High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1191 273 image if available 5225 11025 340.7 62.23 307.66 490.68 248 283 309 330 349 367 381 396 416 0.0786 867 0.925 79.06 24.04 4 0.0404 211 0.0014 23.53 6.846 0.2524 119949.0
43400000
16100000000
6080000000000
0.4363 0.2015 0.0005 0.0000 0.0024 0.0000 0.0052 0.0004 0.0144 0.0012 0.0415 0.0155 0.0735 0.0306 0.0749 0.0196 0.1045 0.0333 0.6830 0.8994 0.0002 0.0000 0.0009 0.0000 0.0014 0.0004 0.0046 0.0012 0.0191 0.0153 0.0353 0.0304 0.0290 0.0163 0.0376 0.0273 0.8719 0.9093 0.0076 0.0000 0.0291 1.0000 0.0443 0.0000 0.0581 0.0000 0.1407 0.0000 0.1361 0.0000 0.1300 0.0000 0.1529 0.0000 0.3012 0.0000 0.0007 0.0021 0.0070 0.0115 0.0369 0.0518 0.0539 0.0869 0.7493 8 10 12 16 25 61 277 673 1103 0.0635 24.60 4.331 0.4441 335399.0
461000000
722000000000
1.24E+15
0.5061 0.1164 0.0746 0.0000 0.2293 0.0218 0.2541 0.1592 0.1602 0.1687 0.1409 0.2082 0.0829 0.1891 0.0304 0.0898 0.0193 0.0939 0.0083 0.0694 0.0000 0.0000 0.0006 0.0006 0.0038 0.0011 0.0065 0.0047 0.0332 0.0356 0.0632 0.0601 0.0397 0.0361 0.0585 0.0593 0.7947 0.8025 0.0003 0.0003 0.0007 0.0003 0.0023 0.0017 0.0056 0.0055 0.0391 0.0464 0.0687 0.0695 0.0444 0.0488 0.0736 0.0768 0.7653 0.7506 0.0003 0.0012 0.0016 0.0068 0.0346 0.0626 0.0392 0.0688 0.7849
BT-20 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 1215 861 image if available 3007 9908 716.7 136.15 119.32 267.01 537 590 633 674 713 750 795 845 901 0.0779 772 1.131 79.76 31.58 2 0.0725 218 0.0010 52.74 7.117 0.1610 532255.0
408000000
323000000000
262000000000000
0.4330 0.2090 0.0005 0.0000 0.0005 0.0000 0.0000 0.0000 0.0125 0.0007 0.0651 0.0200 0.1481 0.0312 0.1456 0.0346 0.1792 0.0481 0.4484 0.8654 0.0004 0.0000 0.0000 0.0000 0.0000 0.0000 0.0060 0.0007 0.0316 0.0198 0.0643 0.0271 0.0583 0.0218 0.0671 0.0305 0.7723 0.9001 0.0040 0.0588 0.0059 0.0588 0.0198 0.0882 0.0931 0.3529 0.1802 0.2941 0.1842 0.0588 0.0911 0.0294 0.1564 0.0588 0.2653 0.0000 0.0000 0.0007 0.0041 0.0244 0.0807 0.1404 0.1065 0.1303 0.5129 7 9 10 11 13 16 31 132 393 0.2663 40.82 3.458 0.6732 85524.5
93100000
121000000000
174000000000000
0.6043 0.0864 0.1806 0.0164 0.2843 0.1228 0.2274 0.2439 0.1237 0.1735 0.1304 0.1571 0.0201 0.1489 0.0201 0.0687 0.0134 0.0491 0.0000 0.0196 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0063 0.0059 0.0680 0.0675 0.1151 0.0990 0.0657 0.0671 0.1024 0.0998 0.6425 0.6607 0.0000 0.0000 0.0000 0.0006 0.0005 0.0011 0.0115 0.0085 0.0781 0.0846 0.1289 0.1455 0.0849 0.0795 0.1226 0.1286 0.5734 0.5516 0.0000 0.0000 0.0010 0.0097 0.0711 0.1178 0.0808 0.1168 0.6027
