 157668.0 | 65700000 | 28200000000 | 12400000000000 | 0.4145 | 0.2342 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0022 | 0.0002 | 0.0141 | 0.0007 | 0.0465 | 0.0115 | 0.1136 | 0.0295 | 0.1207 | 0.0268 | 0.1565 | 0.0404 | 0.5462 | 0.8909 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0010 | 0.0002 | 0.0046 | 0.0002 | 0.0237 | 0.0104 | 0.0542 | 0.0226 | 0.0542 | 0.0139 | 0.0680 | 0.0208 | 0.7940 | 0.9319 | 0.0116 | 0.0192 | 0.0085 | 0.0513 | 0.0263 | 0.1346 | 0.0819 | 0.1795 | 0.1560 | 0.2628 | 0.1745 | 0.1410 | 0.1228 | 0.0769 | 0.1475 | 0.1026 | 0.2710 | 0.0321 | 0.0007 | 0.0018 | 0.0052 | 0.0335 | 0.0767 | 0.1181 | 0.1018 | 0.1243 | 0.5379 | 18 | 23 | 34 | 60 | 103 | 161 | 227 | 307 | 422 | 0.0185 | 43.16 | 6.177 | 0.3683 | 58352.5 | 26900000 | 14800000000 | 9200000000000 | 0.6196 | 0.0820 | 0.0780 | 0.0010 | 0.2479 | 0.0209 | 0.2643 | 0.1364 | 0.1377 | 0.1919 | 0.1220 | 0.2022 | 0.0833 | 0.1816 | 0.0348 | 0.1065 | 0.0236 | 0.0841 | 0.0085 | 0.0754 | 0.0002 | 0.0003 | 0.0011 | 0.0008 | 0.0038 | 0.0025 | 0.0145 | 0.0128 | 0.0768 | 0.0638 | 0.1137 | 0.1016 | 0.0820 | 0.0741 | 0.1214 | 0.1071 | 0.5866 | 0.6370 | 0.0004 | 0.0005 | 0.0019 | 0.0034 | 0.0064 | 0.0118 | 0.0293 | 0.0359 | 0.0981 | 0.1148 | 0.1436 | 0.1489 | 0.0967 | 0.1052 | 0.1272 | 0.1358 | 0.4964 | 0.4437 | 0.0004 | 0.0018 | 0.0034 | 0.0211 | 0.0839 | 0.1343 | 0.0921 | 0.1248 | 0.5384 | |
BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 825 | 684 | 7651 | 20186 | 434.9 | 80.92 | 100.21 | 97.16 | 337 | 366 | 390 | 409 | 429 | 448 | 471 | 501 | 545 | 0.0502 | 1013 | 1.138 | 102.84 | 33.06 | 1 | 0.0322 | 246 | 0.0009 | 43.02 | 7.234 | 0.1788 | 195716.0 | 91000000 | 43700000000 | 21700000000000 | 0.4528 | 0.2044 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0013 | 0.0003 | 0.0109 | 0.0004 | 0.0464 | 0.0156 | 0.1085 | 0.0248 | 0.1193 | 0.0267 | 0.1502 | 0.0416 | 0.5632 | 0.8906 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0047 | 0.0004 | 0.0241 | 0.0132 | 0.0533 | 0.0176 | 0.0554 | 0.0141 | 0.0757 | 0.0217 | 0.7862 | 0.9330 | 0.0026 | 0.0221 | 0.0123 | 0.0608 | 0.0202 | 0.0663 | 0.0792 | 0.1381 | 0.1206 | 0.1547 | 0.1637 | 0.1381 | 0.1021 | 0.1105 | 0.1144 | 0.1050 | 0.3847 | 0.2044 | 0.0011 | 0.0050 | 0.0089 | 0.0319 | 0.0727 | 0.1248 | 0.1040 | 0.1262 | 0.5255 | 9 | 12 | 22 | 46 | 73 | 101 | 133 | 177 | 238 | 0.0261 | 11.79 | 5.435 | 0.4724 | 19482.1 | 5010000 | 1530000000 | 533000000000 | 0.4602 | 0.1900 | 0.0169 | 0.0009 | 0.0928 | 0.0052 | 0.1893 | 0.0424 | 0.1626 | 0.0894 | 0.1630 | 0.1492 | 0.1587 | 0.1861 | 0.0954 | 0.1402 | 0.0745 | 0.1464 | 0.0468 | 0.2402 | 0.0006 | 0.0001 | 0.0007 | 0.0006 | 0.0017 | 0.0015 | 0.0093 | 0.0072 | 0.0425 | 0.0340 | 0.0820 | 0.0612 | 0.0679 | 0.0521 | 0.0976 | 0.0811 | 0.6977 | 0.7621 | 0.0009 | 0.0007 | 0.0013 | 0.0023 | 0.0028 | 0.0042 | 0.0180 | 0.0214 | 0.0688 | 0.0820 | 0.1143 | 0.1324 | 0.0930 | 0.0958 | 0.1199 | 0.1291 | 0.5810 | 0.5321 | 0.0007 | 0.0011 | 0.0034 | 0.0138 | 0.0527 | 0.0963 | 0.0820 | 0.1141 | 0.6359 | |||
