High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 421 124 image if available 5496 10543 841.5 127.28 116.18 190.68 650 752 803 837 864 891 918 946 983 0.0719 758 0.901 57.38 16.12 1 0.0260 143 0.0008 45.33 7.373 0.1837 724381.0
635000000
565000000000
510000000000000
0.4046 0.2403 0.0000 0.0000 0.0002 0.0002 0.0004 0.0000 0.0037 0.0006 0.0217 0.0126 0.0354 0.0196 0.0394 0.0116 0.0630 0.0199 0.8361 0.9356 0.0000 0.0000 0.0000 0.0002 0.0000 0.0000 0.0019 0.0006 0.0126 0.0126 0.0229 0.0196 0.0169 0.0116 0.0272 0.0199 0.9185 0.9356 0.0145 0.0000 0.0364 0.0000 0.0545 0.0000 0.1200 0.0000 0.1200 0.0000 0.1418 0.0000 0.1455 0.0000 0.1091 0.0000 0.2582 0.0000 0.0016 0.0038 0.0047 0.0144 0.0357 0.0510 0.0620 0.0780 0.7489 11 14 18 24 31 47 83 165 375 0.1122 20.14 4.053 0.6479 49852.9
32900000
26200000000
23500000000000
0.4577 0.2035 0.0423 0.0022 0.1482 0.0186 0.2052 0.1010 0.1580 0.1256 0.1612 0.1330 0.1075 0.1627 0.0749 0.1085 0.0619 0.1226 0.0407 0.2259 0.0007 0.0006 0.0007 0.0012 0.0071 0.0066 0.0172 0.0124 0.0487 0.0469 0.0774 0.0650 0.0551 0.0478 0.0804 0.0728 0.7127 0.7468 0.0000 0.0005 0.0004 0.0014 0.0030 0.0038 0.0179 0.0141 0.0640 0.0756 0.0989 0.1136 0.0648 0.0700 0.0942 0.1103 0.6567 0.6108 0.0000 0.0027 0.0027 0.0170 0.0572 0.0877 0.0634 0.0912 0.6781
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 779 772 image if available 630 2293 62.2 11.79 6.82 2.35 48 51 54 57 61 65 69 73 77 0.1522 349 0.662 34.06 7.21 2 0.1444 91 0.0668 0.76 2.979 0.7113 4008.3
267309
18400000
1310000000
0.4337 0.1967 0.0000 0.0000 0.0115 0.0000 0.0253 0.0016 0.0484 0.0081 0.1106 0.0520 0.1521 0.0846 0.1728 0.0618 0.2166 0.1317 0.2627 0.6602 0.0000 0.0000 0.0038 0.0000 0.0075 0.0016 0.0226 0.0048 0.0658 0.0476 0.0921 0.0778 0.0714 0.0429 0.1372 0.0984 0.5996 0.7270 0.0102 0.1333 0.0408 0.0000 0.0612 0.1333 0.1633 0.4000 0.1837 0.0000 0.2245 0.2667 0.1224 0.0000 0.1020 0.0000 0.0918 0.0667 0.0000 0.0000 0.0065 0.0647 0.0971 0.1100 0.1197 0.1553 0.4466 4 5 5 6 6 7 7 8 10 0.0239 6.69 4.216 0.3943 52.0
441.077
4128.92
42300.9
0.5603 0.1272 0.0098 0.0035 0.0446 0.0081 0.1223 0.0190 0.1982 0.0432 0.2580 0.0876 0.1839 0.1643 0.1205 0.2190 0.0509 0.2824 0.0116 0.1729 0.0044 0.0000 0.0196 0.0010 0.0418 0.0068 0.0982 0.0209 0.1483 0.0507 0.1781 0.0989 0.1749 0.1495 0.1477 0.2567 0.1869 0.4155 0.1638 0.1855 0.1048 0.0943 0.1114 0.1006 0.1048 0.1132 0.1201 0.1226 0.1004 0.1164 0.1048 0.1069 0.0873 0.0943 0.1026 0.0660 0.0254 0.0806 0.1569 0.1490 0.1350 0.1060 0.1060 0.0947 0.1464