SK-BR-3 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 1017 554 image if available 378 9755 70.8 9.18 6.27 2.35 58 62 65 69 72 74 76 79 82 0.0685 668 1.025 80.23 26.63 2 0.5556 210 0.0307 2.20 3.799 0.5317 5100.6
373029
27700000
2080000000
0.3766 0.2528 0.0000 0.0000 0.0000 0.0000 0.0060 0.0000 0.0121 0.0053 0.0725 0.0556 0.0816 0.0635 0.0816 0.0503 0.1178 0.0688 0.6284 0.7566 0.0000 0.0000 0.0000 0.0000 0.0058 0.0000 0.0116 0.0053 0.0607 0.0556 0.0665 0.0635 0.0520 0.0503 0.0838 0.0688 0.7197 0.7566 0.0667 0.0000 0.0000 0.0000 0.0667 0.0000 0.2667 0.0000 0.0000 0.0000 0.2667 0.0000 0.2000 0.0000 0.0000 0.0000 0.1333 0.0000 0.0000 0.0093 0.0139 0.0324 0.0694 0.0787 0.0972 0.1481 0.5509 4 4 5 5 6 7 7 8 9 0.2315 0.45 1.048 0.5873 44.8
356.698
3133.82
30121.9
0.5230 0.1563 0.0095 0.0016 0.0423 0.0054 0.1159 0.0156 0.1913 0.0399 0.2491 0.0756 0.2068 0.1496 0.1260 0.2580 0.0507 0.3008 0.0085 0.1535 0.0009 0.0000 0.0033 0.0003 0.0157 0.0022 0.0417 0.0102 0.0896 0.0267 0.1561 0.0434 0.2071 0.1072 0.2316 0.2692 0.2540 0.5409 0.0990 0.1881 0.1831 0.2085 0.1795 0.1599 0.1502 0.1178 0.1272 0.0944 0.0980 0.0655 0.0618 0.0505 0.0512 0.0589 0.0501 0.0565 0.0080 0.0313 0.0735 0.1349 0.1725 0.1695 0.1459 0.1396 0.1248
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 910 235 image if available 5650 9484 613.1 99.25 15.85 17.71 472 537 575 601 623 643 663 690 733 0.0777 737 0.760 87.05 15.26 1 0.0388 219 0.0011 30.87 7.107 0.2252 385716.0
248000000
163000000000
109000000000000
0.3922 0.2485 0.0005 0.0000 0.0002 0.0000 0.0016 0.0000 0.0043 0.0007 0.0256 0.0133 0.0488 0.0204 0.0442 0.0136 0.0551 0.0226 0.8197 0.9294 0.0002 0.0000 0.0000 0.0000 0.0000 0.0000 0.0012 0.0007 0.0151 0.0133 0.0258 0.0204 0.0208 0.0122 0.0270 0.0190 0.9099 0.9344 0.0036 0.2000 0.0145 0.8000 0.0163 0.0000 0.0435 0.0000 0.0870 0.0000 0.1431 0.0000 0.0833 0.0000 0.1105 0.0000 0.4982 0.0000 0.0019 0.0019 0.0061 0.0129 0.0399 0.0633 0.0672 0.0987 0.7081 5 7 8 9 11 13 15 20 32 0.2512 0.44 1.751 0.7487 564.9
50306.4
9130000
2400000000
0.5918 0.0979 0.0534 0.0357 0.0820 0.0510 0.0996 0.0522 0.1245 0.0695 0.1572 0.0948 0.1789 0.1024 0.1727 0.1371 0.1011 0.1779 0.0306 0.2793 0.0244 0.0248 0.0307 0.0322 0.0359 0.0315 0.0432 0.0424 0.0663 0.0619 0.0788 0.0696 0.0772 0.0803 0.1043 0.1080 0.5391 0.5493 0.0219 0.0129 0.0172 0.0233 0.0256 0.0259 0.0339 0.0291 0.0516 0.0505 0.0793 0.0627 0.0652 0.0524 0.0814 0.0996 0.6239 0.6436 0.0286 0.0414 0.0352 0.0447 0.0521 0.0660 0.0663 0.1015 0.5642
