Viability and apoptosis in BRAF(V600E/D) melanoma cell lines monitored by imaging - Dataset (ID:20217)

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Small Molecule Cell Line Drug Concentration Conc Unit Time Point Time Point Unit Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction Replicate
Selumetinib COLO 858 1.0000
uM
 72
hr
 1227 275 0.3458 0.3419 0.2241 0.2586 2
Selumetinib COLO 858 1.0000
uM
 72
hr
 1188 367 0.2982 0.3419 0.3089 0.2586 3
Selumetinib COLO 858 1.0000
uM
 72
hr
 1419 331 0.3952 0.3419 0.2333 0.2586 4
Selumetinib COLO 858 3.1600
uM
 24
hr
 3827 528 1.1020 0.8558 0.1380 0.1486 1
Selumetinib COLO 858 3.1600
uM
 24
hr
 3852 632 1.0756 0.8558 0.1641 0.1486 2
Selumetinib COLO 858 3.1600
uM
 24
hr
 2227 337 0.6313 0.8558 0.1513 0.1486 3
Selumetinib COLO 858 3.1600
uM
 24
hr
 2141 302 0.6143 0.8558 0.1411 0.1486 4
Selumetinib COLO 858 3.1600
uM
 48
hr
 1867 476 0.3178 0.3147 0.2550 0.3128 1
Selumetinib COLO 858 3.1600
uM
 48
hr
 1935 548 0.3169 0.3147 0.2832 0.3128 2
Selumetinib COLO 858 3.1600
uM
 48
hr
 2105 776 0.3037 0.3147 0.3687 0.3128 3
Selumetinib COLO 858 3.1600
uM
 48
hr
 2138 736 0.3203 0.3147 0.3443 0.3128 4
Selumetinib COLO 858 3.1600
uM
 72
hr
 1251 482 0.2793 0.2801 0.3853 0.3831 1
Selumetinib COLO 858 3.1600
uM
 72
hr
 1257 433 0.2993 0.2801 0.3445 0.3831 2
Selumetinib COLO 858 3.1600
uM
 72
hr
 1217 526 0.2510 0.2801 0.4322 0.3831 3
Selumetinib COLO 858 3.1600
uM
 72
hr
 1271 471 0.2906 0.2801 0.3706 0.3831 4
Vemurafenib COLO 858 0.0032
uM
 24
hr
 3250 162 1.0315 0.7818 0.0498 0.0468 1
Vemurafenib COLO 858 0.0032
uM
 24
hr
 3561 190 1.1260 0.7818 0.0534 0.0468 2
Vemurafenib COLO 858 0.0032
uM
 24
hr
 1406 72 0.4456 0.7818 0.0512 0.0468 3
Vemurafenib COLO 858 0.0032
uM
 24
hr
 1622 53 0.5241 0.7818 0.0327 0.0468 4
Vemurafenib COLO 858 0.0032
uM
 48
hr
 4071 171 0.8911 0.9264 0.0420 0.0487 1
Vemurafenib COLO 858 0.0032
uM
 48
hr
 4509 236 0.9763 0.9264 0.0523 0.0487 2
Vemurafenib COLO 858 0.0032
uM
 48
hr
 4356 183 0.9535 0.9264 0.0420 0.0487 3
Vemurafenib COLO 858 0.0032
uM
 48
hr
 4114 241 0.8849 0.9264 0.0586 0.0487 4
Vemurafenib COLO 858 0.0032
uM
 72
hr
 3740 309 1.2462 1.2088 0.0826 0.0879 1
Vemurafenib COLO 858 0.0032
uM
 72
hr
 3397 295 1.1267 1.2088 0.0868 0.0879 2