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 1218 127 image if available 498 20452 136.6 11.03 9.21 3.44 125 129 132 134 137 139 142 145 150 0.0417 853 1.250 19.42 8.06 3 0.1104 55 0.0920 0.84 2.707 0.6980 18782.2
2600000
362000000
50600000000
0.4730 0.1733 0.0000 0.0000 0.0021 0.0000 0.0103 0.0080 0.0103 0.0080 0.0514 0.0502 0.1337 0.1285 0.0638 0.0582 0.1008 0.0683 0.6276 0.6787 0.0000 0.0000 0.0021 0.0000 0.0103 0.0080 0.0103 0.0080 0.0513 0.0502 0.1335 0.1285 0.0637 0.0582 0.0842 0.0683 0.6448 0.6787 1.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0080 0.0080 0.0319 0.0956 0.1873 0.1594 0.1912 0.1753 0.1434 5 6 7 8 9 10 11 12 14 0.3292 0.40 0.993 0.6993 96.6
1114.47
13902.1
185508
0.4877 0.1649 0.0427 0.0010 0.1299 0.0068 0.2175 0.0218 0.2344 0.0618 0.1940 0.1341 0.1196 0.2265 0.0482 0.2611 0.0121 0.2035 0.0016 0.0835 0.0015 0.0001 0.0101 0.0006 0.0312 0.0040 0.0680 0.0142 0.1176 0.0364 0.1753 0.0828 0.2208 0.1592 0.2235 0.3027 0.1521 0.4001 0.0590 0.1703 0.1271 0.2470 0.1772 0.2322 0.1954 0.1620 0.1825 0.0961 0.1334 0.0570 0.0783 0.0237 0.0376 0.0074 0.0095 0.0043 0.0081 0.0349 0.0676 0.1210 0.1670 0.1995 0.1880 0.1467 0.0671
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 692 185 image if available 19415 44441 368.7 56.02 244.04 276.54 299 324 341 357 370 384 398 414 438 0.0403 1792 0.714 124.33 24.70 1 0.0157 305 0.0014 22.18 6.923 0.2357 139081.0
53500000
21000000000
8390000000000
0.4311 0.2269 0.0001 0.0000 0.0008 0.0001 0.0028 0.0001 0.0066 0.0002 0.0259 0.0087 0.0530 0.0182 0.0576 0.0109 0.0865 0.0176 0.7667 0.9443 0.0001 0.0000 0.0004 0.0001 0.0011 0.0001 0.0033 0.0002 0.0141 0.0084 0.0282 0.0172 0.0273 0.0090 0.0375 0.0134 0.8880 0.9517 0.0119 0.0000 0.0209 0.0000 0.0346 0.0000 0.0930 0.0000 0.1169 0.0000 0.1574 0.0000 0.1199 0.0000 0.1306 0.0000 0.3148 0.0000 0.0012 0.0035 0.0100 0.0254 0.0509 0.0848 0.0988 0.1192 0.6061 17 22 30 54 118 220 341 473 647 0.0281 44.65 6.124 0.4266 136024.0
100000000
87800000000
88300000000000
0.4534 0.1804 0.0700 0.0020 0.2411 0.0134 0.3304 0.1499 0.1469 0.1951 0.0898 0.2149 0.0610 0.1886 0.0354 0.0976 0.0173 0.0724 0.0080 0.0662 0.0003 0.0002 0.0010 0.0004 0.0018 0.0013 0.0092 0.0076 0.0506 0.0416 0.1014 0.0881 0.0667 0.0543 0.0944 0.0803 0.6746 0.7262 0.0007 0.0004 0.0014 0.0017 0.0031 0.0043 0.0147 0.0194 0.0670 0.0789 0.1259 0.1392 0.0883 0.0943 0.1136 0.1275 0.5852 0.5343 0.0001 0.0007 0.0030 0.0105 0.0587 0.1131 0.0775 0.1049 0.6315