BT-20 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 1142 | 279 | 6081 | 12680 | 333.3 | 75.05 | 132.72 | 150.99 | 244 | 268 | 287 | 305 | 325 | 343 | 366 | 393 | 433 | 0.0758 | 961 | 1.101 | 113.36 | 37.12 | 1 | 0.0462 | 281 | 0.0013 | 26.51 | 6.910 | 0.2088 | 116744.0 | 43000000 | 16600000000 | 6710000000000 | 0.3801 | 0.2654 | 0.0005 | 0.0000 | 0.0021 | 0.0000 | 0.0042 | 0.0000 | 0.0168 | 0.0011 | 0.0633 | 0.0200 | 0.1116 | 0.0341 | 0.1355 | 0.0320 | 0.1721 | 0.0541 | 0.4938 | 0.8587 | 0.0004 | 0.0000 | 0.0010 | 0.0000 | 0.0020 | 0.0000 | 0.0071 | 0.0005 | 0.0310 | 0.0141 | 0.0482 | 0.0230 | 0.0586 | 0.0181 | 0.0796 | 0.0318 | 0.7721 | 0.9125 | 0.0037 | 0.0088 | 0.0119 | 0.0117 | 0.0165 | 0.0263 | 0.0567 | 0.0380 | 0.1033 | 0.1082 | 0.1435 | 0.1345 | 0.1060 | 0.0936 | 0.1389 | 0.1082 | 0.4196 | 0.4708 | 0.0018 | 0.0043 | 0.0093 | 0.0205 | 0.0751 | 0.1053 | 0.0830 | 0.1165 | 0.5841 | 10 | 15 | 26 | 48 | 77 | 111 | 158 | 228 | 346 | 0.0156 | 26.28 | 5.931 | 0.4048 | 40411.4 | 17400000 | 9060000000 | 5290000000000 | 0.5025 | 0.1413 | 0.0228 | 0.0017 | 0.0773 | 0.0063 | 0.1471 | 0.0370 | 0.1547 | 0.0783 | 0.1747 | 0.1540 | 0.1485 | 0.1778 | 0.1105 | 0.1249 | 0.0905 | 0.1378 | 0.0739 | 0.2822 | 0.0000 | 0.0006 | 0.0013 | 0.0013 | 0.0013 | 0.0021 | 0.0136 | 0.0091 | 0.0417 | 0.0414 | 0.0724 | 0.0662 | 0.0582 | 0.0462 | 0.0751 | 0.0721 | 0.7364 | 0.7610 | 0.0003 | 0.0006 | 0.0021 | 0.0031 | 0.0040 | 0.0037 | 0.0143 | 0.0131 | 0.0562 | 0.0601 | 0.0816 | 0.1055 | 0.0776 | 0.0812 | 0.1052 | 0.1173 | 0.6588 | 0.6153 | 0.0014 | 0.0020 | 0.0034 | 0.0108 | 0.0473 | 0.0756 | 0.0567 | 0.0882 | 0.7146 | |||
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 199 | 260 | 10686 | 24087 | 343.1 | 42.34 | 218.62 | 243.80 | 294 | 309 | 319 | 329 | 339 | 349 | 361 | 376 | 398 | 0.0560 | 1348 | 1.108 | 80.65 | 27.02 | 2 | 0.0188 | 201 | 0.0020 | 20.94 | 6.553 | 0.2495 | 119532.0 | 42300000 | 15200000000 | 5550000000000 | 0.4430 | 0.2105 | 0.0001 | 0.0000 | 0.0002 | 0.0000 | 0.0012 | 0.0000 | 0.0032 | 0.0005 | 0.0194 | 0.0089 | 0.0355 | 0.0176 | 0.0461 | 0.0113 | 0.0755 | 0.0211 | 0.8188 | 0.9407 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0015 | 0.0000 | 0.0114 | 0.0086 | 0.0212 | 0.0159 | 0.0232 | 0.0077 | 0.0352 | 0.0146 | 0.9074 | 0.9532 | 0.0199 | 0.0000 | 0.0385 | 0.0000 | 0.0442 | 0.0000 | 0.0855 | 0.0000 | 0.0954 | 0.0000 | 0.1311 | 0.0000 | 0.1197 | 0.0000 | 0.1211 | 0.0000 | 0.3447 | 0.0000 | 0.0047 | 0.0098 | 0.0155 | 0.0422 | 0.0674 | 0.0986 | 0.1131 | 0.1277 | 0.5211 | 18 | 23 | 29 | 46 | 110 | 198 | 297 | 422 | 589 | 0.0307 | 46.12 | 5.951 | 0.4302 | 107227.0 | 68300000 | 50200000000 | 40800000000000 | 0.5298 | 0.1259 | 0.0245 | 0.0018 | 0.1127 | 0.0149 | 0.2277 | 0.0610 | 0.1750 | 0.0972 | 0.1550 | 0.1809 | 0.1245 | 0.2068 | 0.0732 | 0.1277 | 0.0609 | 0.1204 | 0.0464 | 0.1894 | 0.0000 | 0.0000 | 0.0005 | 0.0002 | 0.0017 | 0.0016 | 0.0077 | 0.0073 | 0.0415 | 0.0338 | 0.0707 | 0.0588 | 0.0495 | 0.0417 | 0.0772 | 0.0625 | 0.7513 | 0.7941 | 0.0004 | 0.0004 | 0.0010 | 0.0016 | 0.0029 | 0.0041 | 0.0139 | 0.0205 | 0.0578 | 0.0653 | 0.0903 | 0.1105 | 0.0763 | 0.0890 | 0.1087 | 0.1110 | 0.6487 | 0.5975 | 0.0001 | 0.0011 | 0.0034 | 0.0105 | 0.0471 | 0.0826 | 0.0615 | 0.0887 | 0.7050 | |
SK-BR-3 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 406 | 653 | 9716 | 23603 | 431.9 | 88.96 | 349.44 | 405.84 | 326 | 380 | 406 | 425 | 442 | 459 | 475 | 495 | 525 | 0.0445 | 1051 | 1.155 | 114.98 | 44.01 | 1 | 0.0310 | 301 | 0.0009 | 57.02 | 7.395 | 0.1756 | 194415.0 | 90200000 | 42900000000 | 20900000000000 | 0.4256 | 0.2144 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0024 | 0.0002 | 0.0073 | 0.0009 | 0.0306 | 0.0101 | 0.0644 | 0.0220 | 0.0617 | 0.0172 | 0.1018 | 0.0289 | 0.7315 | 0.9207 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0001 | 0.0000 | 0.0014 | 0.0003 | 0.0115 | 0.0083 | 0.0248 | 0.0165 | 0.0200 | 0.0081 | 0.0331 | 0.0149 | 0.9091 | 0.9519 | 0.0122 | 0.0252 | 0.0157 | 0.0692 | 0.0332 | 0.0503 | 0.0752 | 0.1195 | 0.1461 | 0.2201 | 0.1785 | 0.1698 | 0.1400 | 0.0943 | 0.1417 | 0.1321 | 0.2572 | 0.1195 | 0.0002 | 0.0018 | 0.0031 | 0.0201 | 0.0458 | 0.0885 | 0.0915 | 0.1196 | 0.6294 | 11 | 15 | 26 | 74 | 177 | 311 | 477 | 692 | 979 | 0.0386 | 101.07 | 6.457 | 0.3962 | 286810.0 | 301000000 | 364000000000 | 491000000000000 | 0.5288 | 0.1335 | 0.0292 | 0.0023 | 0.1390 | 0.0075 | 0.2010 | 0.0674 | 0.1542 | 0.1168 | 0.1584 | 0.1632 | 0.1246 | 0.1791 | 0.0806 | 0.1344 | 0.0556 | 0.1290 | 0.0574 | 0.2002 | 0.0001 | 0.0001 | 0.0006 | 0.0003 | 0.0019 | 0.0007 | 0.0085 | 0.0046 | 0.0443 | 0.0358 | 0.0839 | 0.0706 | 0.0599 | 0.0519 | 0.0888 | 0.0796 | 0.7120 | 0.7564 | 0.0001 | 0.0003 | 0.0008 | 0.0014 | 0.0045 | 0.0043 | 0.0123 | 0.0170 | 0.0555 | 0.0621 | 0.1009 | 0.1122 | 0.0725 | 0.0814 | 0.1086 | 0.1185 | 0.6449 | 0.6027 | 0.0005 | 0.0014 | 0.0034 | 0.0121 | 0.0467 | 0.0905 | 0.0701 | 0.0917 | 0.6837 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 902 | 772 | 9805 | 18751 | 104.4 | 27.00 | 104.60 | 154.09 | 71 | 82 | 90 | 97 | 104 | 110 | 117 | 126 | 139 | 0.0633 | 1186 | 1.212 | 43.08 | 15.81 | 3 | 0.0114 | 112 | 0.0025 | 16.76 | 6.319 | 0.2683 | 11632.2 | 1370000 | 170000000 | 22000000000 | 0.4240 | 0.2204 | 0.0005 | 0.0000 | 0.0007 | 0.0000 | 0.0088 | 0.0007 | 0.0337 | 0.0037 | 0.0934 | 0.0179 | 0.1645 | 0.0465 | 0.1821 | 0.0638 | 0.1963 | 0.0903 | 0.3200 | 0.7770 | 0.0004 | 0.0000 | 0.0000 | 0.0000 | 0.0023 | 0.0001 | 