High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)
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Cell | SM Name | Small Mol Concentration | Small Mol Conc Unit | Other Reagent 1 Name | Other Reagent 1 Detection Channel | Other Reagent 2 Name | Other Reagent 2 Detection Channel | Row | Column | Field | X-coordinate | Y-coordinate | Image | Nuclear area (pixels) | Cytoplasm area (pixels) | Nuclear intensity (AU) | Std Dev of nuclear intensity (AU) | Cytoplasm intensity (AU) | Std Dev of cytoplasm intensity (AU) | 10% quantile of nuclear intensity (AU) | 20% quantile of nuclear intensity (AU) | 30% quantile of nuclear intensity (AU) | 40% quantile of nuclear intensity (AU) | 50% quantile of nuclear intensity (AU) | 60% quantile of nuclear intensity (AU) | 70% quantile of nuclear intensity (AU) | 80% quantile of nuclear intensity (AU) | 90% quantile of nuclear intensity (AU) | Ratio of cytoplasm perimeter to area | Cytoplasm perimeter (pixels) | Nuclear roundness | Nuclear length (pixels) | Nuclear halfwidth (pixels) | Number of nuclei | Ratio of nuclear perimeter to area | Nuclear perimeter (pixels) | Nuclear Haralick ASM | Nuclear Haralick contrast | Nuclear Haralick entropy | Nuclear Haralick IDM | Nuclear Haralick moment 2 | Nuclear Haralick moment 3 | Nuclear Haralick moment 4 | Nuclear Haralick moment 5 | Nuclear radial moment (border) | Nuclear radial moment (center) | Nuclear Threshold Adj Stat 1 (Threshold: 0.2) | Nuclear Threshold Adj Stat 1 (Threshold: 0.4) | Nuclear Threshold Adj Stat 2 (Threshold: 0.2) | Nuclear Threshold Adj Stat 2 (Threshold: 0.4) | Nuclear Threshold Adj Stat 3 (Threshold: 0.2) | Nuclear Threshold Adj Stat 3 (Threshold: 0.4) | Nuclear Threshold Adj Stat 4 (Threshold: 0.2) | Nuclear Threshold Adj Stat 4 (Threshold: 0.4) | Nuclear Threshold Adj Stat 5 (Threshold: 0.2) | Nuclear Threshold Adj Stat 5 (Threshold: 0.4) | Nuclear Threshold Adj Stat 6 (Threshold: 0.2) | Nuclear Threshold Adj Stat 6 (Threshold: 0.4) | Nuclear Threshold Adj Stat 7 (Threshold: 0.2) | Nuclear Threshold Adj Stat 7 (Threshold: 0.4) | Nuclear Threshold Adj Stat 8 (Threshold: 0.2) | Nuclear Threshold Adj Stat 8 (Threshold: 0.4) | Nuclear Threshold Adj Stat 9 (Threshold: 0.2) | Nuclear Threshold Adj Stat 9 (Threshold: 0.4) | Nuclear Threshold Adj Stat 10 (Threshold: 0.2) | Nuclear Threshold Adj Stat 10 (Threshold: 0.4) | Nuclear Threshold Adj Stat 11 (Threshold: 0.2) | Nuclear Threshold Adj Stat 11 (Threshold: 0.4) | Nuclear Threshold Adj Stat 12 (Threshold: 0.2) | Nuclear Threshold Adj Stat 12 (Threshold: 0.4) | Nuclear Threshold Adj Stat 13 (Threshold: 0.2) | Nuclear Threshold Adj Stat 13 (Threshold: 0.4) | Nuclear Threshold Adj Stat 14 (Threshold: 0.2) | Nuclear Threshold Adj Stat 14 (Threshold: 0.4) | Nuclear Threshold Adj Stat 15 (Threshold: 0.2) | Nuclear Threshold Adj Stat 15 (Threshold: 0.4) | Nuclear Threshold Adj Stat 16 (Threshold: 0.2) | Nuclear Threshold Adj Stat 16 (Threshold: 0.4) | Nuclear Threshold Adj Stat 17 (Threshold: 0.2) | Nuclear Threshold Adj Stat 17 (Threshold: 0.4) | Nuclear Threshold Adj Stat 18 (Threshold: 0.2) | Nuclear Threshold Adj Stat 18 (Threshold: 0.4) | Nuclear Threshold Adj Stat 19 (Threshold: 0.2) | Nuclear Threshold Adj Stat 19 (Threshold: 0.4) | Nuclear Threshold Adj Stat 20 (Threshold: 0.2) | Nuclear Threshold Adj Stat 20 (Threshold: 0.4) | Nuclear Threshold Adj Stat 21 (Threshold: 0.2) | Nuclear Threshold Adj Stat 21 (Threshold: 0.4) | Nuclear Threshold Adj Stat 22 (Threshold: 0.2) | Nuclear Threshold Adj Stat 22 (Threshold: 0.4) | Nuclear Threshold Adj Stat 23 (Threshold: 0.2) | Nuclear Threshold Adj Stat 23 (Threshold: 0.4) | Nuclear Threshold Adj Stat 24 (Threshold: 0.2) | Nuclear Threshold Adj Stat 24 (Threshold: 0.4) | Nuclear Threshold Adj Stat 25 (Threshold: 0.2) | Nuclear Threshold Adj Stat 25 (Threshold: 0.4) | Nuclear Threshold Adj Stat 26 (Threshold: 0.2) | Nuclear Threshold Adj Stat 26 (Threshold: 0.4) | Nuclear Threshold Adj Stat 27 (Threshold: 0.2) | Nuclear Threshold Adj Stat 27 (Threshold: 0.4) | Nuclear Threshold Adj Stat 28 | Nuclear Threshold Adj Stat 29 | Nuclear Threshold Adj Stat 30 | Nuclear Threshold Adj Stat 31 | Nuclear Threshold Adj Stat 32 | Nuclear Threshold Adj Stat 33 | Nuclear Threshold Adj Stat 34 | Nuclear Threshold Adj Stat 35 | Nuclear Threshold Adj Stat 36 | 10% quantile of cytoplasm intensity (AU) | 20% quantile of cytoplasm intensity (AU) | 30% quantile of cytoplasm intensity (AU) | 40% quantile of cytoplasm intensity (AU) | 50% quantile of cytoplasm intensity (AU) | 60% quantile of cytoplasm intensity (AU) | 70% quantile of cytoplasm intensity (AU) | 80% quantile of cytoplasm intensity (AU) | 90% quantile of cytoplasm intensity (AU) | Cytoplasmic Haralick ASM | Cytoplasmic Haralick contrast | Cytoplasmic Haralick entropy | Cytoplasmic Haralick IDM | Cytoplasmic Haralick moment 2 | Cytoplasmic Haralick moment 3 | Cytoplasmic Haralick moment 4 | Cytoplasmic Haralick moment 5 | Cytoplasmic radial moment (border) | Cytoplasmic radial moment (center) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) | Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) | Cytoplasmic Threshold Adj Stat 28 | Cytoplasmic Threshold Adj Stat 29 | Cytoplasmic Threshold Adj Stat 30 | Cytoplasmic Threshold Adj Stat 31 | Cytoplasmic Threshold Adj Stat 32 | Cytoplasmic Threshold Adj Stat 33 | Cytoplasmic Threshold Adj Stat 34 | Cytoplasmic Threshold Adj Stat 35 | Cytoplasmic Threshold Adj Stat 36 |