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 1165 419 image if available 423 1848 89.8 13.38 5.99 2.24 70 76 82 87 92 96 99 102 106 0.1580 292 0.987 101.21 28.84 2 0.5816 246 0.0855 0.62 2.720 0.7418 8238.7
771134
73500000
7110000000
0.4178 0.2216 0.0000 0.0000 0.0060 0.0000 0.0149 0.0000 0.0268 0.0071 0.0893 0.0567 0.1220 0.0946 0.1369 0.0520 0.1964 0.0827 0.4077 0.7069 0.0000 0.0000 0.0054 0.0000 0.0109 0.0000 0.0218 0.0071 0.0708 0.0567 0.0627 0.0946 0.0518 0.0520 0.0681 0.0827 0.7084 0.7069 0.0968 0.0000 0.2581 0.0000 0.2581 0.0000 0.1613 0.0000 0.0968 0.0000 0.0968 0.0000 0.0323 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0128 0.0213 0.0383 0.0553 0.0596 0.0851 0.1532 0.5745 3 4 5 6 6 6 7 8 9 0.0815 0.39 0.827 0.2673 40.9
306.966
2499.9
21880.8
0.5165 0.1403 0.0116 0.0008 0.0474 0.0055 0.1063 0.0444 0.2358 0.1014 0.2716 0.1846 0.1884 0.2472 0.1011 0.2274 0.0316 0.1450 0.0063 0.0436 0.0000 0.0000 0.0041 0.0020 0.0186 0.0118 0.0592 0.0341 0.1171 0.1076 0.1860 0.1594 0.2404 0.2270 0.2424 0.2782 0.1322 0.1798 0.1036 0.3053 0.2490 0.2824 0.2829 0.1756 0.1972 0.0954 0.1056 0.0916 0.0418 0.0305 0.0179 0.0153 0.0020 0.0038 0.0000 0.0000 0.0026 0.0290 0.0729 0.1747 0.2186 0.2151 0.1449 0.1010 0.0413
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 1132 783 image if available 5806 15602 539.4 203.19 87.63 159.39 237 320 418 529 593 630 664 708 771 0.0657 1025 0.615 160.90 32.02 5 0.0725 421 0.0005 70.80 7.812 0.1691 332268.0
221000000
155000000000
113000000000000
0.4107 0.2133 0.0000 0.0000 0.0015 0.0005 0.0067 0.0003 0.0370 0.0061 0.1090 0.0389 0.1697 0.0718 0.1398 0.0509 0.1506 0.0799 0.3856 0.7517 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0035 0.0013 0.0213 0.0203 0.0424 0.0428 0.0263 0.0197 0.0354 0.0324 0.8711 0.8834 0.0015 0.0000 0.0078 0.0000 0.0069 0.0000 0.0206 0.0000 0.0553 0.0000 0.0852 0.0000 0.0715 0.0000 0.0832 0.0000 0.6681 1.0000 0.0003 0.0000 0.0003 0.0038 0.0262 0.0487 0.0324 0.0461 0.8422 6 8 9 11 14 23 51 120 297 0.1136 5.25 3.423 0.5908 33081.1
18000000
11400000000
7790000000000
0.5377 0.1183 0.0619 0.0026 0.1417 0.0166 0.2366 0.0806 0.1761 0.1157 0.1747 0.1905 0.0894 0.2027 0.0688 0.1381 0.0303 0.1234 0.0206 0.1298 0.0010 0.0002 0.0007 0.0002 0.0020 0.0017 0.0110 0.0119 0.0483 0.0430 0.0841 0.0733 0.0507 0.0497 0.0741 0.0696 0.7281 0.7502 0.0003 0.0007 0.0012 0.0036 0.0056 0.0029 0.0148 0.0180 0.0545 0.0546 0.0898 0.0971 0.0634 0.0605 0.0756 0.0840 0.6947 0.6788 0.0003 0.0005 0.0038 0.0110 0.0513 0.0880 0.0548 0.0784 0.7120
