High-content imaging of six breast cancer cell lines treated with a library of small molecule kinase inhibitors. - Dataset (ID:20244)

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Cell SM Name Small Mol Concentration Small Mol Conc Unit Other Reagent 1 Name Other Reagent 1 Detection Channel Other Reagent 2 Name Other Reagent 2 Detection Channel Row Column Field X-coordinate Y-coordinate Image Nuclear area (pixels) Cytoplasm area (pixels) Nuclear intensity (AU) Std Dev of nuclear intensity (AU) Cytoplasm intensity (AU) Std Dev of cytoplasm intensity (AU) 10% quantile of nuclear intensity (AU) 20% quantile of nuclear intensity (AU) 30% quantile of nuclear intensity (AU) 40% quantile of nuclear intensity (AU) 50% quantile of nuclear intensity (AU) 60% quantile of nuclear intensity (AU) 70% quantile of nuclear intensity (AU) 80% quantile of nuclear intensity (AU) 90% quantile of nuclear intensity (AU) Ratio of cytoplasm perimeter to area Cytoplasm perimeter (pixels) Nuclear roundness Nuclear length (pixels) Nuclear halfwidth (pixels) Number of nuclei Ratio of nuclear perimeter to area Nuclear perimeter (pixels) Nuclear Haralick ASM Nuclear Haralick contrast Nuclear Haralick entropy Nuclear Haralick IDM Nuclear Haralick moment 2 Nuclear Haralick moment 3 Nuclear Haralick moment 4 Nuclear Haralick moment 5 Nuclear radial moment (border) Nuclear radial moment (center) Nuclear Threshold Adj Stat 1 (Threshold: 0.2) Nuclear Threshold Adj Stat 1 (Threshold: 0.4) Nuclear Threshold Adj Stat 2 (Threshold: 0.2) Nuclear Threshold Adj Stat 2 (Threshold: 0.4) Nuclear Threshold Adj Stat 3 (Threshold: 0.2) Nuclear Threshold Adj Stat 3 (Threshold: 0.4) Nuclear Threshold Adj Stat 4 (Threshold: 0.2) Nuclear Threshold Adj Stat 4 (Threshold: 0.4) Nuclear Threshold Adj Stat 5 (Threshold: 0.2) Nuclear Threshold Adj Stat 5 (Threshold: 0.4) Nuclear Threshold Adj Stat 6 (Threshold: 0.2) Nuclear Threshold Adj Stat 6 (Threshold: 0.4) Nuclear Threshold Adj Stat 7 (Threshold: 0.2) Nuclear Threshold Adj Stat 7 (Threshold: 0.4) Nuclear Threshold Adj Stat 8 (Threshold: 0.2) Nuclear Threshold Adj Stat 8 (Threshold: 0.4) Nuclear Threshold Adj Stat 9 (Threshold: 0.2) Nuclear Threshold Adj Stat 9 (Threshold: 0.4) Nuclear Threshold Adj Stat 10 (Threshold: 0.2) Nuclear Threshold Adj Stat 10 (Threshold: 0.4) Nuclear Threshold Adj Stat 11 (Threshold: 0.2) Nuclear Threshold Adj Stat 11 (Threshold: 0.4) Nuclear Threshold Adj Stat 12 (Threshold: 0.2) Nuclear Threshold Adj Stat 12 (Threshold: 0.4) Nuclear Threshold Adj Stat 13 (Threshold: 0.2) Nuclear Threshold Adj Stat 13 (Threshold: 0.4) Nuclear Threshold Adj Stat 14 (Threshold: 0.2) Nuclear Threshold Adj Stat 14 (Threshold: 0.4) Nuclear Threshold Adj Stat 15 (Threshold: 0.2) Nuclear Threshold Adj Stat 15 (Threshold: 0.4) Nuclear Threshold Adj Stat 16 (Threshold: 0.2) Nuclear Threshold Adj Stat 16 (Threshold: 0.4) Nuclear Threshold Adj Stat 17 (Threshold: 0.2) Nuclear Threshold Adj Stat 17 (Threshold: 0.4) Nuclear Threshold Adj Stat 18 (Threshold: 0.2) Nuclear Threshold Adj Stat 18 (Threshold: 