High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 349 807 image if available 6538 12626 588.0 86.69 128.31 222.66 469 530 562 584 602 620 637 657 683 0.0673 850 0.775 146.56 30.15 1 0.0509 333 0.0010 44.42 7.238 0.1938 353259.0
216000000
134000000000
83900000000000
0.4229 0.2180 0.0000 0.0000 0.0002 0.0000 0.0007 0.0000 0.0030 0.0002 0.0197 0.0106 0.0355 0.0173 0.0365 0.0112 0.0673 0.0176 0.8370 0.9433 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0015 0.0002 0.0129 0.0106 0.0221 0.0173 0.0201 0.0112 0.0312 0.0176 0.9121 0.9433 0.0276 0.0000 0.0379 0.0000 0.0379 0.0000 0.1241 0.0000 0.1310 0.0000 0.1586 0.0000 0.1241 0.0000 0.0931 0.0000 0.2655 0.0000 0.0011 0.0034 0.0053 0.0169 0.0344 0.0573 0.0655 0.0922 0.7238 11 13 16 21 29 46 87 188 404 0.1397 11.93 3.675 0.6149 66036.9
54600000
58200000000
74400000000000
0.4876 0.1751 0.0820 0.0077 0.2182 0.0463 0.2753 0.1683 0.1406 0.1143 0.1083 0.1550 0.0849 0.1907 0.0395 0.1066 0.0249 0.0863 0.0264 0.1248 0.0000 0.0005 0.0009 0.0010 0.0026 0.0022 0.0131 0.0124 0.0707 0.0604 0.0993 0.0897 0.0678 0.0592 0.1013 0.0905 0.6443 0.6841 0.0000 0.0004 0.0004 0.0004 0.0039 0.0019 0.0218 0.0250 0.0761 0.0832 0.1208 0.1271 0.0778 0.0847 0.1127 0.1144 0.5866 0.5630 0.0003 0.0003 0.0029 0.0147 0.0809 0.1055 0.0723 0.1125 0.6106
Hs 578T Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 206 921 image if available 453 2987 114.8 45.79 54.07 106.69 60 72 83 92 107 124 140 163 186 0.1145 342 0.878 44.91 11.18 2 0.2517 114 0.0028 90.22 5.942 0.1266 15262.5
2270000
364000000
61700000000
0.3487 0.2630 0.0000 0.0000 0.0000 0.0000 0.1136 0.0107 0.1894 0.0143 0.2803 0.0964 0.1667 0.1607 0.1212 0.1214 0.0833 0.2250 0.0455 0.3714 0.0000 0.0000 0.0000 0.0000 0.0000 0.0027 0.0217 0.0080 0.0797 0.0507 0.0870 0.0667 0.0833 0.0453 0.1232 0.0907 0.6051 0.7360 0.0000 0.0105 0.0000 0.0000 0.0069 0.0000 0.0417 0.0526 0.1389 0.1263 0.1181 0.1895 0.1042 0.1158 0.1458 0.1579 0.4444 0.3474 0.0000 0.0000 0.0100 0.0348 0.0796 0.1095 0.0945 0.0746 0.5970 19 21 22 23 25 27 30 40 83 0.1621 4.97 2.567 0.7206 14301.8
8310000
5840000000
4430000000000
0.6250 0.1113 0.0402 0.0406 0.1609 0.0449 0.1954 0.0684 0.2471 0.0983 0.1667 0.1581 0.1207 0.1859 0.0517 0.1838 0.0115 0.1496 0.0057 0.0705 0.0018 0.0239 0.0164 0.0239 0.0236 0.0290 0.0436 0.0365 0.1127 0.0982 0.1145 0.1159 0.0836 0.0882 0.1309 0.1461 0.4727 0.4383 0.0080 0.0000 0.0133 0.0215 0.0080 0.0000 0.0372 0.0307 0.1197 0.1350 0.1383 0.1350 0.0851 0.0890 0.1463 0.1442 0.4441 0.4448 0.0022 0.0130 0.0152 0.0304 0.1326 0.1152 0.0870 0.1413 0.4630