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 284 471 image if available 1555 4253 401.1 47.90 19.31 18.63 332 364 381 394 406 416 429 441 459 0.0997 424 1.147 61.20 22.02 1 0.1016 158 0.0027 20.18 6.139 0.2451 163138.0
67200000
28000000000
11800000000000
0.4443 0.1979 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0028 0.0006 0.0285 0.0239 0.0463 0.0303 0.0484 0.0232 0.0855 0.0342 0.7877 0.8877 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0028 0.0006 0.0241 0.0239 0.0345 0.0303 0.0241 0.0232 0.0427 0.0342 0.8711 0.8877 0.0426 0.0000 0.1064 0.0000 0.1064 0.0000 0.1277 0.0000 0.2340 0.0000 0.1702 0.0000 0.0638 0.0000 0.1064 0.0000 0.0426 0.0000 0.0000 0.0060 0.0072 0.0358 0.0656 0.1144 0.1085 0.1323 0.5304 8 10 11 13 14 16 18 23 33 0.2369 0.56 2.092 0.8275 719.8
57928.3
7540000
1230000000
0.5877 0.1129 0.1023 0.0171 0.1338 0.0274 0.1250 0.0499 0.1439 0.0846 0.1452 0.1170 0.1351 0.1471 0.1225 0.1498 0.0682 0.1619 0.0240 0.2452 0.0447 0.0107 0.0494 0.0169 0.0353 0.0331 0.0358 0.0562 0.0529 0.0841 0.0764 0.1041 0.0781 0.1013 0.1193 0.1162 0.5082 0.4774 0.0132 0.0162 0.0154 0.0310 0.0209 0.0398 0.0473 0.0516 0.0780 0.0634 0.0978 0.1165 0.1022 0.0870 0.1516 0.1608 0.4736 0.4336 0.0277 0.0317 0.0222 0.0301 0.0586 0.0705 0.0777 0.1474 0.5341
BT-20 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 328 264 image if available 5714 20546 463.9 85.65 198.91 273.07 350 385 413 441 466 489 515 542 578 0.0555 1140 1.175 43.60 17.69 1 0.0201 115 0.0019 18.72 6.494 0.2565 222566.0
110000000
55900000000
29000000000000
0.4221 0.2293 0.0000 0.0000 0.0010 0.0000 0.0015 0.0000 0.0127 0.0002 0.0579 0.0130 0.1134 0.0244 0.1170 0.0200 0.1731 0.0342 0.5233 0.9083 0.0000 0.0000 0.0008 0.0000 0.0012 0.0000 0.0052 0.0002 0.0208 0.0122 0.0470 0.0219 0.0414 0.0133 0.0718 0.0193 0.8118 0.9331 0.0079 0.1000 0.0068 0.2500 0.0294 0.0750 0.0791 0.2000 0.1672 0.2250 0.2045 0.1000 0.1593 0.0500 0.1390 0.0000 0.2068 0.0000 0.0010 0.0021 0.0058 0.0158 0.0586 0.1059 0.0991 0.1464 0.5653 11 13 16 27 66 139 232 357 585 0.0741 43.15 5.361 0.5048 114131.0
92700000
90900000000
100000000000000
0.4547 0.1787 0.0206 0.0015 0.0989 0.0062 0.1742 0.0387 0.1784 0.0968 0.1954 0.1780 0.1632 0.1878 0.0692 0.1270 0.0643 0.1385 0.0358 0.2256 0.0000 0.0002 0.0004 0.0001 0.0016 0.0013 0.0107 0.0056 0.0397 0.0367 0.0708 0.0642 0.0517 0.0460 0.0770 0.0672 0.7482 0.7786 0.0000 0.0006 0.0017 0.0009 0.0036 0.0038 0.0119 0.0147 0.0501 0.0553 0.0831 0.0909 0.0729 0.0815 0.0904 0.0975 0.6863 0.6548 0.0004 0.0006 0.0018 0.0106 0.0445 0.0816 0.0606 0.0805 0.7194