0.4) Nuclear Threshold Adj Stat 19 (Threshold: 0.2) Nuclear Threshold Adj Stat 19 (Threshold: 0.4) Nuclear Threshold Adj Stat 20 (Threshold: 0.2) Nuclear Threshold Adj Stat 20 (Threshold: 0.4) Nuclear Threshold Adj Stat 21 (Threshold: 0.2) Nuclear Threshold Adj Stat 21 (Threshold: 0.4) Nuclear Threshold Adj Stat 22 (Threshold: 0.2) Nuclear Threshold Adj Stat 22 (Threshold: 0.4) Nuclear Threshold Adj Stat 23 (Threshold: 0.2) Nuclear Threshold Adj Stat 23 (Threshold: 0.4) Nuclear Threshold Adj Stat 24 (Threshold: 0.2) Nuclear Threshold Adj Stat 24 (Threshold: 0.4) Nuclear Threshold Adj Stat 25 (Threshold: 0.2) Nuclear Threshold Adj Stat 25 (Threshold: 0.4) Nuclear Threshold Adj Stat 26 (Threshold: 0.2) Nuclear Threshold Adj Stat 26 (Threshold: 0.4) Nuclear Threshold Adj Stat 27 (Threshold: 0.2) Nuclear Threshold Adj Stat 27 (Threshold: 0.4) Nuclear Threshold Adj Stat 28 Nuclear Threshold Adj Stat 29 Nuclear Threshold Adj Stat 30 Nuclear Threshold Adj Stat 31 Nuclear Threshold Adj Stat 32 Nuclear Threshold Adj Stat 33 Nuclear Threshold Adj Stat 34 Nuclear Threshold Adj Stat 35 Nuclear Threshold Adj Stat 36 10% quantile of cytoplasm intensity (AU) 20% quantile of cytoplasm intensity (AU) 30% quantile of cytoplasm intensity (AU) 40% quantile of cytoplasm intensity (AU) 50% quantile of cytoplasm intensity (AU) 60% quantile of cytoplasm intensity (AU) 70% quantile of cytoplasm intensity (AU) 80% quantile of cytoplasm intensity (AU) 90% quantile of cytoplasm intensity (AU) Cytoplasmic Haralick ASM Cytoplasmic Haralick contrast Cytoplasmic Haralick entropy Cytoplasmic Haralick IDM Cytoplasmic Haralick moment 2 Cytoplasmic Haralick moment 3 Cytoplasmic Haralick moment 4 Cytoplasmic Haralick moment 5 Cytoplasmic radial moment (border) Cytoplasmic radial moment (center) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 1 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 2 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 3 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 4 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 5 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 6 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 7 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 8 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 9 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 10 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 11 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 12 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 13 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 14 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 15 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 16 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 17 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 18 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 19 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 20 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 21 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 22 