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 740 703 image if available 8862 18824 530.1 80.43 114.15 251.56 421 467 496 517 535 553 573 598 631 0.0548 1032 0.545 114.22 22.67 5 0.0372 330 0.0009 38.41 7.314 0.2073 287452.0
159000000
89500000000
51200000000000
0.4491 0.2025 0.0001 0.0000 0.0006 0.0000 0.0007 0.0001 0.0056 0.0007 0.0282 0.0139 0.0564 0.0200 0.0512 0.0144 0.0715 0.0211 0.7858 0.9298 0.0000 0.0000 0.0000 0.0000 0.0000 0.0001 0.0016 0.0007 0.0179 0.0139 0.0306 0.0200 0.0252 0.0144 0.0335 0.0202 0.8913 0.9307 0.0075 1.0000 0.0188 0.0000 0.0225 0.0000 0.0476 0.0000 0.1164 0.0000 0.1640 0.0000 0.1014 0.0000 0.1502 0.0000 0.3717 0.0000 0.0006 0.0036 0.0074 0.0181 0.0434 0.0613 0.0734 0.0863 0.7059 9 10 12 13 15 20 38 121 352 0.1429 9.00 3.049 0.5952 76308.2
79500000
99600000000
139000000000000
0.5235 0.1294 0.0259 0.0023 0.0761 0.0164 0.2120 0.0561 0.1942 0.0865 0.2006 0.1645 0.1003 0.2050 0.1036 0.1458 0.0631 0.1341 0.0243 0.1894 0.0000 0.0004 0.0002 0.0004 0.0012 0.0011 0.0067 0.0072 0.0396 0.0383 0.0538 0.0475 0.0401 0.0385 0.0569 0.0591 0.8015 0.8073 0.0003 0.0000 0.0006 0.0006 0.0017 0.0021 0.0056 0.0079 0.0476 0.0539 0.0673 0.0667 0.0437 0.0521 0.0707 0.0758 0.7625 0.7409 0.0000 0.0005 0.0016 0.0065 0.0428 0.0586 0.0418 0.0664 0.7819
MDA-MB-231 A443654
0.12
uM
DRAQ5 1 TMRE 2 2 11 1 406 806 image if available 3869 9909 688.7 123.70 61.45 130.52 523 588 635 670 698 722 743 770 857 0.0768 761 1.128 89.45 33.12 2 0.0605 234 0.0009 60.15 7.294 0.1719 489556.0
358000000
269000000000
207000000000000
0.3551 0.2759 0.0004 0.0000 0.0004 0.0000 0.0007 0.0000 0.0039 0.0005 0.0389 0.0191 0.0470 0.0343 0.0473 0.0252 0.0666 0.0433 0.7950 0.8776 0.0003 0.0000 0.0003 0.0000 0.0006 0.0000 0.0021 0.0005 0.0251 0.0187 0.0338 0.0305 0.0311 0.0174 0.0429 0.0274 0.8639 0.9056 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0217 0.0000 0.0522 0.0000 0.0435 0.0000 0.0783 0.0000 0.0696 0.0000 0.7348 0.0000 0.0005 0.0014 0.0048 0.0144 0.0393 0.0672 0.0561 0.0859 0.7303 6 8 9 10 11 13 21 63 186 0.1948 6.58 2.831 0.6506 20808.7
11500000
7940000000
6280000000000
0.3866 0.2159 0.0387 0.0072 0.1613 0.0273 0.2355 0.1164 0.2065 0.1193 0.1839 0.1379 0.0903 0.1897 0.0548 0.1149 0.0194 0.1379 0.0097 0.1494 0.0005 0.0000 0.0005 0.0008 0.0009 0.0004 0.0147 0.0132 0.0372 0.0371 0.0689 0.0556 0.0358 0.0342 0.0611 0.0671 0.7804 0.7917 0.0000 0.0000 0.0000 0.0017 0.0032 0.0017 0.0118 0.0121 0.0428 0.0537 0.0707 0.0779 0.0386 0.0467 0.0739 0.0848 0.7590 0.7213 0.0005 0.0005 0.0020 0.0125 0.0435 0.0659 0.0390 0.0649 0.7712