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MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 662 | 697 | 5913 | 18261 | 491.0 | 67.94 | 138.35 | 220.58 | 396 | 436 | 462 | 484 | 500 | 513 | 528 | 544 | 572 | 0.0451 | 824 | 1.176 | 94.54 | 34.99 | 1 | 0.0404 | 239 | 0.0021 | 16.68 | 6.549 | 0.2788 | 245703.0 | 125000000 | 64600000000 | 33900000000000 | 0.4193 | 0.2254 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0010 | 0.0000 | 0.0052 | 0.0002 | 0.0206 | 0.0107 | 0.0401 | 0.0231 | 0.0409 | 0.0105 | 0.0497 | 0.0178 | 0.8421 | 0.9378 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0011 | 0.0002 | 0.0140 | 0.0105 | 0.0257 | 0.0222 | 0.0200 | 0.0095 | 0.0276 | 0.0162 | 0.9112 | 0.9414 | 0.0028 | 0.0000 | 0.0142 | 0.1111 | 0.0426 | 0.1111 | 0.0767 | 0.1111 | 0.1392 | 0.4444 | 0.1193 | 0.2222 | 0.1193 | 0.0000 | 0.1591 | 0.0000 | 0.3267 | 0.0000 | 0.0003 | 0.0033 | 0.0069 | 0.0169 | 0.0350 | 0.0555 | 0.0628 | 0.0872 | 0.7320 | 8 | 10 | 12 | 16 | 27 | 52 | 112 | 246 | 464 | 0.1339 | 21.44 | 4.364 | 0.6125 | 67793.0 | 46900000 | 38600000000 | 36000000000000 | 0.3682 | 0.2671 | 0.0646 | 0.0035 | 0.1579 | 0.0234 | 0.2759 | 0.1034 | 0.1692 | 0.1313 | 0.1344 | 0.1895 | 0.0985 | 0.2004 | 0.0595 | 0.1034 | 0.0236 | 0.1193 | 0.0164 | 0.1258 | 0.0004 | 0.0006 | 0.0011 | 0.0015 | 0.0025 | 0.0023 | 0.0114 | 0.0085 | 0.0461 | 0.0447 | 0.0764 | 0.0614 | 0.0517 | 0.0432 | 0.0719 | 0.0705 | 0.7384 | 0.7673 | 0.0011 | 0.0005 | 0.0009 | 0.0007 | 0.0026 | 0.0033 | 0.0168 | 0.0158 | 0.0521 | 0.0575 | 0.0907 | 0.0945 | 0.0618 | 0.0628 | 0.0783 | 0.0833 | 0.6958 | 0.6816 | 0.0006 | 0.0014 | 0.0028 | 0.0152 | 0.0474 | 0.0861 | 0.0548 | 0.0734 | 0.7183 | |||
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 956 | 595 | 1268 | 9881 | 91.4 | 16.59 | 53.65 | 107.18 | 71 | 75 | 80 | 84 | 89 | 95 | 101 | 108 | 115 | 0.0764 | 755 | 0.686 | 37.00 | 9.00 | 2 | 0.0694 | 88 | 0.0675 | 0.54 | 2.946 | 0.7664 | 8636.4 | 841834 | 84500000 | 8730000000 | 0.3820 | 0.2594 | 0.0034 | 0.0000 | 0.0101 | 0.0000 | 0.0190 | 0.0000 | 0.0324 | 0.0056 | 0.0738 | 0.0272 | 0.1309 | 0.0769 | 0.1119 | 0.0408 | 0.1644 | 0.0665 | 0.4541 | 0.7830 | 0.0027 | 0.0000 | 0.0063 | 0.0000 | 0.0081 | 0.0000 | 0.0181 | 0.0055 | 0.0433 | 0.0268 | 0.0668 | 0.0702 | 0.0542 | 0.0292 | 0.0713 | 0.0489 | 0.7292 | 0.8194 | 0.0140 | 0.0526 | 0.0047 | 0.0000 | 0.0607 | 0.0526 | 0.0467 | 0.1579 | 0.1215 | 0.4211 | 0.1449 | 0.1053 | 0.1402 | 0.0000 | 0.1869 | 0.1579 | 0.2804 | 0.0526 | 0.0017 | 0.0066 | 0.0150 | 0.0282 | 0.0465 | 0.0781 | 0.0880 | 0.0698 | 0.6661 | 5 | 7 | 8 | 10 | 13 | 24 | 48 | 81 | 142 | 0.0679 | 5.33 | 3.029 | 0.5252 | 14364.0 | 10100000 | 10700000000 | 13000000000000 | 0.4553 | 0.2110 | 0.0320 | 0.0021 | 0.1446 | 0.0121 | 0.2309 | 0.0605 | 0.2156 | 0.1517 | 0.1307 | 0.1944 | 0.1154 | 0.1830 | 0.0654 | 0.1161 | 0.0501 | 0.1061 | 0.0153 | 0.1738 | 0.0000 | 0.0000 | 0.0019 | 0.0003 | 0.0042 | 0.0040 | 0.0160 | 0.0130 | 0.0521 | 0.0454 | 0.0878 | 0.0802 | 0.0597 | 0.0519 | 0.0917 | 0.0918 | 0.6867 | 0.7134 | 0.0012 | 0.0009 | 0.0012 | 0.0019 | 0.0058 | 0.0047 | 0.0162 | 0.0160 | 0.0697 | 0.0782 | 0.1107 | 0.1097 | 0.0680 | 0.0763 | 0.1190 | 0.1266 | 0.6082 | 0.5857 | 0.0000 | 0.0029 | 0.0040 | 0.0169 | 0.0606 | 0.0948 | 0.0671 | 0.1168 | 0.6369 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1028 | 672 | 465 | 2154 | 115.4 | 21.95 | 94.06 | 88.63 | 88 | 97 | 102 | 107 | 113 | 119 | 127 | 135 | 145 | 0.1467 | 316 | 0.423 | 90.70 | 21.40 | 1 | 0.5978 | 278 | 0.0052 | 16.34 | 5.463 | 0.2803 | 13796.9 | 1710000 | 218000000 | 28800000000 | 0.4162 | 0.2196 | 0.0000 | 0.0000 | 0.0031 | 0.0000 | 0.0247 | 0.0022 | 0.0556 | 0.0111 | 0.1049 | 0.0509 | 0.1852 | 0.0907 | 0.1420 | 0.0575 | 0.1821 | 0.1062 | 0.3025 | 0.6814 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0050 | 0.0022 | 0.0273 | 0.0086 | 0.0695 | 0.0452 | 0.1042 | 0.0839 | 0.0720 | 0.0344 | 0.1117 | 0.0796 | 0.6104 | 0.7462 | 0.0000 | 0.0000 | 0.0380 | 0.1538 | 0.0380 | 0.0000 | 0.1139 | 0.1538 | 0.1519 | 0.3846 | 0.2152 | 0.0000 | 0.1392 | 0.1538 | 0.1139 | 0.1538 | 0.1899 | 0.0000 | 0.0000 | 0.0045 | 0.0179 | 0.0538 | 0.1345 | 0.1211 | 0.1211 | 0.1704 | 0.3767 | 17 | 26 | 35 | 44 | 58 | 78 | 107 | 164 | 229 | 0.0192 | 12.21 | 4.935 | 0.4816 | 16699.0 | 4090000 | 1190000000 | 384000000000 | 0.5433 | 0.1288 | 0.0185 | 0.0036 | 0.1218 | 0.0145 | 0.1808 | 0.0416 | 0.1734 | 0.1139 | 0.2251 | 0.1953 | 0.0959 | 0.1664 | 0.0812 | 0.1356 | 0.0554 | 0.1447 | 0.0480 | 0.1844 | 0.0000 | 0.0000 | 0.0056 | 0.0009 | 0.0090 | 0.0027 | 0.0124 | 0.0192 | 0.0710 | 0.0602 | 0.1150 | 0.0794 | 0.0744 | 0.0776 | 0.1488 | 0.1487 | 0.5637 | 0.6113 | 0.0016 | 0.0000 | 0.0032 | 0.0018 | 0.0065 | 0.0147 | 0.0260 | 0.0313 | 0.0666 | 0.0792 | 0.1380 | 0.1455 | 0.0893 | 0.0958 | 0.1347 | 0.1602 | 0.5341 | 0.4715 | 0.0014 | 0.0082 | 0.0109 | 0.0301 | 0.0657 | 0.1012 | 0.0821 | 0.1477 | 0.5527 | |
MCF7 | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 209 | 861 | 543 | 4357 | 152.9 | 32.22 | 90.49 | 146.81 | 112 | 125 | 134 | 144 | 152 | 161 | 170 | 181 | 194 | 0.0925 | 403 | 1.074 | 82.81 | 25.61 | 1 | 0.3665 | 199 | 0.0040 | 21.07 | 5.680 | 0.2454 | 24410.0 | 4050000 | 697000000 | 124000000000 | 0.4295 | 0.2088 | 0.0000 | 0.0000 | 0.0029 | 0.0000 | 0.0029 | 0.0000 | 0.0632 | 0.0078 | 0.1523 | 0.0447 | 0.1638 | 0.0953 | 0.1868 | 0.0700 | 0.1782 | 0.1498 | 0.2500 | 0.6323 | 0.0000 | 0.0000 | 0.0022 | 0.0000 | 0.0000 | 0.0000 | 0.0156 | 0.0075 | 0.0690 | 0.0413 | 0.0980 | 0.0732 | 0.0802 | 0.0450 | 0.1114 | 0.0994 | 0.6236 | 0.7336 | 0.0198 | 0.0000 | 0.0099 | 0.0000 | 0.0891 | 0.1053 | 0.1089 | 0.3684 | 0.1782 | 0.3684 | 0.1188 | 0.0526 | 0.1584 | 0.1053 | 0.1386 | 0.0000 | 0.1782 | 0.0000 | 0.0000 | 0.0075 | 0.0491 | 0.0340 | 0.1132 | 0.1208 | 0.1094 | 0.1245 | 0.4415 | 6 | 7 | 9 | 10 | 12 | 26 | 64 | 155 | 335 | 0.1505 | 5.85 | 3.608 | 0.6197 | 29737.3 | 12900000 | 6260000000 | 3270000000000 | 0.5075 | 0.1310 | 0.0714 | 0.0045 | 0.1939 | 0.0201 | 0.2041 | 0.0447 | 0.2857 | 0.1029 | 0.1276 | 0.2282 | 0.0867 | 0.2371 | 0.0255 | 0.1365 | 0.0051 | 0.1275 | 0.0000 | 0.0984 | 0.0016 | 0.0014 | 0.0008 | 0.0000 | 0.0016 | 0.0007 | 0.0195 | 0.0114 | 0.0568 | 0.0549 | 0.0860 | 0.0834 | 0.0543 | 0.0499 | 0.0933 | 0.0848 | 0.6861 | 0.7135 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0029 | 0.0031 | 0.0145 | 0.0157 | 0.0685 | 0.0680 | 0.0858 | 0.0931 | 0.0559 | 0.0596 | 0.1022 | 0.1004 | 0.6702 | 0.6600 | 0.0009 | 0.0000 | 0.0027 | 0.0089 | 0.0608 | 0.0956 | 0.0536 | 0.0903 | 0.6872 | |