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 662 697 image if available 5913 18261 491.0 67.94 138.35 220.58 396 436 462 484 500 513 528 544 572 0.0451 824 1.176 94.54 34.99 1 0.0404 239 0.0021 16.68 6.549 0.2788 245703.0
125000000
64600000000
33900000000000
0.4193 0.2254 0.0000 0.0000 0.0004 0.0000 0.0010 0.0000 0.0052 0.0002 0.0206 0.0107 0.0401 0.0231 0.0409 0.0105 0.0497 0.0178 0.8421 0.9378 0.0000 0.0000 0.0000 0.0000 0.0004 0.0000 0.0011 0.0002 0.0140 0.0105 0.0257 0.0222 0.0200 0.0095 0.0276 0.0162 0.9112 0.9414 0.0028 0.0000 0.0142 0.1111 0.0426 0.1111 0.0767 0.1111 0.1392 0.4444 0.1193 0.2222 0.1193 0.0000 0.1591 0.0000 0.3267 0.0000 0.0003 0.0033 0.0069 0.0169 0.0350 0.0555 0.0628 0.0872 0.7320 8 10 12 16 27 52 112 246 464 0.1339 21.44 4.364 0.6125 67793.0
46900000
38600000000
36000000000000
0.3682 0.2671 0.0646 0.0035 0.1579 0.0234 0.2759 0.1034 0.1692 0.1313 0.1344 0.1895 0.0985 0.2004 0.0595 0.1034 0.0236 0.1193 0.0164 0.1258 0.0004 0.0006 0.0011 0.0015 0.0025 0.0023 0.0114 0.0085 0.0461 0.0447 0.0764 0.0614 0.0517 0.0432 0.0719 0.0705 0.7384 0.7673 0.0011 0.0005 0.0009 0.0007 0.0026 0.0033 0.0168 0.0158 0.0521 0.0575 0.0907 0.0945 0.0618 0.0628 0.0783 0.0833 0.6958 0.6816 0.0006 0.0014 0.0028 0.0152 0.0474 0.0861 0.0548 0.0734 0.7183
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 699 471 image if available 4304 9250 675.2 100.28 112.63 227.13 526 609 656 678 694 707 722 740 781 0.0782 723 1.058 105.04 31.11 1 0.0602 259 0.0017 29.52 6.816 0.2429 465980.0
327000000
234000000000
169000000000000
0.4313 0.2103 0.0000 0.0000 0.0000 0.0000 0.0008 0.0000 0.0028 0.0000 0.0204 0.0139 0.0353 0.0238 0.0311 0.0120 0.0487 0.0205 0.8609 0.9297 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0016 0.0000 0.0149 0.0139 0.0259 0.0238 0.0191 0.0120 0.0254 0.0205 0.9130 0.9297 0.0082 0.0000 0.0163 0.0000 0.0245 0.0000 0.0367 0.0000 0.0816 0.0000 0.0857 0.0000 0.0816 0.0000 0.1143 0.0000 0.5510 0.0000 0.0004 0.0015 0.0038 0.0128 0.0342 0.0556 0.0680 0.0992 0.7244 8 10 12 14 17 26 59 148 341 0.1976 21.25 3.579 0.6813 64269.9
61100000
74500000000
106000000000000
0.4869 0.1485 0.0430 0.0000 0.1471 0.0171 0.1991 0.0910 0.1222 0.1229 0.1357 0.1456 0.1154 0.1581 0.1086 0.1229 0.0633 0.1024 0.0656 0.2400 0.0000 0.0000 0.0008 0.0004 0.0013 0.0011 0.0109 0.0094 0.0419 0.0410 0.0747 0.0556 0.0516 0.0402 0.0763 0.0676 0.7425 0.7847 0.0000 0.0006 0.0010 0.0022 0.0031 0.0028 0.0175 0.0185 0.0577 0.0612 0.0911 0.1021 0.0695 0.0606 0.0901 0.0948 0.6699 0.6571 0.0000 0.0009 0.0032 0.0125 0.0529 0.0779 0.0682 0.0904 0.6939