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 699 471 image if available 4304 9250 675.2 100.28 112.63 227.13 526 609 656 678 694 707 722 740 781 0.0782 723 1.058 105.04 31.11 1 0.0602 259 0.0017 29.52 6.816 0.2429 465980.0
327000000
234000000000
169000000000000
0.4313 0.2103 0.0000 0.0000 0.0000 0.0000 0.0008 0.0000 0.0028 0.0000 0.0204 0.0139 0.0353 0.0238 0.0311 0.0120 0.0487 0.0205 0.8609 0.9297 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0016 0.0000 0.0149 0.0139 0.0259 0.0238 0.0191 0.0120 0.0254 0.0205 0.9130 0.9297 0.0082 0.0000 0.0163 0.0000 0.0245 0.0000 0.0367 0.0000 0.0816 0.0000 0.0857 0.0000 0.0816 0.0000 0.1143 0.0000 0.5510 0.0000 0.0004 0.0015 0.0038 0.0128 0.0342 0.0556 0.0680 0.0992 0.7244 8 10 12 14 17 26 59 148 341 0.1976 21.25 3.579 0.6813 64269.9
61100000
74500000000
106000000000000
0.4869 0.1485 0.0430 0.0000 0.1471 0.0171 0.1991 0.0910 0.1222 0.1229 0.1357 0.1456 0.1154 0.1581 0.1086 0.1229 0.0633 0.1024 0.0656 0.2400 0.0000 0.0000 0.0008 0.0004 0.0013 0.0011 0.0109 0.0094 0.0419 0.0410 0.0747 0.0556 0.0516 0.0402 0.0763 0.0676 0.7425 0.7847 0.0000 0.0006 0.0010 0.0022 0.0031 0.0028 0.0175 0.0185 0.0577 0.0612 0.0911 0.1021 0.0695 0.0606 0.0901 0.0948 0.6699 0.6571 0.0000 0.0009 0.0032 0.0125 0.0529 0.0779 0.0682 0.0904 0.6939
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 409 890 image if available 816 11183 89.7 9.29 105.45 153.75 78 81 84 87 90 92 95 98 101 0.0640 716 0.688 118.34 30.02 4 0.4142 338 0.0250 2.26 3.936 0.5414 8132.4
745123
69000000
6450000000
0.4240 0.2141 0.0000 0.0000 0.0000 0.0000 0.0038 0.0012 0.0166 0.0086 0.0422 0.0319 0.0575 0.0564 0.0665 0.0380 0.1151 0.0576 0.6982 0.8064 0.0000 0.0000 0.0000 0.0000 0.0037 0.0012 0.0137 0.0086 0.0373 0.0319 0.0460 0.0564 0.0522 0.0380 0.0646 0.0576 0.7826 0.8064 0.1304 0.0000 0.0870 0.0000 0.0870 0.0000 0.2174 0.0000 0.1304 0.0000 0.2174 0.0000 0.0870 0.0000 0.0000 0.0000 0.0435 0.0000 0.0048 0.0096 0.0265 0.0265 0.0964 0.1084 0.1084 0.1880 0.4313 12 15 19 25 36 56 93 175 308 0.0583 19.57 4.627 0.5749 34757.8
18600000
13100000000
11000000000000
0.5602 0.1268 0.0620 0.0049 0.1860 0.0220 0.2709 0.1170 0.1685 0.1506 0.1119 0.1935 0.0876 0.1911 0.0539 0.1066 0.0270 0.0980 0.0323 0.1164 0.0006 0.0010 0.0025 0.0017 0.0048 0.0048 0.0202 0.0167 0.0663 0.0628 0.1003 0.0944 0.0621 0.0604 0.1056 0.0980 0.6376 0.6603 0.0011 0.0004 0.0011 0.0008 0.0032 0.0054 0.0231 0.0233 0.0774 0.0848 0.1214 0.1431 0.0781 0.0809 0.1256 0.1268 0.5692 0.5344 0.0010 0.0016 0.0058 0.0214 0.0672 0.1140 0.0643 0.1191 0.6056