MCF7 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 441 | 854 | 1964 | 2153 | 94.0 | 19.07 | 5.89 | 2.19 | 65 | 75 | 84 | 91 | 97 | 103 | 107 | 111 | 116 | 0.2216 | 477 | 0.494 | 340.58 | 73.33 | 1 | 0.5046 | 991 | 0.0224 | 1.75 | 4.105 | 0.5669 | 9205.0 | 931383 | 96800000 | 10300000000 | 0.4309 | 0.2010 | 0.0000 | 0.0000 | 0.0073 | 0.0000 | 0.0147 | 0.0005 | 0.0359 | 0.0058 | 0.0661 | 0.0242 | 0.1184 | 0.0453 | 0.1380 | 0.0353 | 0.1959 | 0.0679 | 0.4237 | 0.8211 | 0.0000 | 0.0000 | 0.0019 | 0.0000 | 0.0013 | 0.0005 | 0.0109 | 0.0052 | 0.0300 | 0.0235 | 0.0504 | 0.0434 | 0.0549 | 0.0314 | 0.0709 | 0.0581 | 0.7797 | 0.8378 | 0.0235 | 0.0909 | 0.0293 | 0.0000 | 0.0704 | 0.1818 | 0.1056 | 0.0909 | 0.1144 | 0.3636 | 0.1525 | 0.2727 | 0.1290 | 0.0000 | 0.1290 | 0.0000 | 0.2463 | 0.0000 | 0.0000 | 0.0027 | 0.0045 | 0.0163 | 0.0506 | 0.0624 | 0.0678 | 0.0850 | 0.7107 | 3 | 4 | 5 | 5 | 6 | 7 | 7 | 8 | 9 | 0.5417 | 0.29 | 0.926 | 0.8524 | 39.5 | 290.243 | 2305.17 | 19573.6 | 0.5333 | 0.1268 | 0.0126 | 0.0006 | 0.0816 | 0.0054 | 0.1641 | 0.0320 | 0.2592 | 0.0633 | 0.2505 | 0.1333 | 0.1534 | 0.1960 | 0.0621 | 0.2340 | 0.0155 | 0.2117 | 0.0010 | 0.1236 | 0.0000 | 0.0000 | 0.0139 | 0.0011 | 0.0357 | 0.0096 | 0.1130 | 0.0340 | 0.1897 | 0.0919 | 0.2161 | 0.1338 | 0.2254 | 0.1875 | 0.1586 | 0.2953 | 0.0476 | 0.2469 | 0.1946 | 0.4222 | 0.2754 | 0.2667 | 0.2402 | 0.1378 | 0.1718 | 0.1244 | 0.0787 | 0.0400 | 0.0311 | 0.0089 | 0.0062 | 0.0000 | 0.0021 | 0.0000 | 0.0000 | 0.0000 | 0.0076 | 0.0552 | 0.1027 | 0.1986 | 0.2182 | 0.1910 | 0.1171 | 0.0849 | 0.0246 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 1049 | 621 | 590 | 4448 | 85.8 | 21.32 | 144.11 | 133.60 | 56 | 64 | 73 | 81 | 87 | 93 | 99 | 106 | 114 | 0.1034 | 460 | 0.497 | 89.47 | 17.12 | 2 | 0.4254 | 251 | 0.0059 | 8.91 | 5.340 | 0.3127 | 7819.9 | 748619 | 74600000 | 7680000000 | 0.5406 | 0.1228 | 0.0066 | 0.0000 | 0.0197 | 0.0037 | 0.0656 | 0.0019 | 0.1016 | 0.0335 | 0.1311 | 0.0764 | 0.2557 | 0.1676 | 0.1213 | 0.0950 | 0.1279 | 0.1639 | 0.1705 | 0.4581 | 0.0000 | 0.0000 | 0.0023 | 0.0018 | 0.0023 | 0.0018 | 0.0227 | 0.0161 | 0.0975 | 0.0698 | 0.2245 | 0.1592 | 0.0998 | 0.0823 | 0.1678 | 0.1485 | 0.3832 | 0.5206 | 0.0000 | 0.0000 | 0.0074 | 0.0909 | 0.0662 | 0.1818 | 0.1103 | 0.2273 | 0.1838 | 0.3636 | 0.2721 | 0.0455 | 0.1176 | 0.0909 | 0.0809 | 0.0000 | 0.1618 | 0.0000 | 0.0032 | 0.0130 | 0.0260 | 0.0747 | 0.1494 | 0.1851 | 0.1071 | 0.1558 | 0.2857 | 25 | 39 | 55 | 74 | 98 | 130 | 170 | 228 | 340 | 0.0100 | 16.93 | 5.669 | 0.4305 | 38612.5 | 14500000 | 6620000000 | 3390000000000 | 0.5378 | 0.1265 | 0.0156 | 0.0023 | 0.0845 | 0.0068 | 0.1831 | 0.0288 | 0.1815 | 0.0788 | 0.1800 | 0.1455 | 0.1315 | 0.1856 | 0.0767 | 0.1667 | 0.0610 | 0.1439 | 0.0861 | 0.2417 | 0.0010 | 0.0013 | 0.0036 | 0.0025 | 0.0051 | 0.0033 | 0.0159 | 0.0134 | 0.0568 | 0.0473 | 0.0967 | 0.0854 | 0.0747 | 0.0703 | 0.0988 | 0.1000 | 0.6474 | 0.6766 | 0.0000 | 0.0037 | 0.0038 | 0.0019 | 0.0198 | 0.0131 | 0.0243 | 0.0411 | 0.0654 | 0.0626 | 0.1209 | 0.1280 | 0.0928 | 0.0888 | 0.1042 | 0.1271 | 0.5688 | 0.5336 | 0.0006 | 0.0000 | 0.0112 | 0.0262 | 0.0611 | 0.1185 | 0.0855 | 0.1017 | 0.5951 | |
BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 766 | 364 | 612 | 7645 | 99.6 | 21.09 | 6.51 | 2.18 | 75 | 79 | 85 | 92 | 98 | 105 | 112 | 119 | 128 | 0.0838 | 641 | 1.001 | 51.04 | 15.00 | 4 | 0.2108 | 129 | 0.0248 | 1.73 | 3.950 | 0.5777 | 10364.9 | 1120000 | 126000000 | 14600000000 | 0.4146 | 0.2180 | 0.0027 | 0.0000 | 0.0054 | 0.0017 | 0.0161 | 0.0000 | 0.0591 | 0.0051 | 0.1371 | 0.0460 | 0.1505 | 0.0937 | 0.1505 | 0.0528 | 0.1828 | 0.0971 | 0.2957 | 0.7036 | 0.0020 | 0.0000 | 0.0041 | 0.0017 | 0.0082 | 0.0000 | 0.0184 | 0.0050 | 0.0573 | 0.0416 | 0.0532 | 0.0832 | 0.0798 | 0.0349 | 0.1002 | 0.0666 | 0.6769 | 0.7671 | 0.0171 | 0.0714 | 0.0256 | 0.0000 | 0.0427 | 0.2143 | 0.1026 | 0.0714 | 0.1538 | 0.3571 | 0.1880 | 0.1429 | 0.1453 | 0.0714 | 0.1282 | 0.0714 | 0.1966 | 0.0000 | 0.0034 | 0.0034 | 0.0000 | 0.0340 | 0.1020 | 0.1156 | 0.0918 | 0.1667 | 0.4830 | 4 | 5 | 5 | 6 | 6 | 7 | 7 | 8 | 9 | 0.0231 | 6.70 | 4.222 | 0.3821 | 47.1 | 374.956 | 3259.55 | 30750.1 | 0.5050 | 0.1580 | 0.0158 | 0.0010 | 0.0559 | 0.0056 | 0.1247 | 0.0165 | 0.1847 | 0.0413 | 0.2309 | 0.0800 | 0.2086 | 0.1523 | 0.1279 | 0.2481 | 0.0454 | 0.2940 | 0.0062 | 0.1611 | 0.0049 | 0.0000 | 0.0237 | 0.0014 | 0.0580 | 0.0062 | 0.1000 | 0.0237 | 0.1395 | 0.0478 | 0.1706 | 0.0950 | 0.1637 | 0.1603 | 0.1675 | 0.2610 | 0.1722 | 0.4047 | 0.1697 | 0.2139 | 0.1713 | 0.1778 | 0.1369 | 0.0909 | 0.1041 | 0.0963 | 0.0881 | 0.1257 | 0.1017 | 0.1176 | 0.1057 | 0.0949 | 0.0857 | 0.0602 | 0.0368 | 0.0227 | 0.0417 | 0.0935 | 0.1240 | 0.1420 | 0.1358 | 0.1317 | 0.1030 | 0.1012 | 0.1272 | |