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 946 911 image if available 326 5218 83.2 12.55 6.61 2.23 66 72 76 80 84 87 90 94 100 0.0922 481 0.870 40.79 10.82 5 0.2883 94 0.0484 1.29 3.265 0.6193 7072.0
613833
54300000
4880000000
0.3970 0.2342 0.0039 0.0000 0.0039 0.0000 0.0078 0.0000 0.0310 0.0153 0.0698 0.0429 0.1512 0.0798 0.1163 0.0583 0.1860 0.0828 0.4302 0.7209 0.0034 0.0000 0.0000 0.0000 0.0069 0.0000 0.0206 0.0153 0.0309 0.0429 0.0997 0.0798 0.0550 0.0583 0.0928 0.0828 0.6907 0.7209 0.0303 0.0000 0.0909 0.0000 0.0909 0.0000 0.1818 0.0000 0.1818 0.0000 0.2121 0.0000 0.1212 0.0000 0.0606 0.0000 0.0303 0.0000 0.0055 0.0000 0.0110 0.0440 0.0714 0.1484 0.1154 0.2033 0.4011 4 5 6 6 6 7 7 9 9 0.0270 9.36 4.124 0.3431 48.6
391.422
3419.3
32319.8
0.5324 0.1461 0.0043 0.0011 0.0274 0.0040 0.0990 0.0214 0.1877 0.0631 0.2444 0.1213 0.2369 0.2069 0.1372 0.2618 0.0545 0.2256 0.0086 0.0948 0.0005 0.0002 0.0028 0.0019 0.0165 0.0091 0.0505 0.0369 0.1170 0.0831 0.1931 0.1470 0.2540 0.2323 0.2307 0.2820 0.1350 0.2075 0.1429 0.4528 0.2778 0.2397 0.2169 0.0896 0.1614 0.0557 0.0750 0.0436 0.0547 0.0533 0.0335 0.0412 0.0247 0.0194 0.0132 0.0048 0.0201 0.0768 0.1695 0.2209 0.1962 0.1531 0.0866 0.0497 0.0271
MDA-MB-231 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 248 500 image if available 1039 2688 496.1 98.73 39.06 62.95 376 424 458 485 504 521 536 562 631 0.1365 367 0.740 130.00 22.83 1 0.2849 296 0.0017 65.54 6.527 0.1617 255811.0
136000000
73900000000
41200000000000
0.4036 0.2366 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0054 0.0020 0.0499 0.0318 0.0823 0.0417 0.0702 0.0328 0.0931 0.0557 0.6991 0.8360 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0011 0.0020 0.0324 0.0307 0.0525 0.0396 0.0357 0.0277 0.0558 0.0455 0.8225 0.8546 0.0000 0.0000 0.0000 0.2000 0.0065 0.6000 0.0258 0.2000 0.0710 0.0000 0.0903 0.0000 0.0645 0.0000 0.1032 0.0000 0.6387 0.0000 0.0000 0.0017 0.0017 0.0174 0.0522 0.0922 0.0783 0.0939 0.6626 7 8 10 13 15 18 23 43 112 0.1239 2.12 3.167 0.7441 5486.9
1350000
417000000
146000000000
0.5373 0.1116 0.0154 0.0541 0.0538 0.0510 0.0846 0.0318 0.1231 0.0701 0.1231 0.0987 0.2077 0.0955 0.1462 0.1178 0.1538 0.2102 0.0923 0.2707 0.0031 0.0211 0.0108 0.0199 0.0093 0.0112 0.0170 0.0211 0.0216 0.0373 0.0386 0.0398 0.0448 0.0460 0.0802 0.1007 0.7747 0.7027 0.0039 0.0020 0.0039 0.0000 0.0019 0.0041 0.0135 0.0122 0.0251 0.0245 0.0290 0.0306 0.0444 0.0510 0.0734 0.0592 0.8050 0.8163 0.0070 0.0053 0.0088 0.0140 0.0298 0.0385 0.0403 0.0788 0.7776