MCF 10A Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 1028 672 image if available 465 2154 115.4 21.95 94.06 88.63 88 97 102 107 113 119 127 135 145 0.1467 316 0.423 90.70 21.40 1 0.5978 278 0.0052 16.34 5.463 0.2803 13796.9
1710000
218000000
28800000000
0.4162 0.2196 0.0000 0.0000 0.0031 0.0000 0.0247 0.0022 0.0556 0.0111 0.1049 0.0509 0.1852 0.0907 0.1420 0.0575 0.1821 0.1062 0.3025 0.6814 0.0000 0.0000 0.0000 0.0000 0.0050 0.0022 0.0273 0.0086 0.0695 0.0452 0.1042 0.0839 0.0720 0.0344 0.1117 0.0796 0.6104 0.7462 0.0000 0.0000 0.0380 0.1538 0.0380 0.0000 0.1139 0.1538 0.1519 0.3846 0.2152 0.0000 0.1392 0.1538 0.1139 0.1538 0.1899 0.0000 0.0000 0.0045 0.0179 0.0538 0.1345 0.1211 0.1211 0.1704 0.3767 17 26 35 44 58 78 107 164 229 0.0192 12.21 4.935 0.4816 16699.0
4090000
1190000000
384000000000
0.5433 0.1288 0.0185 0.0036 0.1218 0.0145 0.1808 0.0416 0.1734 0.1139 0.2251 0.1953 0.0959 0.1664 0.0812 0.1356 0.0554 0.1447 0.0480 0.1844 0.0000 0.0000 0.0056 0.0009 0.0090 0.0027 0.0124 0.0192 0.0710 0.0602 0.1150 0.0794 0.0744 0.0776 0.1488 0.1487 0.5637 0.6113 0.0016 0.0000 0.0032 0.0018 0.0065 0.0147 0.0260 0.0313 0.0666 0.0792 0.1380 0.1455 0.0893 0.0958 0.1347 0.1602 0.5341 0.4715 0.0014 0.0082 0.0109 0.0301 0.0657 0.1012 0.0821 0.1477 0.5527
Hs 578T Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 603 882 image if available 1319 7737 66.4 71.59 51.64 108.03 33 34 36 37 38 40 42 54 179 0.0778 602 1.235 41.48 16.64 4 0.0819 108 0.0362 35.18 4.239 0.5039 9528.0
2260000
632000000
189000000000
0.3313 0.2814 0.0000 0.0369 0.0984 0.0938 0.3770 0.0966 0.2295 0.0966 0.2623 0.0909 0.0328 0.1790 0.0000 0.1932 0.0000 0.1364 0.0000 0.0767 0.0000 0.0236 0.0036 0.0599 0.0036 0.0617 0.0073 0.0617 0.0584 0.0399 0.0730 0.0690 0.0474 0.0853 0.0766 0.0853 0.7299 0.5136 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0094 0.0101 0.0657 0.0653 0.0892 0.1005 0.0469 0.0503 0.0892 0.0804 0.6995 0.6935 0.0000 0.0000 0.0000 0.0170 0.0468 0.0979 0.0511 0.0638 0.7234 9 10 11 12 13 15 17 26 172 0.2813 8.15 2.652 0.7496 14334.9
6050000
2920000000
1530000000000
0.6889 0.0590 0.0938 0.0063 0.2313 0.0472 0.2375 0.1824 0.1813 0.1981 0.1000 0.2390 0.0938 0.1447 0.0250 0.0755 0.0313 0.0503 0.0063 0.0566 0.0000 0.0014 0.0008 0.0007 0.0031 0.0021 0.0178 0.0192 0.0666 0.0655 0.0860 0.0734 0.0713 0.0734 0.0953 0.0962 0.6592 0.6681 0.0000 0.0000 0.0009 0.0018 0.0035 0.0018 0.0221 0.0230 0.0716 0.0718 0.0902 0.0948 0.0875 0.0902 0.1043 0.0976 0.6198 0.6188 0.0008 0.0000 0.0017 0.0215 0.0710 0.0834 0.0859 0.0983 0.6375