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 343 266 image if available 9188 10970 380.5 50.11 368.80 331.03 317 338 353 366 379 392 407 423 446 0.0837 918 1.098 128.97 29.02 1 0.0293 269 0.0014 32.93 6.904 0.2140 147263.0
58000000
23200000000
9410000000000
0.4808 0.1754 0.0001 0.0000 0.0001 0.0000 0.0005 0.0000 0.0047 0.0002 0.0250 0.0095 0.0514 0.0210 0.0529 0.0104 0.0987 0.0165 0.7665 0.9424 0.0000 0.0000 0.0000 0.0000 0.0001 0.0000 0.0012 0.0001 0.0138 0.0095 0.0278 0.0207 0.0261 0.0093 0.0415 0.0143 0.8895 0.9462 0.0218 0.0000 0.0328 0.0000 0.0593 0.0000 0.0874 0.0000 0.1732 0.0000 0.1841 0.0000 0.1435 0.0000 0.1388 0.0000 0.1591 0.0000 0.0011 0.0040 0.0097 0.0303 0.0725 0.1067 0.1129 0.1309 0.5320 26 44 103 182 274 391 529 679 850 0.0115 87.23 6.899 0.3039 245585.0
203000000
190000000000
195000000000000
0.5450 0.1332 0.0240 0.0019 0.1159 0.0052 0.2589 0.0480 0.1785 0.1152 0.1414 0.1989 0.1291 0.2063 0.0765 0.1279 0.0433 0.1290 0.0325 0.1677 0.0004 0.0003 0.0015 0.0005 0.0044 0.0031 0.0158 0.0085 0.0472 0.0440 0.0846 0.0769 0.0584 0.0516 0.0824 0.0766 0.7053 0.7384 0.0003 0.0009 0.0025 0.0032 0.0058 0.0059 0.0156 0.0215 0.0666 0.0792 0.1115 0.1340 0.0860 0.1022 0.1267 0.1240 0.5849 0.5290 0.0000 0.0026 0.0050 0.0109 0.0579 0.0934 0.0690 0.0986 0.6626
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 561 247 image if available 4445 15033 466.1 65.09 63.62 138.06 379 413 433 450 466 481 499 521 551 0.0559 840 1.186 46.40 17.49 1 0.0270 120 0.0015 34.76 6.820 0.2169 221513.0
107000000
52800000000
26400000000000
0.4116 0.2311 0.0000 0.0000 0.0000 0.0000 0.0011 0.0000 0.0035 0.0002 0.0355 0.0137 0.0646 0.0248 0.0635 0.0142 0.0910 0.0205 0.7407 0.9266 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0020 0.0002 0.0221 0.0137 0.0368 0.0248 0.0314 0.0142 0.0456 0.0187 0.8620 0.9284 0.0110 1.0000 0.0192 0.0000 0.0219 0.0000 0.0959 0.0000 0.1479 0.0000 0.1726 0.0000 0.1397 0.0000 0.1288 0.0000 0.2630 0.0000 0.0004 0.0036 0.0085 0.0278 0.0732 0.0996 0.0961 0.1302 0.5606 7 8 9 10 12 15 22 57 200 0.2619 11.61 3.053 0.7574 23105.5
14100000
11000000000
10100000000000
0.4691 0.1844 0.0363 0.0081 0.0726 0.0208 0.0726 0.0728 0.1501 0.0786 0.1622 0.1110 0.1671 0.1260 0.1574 0.1191 0.1090 0.1445 0.0726 0.3191 0.0003 0.0012 0.0013 0.0030 0.0023 0.0044 0.0077 0.0094 0.0229 0.0195 0.0265 0.0301 0.0245 0.0248 0.0368 0.0387 0.8777 0.8689 0.0011 0.0000 0.0011 0.0004 0.0022 0.0024 0.0108 0.0091 0.0238 0.0234 0.0309 0.0313 0.0313 0.0317 0.0395 0.0527 0.8593 0.8490 0.0003 0.0007 0.0048 0.0104 0.0214 0.0308 0.0235 0.0443 0.8637