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 386 559 image if available 1919 9291 297.6 53.29 250.19 260.24 215 254 277 295 308 321 332 343 357 0.0677 629 1.003 87.82 29.21 1 0.1178 226 0.0022 14.65 6.307 0.2647 91416.6
28800000
9250000000
3020000000000
0.3763 0.2593 0.0007 0.0005 0.0007 0.0000 0.0021 0.0005 0.0084 0.0011 0.0439 0.0183 0.0927 0.0458 0.0836 0.0188 0.1157 0.0285 0.6523 0.8864 0.0000 0.0005 0.0000 0.0000 0.0000 0.0005 0.0012 0.0011 0.0265 0.0183 0.0468 0.0458 0.0302 0.0188 0.0406 0.0285 0.8548 0.8864 0.0105 0.0000 0.0000 0.0000 0.1000 0.0000 0.1263 0.0000 0.1842 0.0000 0.1842 0.0000 0.1421 0.0000 0.1421 0.0000 0.1105 0.0000 0.0000 0.0009 0.0036 0.0217 0.0407 0.0724 0.0733 0.1005 0.6869 21 33 58 95 149 231 329 452 626 0.0131 45.83 6.311 0.3810 130308.0
91600000
76700000000
72600000000000
0.6100 0.0919 0.0351 0.0025 0.1174 0.0114 0.2999 0.0602 0.1555 0.1210 0.1525 0.1916 0.1254 0.2020 0.0582 0.1432 0.0381 0.1249 0.0181 0.1432 0.0000 0.0000 0.0007 0.0006 0.0030 0.0017 0.0128 0.0101 0.0650 0.0509 0.0904 0.0798 0.0623 0.0612 0.1067 0.0878 0.6591 0.7078 0.0000 0.0004 0.0020 0.0011 0.0059 0.0061 0.0203 0.0318 0.0764 0.0842 0.1147 0.1248 0.0869 0.1083 0.1275 0.1348 0.5664 0.5084 0.0003 0.0011 0.0046 0.0154 0.0733 0.0984 0.0821 0.1146 0.6102
Hs 578T A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 395 909 image if available 589 5786 12.0 2.37 6.24 2.23 9 10 11 11 12 12 13 14 15 0.0990 573 0.731 73.43 17.00 0 0.3192 188 0.0185 6.32 4.289 0.3960 150.6
1953.66
26252.6
364792
0.3695 0.2656 0.0046 0.0000 0.0069 0.0018 0.0324 0.0036 0.0694 0.0164 0.1019 0.0455 0.1343 0.0764 0.1898 0.1218 0.1736 0.1818 0.2870 0.5527 0.0000 0.0000 0.0077 0.0000 0.0174 0.0017 0.0367 0.0156 0.0405 0.0363 0.0656 0.0554 0.1158 0.0606 0.1409 0.1125 0.5753 0.7180 0.0581 0.2857 0.0930 0.2500 0.1860 0.1071 0.1163 0.1786 0.1744 0.1071 0.1163 0.0714 0.0814 0.0000 0.1163 0.0000 0.0581 0.0000 0.0153 0.0337 0.0706 0.0982 0.1135 0.1350 0.1380 0.1503 0.2454 3 4 5 6 6 7 7 8 9 0.0198 11.10 4.314 0.3248 43.9
336.777
2778.03
24382.5
0.5530 0.1191 0.0068 0.0000 0.0407 0.0041 0.1143 0.0182 0.2166 0.0597 0.2673 0.1261 0.2088 0.2311 0.1023 0.2725 0.0370 0.2133 0.0062 0.0750 0.0000 0.0000 0.0016 0.0006 0.0121 0.0032 0.0364 0.0132 0.0907 0.0355 0.1684 0.0778 0.2678 0.1906 0.2778 0.3647 0.1454 0.3144 0.1144 0.2816 0.2397 0.3609 0.2950 0.2346 0.1896 0.0927 0.1073 0.0268 0.0392 0.0034 0.0141 0.0000 0.0006 0.0000 0.0000 0.0000 0.0018 0.0090 0.0356 0.0844 0.1569 0.2511 0.2490 0.1644 0.0477