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 23 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 24 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 25 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 26 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.2) Cytoplasmic Threshold Adj Stat 27 (Threshold: 0.4) Cytoplasmic Threshold Adj Stat 28 Cytoplasmic Threshold Adj Stat 29 Cytoplasmic Threshold Adj Stat 30 Cytoplasmic Threshold Adj Stat 31 Cytoplasmic Threshold Adj Stat 32 Cytoplasmic Threshold Adj Stat 33 Cytoplasmic Threshold Adj Stat 34 Cytoplasmic Threshold Adj Stat 35 Cytoplasmic Threshold Adj Stat 36
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 340 406 image if available 471 6514 857.4 228.67 9.61 2.99 549 627 690 770 842 920 1002 1103 1189 0.0711 463 1.310 25.32 10.63 1 0.1423 67 0.0025 78.35 6.025 0.1012 787377.0
767000000
784000000000
832000000000000
0.3659 0.2545 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0099 0.0024 0.1034 0.0622 0.2512 0.0909 0.1281 0.0646 0.1823 0.0933 0.3251 0.6866 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0061 0.0022 0.0515 0.0500 0.0879 0.0609 0.0424 0.0391 0.0515 0.0543 0.7606 0.7935 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0079 0.0476 0.0787 0.1667 0.1496 0.1667 0.0315 0.0952 0.1260 0.1667 0.6063 0.3571 0.0000 0.0000 0.0000 0.0089 0.0536 0.1161 0.0402 0.0714 0.7098 6 7 8 9 9 10 11 12 13 0.0120 10.83 4.800 0.3191 101.2
1165.12
14657.4
201923
0.4760 0.1625 0.0062 0.0009 0.0309 0.0025 0.0752 0.0063 0.1498 0.0201 0.2096 0.0366 0.2372 0.0807 0.1938 0.1532 0.0783 0.3133 0.0190 0.3862 0.0016 0.0000 0.0096 0.0007 0.0200 0.0031 0.0446 0.0111 0.0824 0.0214 0.1177 0.0415 0.1815 0.0663 0.2235 0.1853 0.3192 0.6707 0.1143 0.2295 0.1414 0.1525 0.1455 0.1311 0.1299 0.0803 0.1225 0.0738 0.1049 0.0754 0.0683 0.0623 0.0751 0.1049 0.0981 0.0902 0.0313 0.0568 0.1064 0.1471 0.1279 0.1328 0.1432 0.1233 0.1312
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 1002 903 image if available 2590 6854 671.8 130.82 57.85 118.91 504 556 597 632 666 700 730 773 852 0.0926 635 0.749 181.18 45.31 2 0.1853 480 0.0008 66.05 7.317 0.1448 468423.0
339000000
253000000000
195000000000000
0.4212 0.2260 0.0000 0.0000 0.0000 0.0000 0.0006 0.0004 0.0062 0.0020 0.0506 0.0208 0.1069 0.0425 0.0771 0.0261 0.1187 0.0357 0.6398 0.8725 0.0000 0.0000 0.0000 0.0000 0.0000 0.0004 0.0032 0.0008 0.0272 0.0159 0.0614 0.0348 0.0378 0.0147 0.0591 0.0224 0.8113 0.9111 0.0051 0.0000 0.0000 0.0000 0.0103 0.0220 0.0282 0.0879 0.0872 0.1209 0.1385 0.1758 0.0923 0.1868 0.1256 0.1538 0.5128 0.2527 0.0008 0.0000 0.0040 0.0217 0.0593 0.1051 0.0842 0.1043 0.6207 10 12 13 16 22 33 42 64 129 0.1077 12.25 3.455 0.7303 17483.7
14800000
20400000000
35900000000000
0.6243 0.0943 0.0239 0.0079 0.0613 0.0126 0.0733 0.0238 0.1346 0.0516 0.1891 0.0827 0.1704 0.1263 0.1891 0.1468 0.1193 0.1640 0.0392 0.3843 0.0054 0.0046 0.0113 0.0057 0.0097 0.0092 0.0199 0.0218 0.0485 0.0402 0.0889 0.0766 0.0711 0.0808 0.0867 0.0938 0.6584 0.6673 0.0039 0.0018 0.0024 0.0027 0.0087 0.0064 0.0221 0.0282 0.0559 0.0645 0.1087 0.1064 0.0693 0.0709 0.0969 0.0982 0.6320 0.6209 0.0026 0.0066 0.0066 0.0178 0.0540 0.0949 0.0639 0.0988 0.6548