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 591 322 image if available 3805 8120 447.6 140.46 62.41 102.20 225 309 397 453 481 505 531 568 598 0.0792 643 1.179 95.75 35.78 2 0.0636 242 0.0012 24.22 7.023 0.2589 220069.0
114000000
61800000000
34400000000000
0.3868 0.2449 0.0017 0.0000 0.0000 0.0000 0.0011 0.0003 0.0114 0.0030 0.0542 0.0207 0.0787 0.0353 0.0685 0.0267 0.1038 0.0443 0.6805 0.8697 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0014 0.0019 0.0183 0.0158 0.0254 0.0260 0.0183 0.0167 0.0268 0.0236 0.9097 0.9160 0.0009 0.0000 0.0037 0.0000 0.0083 0.0000 0.0111 0.0000 0.0426 0.0000 0.0546 0.0000 0.0592 0.0000 0.0823 0.0000 0.7373 1.0000 0.0000 0.0000 0.0017 0.0047 0.0236 0.0356 0.0347 0.0592 0.8404 8 9 11 12 16 24 45 91 190 0.1789 5.12 3.242 0.6875 14337.8
5250000
2370000000
1220000000000
0.6067 0.0913 0.0581 0.0060 0.1183 0.0249 0.1618 0.0957 0.1390 0.1256 0.1784 0.1446 0.1515 0.1605 0.1224 0.1296 0.0456 0.0987 0.0249 0.2144 0.0017 0.0015 0.0035 0.0026 0.0035 0.0045 0.0138 0.0146 0.0558 0.0544 0.0878 0.0773 0.0636 0.0484 0.0930 0.0926 0.6775 0.7041 0.0005 0.0006 0.0005 0.0006 0.0033 0.0024 0.0169 0.0192 0.0754 0.0800 0.1038 0.1191 0.0644 0.0565 0.1032 0.1179 0.6319 0.6037 0.0010 0.0034 0.0039 0.0186 0.0658 0.0932 0.0677 0.0991 0.6472
MDA-MB-231 Barasertib
10
uM
DRAQ5 1 TMRE 2 1 15 1 587 223 image if available 7211 12710 578.3 90.41 89.40 111.01 452 510 547 574 591 608 625 646 680 0.0629 799 0.795 89.56 23.85 3 0.0344 248 0.0009 62.64 7.370 0.1958 342572.0
207000000
127000000000
79600000000000
0.4491 0.1905 0.0000 0.0000 0.0003 0.0000 0.0012 0.0000 0.0041 0.0004 0.0233 0.0117 0.0460 0.0246 0.0364 0.0110 0.0566 0.0202 0.8320 0.9321 0.0000 0.0000 0.0003 0.0000 0.0005 0.0000 0.0017 0.0004 0.0145 0.0117 0.0316 0.0246 0.0189 0.0110 0.0268 0.0179 0.9057 0.9343 0.0091 1.0000 0.0146 0.0000 0.0183 0.0000 0.0530 0.0000 0.0804 0.0000 0.1005 0.0000 0.1024 0.0000 0.0951 0.0000 0.5265 0.0000 0.0002 0.0019 0.0045 0.0124 0.0426 0.0660 0.0670 0.0881 0.7172 10 14 19 27 40 63 103 156 234 0.0268 20.05 5.200 0.4970 20313.0
7180000
3310000000
1810000000000
0.4322 0.2068 0.0263 0.0009 0.1259 0.0110 0.2488 0.0568 0.1902 0.1088 0.1746 0.1845 0.1190 0.2039 0.0576 0.1352 0.0371 0.1325 0.0205 0.1664 0.0006 0.0000 0.0021 0.0011 0.0049 0.0034 0.0148 0.0150 0.0490 0.0449 0.0884 0.0752 0.0504 0.0554 0.0762 0.0747 0.7136 0.7303 0.0008 0.0006 0.0022 0.0034 0.0048 0.0079 0.0202 0.0248 0.0619 0.0657 0.0967 0.1116 0.0695 0.0730 0.0948 0.0920 0.6491 0.6210 0.0000 0.0017 0.0031 0.0174 0.0513 0.0911 0.0613 0.0830 0.6913