0.0076 | 0.0017 | 0.0290 | 0.0096 | 0.0611 | 0.0214 | 0.0697 | 0.0191 | 0.0939 | 0.0324 | 0.7359 | 0.9158 | 0.0079 | 0.0174 | 0.0153 | 0.0349 | 0.0227 | 0.0654 | 0.0811 | 0.1497 | 0.1293 | 0.1715 | 0.1688 | 0.2035 | 0.1433 | 0.1206 | 0.1539 | 0.1206 | 0.2777 | 0.1163 | 0.0006 | 0.0026 | 0.0102 | 0.0307 | 0.0718 | 0.1201 | 0.1160 | 0.1498 | 0.4982 | 11 | 13 | 15 | 19 | 27 | 52 | 104 | 180 | 312 | 0.1458 | 19.88 | 4.207 | 0.6121 | 34684.3 | 18400000 | 13400000000 | 12900000000000 | 0.5548 | 0.1144 | 0.1016 | 0.0053 | 0.2744 | 0.0473 | 0.2848 | 0.2020 | 0.1392 | 0.1879 | 0.0992 | 0.2113 | 0.0544 | 0.1673 | 0.0200 | 0.0877 | 0.0168 | 0.0513 | 0.0096 | 0.0400 | 0.0003 | 0.0003 | 0.0008 | 0.0006 | 0.0014 | 0.0010 | 0.0124 | 0.0106 | 0.0714 | 0.0584 | 0.1103 | 0.0965 | 0.0716 | 0.0610 | 0.1148 | 0.1027 | 0.6169 | 0.6690 | 0.0000 | 0.0002 | 0.0014 | 0.0022 | 0.0034 | 0.0082 | 0.0241 | 0.0253 | 0.0928 | 0.1033 | 0.1418 | 0.1582 | 0.0932 | 0.1072 | 0.1495 | 0.1476 | 0.4938 | 0.4478 | 0.0004 | 0.0007 | 0.0034 | 0.0164 | 0.0820 | 0.1252 | 0.0852 | 0.1331 | 0.5536 | |
BT-20 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1211 | 757 | 6987 | 17413 | 330.1 | 42.49 | 131.75 | 174.14 | 277 | 295 | 309 | 320 | 331 | 341 | 352 | 366 | 384 | 0.0637 | 1110 | 0.875 | 72.84 | 16.16 | 1 | 0.0238 | 166 | 0.0022 | 16.55 | 6.447 | 0.2611 | 110777.0 | 37800000 | 13100000000 | 4580000000000 | 0.4400 | 0.2087 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0010 | 0.0000 | 0.0062 | 0.0000 | 0.0213 | 0.0109 | 0.0321 | 0.0178 | 0.0485 | 0.0100 | 0.0745 | 0.0186 | 0.8160 | 0.9427 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0003 | 0.0000 | 0.0027 | 0.0000 | 0.0128 | 0.0109 | 0.0169 | 0.0178 | 0.0198 | 0.0095 | 0.0305 | 0.0166 | 0.9167 | 0.9453 | 0.0122 | 0.0000 | 0.0389 | 1.0000 | 0.0681 | 0.0000 | 0.1387 | 0.0000 | 0.1363 | 0.0000 | 0.1533 | 0.0000 | 0.1314 | 0.0000 | 0.1265 | 0.0000 | 0.1946 | 0.0000 | 0.0017 | 0.0047 | 0.0111 | 0.0255 | 0.0505 | 0.0813 | 0.0921 | 0.1160 | 0.6171 | 11 | 14 | 16 | 20 | 45 | 85 | 148 | 242 | 391 | 0.0761 | 18.56 | 4.883 | 0.5466 | 47679.7 | 24000000 | 14300000000 | 9510000000000 | 0.5710 | 0.1004 | 0.0354 | 0.0022 | 0.1286 | 0.0170 | 0.1973 | 0.0815 | 0.1517 | 0.1130 | 0.1402 | 0.1735 | 0.1156 | 0.1590 | 0.0860 | 0.1101 | 0.0744 | 0.1093 | 0.0708 | 0.2342 | 0.0002 | 0.0003 | 0.0005 | 0.0013 | 0.0017 | 0.0015 | 0.0103 | 0.0083 | 0.0444 | 0.0392 | 0.0713 | 0.0616 | 0.0547 | 0.0447 | 0.0799 | 0.0686 | 0.7370 | 0.7746 | 0.0002 | 0.0007 | 0.0022 | 0.0016 | 0.0044 | 0.0034 | 0.0156 | 0.0158 | 0.0577 | 0.0657 | 0.0944 | 0.1062 | 0.0716 | 0.0725 | 0.0954 | 0.1069 | 0.6586 | 0.6274 | 0.0004 | 0.0009 | 0.0034 | 0.0130 | 0.0497 | 0.0852 | 0.0639 | 0.0887 | 0.6949 | |
MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1052 | 425 | 3025 | 6544 | 395.4 | 125.68 | 137.78 | 188.28 | 223 | 262 | 321 | 379 | 427 | 461 | 488 | 513 | 538 | 0.0767 | 502 | 0.961 | 105.32 | 29.00 | 2 | 0.0826 | 250 | 0.0010 | 36.99 | 7.117 | 0.2145 | 172122.0 | 79400000 | 38000000000 | 18700000000000 | 0.3829 | 0.2510 | 0.0000 | 0.0004 | 0.0066 | 0.0000 | 0.0094 | 0.0020 | 0.0169 | 0.0065 | 0.0778 | 0.0296 | 0.1321 | 0.0455 | 0.0965 | 0.0386 | 0.1781 | 0.0771 | 0.4827 | 0.8002 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0005 | 0.0008 | 0.0014 | 0.0034 | 0.0182 | 0.0191 | 0.0383 | 0.0309 | 0.0163 | 0.0202 | 0.0299 | 0.0313 | 0.8954 | 0.8944 | 0.0019 | 0.0438 | 0.0028 | 0.0500 | 0.0112 | 0.0813 | 0.0168 | 0.0625 | 0.0493 | 0.1125 | 0.0503 | 0.1250 | 0.0615 | 0.1438 | 0.0829 | 0.1250 | 0.7235 | 0.2563 | 0.0000 | 0.0000 | 0.0012 | 0.0058 | 0.0226 | 0.0423 | 0.0359 | 0.0469 | 0.8454 | 11 | 15 | 21 | 35 | 61 | 94 | 140 | 217 | 376 | 0.0253 | 45.28 | 5.475 | 0.4795 | 54428.7 | 33000000 | 24600000000 | 20600000000000 | 0.5487 | 0.1238 | 0.0167 | 0.0007 | 0.0866 | 0.0051 | 0.1596 | 0.0425 | 0.1368 | 0.0717 | 0.1733 | 0.1281 | 0.1459 | 0.1801 | 0.1277 | 0.1274 | 0.0745 | 0.1384 | 0.0790 | 0.3060 | 0.0004 | 0.0000 | 0.0013 | 0.0000 | 0.0017 | 0.0014 | 0.0118 | 0.0099 | 0.0557 | 0.0437 | 0.0861 | 0.0757 | 0.0621 | 0.0493 | 0.0807 | 0.0746 | 0.7002 | 0.7454 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0082 | 0.0068 | 0.0211 | 0.0271 | 0.0637 | 0.0780 | 0.1129 | 0.1248 | 0.0825 | 0.0753 | 0.0953 | 0.1031 | 0.6152 | 0.5848 | 0.0000 | 0.0010 | 0.0035 | 0.0129 | 0.0662 | 0.1005 | 0.0672 | 0.0985 | 0.6502 | |
MCF7 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 524 | 141 | 4317 | 6246 | 463.8 | 114.50 | 71.69 | 106.41 | 339 | 369 | 392 | 415 | 440 | 467 | 500 | 549 | 629 | 0.1005 | 628 | 1.211 | 95.02 | 37.48 | 1 | 0.0563 | 243 | 0.0011 | 40.02 | 7.058 | 0.1884 | 228193.0 | 119000000 | 66600000000 | 39500000000000 | 0.3905 | 0.2504 | 0.0000 | 0.0000 | 0.0012 | 0.0005 | 0.0054 | 0.0005 | 0.0173 | 0.0033 | 0.0695 | 0.0228 | 0.1245 | 0.0415 | 0.1318 | 0.0400 | 0.1690 | 0.0488 | 0.4814 | 0.8426 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0026 | 0.0000 | 0.0076 | 0.0009 | 0.0334 | 0.0140 | 0.0577 | 0.0244 | 0.0633 | 0.0147 | 0.0882 | 0.0216 | 0.7466 | 0.9244 | 0.0037 | 0.0000 | 0.0049 | 0.0057 | 0.0099 | 0.0345 | 0.0469 | 0.0690 | 0.0877 | 0.1293 | 0.1395 | 0.1264 | 0.1025 | 0.1264 | 0.1173 | 0.1494 | 0.4877 | 0.3592 | 0.0006 | 0.0051 | 0.0130 | 0.0395 | 0.0745 | 0.1072 | 0.0874 | 0.0987 | 0.5742 | 7 | 10 | 12 | 15 | 21 | 31 | 56 | 127 | 227 | 0.0902 | 12.13 | 4.224 | 0.6055 | 16459.4 | 5640000 | 2380000000 | 1160000000000 | 0.4828 | 0.1513 | 0.0532 | 0.0047 | 0.1894 | 0.0235 | 0.2990 | 0.0691 | 0.2359 | 0.1821 | 0.1196 | 0.2323 | 0.0698 | 0.2276 | 0.0266 | 0.1366 | 0.0000 | 0.0754 | 0.0066 | 0.0487 | 0.0000 | 0.0014 | 0.0000 | 0.0014 | 0.0022 | 0.0039 | 0.0129 | 0.0082 | 0.0533 | 0.0488 | 0.0787 | 0.0768 | 0.0566 | 0.0497 | 0.0981 | 0.0888 | 0.6983 | 0.7209 | 0.0000 | 0.0000 | 0.0013 | 0.0021 | 0.0058 | 0.0077 | 0.0154 | 0.0112 | 0.0624 | 0.0732 | 0.0977 | 0.0962 | 0.0585 | 0.0635 | 0.1145 | 0.1123 | 0.6444 | 0.6339 | 0.0000 | 0.0018 | 0.0035 | 0.0183 | 0.0589 | 0.0796 | 0.0654 | 0.0961 | 0.6765 | |||