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 561 247 image if available 4445 15033 466.1 65.09 63.62 138.06 379 413 433 450 466 481 499 521 551 0.0559 840 1.186 46.40 17.49 1 0.0270 120 0.0015 34.76 6.820 0.2169 221513.0
107000000
52800000000
26400000000000
0.4116 0.2311 0.0000 0.0000 0.0000 0.0000 0.0011 0.0000 0.0035 0.0002 0.0355 0.0137 0.0646 0.0248 0.0635 0.0142 0.0910 0.0205 0.7407 0.9266 0.0000 0.0000 0.0000 0.0000 0.0002 0.0000 0.0020 0.0002 0.0221 0.0137 0.0368 0.0248 0.0314 0.0142 0.0456 0.0187 0.8620 0.9284 0.0110 1.0000 0.0192 0.0000 0.0219 0.0000 0.0959 0.0000 0.1479 0.0000 0.1726 0.0000 0.1397 0.0000 0.1288 0.0000 0.2630 0.0000 0.0004 0.0036 0.0085 0.0278 0.0732 0.0996 0.0961 0.1302 0.5606 7 8 9 10 12 15 22 57 200 0.2619 11.61 3.053 0.7574 23105.5
14100000
11000000000
10100000000000
0.4691 0.1844 0.0363 0.0081 0.0726 0.0208 0.0726 0.0728 0.1501 0.0786 0.1622 0.1110 0.1671 0.1260 0.1574 0.1191 0.1090 0.1445 0.0726 0.3191 0.0003 0.0012 0.0013 0.0030 0.0023 0.0044 0.0077 0.0094 0.0229 0.0195 0.0265 0.0301 0.0245 0.0248 0.0368 0.0387 0.8777 0.8689 0.0011 0.0000 0.0011 0.0004 0.0022 0.0024 0.0108 0.0091 0.0238 0.0234 0.0309 0.0313 0.0313 0.0317 0.0395 0.0527 0.8593 0.8490 0.0003 0.0007 0.0048 0.0104 0.0214 0.0308 0.0235 0.0443 0.8637
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 458 196 image if available 2487 4852 502.4 108.13 28.97 67.04 323 396 462 498 525 549 572 595 625 0.1008 489 1.136 122.50 41.00 3 0.1186 295 0.0011 45.67 6.999 0.1815 264107.0
144000000
80400000000
45900000000000
0.4074 0.2236 0.0000 0.0000 0.0007 0.0017 0.0013 0.0017 0.0137 0.0038 0.0586 0.0196 0.1036 0.0325 0.0971 0.0282 0.1153 0.0440 0.6098 0.8684 0.0000 0.0000 0.0000 0.0017 0.0000 0.0017 0.0036 0.0038 0.0214 0.0196 0.0300 0.0311 0.0254 0.0230 0.0376 0.0358 0.8821 0.8834 0.0000 0.0000 0.0093 0.5000 0.0231 0.5000 0.0579 0.0000 0.1435 0.0000 0.2176 0.0000 0.0995 0.0000 0.1435 0.0000 0.3056 0.0000 0.0000 0.0021 0.0027 0.0103 0.0397 0.0637 0.0582 0.0794 0.7440 7 9 10 12 13 16 20 25 39 0.2290 1.64 2.351 0.8187 5332.5
2350000
1240000000
703000000000
0.6224 0.1004 0.0481 0.0325 0.0611 0.0293 0.0722 0.0357 0.0907 0.0325 0.1389 0.0523 0.1889 0.0722 0.1611 0.1094 0.1333 0.1665 0.1056 0.4695 0.0208 0.0226 0.0271 0.0203 0.0253 0.0231 0.0316 0.0220 0.0479 0.0365 0.0949 0.0602 0.0723 0.0747 0.1102 0.1169 0.5700 0.6238 0.0212 0.0086 0.0194 0.0107 0.0212 0.0086 0.0300 0.0193 0.0423 0.0428 0.0758 0.0600 0.0406 0.0450 0.0882 0.0878 0.6614 0.7173 0.0202 0.0265 0.0277 0.0429 0.0542 0.0845 0.0605 0.0782 0.6053
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 461 123 image if available 3257 6809 514.7 105.53 61.25 124.20 368 433 474 500 525 551 579 608 638 0.0824 561 0.766 87.00 16.03 3 0.0620 202 0.0010 52.75 7.148 0.1825 276060.0
153000000
86800000000
50400000000000