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 422 387 image if available 8367 21686 338.6 51.23 216.62 253.93 275 292 307 321 337 351 367 383 406 0.0592 1284 1.224 118.07 44.69 1 0.0354 296 0.0016 21.25 6.715 0.2518 117279.0
41500000
15000000000
5540000000000
0.4429 0.2078 0.0001 0.0000 0.0004 0.0000 0.0013 0.0000 0.0080 0.0001 0.0305 0.0112 0.0543 0.0192 0.0664 0.0146 0.1150 0.0208 0.7238 0.9341 0.0001 0.0000 0.0003 0.0000 0.0005 0.0000 0.0034 0.0000 0.0155 0.0105 0.0264 0.0169 0.0305 0.0096 0.0535 0.0147 0.8698 0.9484 0.0147 0.0000 0.0209 0.0000 0.0466 0.0000 0.0798 0.0000 0.1325 0.0000 0.1509 0.0000 0.1166 0.0000 0.1387 0.0000 0.2994 0.0000 0.0029 0.0037 0.0079 0.0179 0.0489 0.0872 0.0769 0.1138 0.6407 23 31 44 65 97 158 256 389 599 0.0168 30.30 6.006 0.4494 111401.0
80200000
68700000000
66100000000000
0.5043 0.1472 0.0237 0.0026 0.1369 0.0072 0.2565 0.0574 0.1751 0.1186 0.1568 0.1945 0.1196 0.2092 0.0501 0.1261 0.0356 0.1132 0.0458 0.1711 0.0002 0.0003 0.0005 0.0006 0.0022 0.0014 0.0105 0.0091 0.0514 0.0447 0.0911 0.0790 0.0565 0.0498 0.0825 0.0754 0.7050 0.7396 0.0003 0.0002 0.0011 0.0016 0.0023 0.0053 0.0156 0.0192 0.0627 0.0685 0.1061 0.1174 0.0749 0.0819 0.0955 0.0997 0.6414 0.6062 0.0001 0.0003 0.0026 0.0142 0.0598 0.0932 0.0668 0.0874 0.6756
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 792 805 image if available 4919 8206 382.1 68.91 141.31 188.12 300 324 344 360 375 392 412 438 476 0.0898 737 1.029 141.51 47.89 1 0.0732 360 0.0011 37.46 7.089 0.1984 150764.0
61400000
25800000000
11200000000000
0.4301 0.2151 0.0000 0.0000 0.0008 0.0000 0.0030 0.0000 0.0107 0.0015 0.0411 0.0153 0.0748 0.0283 0.0789 0.0233 0.1114 0.0344 0.6794 0.8971 0.0000 0.0000 0.0002 0.0000 0.0016 0.0000 0.0041 0.0008 0.0202 0.0133 0.0357 0.0198 0.0359 0.0131 0.0538 0.0182 0.8484 0.9348 0.0014 0.0000 0.0043 0.0000 0.0216 0.0000 0.0620 0.0000 0.1037 0.0000 0.1527 0.0000 0.1081 0.0000 0.1326 0.0000 0.4135 0.0000 0.0022 0.0022 0.0118 0.0263 0.0679 0.1121 0.0937 0.1222 0.5617 17 22 29 36 53 94 149 244 370 0.0319 21.94 5.086 0.5347 55351.4
34100000
26500000000
23500000000000
0.4596 0.1622 0.0237 0.0014 0.1379 0.0121 0.2020 0.0752 0.1323 0.1079 0.1295 0.1526 0.1337 0.1923 0.0975 0.1214 0.0641 0.1008 0.0794 0.2363 0.0000 0.0000 0.0010 0.0003 0.0007 0.0012 0.0104 0.0064 0.0542 0.0436 0.0808 0.0753 0.0636 0.0516 0.0855 0.0680 0.7037 0.7537 0.0013 0.0000 0.0000 0.0010 0.0018 0.0015 0.0075 0.0185 0.0755 0.0713 0.1132 0.1307 0.0644 0.0723 0.1012 0.1142 0.6350 0.5905 0.0004 0.0008 0.0016 0.0117 0.0600 0.1028 0.0631 0.0919 0.6678