MDA-MB-231 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 986 | 375 | 3412 | 6862 | 481.9 | 117.20 | 93.02 | 146.48 | 305 | 387 | 443 | 490 | 520 | 538 | 554 | 572 | 596 | 0.0851 | 584 | 0.932 | 72.01 | 24.21 | 1 | 0.0592 | 202 | 0.0011 | 37.12 | 7.131 | 0.2177 | 245995.0 | 130000000 | 70600000000 | 39000000000000 | 0.3975 | 0.2313 | 0.0000 | 0.0000 | 0.0009 | 0.0000 | 0.0023 | 0.0000 | 0.0153 | 0.0006 | 0.0384 | 0.0161 | 0.0685 | 0.0274 | 0.0782 | 0.0187 | 0.1319 | 0.0332 | 0.6645 | 0.9040 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0029 | 0.0003 | 0.0179 | 0.0160 | 0.0285 | 0.0249 | 0.0223 | 0.0150 | 0.0347 | 0.0278 | 0.8936 | 0.9159 | 0.0209 | 0.0435 | 0.0104 | 0.0000 | 0.0330 | 0.0000 | 0.0557 | 0.0435 | 0.0783 | 0.3478 | 0.0870 | 0.1739 | 0.0991 | 0.0000 | 0.1113 | 0.3043 | 0.5043 | 0.0870 | 0.0000 | 0.0000 | 0.0000 | 0.0060 | 0.0247 | 0.0451 | 0.0400 | 0.0679 | 0.8162 | 10 | 13 | 16 | 21 | 27 | 40 | 68 | 138 | 287 | 0.0426 | 28.93 | 4.699 | 0.5709 | 30108.0 | 15300000 | 9600000000 | 6980000000000 | 0.4972 | 0.1660 | 0.0636 | 0.0056 | 0.1051 | 0.0237 | 0.0954 | 0.0847 | 0.1345 | 0.0790 | 0.1614 | 0.0926 | 0.1809 | 0.1400 | 0.1394 | 0.1264 | 0.0831 | 0.1072 | 0.0367 | 0.3409 | 0.0005 | 0.0013 | 0.0005 | 0.0017 | 0.0036 | 0.0031 | 0.0180 | 0.0144 | 0.0598 | 0.0423 | 0.0721 | 0.0737 | 0.0562 | 0.0471 | 0.0814 | 0.0702 | 0.7079 | 0.7462 | 0.0013 | 0.0000 | 0.0020 | 0.0007 | 0.0007 | 0.0000 | 0.0196 | 0.0156 | 0.0607 | 0.0675 | 0.0881 | 0.0896 | 0.0529 | 0.0490 | 0.0783 | 0.0888 | 0.6965 | 0.6887 | 0.0012 | 0.0012 | 0.0029 | 0.0175 | 0.0544 | 0.0807 | 0.0526 | 0.0807 | 0.7089 | |
MCF7 | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1052 | 727 | 435 | 10158 | 216.6 | 37.95 | 134.54 | 228.49 | 169 | 184 | 193 | 205 | 215 | 223 | 235 | 249 | 268 | 0.0475 | 483 | 1.039 | 156.49 | 50.48 | 1 | 0.9218 | 401 | 0.0052 | 14.90 | 5.415 | 0.3014 | 48369.5 | 11100000 | 2630000000 | 636000000000 | 0.4349 | 0.2080 | 0.0000 | 0.0000 | 0.0096 | 0.0000 | 0.0096 | 0.0000 | 0.0382 | 0.0047 | 0.1019 | 0.0606 | 0.1656 | 0.0629 | 0.1624 | 0.0606 | 0.1943 | 0.0956 | 0.3185 | 0.7156 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0186 | 0.0023 | 0.0849 | 0.0621 | 0.1088 | 0.0552 | 0.0928 | 0.0437 | 0.1432 | 0.0759 | 0.5517 | 0.7609 | 0.0000 | 0.1667 | 0.0000 | 0.0000 | 0.0635 | 0.1667 | 0.1905 | 0.3333 | 0.1429 | 0.3333 | 0.2540 | 0.0000 | 0.1270 | 0.0000 | 0.0635 | 0.0000 | 0.1587 | 0.0000 | 0.0000 | 0.0095 | 0.0237 | 0.0616 | 0.1754 | 0.1469 | 0.1280 | 0.1801 | 0.2749 | 5 | 7 | 8 | 9 | 11 | 16 | 98 | 264 | 495 | 0.1308 | 20.25 | 3.815 | 0.5357 | 70302.5 | 49000000 | 40900000000 | 40000000000000 | 0.5326 | 0.1283 | 0.0600 | 0.0028 | 0.2086 | 0.0308 | 0.2229 | 0.1413 | 0.2086 | 0.1636 | 0.1400 | 0.2070 | 0.0686 | 0.1930 | 0.0514 | 0.1035 | 0.0371 | 0.0867 | 0.0029 | 0.0713 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0003 | 0.0000 | 0.0037 | 0.0047 | 0.0269 | 0.0233 | 0.0561 | 0.0472 | 0.0326 | 0.0315 | 0.0668 | 0.0585 | 0.8136 | 0.8348 | 0.0000 | 0.0000 | 0.0004 | 0.0004 | 0.0011 | 0.0020 | 0.0049 | 0.0053 | 0.0377 | 0.0422 | 0.0681 | 0.0763 | 0.0518 | 0.0666 | 0.0883 | 0.0849 | 0.7477 | 0.7223 | 0.0000 | 0.0000 | 0.0011 | 0.0029 | 0.0350 | 0.0622 | 0.0404 | 0.0733 | 0.7851 | |
MCF 10A | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 273 | 873 | 959 | 20054 | 113.6 | 15.41 | 28.35 | 38.32 | 95 | 99 | 103 | 107 | 113 | 117 | 121 | 127 | 135 | 0.0524 | 1050 | 1.034 | 39.40 | 13.04 | 0 | 0.1064 | 102 | 0.0763 | 0.50 | 2.832 | 0.7708 | 13136.1 | 1550000 | 186000000 | 22800000000 | 0.4056 | 0.2400 | 0.0012 | 0.0000 | 0.0036 | 0.0010 | 0.0083 | 0.0031 | 0.0154 | 0.0073 | 0.0473 | 0.0241 | 0.0746 | 0.0640 | 0.0734 | 0.0325 | 0.1006 | 0.0598 | 0.6757 | 0.8080 | 0.0011 | 0.0000 | 0.0032 | 0.0010 | 0.0076 | 0.0031 | 0.0108 | 0.0073 | 0.0314 | 0.0229 | 0.0541 | 0.0615 | 0.0400 | 0.0250 | 0.0639 | 0.0532 | 0.7879 | 0.8259 | 0.0000 | 0.0000 | 0.0127 | 0.1667 | 0.0506 | 0.0000 | 0.1013 | 0.5000 | 0.1266 | 0.3333 | 0.1392 | 0.0000 | 0.1266 | 0.0000 | 0.1266 | 0.0000 | 0.3165 | 0.0000 | 0.0022 | 0.0043 | 0.0152 | 0.0260 | 0.0390 | 0.0758 | 0.0736 | 0.1017 | 0.6623 | 11 | 13 | 15 | 17 | 20 | 22 | 26 | 31 | 40 | 0.3245 | 0.91 | 1.880 | 0.8551 | 2272.4 | 507754 | 174000000 | 71000000000 | 0.5696 | 0.1296 | 0.0433 | 0.0176 | 0.0600 | 0.0218 | 0.0785 | 0.0264 | 0.1039 | 0.0386 | 0.1265 | 0.0642 | 0.1678 | 0.0809 | 0.1887 | 0.1079 | 0.1421 | 0.1846 | 0.0893 | 0.4581 | 0.0240 | 0.0144 | 0.0282 | 0.0178 | 0.0330 | 0.0204 | 0.0353 | 0.0280 | 0.0502 | 0.0467 | 0.0618 | 0.0603 | 0.0746 | 0.0721 | 0.1061 | 0.1150 | 0.5867 | 0.6253 | 0.0284 | 0.0348 | 0.0315 | 0.0221 | 0.0495 | 0.0172 | 0.0486 | 0.0255 | 0.0769 | 0.0594 | 0.0874 | 0.0790 | 0.0867 | 0.0795 | 0.1126 | 0.1286 | 0.4784 | 0.5540 | 0.0222 | 0.0261 | 0.0286 | 0.0380 | 0.0551 | 0.0752 | 0.0968 | 0.1505 | 0.5076 | |
BT-20 | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 201 | 479 | 6474 | 26300 | 321.0 | 57.21 | 100.08 | 124.51 | 249 | 270 | 287 | 303 | 318 | 334 | 351 | 372 | 398 | 0.0455 | 1196 | 1.134 | 99.86 | 37.59 | 2 | 0.0394 | 255 | 0.0006 | 73.06 | 7.553 | 0.1323 | 106297.0 | 36300000 | 12700000000 | 4580000000000 | 0.4555 | 0.1968 | 0.0004 | 0.0000 | 0.0013 | 0.0000 | 0.0030 | 0.0002 | 0.0144 | 0.0008 | 0.0453 | 0.0123 | 0.1133 | 0.0261 | 0.1258 | 0.0247 | 0.1709 | 0.0467 | 0.5257 | 0.8892 | 0.0000 | 0.0000 | 0.0002 | 0.0000 | 0.0007 | 0.0002 | 0.0069 | 0.0003 | 0.0227 | 0.0113 | 0.0501 | 0.0206 | 0.0538 | 0.0157 | 0.0774 | 0.0244 | 0.7881 | 0.9275 | 0.0044 | 0.0805 | 0.0187 | 0.0575 | 0.0430 | 0.1839 | 0.0926 | 0.0920 | 0.1599 | 0.3103 | 0.1985 | 0.1379 | 0.1279 | 0.0460 | 0.1709 | 0.0805 | 0.1841 | 0.0115 | 0.0010 | 0.0025 | 0.0127 | 0.0290 | 0.0762 | 0.1275 | 0.1093 | 0.1393 | 0.5025 | 11 | 13 | 15 | 20 | 36 | 70 | 125 | 189 | 272 | 0.0574 | 15.56 | 4.832 | 0.5328 | 25517.2 | 9400000 | 4360000000 | 2400000000000 | 0.4719 | 0.1702 | 0.0761 | 0.0028 | 0.2702 | 0.0198 | 0.3311 | 0.1800 | 0.1322 | 0.2075 | 0.0992 | 0.2192 | 0.0530 | 0.1607 | 0.0236 | 0.0959 | 0.0105 | 0.0697 | 0.0042 | 0.0445 | 0.0001 | 0.0000 | 0.0007 | 0.0004 | 0.0009 | 0.0012 | 0.0101 | 0.0086 | 0.0551 | 0.0465 | 0.1067 | 0.0874 | 0.0756 | 0.0609 | 0.1039 | 0.0939 | 0.6470 | 0.7011 | 0.0004 | 0.0005 | 0.0005 | 0.0019 | 0.0037 | 0.0034 | 0.0152 | 0.0180 | 0.0736 | 0.0826 | 0.1416 | 0.1590 | 0.0968 | 0.1084 | 0.1346 | 0.1429 | 0.5337 | 0.4833 | 0.0006 | 0.0003 | 0.0023 | 0.0133 | 0.0603 | 0.1279 | 0.0841 | 0.1215 | 0.5898 | |