0.4286 0.2196 0.0000 0.0000 0.0014 0.0000 0.0068 0.0000 0.0140 0.0013 0.0512 0.0198 0.0978 0.0406 0.0965 0.0227 0.1277 0.0373 0.6046 0.8782 0.0000 0.0000 0.0000 0.0000 0.0004 0.0000 0.0029 0.0013 0.0220 0.0197 0.0447 0.0384 0.0293 0.0184 0.0411 0.0288 0.8596 0.8934 0.0077 0.1333 0.0173 0.1333 0.0288 0.0667 0.0865 0.1333 0.1404 0.2667 0.1442 0.1333 0.1231 0.0000 0.1654 0.1333 0.2865 0.0000 0.0011 0.0023 0.0079 0.0186 0.0514 0.0814 0.0729 0.1040 0.6605 7 9 11 12 14 19 31 56 175 0.1883 7.43 3.201 0.7374 19174.6
10600000
7360000000
5780000000000
0.4921 0.1647 0.0338 0.0142 0.0549 0.0252 0.0717 0.0377 0.0928 0.0660 0.1392 0.0849 0.1814 0.1289 0.2363 0.1321 0.1097 0.1525 0.0802 0.3585 0.0034 0.0045 0.0048 0.0078 0.0034 0.0111 0.0109 0.0167 0.0212 0.0279 0.0519 0.0507 0.0355 0.0423 0.0444 0.0591 0.8245 0.7799 0.0000 0.0000 0.0008 0.0000 0.0016 0.0000 0.0073 0.0078 0.0334 0.0336 0.0465 0.0509 0.0302 0.0259 0.0522 0.0578 0.8280 0.8240 0.0008 0.0008 0.0046 0.0106 0.0236 0.0540 0.0274 0.0547 0.8237
MDA-MB-231 A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 200 513 image if available 11296 11224 660.4 94.02 95.02 136.71 543 587 617 640 661 683 708 735 774 0.1009 1133 0.918 133.74 44.91 2 0.0313 353 0.0006 79.90 7.739 0.1635 444990.0
305000000
213000000000
152000000000000
0.4251 0.2228 0.0000 0.0000 0.0005 0.0000 0.0017 0.0000 0.0042 0.0006 0.0187 0.0081 0.0399 0.0182 0.0436 0.0113 0.0656 0.0181 0.8257 0.9436 0.0000 0.0000 0.0002 0.0000 0.0006 0.0000 0.0022 0.0004 0.0107 0.0077 0.0240 0.0167 0.0219 0.0084 0.0314 0.0139 0.9090 0.9530 0.0074 0.0816 0.0173 0.0204 0.0222 0.0408 0.0937 0.2245 0.0912 0.2245 0.1307 0.2041 0.1097 0.0816 0.1233 0.1224 0.4044 0.0000 0.0016 0.0026 0.0092 0.0209 0.0527 0.0772 0.0800 0.1071 0.6486 12 16 20 27 38 53 81 138 272 0.0564 8.94 4.344 0.6275 27717.6
13300000
8080000000
5720000000000
0.4886 0.1747 0.0110 0.0020 0.0386 0.0109 0.0684 0.0288 0.1323 0.0387 0.2183 0.1107 0.1940 0.1846 0.1147 0.1166 0.1422 0.1509 0.0805 0.3568 0.0009 0.0007 0.0031 0.0037 0.0037 0.0072 0.0119 0.0120 0.0417 0.0400 0.0716 0.0744 0.0409 0.0423 0.0707 0.0596 0.7555 0.7601 0.0008 0.0004 0.0011 0.0022 0.0042 0.0043 0.0168 0.0173 0.0348 0.0381 0.0880 0.0934 0.0513 0.0510 0.0677 0.0636 0.7353 0.7297 0.0007 0.0010 0.0036 0.0116 0.0416 0.0819 0.0459 0.0714 0.7423
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 919 900 image if available 2948 8244 666.3 129.72 46.17 98.68 485 545 590 628 667 705 744 787 840 0.0761 627 1.113 69.64 24.02 1 0.0580 171 0.0007 51.40 7.349 0.1601 460748.0
329000000
243000000000
184000000000000
0.3935 0.2423 0.0000 0.0000 0.0016 0.0000 0.0016 0.0000 0.0110 0.0014 0.0460 0.0183 0.0826 0.0341 0.0727 0.0251 0.1130 0.0389 0.6715 0.8822 0.0000 0.0000 0.0004 0.0000 0.0000 0.0000 0.0041 0.0007 0.0202 0.0156 0.0326 0.0302 0.0223 0.0156 0.0396 0.0282 0.8808 0.9097 0.0019 0.0000 0.0039 0.0476 0.0273 0.0476 0.0253 0.1905 0.0916 0.2857 0.1443 0.1190 0.1033 0.2381 0.1618 0.0714 0.4405 0.0000 0.0007 0.0007 0.0027 0.0115 0.0392 0.0635 0.0581 0.0878 0.7360 9 11 12 14 16 21 28 43 87 0.1378 4.69 3.060 0.7458 11867.4
6550000
4590000000
3630000000000