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 652 166 image if available 1359 6119 428.9 60.31 32.37 70.62 351 373 390 405 426 446 465 483 508 0.0709 434 0.794 97.08 19.70 1 0.1670 227 0.0023 22.07 6.272 0.2405 187585.0
83600000
38000000000
17500000000000
0.4204 0.2216 0.0009 0.0000 0.0000 0.0000 0.0026 0.0000 0.0061 0.0000 0.0462 0.0221 0.0688 0.0324 0.0592 0.0191 0.0897 0.0316 0.7265 0.8948 0.0000 0.0000 0.0000 0.0000 0.0024 0.0000 0.0016 0.0000 0.0293 0.0221 0.0443 0.0324 0.0332 0.0191 0.0546 0.0316 0.8347 0.8948 0.0259 0.0000 0.0000 0.0000 0.0000 0.0000 0.0776 0.0000 0.1638 0.0000 0.1983 0.0000 0.1207 0.0000 0.1379 0.0000 0.2759 0.0000 0.0000 0.0046 0.0077 0.0107 0.0475 0.0644 0.0706 0.0982 0.6963 6 8 9 10 11 13 15 23 79 0.3514 3.58 2.313 0.8106 6034.5
2460000
1350000000
863000000000
0.6003 0.1052 0.0807 0.0227 0.0807 0.0644 0.1211 0.0814 0.2870 0.1458 0.1435 0.1496 0.1480 0.1458 0.0762 0.1326 0.0583 0.1307 0.0045 0.1269 0.0088 0.0079 0.0044 0.0186 0.0071 0.0193 0.0274 0.0336 0.0398 0.0480 0.0548 0.0523 0.0610 0.0651 0.0839 0.0938 0.7129 0.6614 0.0000 0.0000 0.0044 0.0023 0.0055 0.0046 0.0143 0.0161 0.0539 0.0506 0.0462 0.0598 0.0616 0.0529 0.0935 0.0978 0.7206 0.7158 0.0020 0.0050 0.0090 0.0160 0.0548 0.0439 0.0499 0.1017 0.7178
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 873 826 image if available 3064 6137 665.1 116.47 15.42 8.04 492 567 616 649 680 707 733 763 800 0.0893 548 0.993 122.00 37.22 1 0.0979 300 0.0008 64.26 7.305 0.1764 455869.0
321000000
230000000000
169000000000000
0.4008 0.2360 0.0000 0.0000 0.0004 0.0003 0.0026 0.0000 0.0061 0.0010 0.0299 0.0170 0.0464 0.0304 0.0438 0.0180 0.0520 0.0277 0.8189 0.9056 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0023 0.0010 0.0186 0.0166 0.0266 0.0282 0.0190 0.0159 0.0274 0.0239 0.9060 0.9143 0.0000 0.0000 0.0063 0.0000 0.0031 0.0000 0.0563 0.0000 0.0875 0.0000 0.1125 0.0000 0.0906 0.0000 0.1125 0.0000 0.5313 0.0000 0.0006 0.0053 0.0029 0.0135 0.0224 0.0494 0.0371 0.0530 0.8158 9 10 11 12 13 15 16 19 25 0.3326 0.28 1.109 0.7287 302.3
7707.87
246475
9230000
0.5740 0.1078 0.0370 0.0041 0.0648 0.0041 0.1039 0.0126 0.1337 0.0236 0.1566 0.0577 0.1880 0.1004 0.1606 0.1497 0.1151 0.2427 0.0403 0.4050 0.0184 0.0004 0.0317 0.0011 0.0455 0.0041 0.0608 0.0114 0.0782 0.0408 0.0945 0.0788 0.0862 0.1063 0.1277 0.1658 0.4570 0.5914 0.0395 0.0410 0.0482 0.0420 0.0556 0.0400 0.0649 0.0470 0.0803 0.0561 0.0770 0.0681 0.0663 0.0681 0.1071 0.1692 0.4612 0.4685 0.0423 0.0379 0.0347 0.0520 0.0863 0.1089 0.1044 0.1262 0.4073