MCF7 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 820 | 689 | 340 | 1923 | 397.1 | 79.43 | 199.34 | 201.26 | 294 | 333 | 352 | 372 | 390 | 408 | 435 | 465 | 504 | 0.1394 | 268 | 1.182 | 145.07 | 47.10 | 3 | 1.0029 | 341 | 0.0036 | 115.51 | 5.687 | 0.1125 | 163958.0 | 70300000 | 31200000000 | 14300000000000 | 0.3965 | 0.2306 | 0.0000 | 0.0000 | 0.0174 | 0.0000 | 0.0217 | 0.0000 | 0.0957 | 0.0245 | 0.1478 | 0.0890 | 0.1913 | 0.1196 | 0.1783 | 0.0706 | 0.1043 | 0.1135 | 0.2435 | 0.5828 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0069 | 0.0000 | 0.0241 | 0.0118 | 0.1069 | 0.0737 | 0.1621 | 0.1121 | 0.1241 | 0.0619 | 0.1241 | 0.1003 | 0.4517 | 0.6401 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0500 | 0.2308 | 0.1333 | 0.0000 | 0.2000 | 0.3077 | 0.2167 | 0.1538 | 0.0833 | 0.1538 | 0.1500 | 0.1538 | 0.1667 | 0.0000 | 0.0000 | 0.0000 | 0.0189 | 0.0818 | 0.1635 | 0.2075 | 0.1258 | 0.1635 | 0.2390 | 20 | 36 | 64 | 93 | 120 | 173 | 254 | 366 | 476 | 0.0098 | 59.99 | 5.843 | 0.3632 | 80219.5 | 45700000 | 32800000000 | 28000000000000 | 0.5269 | 0.1237 | 0.0813 | 0.0000 | 0.2536 | 0.0321 | 0.3971 | 0.1514 | 0.1579 | 0.2041 | 0.0478 | 0.2110 | 0.0287 | 0.2064 | 0.0144 | 0.0940 | 0.0191 | 0.0550 | 0.0000 | 0.0459 | 0.0000 | 0.0000 | 0.0000 | 0.0010 | 0.0012 | 0.0042 | 0.0135 | 0.0156 | 0.0800 | 0.0582 | 0.1441 | 0.1163 | 0.0985 | 0.0789 | 0.1195 | 0.1184 | 0.5431 | 0.6075 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0017 | 0.0057 | 0.0332 | 0.0361 | 0.1144 | 0.1347 | 0.1841 | 0.1822 | 0.1061 | 0.1101 | 0.1426 | 0.1480 | 0.4179 | 0.3833 | 0.0000 | 0.0000 | 0.0000 | 0.0142 | 0.1095 | 0.1551 | 0.1053 | 0.1351 | 0.4808 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 1243 | 854 | 722 | 7966 | 63.7 | 17.26 | 99.18 | 192.37 | 47 | 51 | 53 | 56 | 60 | 63 | 68 | 74 | 85 | 0.0734 | 585 | 0.421 | 183.11 | 37.80 | 0 | 0.8726 | 630 | 0.0093 | 10.56 | 5.018 | 0.3434 | 4360.7 | 324711 | 26600000 | 2420000000 | 0.4665 | 0.1732 | 0.0048 | 0.0000 | 0.0238 | 0.0000 | 0.0499 | 0.0060 | 0.0950 | 0.0255 | 0.1354 | 0.0510 | 0.1853 | 0.0990 | 0.1663 | 0.1049 | 0.1663 | 0.1094 | 0.1734 | 0.6042 | 0.0000 | 0.0000 | 0.0073 | 0.0000 | 0.0128 | 0.0028 | 0.0475 | 0.0097 | 0.0786 | 0.0444 | 0.1408 | 0.0819 | 0.1261 | 0.0611 | 0.1481 | 0.0833 | 0.4388 | 0.7167 | 0.0000 | 0.0000 | 0.0317 | 0.0377 | 0.0159 | 0.0755 | 0.0952 | 0.0755 | 0.1825 | 0.3019 | 0.1825 | 0.1321 | 0.1508 | 0.0566 | 0.1508 | 0.2075 | 0.1905 | 0.1132 | 0.0036 | 0.0180 | 0.0288 | 0.0791 | 0.1259 | 0.1691 | 0.1295 | 0.1511 | 0.2950 | 10 | 12 | 14 | 15 | 17 | 19 | 31 | 113 | 371 | 0.1151 | 73.14 | 4.084 | 0.5429 | 46837.2 | 32700000 | 27500000000 | 26300000000000 | 0.6007 | 0.1115 | 0.2664 | 0.0211 | 0.4953 | 0.1607 | 0.2103 | 0.5011 | 0.0280 | 0.1882 | 0.0000 | 0.0782 | 0.0000 | 0.0338 | 0.0000 | 0.0127 | 0.0000 | 0.0042 | 0.0000 | 0.0000 | 0.0006 | 0.0005 | 0.0022 | 0.0015 | 0.0056 | 0.0036 | 0.0185 | 0.0247 | 0.0888 | 0.0781 | 0.1355 | 0.1183 | 0.0748 | 0.0848 | 0.1231 | 0.1177 | 0.5509 | 0.5707 | 0.0006 | 0.0007 | 0.0013 | 0.0041 | 0.0083 | 0.0082 | 0.0230 | 0.0211 | 0.0856 | 0.0958 | 0.1540 | 0.1501 | 0.0818 | 0.0795 | 0.1176 | 0.1291 | 0.5278 | 0.5115 | 0.0012 | 0.0024 | 0.0054 | 0.0198 | 0.0929 | 0.1360 | 0.0827 | 0.1210 | 0.5386 | |
Hs 578T | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 1173 | 230 | 893 | 1587 | 58.0 | 13.43 | 491.67 | 350.26 | 39 | 45 | 50 | 54 | 59 | 63 | 67 | 71 | 75 | 0.1878 | 298 | 1.216 | 22.85 | 8.25 | 1 | 0.0694 | 62 | 0.0063 | 5.77 | 5.275 | 0.3973 | 3548.7 | 226676 | 15000000 | 1020000000 | 0.4245 | 0.2042 | 0.0041 | 0.0000 | 0.0104 | 0.0000 | 0.0228 | 0.0012 | 0.0352 | 0.0119 | 0.1056 | 0.0380 | 0.1201 | 0.0403 | 0.1677 | 0.0712 | 0.1822 | 0.0830 | 0.3520 | 0.7544 | 0.0014 | 0.0000 | 0.0014 | 0.0000 | 0.0058 | 0.0012 | 0.0159 | 0.0116 | 0.0418 | 0.0359 | 0.0390 | 0.0348 | 0.0592 | 0.0475 | 0.0649 | 0.0487 | 0.7706 | 0.8204 | 0.0095 | 0.0500 | 0.0143 | 0.1000 | 0.0190 | 0.0500 | 0.0476 | 0.2000 | 0.1381 | 0.3000 | 0.1095 | 0.1000 | 0.1810 | 0.0000 | 0.1905 | 0.2000 | 0.2905 | 0.0000 | 0.0043 | 0.0151 | 0.0151 | 0.0129 | 0.0430 | 0.0688 | 0.0860 | 0.1011 | 0.6538 | 107 | 162 | 233 | 315 | 418 | 517 | 636 | 803 | 998 | 0.0021 | 39.34 | 6.548 | 0.2363 | 364349.0 | 335000000 | 350000000000 | 398000000000000 | 0.5161 | 0.1411 | 0.0070 | 0.0000 | 0.0702 | 0.0035 | 0.1579 | 0.0228 | 0.2316 | 0.0683 | 0.2140 | 0.1278 | 0.1789 | 0.2277 | 0.0877 | 0.1611 | 0.0386 | 0.1664 | 0.0140 | 0.2224 | 0.0000 | 0.0000 | 0.0012 | 0.0000 | 0.0061 | 0.0020 | 0.0255 | 0.0201 | 0.0522 | 0.0413 | 0.0765 | 0.0554 | 0.0667 | 0.0564 | 0.1129 | 0.0816 | 0.6590 | 0.7432 | 0.0019 | 0.0000 | 0.0000 | 0.0047 | 0.0111 | 0.0213 | 0.0390 | 0.0332 | 0.0686 | 0.0900 | 0.1317 | 0.1232 | 0.0891 | 0.0853 | 0.1132 | 0.1422 | 0.5455 | 0.5000 | 0.0000 | 0.0059 | 0.0089 | 0.0341 | 0.0548 | 0.0904 | 0.0919 | 0.1407 | 0.5733 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 279 | 429 | 995 | 12586 | 70.7 | 14.90 | 155.58 | 186.93 | 55 | 59 | 63 | 66 | 69 | 72 | 76 | 81 | 90 | 0.0678 | 853 | 0.399 | 137.53 | 31.00 | 1 | 0.5668 | 564 | 0.0090 | 7.28 | 5.031 | 0.3913 | 5218.8 | 403150 | 32700000 | 2780000000 | 0.5290 | 0.1303 | 0.0014 | 0.0000 | 0.0041 | 0.0000 | 0.0218 | 0.0032 | 0.0476 | 0.0139 | 0.1252 | 0.0586 | 0.1823 | 0.1471 | 0.1469 | 0.0768 | 0.1524 | 0.1333 | 0.3184 | 0.5672 | 0.0012 | 0.0000 | 0.0012 | 0.0000 | 0.0046 | 0.0020 | 0.0207 | 0.0061 | 0.0794 | 0.0499 | 0.1427 | 0.1314 | 0.0863 | 0.0540 | 0.1116 | 0.0967 | 0.5524 | 0.6599 | 0.0149 | 0.0455 | 0.0149 | 0.0000 | 0.0522 | 0.1136 | 0.1343 | 0.1136 | 0.2015 | 0.2955 | 0.2015 | 0.2045 | 0.1119 | 0.0227 | 0.1269 | 0.1818 | 0.1418 | 0.0227 | 0.0068 | 0.0158 | 0.0158 | 0.0813 | 0.1512 | 0.1558 | 0.1129 | 0.1490 | 0.3115 | 16 | 20 | 30 | 53 | 84 | 116 | 167 | 264 | 418 | 0.0235 | 46.09 | 5.759 | 0.4355 | 59144.7 | 33000000 | 22700000000 | 17700000000000 | 0.5490 | 0.1235 | 0.0353 | 0.0025 | 0.1470 | 0.0151 | 0.2292 | 0.0792 | 0.1425 | 0.1235 | 0.1447 | 0.1704 | 0.1190 | 0.1746 | 0.0816 | 0.1179 | 0.0654 | 0.1193 | 0.0353 | 0.1975 | 0.0004 | 0.0007 | 0.0004 | 0.0019 | 0.0042 | 0.0029 | 0.0129 | 0.0102 | 0.0601 | 0.0507 | 0.1106 | 0.0865 | 0.0811 | 0.0676 | 0.1162 | 0.1025 | 0.6141 | 0.6771 | 0.0009 | 0.0010 | 0.0023 | 0.0017 | 0.0032 | 0.0023 | 0.0227 | 0.0252 | 0.0827 | 0.1026 | 0.1474 | 0.1437 | 0.0903 | 0.1010 | 0.1282 | 0.1400 | 0.5223 | 0.4826 | 0.0002 | 0.0015 | 0.0037 | 0.0187 | 0.0791 | 0.1231 | 0.0843 | 0.1271 | 0.5622 | |
BT-20 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 1215 | 861 | 3007 | 9908 | 716.7 | 136.15 | 119.32 | 267.01 | 537 | 590 | 633 | 674 | 713 | 750 | 795 | 845 | 901 | 0.0779 | 772 | 1.131 | 79.76 | 31.58 | 2 | 0.0725 | 218 | 0.0010 | 52.74 | 7.117 | 0.1610 | 532255.0 | 408000000 | 323000000000 | 262000000000000 | 0.4330 | 0.2090 | 0.0005 | 0.0000 | 0.0005 | 0.0000 | 0.0000 | 0.0000 | 0.0125 | 0.0007 | 0.0651 | 0.0200 | 0.1481 | 0.0312 | 0.1456 | 0.0346 | 0.1792 | 0.0481 | 0.4484 | 0.8654 | 0.0004 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0060 | 0.0007 | 0.0316 | 0.0198 | 0.0643 | 0.0271 | 0.0583 | 0.0218 | 0.0671 | 0.0305 | 0.7723 | 0.9001 | 0.0040 | 0.0588 | 0.0059 | 0.0588 | 0.0198 | 0.0882 | 0.0931 | 0.3529 | 0.1802 | 0.2941 | 0.1842 | 0.0588 | 0.0911 | 0.0294 | 0.1564 | 0.0588 | 0.2653 | 0.0000 | 0.0000 | 0.0007 | 0.0041 | 0.0244 | 0.0807 | 0.1404 | 0.1065 | 0.1303 | 0.5129 | 7 | 9 | 10 | 11 | 13 | 16 | 31 | 132 | 393 | 0.2663 | 40.82 | 3.458 | 0.6732 | 85524.5 | 93100000 | 121000000000 | 174000000000000 | 0.6043 | 0.0864 | 0.1806 | 0.0164 | 0.2843 | 0.1228 | 0.2274 | 0.2439 | 0.1237 | 0.1735 | 0.1304 | 0.1571 | 0.0201 | 0.1489 | 0.0201 | 0.0687 | 0.0134 | 0.0491 | 0.0000 | 0.0196 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0063 | 0.0059 | 0.0680 | 0.0675 | 0.1151 | 0.0990 | 0.0657 | 0.0671 | 0.1024 | 0.0998 | 0.6425 | 0.6607 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0005 | 0.0011 | 0.0115 | 0.0085 | 0.0781 | 0.0846 | 0.1289 | 0.1455 | 0.0849 | 0.0795 | 0.1226 | 0.1286 | 0.5734 | 0.5516 | 0.0000 | 0.0000 | 0.0010 | 0.0097 | 0.0711 | 0.1178 | 0.0808 | 0.1168 | 0.6027 | |
BT-20 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 462 | 109 | 459 | 1169 | 64.3 | 13.23 | 8.02 | 2.47 | 48 | 52 | 57 | 61 | 64 | 67 | 71 | 74 | 79 | 0.2515 | 294 | 0.892 | 64.33 | 20.81 | 1 | 0.3791 | 174 | 0.0526 | 1.06 | 3.212 | 0.6390 | 4308.5 | 301320 | 22000000 | 1690000000 | 0.4020 | 0.2263 | 0.0000 | 0.0000 | 0.0063 | 0.0023 | 0.0094 | 0.0068 | 0.0408 | 0.0068 | 0.0940 | 0.0502 | 0.1160 | 0.1073 | 0.1473 | 0.0662 | 0.2508 | 0.0936 | 0.3354 | 0.6667 | 0.0000 | 0.0000 | 0.0026 | 0.0022 | 0.0026 | 0.0066 | 0.0238 | 0.0044 | 0.0556 | 0.0462 | 0.0635 | 0.0879 | 0.0714 | 0.0505 | 0.1111 | 0.0725 | 0.6693 | 0.7297 | 0.0678 | 0.0000 | 0.0508 | 0.0000 | 0.1356 | 0.0588 | 0.0339 | 0.1176 | 0.2034 | 0.2941 | 0.1186 | 0.1176 | 0.0678 | 0.1176 | 0.1356 | 0.2353 | 0.1864 | 0.0588 | 0.0041 | 0.0041 | 0.0245 | 0.0245 | 0.0735 | 0.0939 | 0.0898 | 0.1796 | 0.5061 | 5 | 6 | 7 | 7 | 8 | 9 | 9 | 10 | 11 | 0.0200 | 12.70 | 4.330 | 0.3019 | 70.5 | 664.57 | 6651.59 | 70129.1 | 0.5248 | 0.1240 | 0.0136 | 0.0000 | 0.0492 | 0.0010 | 0.1121 | 0.0149 | 0.2462 | 0.0378 | 0.2394 | 0.0746 | 0.2190 | 0.1303 | 0.1002 | 0.2139 | 0.0187 | 0.2806 | 0.0017 | 0.2468 | 0.0000 | 0.0000 | 0.0099 | 0.0009 | 0.0221 | 0.0027 | 0.0585 | 0.0220 | 0.1170 | 0.0577 | 0.2064 | 0.0843 | 0.2274 | 0.1357 | 0.2506 | 0.2878 | 0.1082 | 0.4088 | 0.1199 | 0.5814 | 0.2461 | 0.2907 | 0.2366 | 0.0814 | 0.1924 | 0.0349 | 0.1293 | 0.0116 | 0.0536 | 0.0000 | 0.0158 | 0.0000 | 0.0032 | 0.0000 | 0.0032 | 0.0000 | 0.0126 | 0.0535 | 0.1258 | 0.2013 | 0.2186 | 0.1714 | 0.1336 | 0.0708 | 0.0126 | |
BT-20 | A443654 | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 12 | 1 | 895 | 609 | 4883 | 16388 | 528.4 | 82.82 | 129.28 | 239.46 | 424 | 462 | 486 | 505 | 525 | 545 | 568 | 595 | 639 | 0.0616 | 1009 | 0.725 | 104.48 | 25.55 | 1 | 0.0555 | 271 | 0.0023 | 18.30 | 6.393 | 0.2729 | 286071.0 | 158000000 | 89700000000 | 51900000000000 | 0.4173 | 0.2298 | 0.0003 | 0.0000 | 0.0003 | 0.0000 | 0.0016 | 0.0000 | 0.0054 | 0.0004 | 0.0293 | 0.0147 | 0.0673 | 0.0263 | 0.0671 | 0.0165 | 0.1041 | 0.0296 | 0.7248 | 0.9125 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0023 | 0.0004 | 0.0181 | 0.0138 | 0.0331 | 0.0232 | 0.0342 | 0.0135 | 0.0512 | 0.0220 | 0.8611 | 0.9271 | 0.0036 | 0.0000 | 0.0018 | 0.0000 | 0.0309 | 0.0882 | 0.0436 | 0.2353 | 0.1291 | 0.2941 | 0.1673 | 0.0882 | 0.0800 | 0.1765 | 0.1436 | 0.0882 | 0.4000 | 0.0294 | 0.0013 | 0.0051 | 0.0131 | 0.0300 | 0.0656 | 0.1016 | 0.0863 | 0.1121 | 0.5849 | 7 | 9 | 10 | 11 | 13 | 18 | 55 | 222 | 459 | 0.2514 | 33.66 | 3.796 | 0.6421 | 74049.5 | 59100000 | 55800000000 | 58800000000000 | 0.5654 | 0.1070 | 0.1457 | 0.0103 | 0.2870 | 0.0432 | 0.3576 | 0.2613 | 0.1369 | 0.2469 | 0.0397 | 0.2171 | 0.0221 | 0.1235 | 0.0110 | 0.0463 | 0.0000 | 0.0267 | 0.0000 | 0.0247 | 0.0000 | 0.0002 | 0.0000 | 0.0000 | 0.0009 | 0.0004 | 0.0085 | 0.0063 | 0.0461 | 0.0469 | 0.0811 | 0.0735 | 0.0507 | 0.0480 | 0.0726 | 0.0676 | 0.7401 | 0.7571 | 0.0000 | 0.0003 | 0.0005 | 0.0000 | 0.0013 | 0.0030 | 0.0108 | 0.0120 | 0.0569 | 0.0569 | 0.0857 | 0.0867 | 0.0607 | 0.0684 | 0.0810 | 0.0878 | 0.7031 | 0.6848 | 0.0000 | 0.0000 | 0.0005 | 0.0097 | 0.0508 | 0.0832 | 0.0557 | 0.0735 | 0.7266 | |