0.6519 0.0809 0.0058 0.0114 0.0378 0.0178 0.0683 0.0242 0.1541 0.0604 0.1788 0.0768 0.1788 0.1230 0.1541 0.1393 0.1424 0.1628 0.0799 0.3845 0.0010 0.0064 0.0066 0.0092 0.0082 0.0104 0.0255 0.0249 0.0541 0.0385 0.0745 0.0686 0.0760 0.0735 0.1102 0.0951 0.6439 0.6732 0.0008 0.0018 0.0063 0.0055 0.0181 0.0101 0.0291 0.0194 0.0708 0.0738 0.0904 0.1042 0.0818 0.0821 0.1344 0.1245 0.5684 0.5784 0.0032 0.0051 0.0154 0.0199 0.0656 0.0836 0.0855 0.1215 0.6000
Hs 578T A443654
1.1
uM
DRAQ5 1 TMRE 2 1 12 1 992 554 image if available 458 453 58.6 18.24 15.98 3.18 38 42 46 52 56 61 66 72 84 0.4040 183 0.735 110.07 27.07 1 0.6135 281 0.0119 5.25 4.713 0.4351 3769.0
265175
20300000
1680000000
0.3546 0.2594 0.0000 0.0000 0.0199 0.0000 0.0448 0.0000 0.0597 0.0052 0.1294 0.0735 0.2139 0.1417 0.1791 0.0761 0.1343 0.1155 0.2189 0.5879 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0164 0.0046 0.0656 0.0371 0.1049 0.0928 0.0721 0.0278 0.0951 0.0603 0.6459 0.7773 0.0096 0.0000 0.0000 0.0000 0.0096 0.0600 0.0673 0.1800 0.2019 0.1000 0.1731 0.2800 0.0865 0.1400 0.1635 0.0600 0.2885 0.1800 0.0000 0.0000 0.0048 0.0335 0.1435 0.1483 0.1100 0.1627 0.3971 12 13 14 15 16 17 17 18 20 0.8738 0.06 0.306 0.9702 265.5
4574.87
81636.7
1510000
0.5349 0.1049 0.0031 0.0000 0.0217 0.0000 0.0683 0.0046 0.1211 0.0207 0.2050 0.1359 0.1739 0.1544 0.1739 0.1613 0.1801 0.1521 0.0528 0.3710 0.0026 0.0000 0.0078 0.0000 0.0284 0.0045 0.0413 0.0089 0.1835 0.1250 0.1550 0.1473 0.1576 0.1518 0.1938 0.1384 0.2300 0.4241 0.2923 0.5000 0.1846 0.2143 0.1385 0.2143 0.1846 0.0714 0.1077 0.0000 0.0615 0.0000 0.0308 0.0000 0.0000 0.0000 0.0000 0.0000 0.0195 0.0586 0.1328 0.1445 0.1758 0.1680 0.1367 0.1055 0.0586
SK-BR-3
0
DRAQ5 1 TMRE 2 2 2 1 927 522 image if available 3614 6289 297.5 144.28 59.44 77.60 127 157 192 233 266 305 406 465 511 0.1040 654 1.229 109.25 47.52 2 0.0819 296 0.0028 6.07 6.131 0.4083 109347.0
45800000
20700000000
9820000000000
0.3640 0.2549 0.0012 0.0000 0.0012 0.0006 0.0036 0.0025 0.0324 0.0086 0.1032 0.0531 0.1429 0.0834 0.1273 0.0562 0.1020 0.0828 0.4862 0.7128 0.0005 0.0000 0.0005 0.0004 0.0005 0.0015 0.0076 0.0030 0.0219 0.0203 0.0343 0.0263 0.0281 0.0192 0.0357 0.0312 0.8710 0.8980 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0016 0.0039 0.0331 0.0347 0.0410 0.0597 0.0316 0.0414 0.0458 0.0462 0.8469 0.8141 0.0020 0.0013 0.0027 0.0054 0.0229 0.0404 0.0242 0.0310 0.8700 8 11 14 19 26 38 58 92 162 0.0962 2.42 3.459 0.6933 9553.8
2410000
755000000
271000000000
0.5400 0.1318 0.0018 0.0033 0.0126 0.0122 0.0650 0.0236 0.1733 0.0447 0.2365 0.0943 0.2166 0.1561 0.1480 0.1423 0.1137 0.1740 0.0325 0.3496 0.0000 0.0015 0.0005 0.0034 0.0032 0.0076 0.0142 0.0125 0.0500 0.0386 0.0866 0.0773 0.0596 0.0583 0.0830 0.0735 0.7030 0.7273 0.0000 0.0000 0.0012 0.0014 0.0037 0.0064 0.0197 0.0227 0.0614 0.0716 0.1020 0.1106 0.0694 0.0738 0.0860 0.0865 0.6566 0.6270 0.0011 0.0027 0.0043 0.0160 0.0543 0.1005 0.0660 0.0787 0.6766
MDA-MB-231 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 954 880 image if available 1679 5441 653.6 119.11 75.62 146.47 478 542 591 627 661 696 731 766 800 0.0884 481 0.755 132.23 36.35 1 0.2287 384 0.0009 82.04 7.094 0.1478 441315.0