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 855 | 618 | 6392 | 8692 | 565.9 | 136.42 | 151.51 | 154.48 | 405 | 449 | 487 | 519 | 551 | 583 | 618 | 669 | 747 | 0.0962 | 836 | 1.181 | 149.16 | 56.30 | 1 | 0.0601 | 384 | 0.0005 | 84.49 | 7.736 | 0.1296 | 338887.0 | 215000000 | 144000000000 | 102000000000000 | 0.4381 | 0.2035 | 0.0003 | 0.0000 | 0.0013 | 0.0002 | 0.0021 | 0.0003 | 0.0167 | 0.0026 | 0.0632 | 0.0204 | 0.1182 | 0.0408 | 0.1292 | 0.0333 | 0.1665 | 0.0493 | 0.5027 | 0.8530 | 0.0000 | 0.0000 | 0.0008 | 0.0002 | 0.0008 | 0.0002 | 0.0063 | 0.0016 | 0.0281 | 0.0131 | 0.0505 | 0.0215 | 0.0583 | 0.0156 | 0.0783 | 0.0233 | 0.7769 | 0.9246 | 0.0026 | 0.0102 | 0.0061 | 0.0051 | 0.0104 | 0.0255 | 0.0494 | 0.0561 | 0.1223 | 0.1378 | 0.1405 | 0.2168 | 0.1119 | 0.1173 | 0.1474 | 0.1505 | 0.4094 | 0.2806 | 0.0014 | 0.0034 | 0.0085 | 0.0263 | 0.0650 | 0.1026 | 0.0988 | 0.1173 | 0.5766 | 16 | 30 | 48 | 69 | 98 | 135 | 183 | 254 | 363 | 0.0144 | 28.33 | 5.755 | 0.4071 | 46815.8 | 20900000 | 11800000000 | 7940000000000 | 0.4493 | 0.1881 | 0.0467 | 0.0022 | 0.1642 | 0.0178 | 0.2921 | 0.0975 | 0.1659 | 0.1300 | 0.1366 | 0.1820 | 0.0977 | 0.1971 | 0.0467 | 0.1443 | 0.0285 | 0.1109 | 0.0216 | 0.1183 | 0.0000 | 0.0000 | 0.0016 | 0.0020 | 0.0024 | 0.0004 | 0.0199 | 0.0124 | 0.0749 | 0.0587 | 0.1204 | 0.0974 | 0.0863 | 0.0733 | 0.1178 | 0.1060 | 0.5768 | 0.6498 | 0.0004 | 0.0009 | 0.0008 | 0.0023 | 0.0046 | 0.0072 | 0.0347 | 0.0432 | 0.1206 | 0.1292 | 0.1583 | 0.1567 | 0.0946 | 0.1094 | 0.1389 | 0.1531 | 0.4472 | 0.3980 | 0.0010 | 0.0016 | 0.0035 | 0.0247 | 0.0958 | 0.1380 | 0.0986 | 0.1415 | 0.4954 | |
MCF 10A | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 426 | 374 | 4318 | 14420 | 143.7 | 34.49 | 119.50 | 125.97 | 103 | 114 | 123 | 131 | 140 | 148 | 158 | 170 | 188 | 0.0620 | 894 | 1.020 | 115.11 | 27.29 | 1 | 0.0602 | 260 | 0.0019 | 27.37 | 6.560 | 0.2321 | 21832.7 | 3510000 | 599000000 | 108000000000 | 0.4264 | 0.2220 | 0.0004 | 0.0000 | 0.0035 | 0.0005 | 0.0196 | 0.0012 | 0.0369 | 0.0027 | 0.0914 | 0.0222 | 0.1656 | 0.0530 | 0.1672 | 0.0527 | 0.1770 | 0.0782 | 0.3383 | 0.7894 | 0.0003 | 0.0000 | 0.0006 | 0.0000 | 0.0051 | 0.0000 | 0.0113 | 0.0014 | 0.0416 | 0.0148 | 0.0794 | 0.0319 | 0.0708 | 0.0195 | 0.1002 | 0.0380 | 0.6908 | 0.8945 | 0.0049 | 0.0114 | 0.0160 | 0.0114 | 0.0294 | 0.0456 | 0.0896 | 0.1787 | 0.1521 | 0.2129 | 0.1816 | 0.2053 | 0.1411 | 0.0913 | 0.1546 | 0.1293 | 0.2307 | 0.1141 | 0.0005 | 