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 465 643 image if available 8720 12380 327.7 56.71 178.47 263.33 253 288 306 320 333 346 358 371 394 0.0826 1023 1.053 189.34 55.01 1 0.0515 449 0.0016 19.71 6.739 0.2552 110617.0
38300000
13500000000
4860000000000
0.4132 0.2316 0.0001 0.0000 0.0000 0.0001 0.0010 0.0001 0.0059 0.0010 0.0246 0.0101 0.0541 0.0199 0.0557 0.0130 0.0950 0.0226 0.7636 0.9332 0.0000 0.0000 0.0000 0.0001 0.0000 0.0001 0.0030 0.0009 0.0126 0.0096 0.0228 0.0178 0.0228 0.0096 0.0370 0.0162 0.9017 0.9456 0.0114 0.0000 0.0227 0.0000 0.0272 0.0000 0.0681 0.0000 0.0988 0.0000 0.1703 0.0000 0.1067 0.0000 0.1226 0.0000 0.3723 0.0000 0.0008 0.0019 0.0071 0.0173 0.0483 0.0854 0.0861 0.1201 0.6330 18 25 36 52 72 98 148 262 503 0.0250 35.86 5.284 0.5431 101188.0
92200000
104000000000
133000000000000
0.5504 0.1103 0.0118 0.0028 0.0634 0.0052 0.1160 0.0282 0.1461 0.0612 0.1912 0.1266 0.1751 0.1507 0.1224 0.1351 0.0988 0.1573 0.0752 0.3329 0.0005 0.0002 0.0003 0.0011 0.0024 0.0023 0.0079 0.0094 0.0482 0.0428 0.0854 0.0656 0.0514 0.0563 0.0801 0.0808 0.7238 0.7415 0.0000 0.0000 0.0021 0.0008 0.0042 0.0035 0.0101 0.0097 0.0538 0.0635 0.0894 0.0884 0.0594 0.0666 0.0876 0.0970 0.6934 0.6706 0.0000 0.0003 0.0031 0.0089 0.0520 0.0851 0.0560 0.0875 0.7072
MDA-MB-231 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 827 97 image if available 4779 9869 431.6 72.01 52.87 95.06 321 371 401 423 444 465 484 498 512 0.0808 797 0.816 113.09 23.00 3 0.0515 246 0.0015 19.21 6.788 0.2616 191443.0
86800000
40100000000
18800000000000
0.4012 0.2344 0.0000 0.0000 0.0003 0.0000 0.0037 0.0004 0.0072 0.0011 0.0289 0.0142 0.0520 0.0223 0.0494 0.0161 0.0921 0.0212 0.7664 0.9247 0.0000 0.0000 0.0000 0.0000 0.0007 0.0004 0.0024 0.0011 0.0169 0.0142 0.0276 0.0223 0.0203 0.0161 0.0286 0.0212 0.9034 0.9247 0.0406 0.0000 0.0406 0.0000 0.0969 0.0000 0.1031 0.0000 0.1406 0.0000 0.1875 0.0000 0.1125 0.0000 0.1188 0.0000 0.1594 0.0000 0.0026 0.0015 0.0060 0.0139 0.0285 0.0490 0.0401 0.0487 0.8098 5 6 8 9 10 13 28 75 177 0.2057 10.66 3.527 0.6733 11831.5
4010000
1640000000
755000000000
0.4322 0.1951 0.0842 0.0023 0.1811 0.0240 0.2704 0.1244 0.1505 0.1210 0.1505 0.2237 0.1148 0.1872 0.0332 0.1016 0.0128 0.1062 0.0026 0.1096 0.0000 0.0000 0.0020 0.0007 0.0032 0.0060 0.0134 0.0112 0.0512 0.0417 0.0721 0.0684 0.0473 0.0407 0.0776 0.0691 0.7333 0.7622 0.0005 0.0005 0.0014 0.0015 0.0061 0.0051 0.0182 0.0243 0.0634 0.0694 0.0895 0.0861 0.0541 0.0597 0.0848 0.0891 0.6822 0.6643 0.0009 0.0017 0.0021 0.0167 0.0541 0.0824 0.0558 0.0815 0.7048