Phosphorylation state and protein levels measured in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20219)
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| Small Molecule | Cell Line | 2nd Drug | Drug Concentration | Conc Unit | Time Point | Time Point Unit | Image | Measured Protein (Alexa Fluor 488) | Measured Protein Value (488) | Measured Protein (Alexa Fluor 568) | Measured Protein Value (568) | Measured Protein (Alexa Fluor 647) | Measured Protein Value (647) | Replicate | Plate Name | Plate Well |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 737.49 | p-Rb(S807/S811) | 41.43 | p-cJun(S73) | 27.30 | 1 | WM115-signal3 | F5 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 783.22 | p-Rb(S807/S811) | 57.39 | p-cJun(S73) | 35.93 | 1 | WM115-signal3 | F6 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 863.33 | p-Rb(S807/S811) | 76.07 | p-cJun(S73) | 41.68 | 1 | WM115-signal3 | F7 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 795.90 | p-Rb(S807/S811) | 74.91 | p-cJun(S73) | 44.16 | 1 | WM115-signal3 | F8 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 782.06 | p-Rb(S807/S811) | 76.06 | p-cJun(S73) | 46.14 | 1 | WM115-signal3 | F9 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0033 | uM | 24 | hr | | Ki-67 | 698.42 | p-Rb(S807/S811) | 71.10 | p-cJun(S73) | 47.45 | 2 | WM115-signal3 | G10 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0000 | uM | 24 | hr | | Ki-67 | 696.53 | p-Rb(S807/S811) | 75.37 | p-cJun(S73) | 50.95 | 2 | WM115-signal3 | G11 |
| Vemurafenib | WM-115 | JNK-IN-8 | 5.0000 | uM | 24 | hr | | Ki-67 | 637.76 | p-Rb(S807/S811) | 61.90 | p-cJun(S73) | 19.77 | 2 | WM115-signal3 | G2 |
| Vemurafenib | WM-115 | JNK-IN-8 | 2.0000 | uM | 24 | hr | | Ki-67 | 657.65 | p-Rb(S807/S811) | 46.72 | p-cJun(S73) | 17.87 | 2 | WM115-signal3 | G3 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.8000 | uM | 24 | hr | | Ki-67 | 682.82 | p-Rb(S807/S811) | 40.64 | p-cJun(S73) | 20.31 | 2 | WM115-signal3 | G4 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.3200 | uM | 24 | hr | | Ki-67 | 738.56 | p-Rb(S807/S811) | 42.13 | p-cJun(S73) | 27.75 | 2 | WM115-signal3 | G5 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.1280 | uM | 24 | hr | | Ki-67 | 779.71 | p-Rb(S807/S811) | 58.29 | p-cJun(S73) | 34.35 | 2 | WM115-signal3 | G6 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0512 | uM | 24 | hr | | Ki-67 | 764.21 | p-Rb(S807/S811) | 71.74 | p-cJun(S73) | 39.60 | 2 | WM115-signal3 | G7 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0205 | uM | 24 | hr | | Ki-67 | 796.29 | p-Rb(S807/S811) | 74.93 | p-cJun(S73) | 42.86 | 2 | WM115-signal3 | G8 |
| Vemurafenib | WM-115 | JNK-IN-8 | 0.0082 | uM | 24 | hr | | Ki-67 | 732.41 | p-Rb(S807/S811) | 74.91 | p-cJun(S73) | 46.30 | 2 | WM115-signal3 | G9 |
| Vemurafenib | WM1552C | 0.0033 | uM | 24 | hr | | p27 Kip1 | 246.89 | p-Rb(S807/S811) | 106.93 | p-ERK(T202/Y204) | 243.94 | 1 | WM1552C-signal1 | B10 | |
| Vemurafenib | WM1552C | 0.0000 | uM | 24 | hr | | p27 Kip1 | 243.77 | p-Rb(S807/S811) | 107.70 | p-ERK(T202/Y204) | 254.74 | 1 | WM1552C-signal1 | B11 | |
| Vemurafenib | WM1552C | 5.0000 | uM | 24 | hr | | p27 Kip1 | 446.61 | p-Rb(S807/S811) | 44.76 | p-ERK(T202/Y204) | 19.95 | 1 | WM1552C-signal1 | B2 | |
| Vemurafenib | WM1552C | 2.0000 | uM | 24 | hr | | p27 Kip1 | 473.39 | p-Rb(S807/S811) | 42.61 | p-ERK(T202/Y204) | 22.62 | 1 | WM1552C-signal1 | B3 | |
| Vemurafenib | WM1552C | 0.8000 | uM | 24 | hr | | p27 Kip1 | 442.40 | p-Rb(S807/S811) | 51.64 | p-ERK(T202/Y204) | 26.95 | 1 | WM1552C-signal1 | B4 | |
| Vemurafenib | WM1552C | 0.3200 | uM | 24 | hr | | p27 Kip1 | 337.86 | p-Rb(S807/S811) | 61.82 | p-ERK(T202/Y204) | 50.97 | 1 | WM1552C-signal1 | B5 | |
| Vemurafenib | WM1552C | 0.1280 | uM | 24 | hr | | p27 Kip1 | 284.96 | p-Rb(S807/S811) | 88.69 | p-ERK(T202/Y204) | 119.29 | 1 | WM1552C-signal1 | B6 | |
| Vemurafenib | WM1552C | 0.0512 | uM | 24 | hr | | p27 Kip1 | 269.92 | p-Rb(S807/S811) | 94.99 | p-ERK(T202/Y204) | 160.06 | 1 | WM1552C-signal1 | B7 | |
| Vemurafenib | WM1552C | 0.0205 | uM | 24 | hr | | p27 Kip1 | 252.92 | p-Rb(S807/S811) | 100.14 | p-ERK(T202/Y204) | 207.93 | 1 | WM1552C-signal1 | B8 | |
| Vemurafenib | WM1552C | 0.0082 | uM | 24 | hr | | p27 Kip1 | 242.69 | p-Rb(S807/S811) | 101.68 | p-ERK(T202/Y204) | 236.72 | 1 | WM1552C-signal1 | B9 |