307000000
218000000000
159000000000000
0.3946 0.2342 0.0000 0.0000 0.0000 0.0000 0.0009 0.0000 0.0086 0.0018 0.0522 0.0283 0.0779 0.0361 0.0693 0.0307 0.1259 0.0451 0.6652 0.8581 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0021 0.0018 0.0313 0.0281 0.0392 0.0329 0.0271 0.0257 0.0499 0.0418 0.8504 0.8698 0.0042 0.0000 0.0169 0.0000 0.0254 0.0000 0.0424 0.0000 0.0890 0.0000 0.1271 0.0000 0.1144 0.0000 0.1271 0.0000 0.4534 0.0000 0.0011 0.0011 0.0034 0.0103 0.0525 0.0627 0.0490 0.0855 0.7343 7 9 11 13 17 28 60 104 173 0.0733 1.76 2.761 0.5531 27168.4
17800000
14800000000
13800000000000
0.4065 0.2202 0.0128 0.0026 0.0204 0.0102 0.0510 0.0269 0.1301 0.0409 0.1913 0.0882 0.2041 0.1317 0.1735 0.1228 0.1301 0.2008 0.0867 0.3760 0.0000 0.0000 0.0000 0.0016 0.0018 0.0027 0.0092 0.0070 0.0308 0.0271 0.0450 0.0411 0.0431 0.0319 0.0603 0.0541 0.8097 0.8343 0.0008 0.0009 0.0000 0.0019 0.0049 0.0075 0.0130 0.0160 0.0381 0.0479 0.0657 0.0695 0.0536 0.0638 0.0869 0.0892 0.7370 0.7033 0.0000 0.0063 0.0042 0.0105 0.0359 0.0450 0.0549 0.0703 0.7729
MDA-MB-231 Barasertib
1.1
uM
DRAQ5 1 TMRE 2 1 16 1 886 459 image if available 3618 10342 579.4 120.00 16.41 14.61 402 502 541 570 596 621 644 667 707 0.0617 638 0.872 72.47 21.02 4 0.0506 183 0.0010 57.19 7.152 0.1994 350122.0
218000000
140000000000
91900000000000
0.4429 0.2126 0.0004 0.0000 0.0000 0.0003 0.0008 0.0006 0.0086 0.0012 0.0409 0.0173 0.0601 0.0352 0.0530 0.0212 0.0823 0.0391 0.7539 0.8852 0.0000 0.0000 0.0000 0.0003 0.0000 0.0006 0.0013 0.0009 0.0167 0.0167 0.0279 0.0301 0.0196 0.0140 0.0382 0.0289 0.8963 0.9084 0.0088 0.0000 0.0044 0.0980 0.0199 0.0000 0.0508 0.0980 0.1258 0.1569 0.1523 0.1765 0.1192 0.0588 0.1501 0.1373 0.3687 0.2745 0.0000 0.0005 0.0063 0.0146 0.0466 0.0777 0.0670 0.0869 0.7005 6 8 9 11 13 15 17 20 29 0.2798 0.41 1.932 0.8610 482.7
28156.6
2820000
388000000
0.4309 0.2072 0.0435 0.0205 0.0470 0.0372 0.0509 0.0455 0.0895 0.0516 0.1126 0.0612 0.1545 0.0846 0.2073 0.1008 0.1905 0.1706 0.1043 0.4280 0.0225 0.0151 0.0206 0.0257 0.0213 0.0301 0.0324 0.0319 0.0506 0.0421 0.0689 0.0635 0.0845 0.0648 0.1386 0.1026 0.5606 0.6242 0.0382 0.0267 0.0326 0.0130 0.0336 0.0298 0.0424 0.0360 0.0559 0.0477 0.0634 0.0701 0.0662 0.0775 0.1058 0.0967 0.5620 0.6026 0.0209 0.0300 0.0386 0.0551 0.0695 0.0973 0.0921 0.1086 0.4879
SK-BR-3 Barasertib
0.12
uM
DRAQ5 1 TMRE 2 2 15 1 524 311 image if available 7833 16316 159.4 129.05 84.65 174.06 65 76 86 97 114 131 150 185 382 0.0834 1360 1.188 60.96 23.71 5 0.0200 157 0.0057 7.18 5.903 0.4831 42052.4
16100000
7440000000
3750000000000
0.4134 0.2024 0.0022 0.0044 0.0039 0.0032 0.0061 0.0041 0.0335 0.0116 0.0754 0.0367 0.0972 0.0576 0.0972 0.0547 0.1056 0.0789 0.5788 0.7488 0.0012 0.0031 0.0021 0.0023 0.0027 0.0029 0.0140 0.0079 0.0273 0.0211 0.0334 0.0280 0.0404 0.0320 0.0507 0.0445 0.8282 0.8580 0.0007 0.0000 0.0007 0.0000 0.0033 0.0000 0.0086 0.0022 0.0213 0.0230 0.0452 0.0445 0.0219 0.0208 0.0359 0.0408 0.8625 0.8687 0.0005 0.0039 0.0043 0.0096 0.0294 0.0487 0.0352 0.0545 0.8140 8 10 12 15 18 24 39 87 242 0.1992 8.64 2.988 0.7068 37461.6