MDA-MB-231 | 0 | DRAQ5 | 1 | TMRE | 2 | 2 | 2 | 1 | 209 | 570 | 4703 | 11257 | 455.0 | 77.10 | 137.18 | 277.92 | 340 | 398 | 427 | 444 | 459 | 475 | 493 | 516 | 549 | 0.0636 | 716 | 0.833 | 89.36 | 25.02 | 3 | 0.0515 | 242 | 0.0019 | 16.09 | 6.616 | 0.2886 | 212933.0 | 102000000 | 50100000000 | 25100000000000 | 0.4498 | 0.1891 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0011 | 0.0002 | 0.0053 | 0.0006 | 0.0283 | 0.0153 | 0.0415 | 0.0267 | 0.0404 | 0.0162 | 0.0569 | 0.0265 | 0.8258 | 0.9144 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0022 | 0.0006 | 0.0175 | 0.0150 | 0.0253 | 0.0249 | 0.0212 | 0.0146 | 0.0305 | 0.0226 | 0.9033 | 0.9222 | 0.0040 | 0.0000 | 0.0120 | 0.1429 | 0.0080 | 0.2143 | 0.0300 | 0.1429 | 0.0580 | 0.2857 | 0.0920 | 0.1429 | 0.0820 | 0.0714 | 0.0900 | 0.0000 | 0.6240 | 0.0000 | 0.0032 | 0.0069 | 0.0105 | 0.0242 | 0.0395 | 0.0492 | 0.0629 | 0.0786 | 0.7251 | 9 | 11 | 13 | 15 | 18 | 27 | 60 | 180 | 452 | 0.1894 | 29.54 | 3.820 | 0.6610 | 96051.8 | 107000000 | 152000000000 | 257000000000000 | 0.3706 | 0.2754 | 0.0734 | 0.0034 | 0.1353 | 0.0339 | 0.2638 | 0.1141 | 0.1789 | 0.1548 | 0.1628 | 0.1390 | 0.0757 | 0.1921 | 0.0436 | 0.1209 | 0.0367 | 0.1028 | 0.0298 | 0.1390 | 0.0004 | 0.0000 | 0.0007 | 0.0010 | 0.0032 | 0.0010 | 0.0140 | 0.0094 | 0.0415 | 0.0439 | 0.0727 | 0.0638 | 0.0466 | 0.0449 | 0.0659 | 0.0651 | 0.7550 | 0.7708 | 0.0000 | 0.0000 | 0.0034 | 0.0014 | 0.0038 | 0.0027 | 0.0089 | 0.0119 | 0.0539 | 0.0562 | 0.0883 | 0.0965 | 0.0526 | 0.0562 | 0.0870 | 0.0942 | 0.7020 | 0.6808 | 0.0004 | 0.0012 | 0.0019 | 0.0105 | 0.0487 | 0.0790 | 0.0487 | 0.0821 | 0.7275 | |||
MDA-MB-231 | A443654 | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 11 | 1 | 125 | 813 | 4044 | 8852 | 602.6 | 91.52 | 41.19 | 63.75 | 467 | 546 | 581 | 603 | 621 | 637 | 653 | 670 | 697 | 0.0916 | 811 | 0.861 | 103.18 | 25.63 | 4 | 0.0601 | 243 | 0.0019 | 32.85 | 6.649 | 0.2422 | 371488.0 | 233000000 | 149000000000 | 95900000000000 | 0.4344 | 0.2018 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0006 | 0.0000 | 0.0029 | 0.0008 | 0.0262 | 0.0168 | 0.0455 | 0.0300 | 0.0385 | 0.0173 | 0.0691 | 0.0297 | 0.8172 | 0.9055 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0000 | 0.0011 | 0.0008 | 0.0201 | 0.0167 | 0.0321 | 0.0289 | 0.0201 | 0.0157 | 0.0338 | 0.0282 | 0.8928 | 0.9097 | 0.0279 | 0.0000 | 0.0391 | 0.0000 | 0.0615 | 0.1429 | 0.1006 | 0.2857 | 0.1006 | 0.2857 | 0.1564 | 0.2857 | 0.1229 | 0.0000 | 0.0950 | 0.0000 | 0.2961 | 0.0000 | 0.0008 | 0.0021 | 0.0062 | 0.0181 | 0.0402 | 0.0743 | 0.0812 | 0.0952 | 0.6820 | 9 | 11 | 14 | 16 | 19 | 24 | 32 | 45 | 88 | 0.0559 | 3.74 | 3.856 | 0.6364 | 5760.6 | 1520000 | 505000000 | 191000000000 | 0.4879 | 0.1680 | 0.0222 | 0.0179 | 0.0677 | 0.0335 | 0.0812 | 0.0288 | 0.1141 | 0.0594 | 0.1460 | 0.0957 | 0.1470 | 0.0868 | 0.1692 | 0.1094 | 0.1335 | 0.1627 | 0.1190 | 0.4059 | 0.0058 | 0.0099 | 0.0173 | 0.0192 | 0.0142 | 0.0128 | 0.0242 | 0.0271 | 0.0468 | 0.0434 | 0.0560 | 0.0449 | 0.0629 | 0.0545 | 0.0844 | 0.0813 | 0.6884 | 0.7067 | 0.0032 | 0.0069 | 0.0153 | 0.0122 | 0.0159 | 0.0130 | 0.0312 | 0.0298 | 0.0503 | 0.0519 | 0.0751 | 0.0833 | 0.0649 | 0.0596 | 0.0808 | 0.0795 | 0.6635 | 0.6639 | 0.0049 | 0.0113 | 0.0157 | 0.0300 | 0.0458 | 0.0679 | 0.0684 | 0.0915 | 0.6644 | |
MCF 10A | Barasertib | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 15 | 1 | 56 | 911 | 384 | 7332 | 60.6 | 12.76 | 165.06 | 118.18 | 45 | 50 | 53 | 57 | 60 | 63 | 67 | 71 | 76 | 0.0614 | 450 | 0.519 | 130.54 | 26.91 | 0 | 1.0260 | 394 | 0.0099 | 9.19 | 4.826 | 0.3167 | 3828.9 | 252540 | 17400000 | 1250000000 | 0.4554 | 0.1729 | 0.0036 | 0.0000 | 0.0109 | 0.0028 | 0.0182 | 0.0055 | 0.0691 | 0.0194 | 0.1309 | 0.0720 | 0.1709 | 0.1219 | 0.1782 | 0.0914 | 0.2000 | 0.1607 | 0.2182 | 0.5263 | 0.0000 | 0.0000 | 0.0000 | 0.0027 | 0.0093 | 0.0027 | 0.0247 | 0.0107 | 0.0957 | 0.0587 | 0.1235 | 0.1147 | 0.1173 | 0.0667 | 0.1420 | 0.1333 | 0.4877 | 0.6107 | 0.1020 | 0.0000 | 0.0612 | 0.1429 | 0.1224 | 0.0714 | 0.1020 | 0.3571 | 0.1633 | 0.2857 | 0.1837 | 0.0714 | 0.1633 | 0.0714 | 0.0612 | 0.0000 | 0.0408 | 0.0000 | 0.0053 | 0.0000 | 0.0106 | 0.0638 | 0.1596 | 0.1702 | 0.1596 | 0.1915 | 0.2394 | 18 | 37 | 71 | 117 | 158 | 195 | 232 | 274 | 329 | 0.0075 | 22.50 | 6.081 | 0.3343 | 41207.1 | 12200000 | 3970000000 | 1400000000000 | 0.4642 | 0.1955 | 0.0148 | 0.0016 | 0.1134 | 0.0089 | 0.1997 | 0.0335 | 0.1935 | 0.0895 | 0.1671 | 0.1734 | 0.1507 | 0.1952 | 0.0870 | 0.1593 | 0.0583 | 0.1613 | 0.0155 | 0.1774 | 0.0000 | 0.0000 | 0.0005 | 0.0013 | 0.0024 | 0.0011 | 0.0128 | 0.0077 | 0.0443 | 0.0302 | 0.0775 | 0.0562 | 0.0828 | 0.0523 | 0.1239 | 0.0826 | 0.6558 | 0.7687 | 0.0003 | 0.0023 | 0.0052 | 0.0099 | 0.0108 | 0.0185 | 0.0241 | 0.0468 | 0.0927 | 0.1342 | 0.1524 | 0.1640 | 0.1405 | 0.1486 | 0.1552 | 0.1721 | 0.4188 | 0.3036 | 0.0011 | 0.0025 | 0.0040 | 0.0178 | 0.0627 | 0.1136 | 0.1110 | 0.1627 | 0.5246 | |