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 287 208 image if available 5091 12471 474.1 73.02 68.38 135.66 363 414 452 475 490 504 518 533 553 0.0763 952 1.174 64.62 19.85 1 0.0297 151 0.0020 19.65 6.571 0.2736 230087.0
114000000
57200000000
29100000000000
0.4330 0.2034 0.0002 0.0000 0.0000 0.0000 0.0019 0.0000 0.0074 0.0012 0.0203 0.0121 0.0432 0.0234 0.0404 0.0127 0.0650 0.0183 0.8215 0.9322 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0032 0.0012 0.0131 0.0121 0.0257 0.0234 0.0181 0.0127 0.0235 0.0183 0.9163 0.9322 0.0328 0.0000 0.0615 0.0000 0.1025 0.0000 0.1311 0.0000 0.1352 0.0000 0.1352 0.0000 0.1230 0.0000 0.0820 0.0000 0.1967 0.0000 0.0000 0.0026 0.0065 0.0091 0.0308 0.0587 0.0532 0.0834 0.7557 6 8 9 11 15 21 36 71 216 0.1260 12.46 3.408 0.6217 23078.9
13100000
9690000000
8870000000000
0.4949 0.1599 0.0417 0.0057 0.1106 0.0278 0.1571 0.0785 0.1234 0.0849 0.1619 0.1091 0.1250 0.1320 0.1106 0.1084 0.1090 0.1434 0.0609 0.3103 0.0024 0.0014 0.0044 0.0028 0.0051 0.0068 0.0139 0.0160 0.0493 0.0376 0.0748 0.0673 0.0479 0.0450 0.0816 0.0730 0.7206 0.7501 0.0000 0.0014 0.0017 0.0009 0.0043 0.0047 0.0181 0.0161 0.0513 0.0584 0.0945 0.1011 0.0513 0.0570 0.0815 0.0783 0.6972 0.6820 0.0008 0.0012 0.0043 0.0152 0.0519 0.0831 0.0542 0.0807 0.7087
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 400 407 image if available 6276 11399 375.7 86.02 140.41 164.45 245 323 357 378 396 413 428 444 463 0.0798 910 1.138 23.43 8.49 5 0.0099 62 0.0020 19.90 6.638 0.2782 148520.0
60600000
25300000000
10700000000000
0.3938 0.2401 0.0005 0.0000 0.0014 0.0000 0.0021 0.0000 0.0137 0.0000 0.0354 0.0108 0.0722 0.0252 0.0748 0.0104 0.1107 0.0183 0.6891 0.9352 0.0000 0.0000 0.0002 0.0000 0.0000 0.0000 0.0011 0.0000 0.0137 0.0108 0.0298 0.0252 0.0216 0.0104 0.0319 0.0169 0.9017 0.9367 0.0072 1.0000 0.0184 0.0000 0.0419 0.0000 0.0593 0.0000 0.0992 0.0000 0.1329 0.0000 0.1299 0.0000 0.1227 0.0000 0.3885 0.0000 0.0000 0.0010 0.0031 0.0067 0.0347 0.0601 0.0515 0.0772 0.7656 9 11 15 29 67 119 185 272 389 0.0593 7.25 4.451 0.5348 46754.1
20300000
10200000000
5650000000000
0.4511 0.1880 0.0237 0.0010 0.1225 0.0110 0.2381 0.0628 0.1729 0.1187 0.1275 0.1830 0.1265 0.1945 0.0810 0.1237 0.0632 0.1062 0.0445 0.1990 0.0000 0.0000 0.0008 0.0002 0.0017 0.0009 0.0089 0.0072 0.0450 0.0402 0.0820 0.0693 0.0542 0.0504 0.0858 0.0775 0.7214 0.7543 0.0003 0.0003 0.0030 0.0015 0.0041 0.0034 0.0160 0.0153 0.0574 0.0644 0.0907 0.1103 0.0655 0.0754 0.1045 0.1051 0.6586 0.6243 0.0002 0.0002 0.0019 0.0112 0.0594 0.0827 0.0622 0.0946 0.6875