0.0031 | 0.0112 | 0.0386 | 0.0910 | 0.1352 | 0.1256 | 0.1546 | 0.4403 | 17 | 24 | 35 | 47 | 65 | 91 | 142 | 211 | 313 | 0.0080 | 38.15 | 6.234 | 0.3884 | 30147.3 | 10600000 | 4400000000 | 2040000000000 | 0.5107 | 0.1394 | 0.0427 | 0.0034 | 0.1280 | 0.0141 | 0.2110 | 0.0584 | 0.1420 | 0.1202 | 0.1528 | 0.1742 | 0.1412 | 0.1803 | 0.1009 | 0.1302 | 0.0559 | 0.1289 | 0.0256 | 0.1903 | 0.0007 | 0.0013 | 0.0025 | 0.0025 | 0.0054 | 0.0058 | 0.0116 | 0.0120 | 0.0497 | 0.0465 | 0.0797 | 0.0690 | 0.0606 | 0.0582 | 0.0869 | 0.0833 | 0.7029 | 0.7214 | 0.0002 | 0.0008 | 0.0009 | 0.0008 | 0.0044 | 0.0074 | 0.0114 | 0.0183 | 0.0634 | 0.0731 | 0.0992 | 0.1123 | 0.0727 | 0.0847 | 0.1113 | 0.1107 | 0.6365 | 0.5920 | 0.0004 | 0.0021 | 0.0035 | 0.0136 | 0.0496 | 0.0910 | 0.0683 | 0.0899 | 0.6816 | |||
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 844 | 729 | 5195 | 6746 | 513.2 | 118.34 | 131.41 | 201.76 | 374 | 422 | 455 | 484 | 509 | 533 | 559 | 598 | 663 | 0.1269 | 856 | 1.179 | 136.50 | 52.00 | 4 | 0.0670 | 348 | 0.0006 | 81.67 | 7.590 | 0.1403 | 277409.0 | 157000000 | 93300000000 | 57800000000000 | 0.4641 | 0.1828 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0092 | 0.0002 | 0.0187 | 0.0015 | 0.0728 | 0.0317 | 0.1260 | 0.0589 | 0.1091 | 0.0502 | 0.1534 | 0.0757 | 0.5108 | 0.7819 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0037 | 0.0008 | 0.0387 | 0.0254 | 0.0701 | 0.0404 | 0.0576 | 0.0258 | 0.0831 | 0.0416 | 0.7456 | 0.8661 | 0.0059 | 0.0100 | 0.0118 | 0.0134 | 0.0178 | 0.0334 | 0.0675 | 0.1104 | 0.1349 | 0.1371 | 0.1527 | 0.1605 | 0.0982 | 0.1171 | 0.1396 | 0.1371 | 0.3716 | 0.2809 | 0.0012 | 0.0020 | 0.0083 | 0.0313 | 0.0944 | 0.1583 | 0.1035 | 0.1432 | 0.4578 | 7 | 9 | 11 | 15 | 30 | 63 | 128 | 229 | 416 | 0.1248 | 27.25 | 4.487 | 0.5729 | 57968.2 | 37400000 | 29800000000 | 27700000000000 | 0.6421 | 0.0717 | 0.0374 | 0.0045 | 0.1828 | 0.0269 | 0.3106 | 0.1256 | 0.1806 | 0.1469 | 0.1564 | 0.2096 | 0.0639 | 0.2096 | 0.0419 | 0.1188 | 0.0176 | 0.0953 | 0.0088 | 0.0628 | 0.0000 | 0.0004 | 0.0004 | 0.0024 | 0.0009 | 0.0028 | 0.0121 | 0.0108 | 0.0689 | 0.0667 | 0.1123 | 0.0895 | 0.0671 | 0.0667 | 0.0988 | 0.0927 | 0.6395 | 0.6681 | 0.0000 | 0.0000 | 0.0011 | 0.0000 | 0.0028 | 0.0050 | 0.0213 | 0.0292 | 0.0786 | 0.0856 | 0.1296 | 0.1290 | 0.0836 | 0.0862 | 0.1072 | 0.1141 | 0.5758 | 0.5509 | 0.0000 | 0.0010 | 0.0035 | 0.0180 | 0.0721 | 0.1181 | 0.0756 | 0.1086 | 0.6031 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 771 | 729 | 699 | 8074 | 51.0 | 15.12 | 134.99 | 188.23 | 31 | 35 | 40 | 45 | 50 | 56 | 62 | 67 | 72 | 0.0588 | 475 | 1.025 | 40.01 | 10.20 | 1 | 0.1373 | 96 | 0.0059 | 6.82 | 5.319 | 0.3605 | 2826.1 | 167621 | 10500000 | 678000000 | 0.3593 | 0.2671 | 0.0074 | 0.0000 | 0.0223 | 0.0106 | 0.0186 | 0.0195 | 0.0483 | 0.0283 | 0.1264 | 0.0496 | 0.1561 | 0.0637 | 0.1822 | 0.0991 | 0.2119 | 0.1558 | 0.2268 | 0.5735 | 0.0000 | 0.0000 | 0.0021 | 0.0016 | 0.0021 | 0.0094 | 0.0125 | 0.0141 | 0.0480 | 0.0297 | 0.0438 | 0.0375 | 0.0438 | 0.0531 | 0.0710 | 0.0688 | 0.7766 | 0.7859 | 0.0000 | 0.0267 | 0.0095 | 0.0533 | 0.0095 | 0.0533 | 0.0714 | 0.1867 | 0.0571 | 0.1333 | 0.0857 | 0.2000 | 0.1333 | 0.1733 | 0.1762 | 0.1467 | 0.4571 | 0.0267 | 0.0000 | 0.0029 | 0.0086 | 0.0201 | 0.0430 | 0.0630 | 0.0516 | 0.0860 | 0.7249 | 17 | 20 | 22 | 27 | 42 | 69 | 121 | 231 | 414 | 0.1036 | 10.05 | 4.238 | 0.6273 | 53649.5 | 30800000 | 20700000000 | 15500000000000 | 0.6068 | 0.0942 | 0.0493 | 0.0037 | 0.1637 | 0.0266 | 0.2249 | 0.1322 | 0.1657 | 0.1506 | 0.1400 | 0.1304 | 0.1183 | 0.1680 | 0.0552 | 0.1074 | 0.0414 | 0.0973 | 0.0414 | 0.1837 | 0.0004 | 0.0007 | 0.0012 | 0.0013 | 0.0046 | 0.0030 | 0.0150 | 0.0167 | 0.0547 | 0.0407 | 0.0875 | 0.0781 | 0.0586 | 0.0524 | 0.0848 | 0.0851 | 0.6933 | 0.7219 | 0.0005 | 0.0005 | 0.0019 | 0.0042 | 0.0043 | 0.0100 | 0.0168 | 0.0173 | 0.0570 | 0.0614 | 0.1049 | 0.0992 | 0.0608 | 0.0719 | 0.0967 | 0.1028 | 0.6571 | 0.6327 | 0.0000 | 0.0039 | 0.0035 | 0.0195 | 0.0500 | 0.0925 | 0.0626 | 0.0947 | 0.6733 | |
Hs 578T | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 207 | 478 | 13048 | 26519 | 97.0 | 27.99 | 161.98 | 234.77 | 64 | 74 | 81 | 88 | 95 | 102 | 109 | 119 | 134 | 0.0514 | 1363 | 0.414 | 318.40 | 44.82 | 2 | 0.0676 | 882 | 0.0022 | 19.38 | 6.429 | 0.2488 | 10191.1 | 1150000 | 139000000 | 17800000000 | 0.4486 | 0.1898 | 0.0006 | 0.0001 | 0.0026 | 0.0001 | 0.0142 | 0.0005 | 0.0573 | 0.0057 | 0.1294 | 0.0245 | 0.1873 | 0.0596 | 0.1931 | 0.0819 | 0.1988 | 0.1265 | 0.2168 | 0.7010 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0021 | 0.0002 | 0.0123 | 0.0021 | 0.0425 | 0.0125 | 0.0796 | 0.0275 | 0.0907 | 0.0335 | 0.1311 | 0.0529 | 0.6415 | 0.8713 | 0.0086 | 0.0180 | 0.0124 | 0.0237 | 0.0341 | 0.0606 | 0.0834 | 0.1219 | 0.1405 | 0.1457 | 0.1777 | 0.1833 | 0.1230 | 0.1129 | 0.1467 | 0.1211 | 0.2735 | 0.2128 | 0.0013 | 0.0034 | 0.0092 | 0.0433 | 0.0938 | 0.1445 | 0.1259 | 0.1491 | 0.4295 | 12 | 14 | 16 | 18 | 33 | 81 | 172 | 311 | 501 | 0.1539 | 30.24 | 4.603 | 0.5818 | 81353.0 | 57600000 | 49500000000 | 48800000000000 | 0.6313 | 0.0832 | 0.0968 | 0.0061 | 0.2891 | 0.0382 | 0.3119 | 0.2073 | 0.1514 | 0.1858 | 0.0786 | 0.1931 | 0.0396 | 0.1633 | 0.0221 | 0.0966 | 0.0084 | 0.0664 | 0.0019 | 0.0433 | 0.0002 | 0.0001 | 0.0014 | 0.0006 | 0.0029 | 0.0019 | 0.0159 | 0.0126 | 0.0664 | 0.0555 | 0.1013 | 0.0925 | 0.0752 | 0.0680 | 0.1062 | 0.0957 | 0.6305 | 0.6731 | 0.0001 | 0.0004 | 0.0027 | 0.0026 | 0.0041 | 0.0069 | 0.0213 | 0.0238 | 0.0829 | 0.0859 | 0.1261 | 0.1347 | 0.0905 | 0.1014 | 0.1246 | 0.1340 | 0.5478 | 0.5103 | 0.0002 | 0.0021 | 0.0035 | 0.0166 | 0.0752 | 0.1103 | 0.0892 | 0.1185 | 0.5844 |