MDA-MB-231 | Barasertib | 1.1 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 16 | 1 | 919 | 900 | 2948 | 8244 | 666.3 | 129.72 | 46.17 | 98.68 | 485 | 545 | 590 | 628 | 667 | 705 | 744 | 787 | 840 | 0.0761 | 627 | 1.113 | 69.64 | 24.02 | 1 | 0.0580 | 171 | 0.0007 | 51.40 | 7.349 | 0.1601 | 460748.0 | 329000000 | 243000000000 | 184000000000000 | 0.3935 | 0.2423 | 0.0000 | 0.0000 | 0.0016 | 0.0000 | 0.0016 | 0.0000 | 0.0110 | 0.0014 | 0.0460 | 0.0183 | 0.0826 | 0.0341 | 0.0727 | 0.0251 | 0.1130 | 0.0389 | 0.6715 | 0.8822 | 0.0000 | 0.0000 | 0.0004 | 0.0000 | 0.0000 | 0.0000 | 0.0041 | 0.0007 | 0.0202 | 0.0156 | 0.0326 | 0.0302 | 0.0223 | 0.0156 | 0.0396 | 0.0282 | 0.8808 | 0.9097 | 0.0019 | 0.0000 | 0.0039 | 0.0476 | 0.0273 | 0.0476 | 0.0253 | 0.1905 | 0.0916 | 0.2857 | 0.1443 | 0.1190 | 0.1033 | 0.2381 | 0.1618 | 0.0714 | 0.4405 | 0.0000 | 0.0007 | 0.0007 | 0.0027 | 0.0115 | 0.0392 | 0.0635 | 0.0581 | 0.0878 | 0.7360 | 9 | 11 | 12 | 14 | 16 | 21 | 28 | 43 | 87 | 0.1378 | 4.69 | 3.060 | 0.7458 | 11867.4 | 6550000 | 4590000000 | 3630000000000 | 0.6519 | 0.0809 | 0.0058 | 0.0114 | 0.0378 | 0.0178 | 0.0683 | 0.0242 | 0.1541 | 0.0604 | 0.1788 | 0.0768 | 0.1788 | 0.1230 | 0.1541 | 0.1393 | 0.1424 | 0.1628 | 0.0799 | 0.3845 | 0.0010 | 0.0064 | 0.0066 | 0.0092 | 0.0082 | 0.0104 | 0.0255 | 0.0249 | 0.0541 | 0.0385 | 0.0745 | 0.0686 | 0.0760 | 0.0735 | 0.1102 | 0.0951 | 0.6439 | 0.6732 | 0.0008 | 0.0018 | 0.0063 | 0.0055 | 0.0181 | 0.0101 | 0.0291 | 0.0194 | 0.0708 | 0.0738 | 0.0904 | 0.1042 | 0.0818 | 0.0821 | 0.1344 | 0.1245 | 0.5684 | 0.5784 | 0.0032 | 0.0051 | 0.0154 | 0.0199 | 0.0656 | 0.0836 | 0.0855 | 0.1215 | 0.6000 | |
MCF 10A | Barasertib | 10 | uM | DRAQ5 | 1 | TMRE | 2 | 1 | 15 | 1 | 710 | 620 | 2360 | 11953 | 110.5 | 24.96 | 211.01 | 181.60 | 79 | 90 | 97 | 103 | 109 | 115 | 122 | 130 | 142 | 0.0590 | 705 | 0.447 | 155.82 | 21.02 | 1 | 0.1462 | 345 | 0.0035 | 13.00 | 5.933 | 0.3106 | 12827.3 | 1560000 | 199000000 | 26300000000 | 0.4832 | 0.1861 | 0.0020 | 0.0000 | 0.0067 | 0.0009 | 0.0153 | 0.0032 | 0.0313 | 0.0074 | 0.0825 | 0.0300 | 0.1297 | 0.0669 | 0.1457 | 0.0646 | 0.1816 | 0.0817 | 0.4052 | 0.7453 | 0.0000 | 0.0000 | 0.0021 | 0.0004 | 0.0046 | 0.0022 | 0.0108 | 0.0043 | 0.0344 | 0.0195 | 0.0729 | 0.0468 | 0.0667 | 0.0299 | 0.0959 | 0.0468 | 0.7127 | 0.8501 | 0.0135 | 0.0000 | 0.0202 | 0.0142 | 0.0314 | 0.0638 | 0.0695 | 0.1702 | 0.1457 | 0.2766 | 0.1570 | 0.2057 | 0.1771 | 0.1135 | 0.1592 | 0.0922 | 0.2265 | 0.0638 | 0.0026 | 0.0026 | 0.0105 | 0.0438 | 0.0771 | 0.1402 | 0.1174 | 0.1446 | 0.4610 | 19 | 35 | 72 | 116 | 165 | 219 | 291 | 373 | 476 | 0.0088 | 40.77 | 6.716 | 0.3192 | 77499.7 | 35900000 | 19100000000 | 11300000000000 | 0.4707 | 0.1858 | 0.0171 | 0.0021 | 0.0769 | 0.0036 | 0.2135 | 0.0261 | 0.1532 | 0.0751 | 0.1780 | 0.1641 | 0.1449 | 0.2033 | 0.1100 | 0.1570 | 0.0651 | 0.1501 | 0.0414 | 0.2187 | 0.0003 | 0.0006 | 0.0014 | 0.0012 | 0.0042 | 0.0020 | 0.0115 | 0.0070 | 0.0431 | 0.0341 | 0.0776 | 0.0678 | 0.0739 | 0.0548 | 0.0927 | 0.0836 | 0.6952 | 0.7490 | 0.0010 | 0.0009 | 0.0021 | 0.0014 | 0.0067 | 0.0080 | 0.0200 | 0.0233 | 0.0562 | 0.0639 | 0.0998 | 0.1198 | 0.0814 | 0.0974 | 0.1131 | 0.1263 | 0.6197 | 0.5591 | 0.0002 | 0.0010 | 0.0051 | 0.0156 | 0.0562 | 0.0902 | 0.0770 | 0.0984 | 0.6564 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 898 | 503 | 7597 | 15942 | 143.4 | 27.73 | 173.50 | 120.68 | 110 | 119 | 126 | 132 | 140 | 148 | 157 | 168 | 183 | 0.0661 | 1053 | 1.190 | 84.90 | 37.16 | 1 | 0.0309 | 235 | 0.0025 | 15.67 | 6.274 | 0.2752 | 21329.9 | 3290000 | 525000000 | 86500000000 | 0.4372 | 0.2078 | 0.0006 | 0.0000 | 0.0010 | 0.0000 | 0.0046 | 0.0001 | 0.0191 | 0.0007 | 0.0570 | 0.0136 | 0.1188 | 0.0324 | 0.1394 | 0.0300 | 0.1797 | 0.0527 | 0.4799 | 0.8705 | 0.0000 | 0.0000 | 0.0005 | 0.0000 | 0.0020 | 0.0000 | 0.0096 | 0.0000 | 0.0278 | 0.0107 | 0.0488 | 0.0198 | 0.0578 | 0.0112 | 0.0842 | 0.0195 | 0.7694 | 0.9388 | 0.0070 | 0.0409 | 0.0141 | 0.0591 | 0.0273 | 0.0955 | 0.0703 | 0.1955 | 0.1453 | 0.2727 | 0.1641 | 0.1500 | 0.1258 | 0.0545 | 0.1516 | 0.0864 | 0.2945 | 0.0455 | 0.0017 | 0.0034 | 0.0095 | 0.0337 | 0.0685 | 0.1129 | 0.1067 | 0.1314 | 0.5322 | 41 | 69 | 95 | 120 | 148 | 179 | 215 | 264 | 340 | 0.0019 | 36.17 | 6.887 | 0.2809 | 44665.2 | 14900000 | 5940000000 | 2730000000000 | 0.4612 | 0.1723 | 0.0167 | 0.0012 | 0.0841 | 0.0062 | 0.1709 | 0.0303 | 0.1727 | 0.0682 | 0.1885 | 0.1425 | 0.1471 | 0.1913 | 0.0984 | 0.1576 | 0.0707 | 0.1542 | 0.0507 | 0.2485 | 0.0012 | 0.0005 | 0.0036 | 0.0018 | 0.0077 | 0.0047 | 0.0185 | 0.0109 | 0.0606 | 0.0516 | 0.1144 | 0.0972 | 0.0887 | 0.0746 | 0.1158 | 0.0983 | 0.5895 | 0.6604 | 0.0006 | 0.0021 | 0.0065 | 0.0130 | 0.0156 | 0.0199 | 0.0449 | 0.0483 | 0.1050 | 0.1174 | 0.1463 | 0.1612 | 0.1156 | 0.1174 | 0.1360 | 0.1333 | 0.4295 | 0.3874 | 0.0013 | 0.0034 | 0.0091 | 0.0235 | 0.0795 | 0.1362 | 0.1016 | 0.1281 | 0.5171 | |
MCF 10A | A443654 | 0.12 | uM | DRAQ5 | 1 | TMRE | 2 | 2 | 11 | 1 | 937 | 869 | 4358 | 4787 | 150.5 | 35.67 | 215.35 | 167.50 | 110 | 121 | 130 | 138 | 145 | 153 | 163 | 177 | 197 | 0.1249 | 598 | 1.001 | 107.62 | 26.02 | 1 | 0.0569 | 248 | 0.0019 | 28.98 | 6.582 | 0.2338 | 23927.0 | 4030000 | 718000000 | 136000000000 | 0.4618 | 0.1848 | 0.0007 | 0.0000 | 0.0000 | 0.0000 | 0.0054 | 0.0000 | 0.0307 | 0.0025 | 0.0928 | 0.0234 | 0.1506 | 0.0557 | 0.1593 | 0.0605 | 0.1827 | 0.0891 | 0.3778 | 0.7688 | 0.0003 | 0.0000 | 0.0000 | 0.0000 | 0.0028 | 0.0000 | 0.0113 | 0.0009 | 0.0423 | 0.0174 | 0.0675 | 0.0300 | 0.0805 | 0.0244 | 0.1032 | 0.0449 | 0.6920 | 0.8824 | 0.0053 | 0.0070 | 0.0119 | 0.0105 | 0.0185 | 0.0281 | 0.0793 | 0.1333 | 0.1506 | 0.2702 | 0.2127 | 0.1754 | 0.1136 | 0.1053 | 0.1532 | 0.1368 | 0.2550 | 0.1333 | 0.0032 | 0.0048 | 0.0117 | 0.0472 | 0.0881 | 0.1342 | 0.1146 | 0.1363 | 0.4599 | 40 | 68 | 99 | 133 | 170 | 220 | 274 | 347 | 446 | 0.0016 | 96.66 | 7.105 | 0.2131 | 74423.1 | 33600000 | 18100000000 | 10900000000000 | 0.5058 | 0.1647 | 0.0429 | 0.0024 | 0.1767 | 0.0102 | 0.2798 | 0.0783 | 0.1951 | 0.1428 | 0.1325 | 0.2055 | 0.0994 | 0.2127 | 0.0393 | 0.1350 | 0.0172 | 0.1183 | 0.0172 | 0.0950 | 0.0008 | 0.0007 | 0.0013 | 0.0020 | 0.0029 | 0.0038 | 0.0256 | 0.0133 | 0.0797 | 0.0673 | 0.1472 | 0.1206 | 0.1065 | 0.0823 | 0.1254 | 0.1209 | 0.5107 | 0.5891 | 0.0000 | 0.0016 | 0.0051 | 0.0048 | 0.0134 | 0.0104 | 0.0535 | 0.0670 | 0.1217 | 0.1316 | 0.1637 | 0.2041 | 0.1312 | 0.1276 | 0.1548 | 0.1515 | 0.3567 | 0.3014 | 0.0010 | 0.0035 | 0.0051 | 0.0238 | 0.1190 | 0.1570 | 0.1023 | 0.1489 | 0.4392 |