Hs 578T
0
DRAQ5 1 TMRE 2 2 2 1 963 51 image if available 463 2383 135.5 54.95 285.62 357.76 57 79 96 118 140 159 176 191 206 0.1389 331 0.806 83.49 17.80 1 0.4125 191 0.0030 40.37 5.894 0.2035 21382.7
3690000
675000000
128000000000
0.3277 0.2693 0.0000 0.0000 0.0000 0.0000 0.0794 0.0000 0.2063 0.0037 0.3016 0.0967 0.2381 0.2528 0.0952 0.1413 0.0635 0.1450 0.0159 0.3606 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0066 0.0027 0.0459 0.0495 0.1180 0.1016 0.0525 0.0330 0.0721 0.0549 0.7049 0.7582 0.0000 0.0000 0.0000 0.0105 0.0000 0.0000 0.0168 0.0947 0.0726 0.1053 0.2123 0.2947 0.0894 0.0526 0.1285 0.1053 0.4804 0.3368 0.0000 0.0000 0.0000 0.0124 0.0664 0.1286 0.0747 0.1079 0.6100 17 24 32 51 103 203 340 571 860 0.0209 106.06 5.674 0.3655 209519.0
201000000
220000000000
261000000000000
0.5461 0.1235 0.1000 0.0053 0.1944 0.0317 0.2833 0.1504 0.1389 0.1926 0.1444 0.1636 0.0833 0.1900 0.0444 0.0765 0.0056 0.1187 0.0056 0.0712 0.0000 0.0000 0.0011 0.0000 0.0169 0.0137 0.0349 0.0235 0.0992 0.0832 0.1680 0.1566 0.0891 0.0861 0.1184 0.1252 0.4724 0.5117 0.0057 0.0016 0.0127 0.0109 0.0255 0.0264 0.0368 0.0358 0.0990 0.0995 0.1457 0.1384 0.0905 0.1151 0.1132 0.1073 0.4710 0.4650 0.0012 0.0037 0.0224 0.0387 0.1110 0.1459 0.1010 0.1035 0.4726
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 792 805 image if available 4919 8206 382.1 68.91 141.31 188.12 300 324 344 360 375 392 412 438 476 0.0898 737 1.029 141.51 47.89 1 0.0732 360 0.0011 37.46 7.089 0.1984 150764.0
61400000
25800000000
11200000000000
0.4301 0.2151 0.0000 0.0000 0.0008 0.0000 0.0030 0.0000 0.0107 0.0015 0.0411 0.0153 0.0748 0.0283 0.0789 0.0233 0.1114 0.0344 0.6794 0.8971 0.0000 0.0000 0.0002 0.0000 0.0016 0.0000 0.0041 0.0008 0.0202 0.0133 0.0357 0.0198 0.0359 0.0131 0.0538 0.0182 0.8484 0.9348 0.0014 0.0000 0.0043 0.0000 0.0216 0.0000 0.0620 0.0000 0.1037 0.0000 0.1527 0.0000 0.1081 0.0000 0.1326 0.0000 0.4135 0.0000 0.0022 0.0022 0.0118 0.0263 0.0679 0.1121 0.0937 0.1222 0.5617 17 22 29 36 53 94 149 244 370 0.0319 21.94 5.086 0.5347 55351.4
34100000
26500000000
23500000000000
0.4596 0.1622 0.0237 0.0014 0.1379 0.0121 0.2020 0.0752 0.1323 0.1079 0.1295 0.1526 0.1337 0.1923 0.0975 0.1214 0.0641 0.1008 0.0794 0.2363 0.0000 0.0000 0.0010 0.0003 0.0007 0.0012 0.0104 0.0064 0.0542 0.0436 0.0808 0.0753 0.0636 0.0516 0.0855 0.0680 0.7037 0.7537 0.0013 0.0000 0.0000 0.0010 0.0018 0.0015 0.0075 0.0185 0.0755 0.0713 0.1132 0.1307 0.0644 0.0723 0.1012 0.1142 0.6350 0.5905 0.0004 0.0008 0.0016 0.0117 0.0600 0.1028 0.0631 0.0919 0.6678