26400000
22100000000
20600000000000
0.5330 0.1352 0.0090 0.0029 0.0336 0.0070 0.0493 0.0187 0.1087 0.0531 0.1659 0.0904 0.1839 0.1376 0.1390 0.1405 0.1312 0.1359 0.1794 0.4140 0.0005 0.0009 0.0029 0.0023 0.0029 0.0042 0.0098 0.0168 0.0383 0.0349 0.0554 0.0519 0.0449 0.0496 0.0660 0.0575 0.7794 0.7817 0.0021 0.0004 0.0017 0.0035 0.0045 0.0047 0.0141 0.0116 0.0497 0.0520 0.0783 0.0849 0.0583 0.0621 0.0852 0.0791 0.7060 0.7017 0.0009 0.0033 0.0045 0.0117 0.0415 0.0667 0.0505 0.0739 0.7471
BT-20 A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 765 448 image if available 1036 4704 600.2 210.48 6.20 1.84 332 391 444 509 577 659 743 818 904 0.0897 422 1.225 53.31 21.95 1 0.1332 138 0.0016 24.08 6.554 0.2404 404516.0
298000000
234000000000
192000000000000
0.3419 0.2894 0.0000 0.0000 0.0000 0.0000 0.0000 0.0014 0.0031 0.0043 0.1242 0.0558 0.2329 0.1016 0.1304 0.0629 0.1739 0.0801 0.3354 0.6938 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0011 0.0392 0.0339 0.0633 0.0532 0.0271 0.0271 0.0542 0.0407 0.8163 0.8439 0.0000 0.0000 0.0000 0.0000 0.0000 0.0000 0.0058 0.0324 0.0585 0.0649 0.0848 0.1135 0.0409 0.0757 0.0673 0.0811 0.7427 0.6324 0.0000 0.0000 0.0021 0.0062 0.0374 0.0811 0.0395 0.0457 0.7879 4 5 5 6 6 7 7 8 8 0.0274 6.20 3.980 0.3875 41.8
302.145
2320.55
18932.6
0.4537 0.1856 0.0023 0.0005 0.0113 0.0013 0.0441 0.0090 0.1027 0.0249 0.1782 0.0542 0.2398 0.1111 0.2262 0.2325 0.1613 0.3262 0.0341 0.2402 0.0000 0.0000 0.0017 0.0005 0.0047 0.0016 0.0231 0.0099 0.0540 0.0309 0.1005 0.0574 0.1816 0.1030 0.3028 0.2870 0.3314 0.5097 0.1740 0.3416 0.2290 0.2805 0.1980 0.1584 0.1530 0.1041 0.1140 0.0679 0.0770 0.0181 0.0260 0.0158 0.0230 0.0090 0.0060 0.0045 0.0029 0.0141 0.0417 0.0959 0.1617 0.2172 0.2159 0.1543 0.0962
MCF 10A A443654
10
uM
DRAQ5 1 TMRE 2 1 11 1 797 276 image if available 3081 14857 257.1 73.60 95.99 124.19 175 187 202 218 241 266 296 325 367 0.0703 1045 0.709 60.54 16.03 2 0.0568 175 0.0097 3.01 5.047 0.5308 71538.3
21500000
6880000000
2330000000000
0.3683 0.2682 0.0023 0.0000 0.0053 0.0000 0.0107 0.0015 0.0328 0.0041 0.0710 0.0354 0.1154 0.0479 0.1054 0.0420 0.1398 0.0593 0.5172 0.8099 0.0014 0.0000 0.0019 0.0000 0.0043 0.0007 0.0125 0.0013 0.0288 0.0202 0.0389 0.0276 0.0408 0.0189 0.0504 0.0315 0.8209 0.8998 0.0013 0.0000 0.0000 0.0111 0.0090 0.0028 0.0168 0.0306 0.0530 0.0889 0.0917 0.1306 0.0646 0.1139 0.0904 0.1500 0.6731 0.4722 0.0015 0.0015 0.0052 0.0126 0.0238 0.0535 0.0416 0.0558 0.8045 12 19 29 42 54 70 95 135 230 0.0663 4.54 3.869 0.7237 24635.6
11400000
7270000000
5520000000000
0.4425 0.1810 0.0092 0.0039 0.0252 0.0102 0.0406 0.0158 0.0729 0.0304 0.1237 0.0621 0.1566 0.0900 0.1494 0.0954 0.1869 0.1280 0.2356 0.5641 0.0025 0.0017 0.0033 0.0049 0.0040 0.0052 0.0113 0.0100 0.0302 0.0240 0.0458 0.0344 0.0473 0.0408 0.0691 0.0611 0.7864 0.8179 0.0008 0.0007 0.0034 0.0027 0.0059 0.0050 0.0163 0.0174 0.0487 0.0557 0.0704 0.0795 0.0637 0.0651 0.0789 0.0849 0.7118 0.6890 0.0011 0.0052 0.0059 0.0142 0.0363 0.0542 0.0582 0.0716 0.7533