MDA-MB-231
0
DRAQ5 1 TMRE 2 2 2 1 1249 769 image if available 4803 11247 502.2 83.00 67.05 122.38 382 431 463 488 508 528 552 579 608 0.0648 729 1.156 88.46 33.06 1 0.0477 229 0.0014 23.98 6.830 0.2358 259094.0
137000000
73800000000
40500000000000
0.4284 0.2133 0.0011 0.0000 0.0019 0.0000 0.0044 0.0000 0.0091 0.0002 0.0299 0.0136 0.0517 0.0206 0.0575 0.0124 0.0811 0.0183 0.7632 0.9350 0.0000 0.0000 0.0000 0.0000 0.0007 0.0000 0.0014 0.0002 0.0170 0.0136 0.0276 0.0206 0.0218 0.0124 0.0377 0.0183 0.8937 0.9350 0.0072 0.0000 0.0181 0.0000 0.0325 0.0000 0.0597 0.0000 0.0868 0.0000 0.1374 0.0000 0.1230 0.0000 0.1754 0.0000 0.3599 0.0000 0.0019 0.0016 0.0054 0.0140 0.0384 0.0594 0.0602 0.0889 0.7301 6 8 10 12 15 20 38 86 207 0.1665 6.51 3.350 0.6502 19470.7
8860000
4860000000
2970000000000
0.5816 0.0962 0.0324 0.0043 0.1477 0.0208 0.2216 0.0720 0.2090 0.1276 0.1658 0.1753 0.1189 0.1840 0.0613 0.1372 0.0216 0.1345 0.0216 0.1441 0.0007 0.0003 0.0010 0.0009 0.0034 0.0039 0.0172 0.0128 0.0540 0.0538 0.0890 0.0805 0.0639 0.0589 0.0907 0.0838 0.6801 0.7050 0.0000 0.0005 0.0013 0.0019 0.0030 0.0033 0.0166 0.0196 0.0675 0.0650 0.0968 0.1182 0.0739 0.0715 0.0994 0.1005 0.6416 0.6196 0.0004 0.0015 0.0034 0.0145 0.0574 0.1015 0.0624 0.0915 0.6673
BT-20 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 465 643 image if available 8720 12380 327.7 56.71 178.47 263.33 253 288 306 320 333 346 358 371 394 0.0826 1023 1.053 189.34 55.01 1 0.0515 449 0.0016 19.71 6.739 0.2552 110617.0
38300000
13500000000
4860000000000
0.4132 0.2316 0.0001 0.0000 0.0000 0.0001 0.0010 0.0001 0.0059 0.0010 0.0246 0.0101 0.0541 0.0199 0.0557 0.0130 0.0950 0.0226 0.7636 0.9332 0.0000 0.0000 0.0000 0.0001 0.0000 0.0001 0.0030 0.0009 0.0126 0.0096 0.0228 0.0178 0.0228 0.0096 0.0370 0.0162 0.9017 0.9456 0.0114 0.0000 0.0227 0.0000 0.0272 0.0000 0.0681 0.0000 0.0988 0.0000 0.1703 0.0000 0.1067 0.0000 0.1226 0.0000 0.3723 0.0000 0.0008 0.0019 0.0071 0.0173 0.0483 0.0854 0.0861 0.1201 0.6330 18 25 36 52 72 98 148 262 503 0.0250 35.86 5.284 0.5431 101188.0
92200000
104000000000
133000000000000
0.5504 0.1103 0.0118 0.0028 0.0634 0.0052 0.1160 0.0282 0.1461 0.0612 0.1912 0.1266 0.1751 0.1507 0.1224 0.1351 0.0988 0.1573 0.0752 0.3329 0.0005 0.0002 0.0003 0.0011 0.0024 0.0023 0.0079 0.0094 0.0482 0.0428 0.0854 0.0656 0.0514 0.0563 0.0801 0.0808 0.7238 0.7415 0.0000 0.0000 0.0021 0.0008 0.0042 0.0035 0.0101 0.0097 0.0538 0.0635 0.0894 0.0884 0.0594 0.0666 0.0876 0.0970 0.6934 0.6706 0.0000 0.0003 0.0031 0.0089 0.0520 0.0851 0.0560 0.0875 0.7072